Cannabinoid receptor expression in non-small cell lung cancer. Effectiveness of tetrahydrocannabinol and cannabidiol inhibiting cell proliferation and epithelial-mesenchymal transition in vitro.
Lara MilianManuel MataJavier AlcacerMaría OliverMaría Sancho-TelloJosé Javier Martín de LlanoCarlos CampsJosé GalbisJulian CarreteroCarmen CardaPublished in: PloS one (2020)
The expression levels of CB1 and CB2 have a potential use as markers of survival in patients with NSCLC. THC and CBD inhibited the proliferation and expression of EGFR in the lung cancer cells studied. Finally, the THC/CBD combination restored the epithelial phenotype in vitro.
Keyphrases
- epithelial mesenchymal transition
- poor prognosis
- small cell lung cancer
- signaling pathway
- cell proliferation
- randomized controlled trial
- systematic review
- epidermal growth factor receptor
- tyrosine kinase
- pi k akt
- transforming growth factor
- long non coding rna
- advanced non small cell lung cancer
- risk assessment
- brain metastases