Preventive Intervention Program on the Outcomes of Very Preterm Infants and Caregivers: A Multicenter Randomized Controlled Trial.
Young-Ah YounSeung-Han ShinEe Kyung KimHye-Jeong JinYoung-Hwa JungJu Sun HeoJi-Hyun JeonJoo-Hyun ParkIn-Kyung SungPublished in: Brain sciences (2021)
Increased survival in the very preterm population results in a higher risk of developing neurodevelopmental and behavioral disabilities among survivors. We examined the outcomes of very preterm infants and parents after a preventive intervention program of four home visits by a specialized nurse, 5 days, 2 weeks, and 1 month after discharge, respectively, and at CA 2 months, followed by up to 12 times of group sessions between CA 3 and 6 months. Our multicenter randomized controlled trial assessed 138 preterm infants (gestational age ≤30 weeks or birth weight ≤1500 g) enrolled from the three participating hospitals. We randomly allocated the preterm babies to either the intervention or the control group. The primary outcome was the neurodevelopmental outcomes of Bayley-III scores at CA 10 and 24 months. At CA 10 months and 24 months, there were no significant differences between the intervention and control groups in the cognitive, motor, and language domains of Bayley-III scores. In addition, there were no significant differences in the mother's depression scale, mother-child attachment, and the modified Infant and Toddler Social and Emotional Assessment.
Keyphrases
- gestational age
- randomized controlled trial
- preterm infants
- birth weight
- low birth weight
- preterm birth
- study protocol
- healthcare
- palliative care
- mental health
- autism spectrum disorder
- cross sectional
- primary care
- systematic review
- young adults
- physical activity
- quality improvement
- metabolic syndrome
- clinical trial
- type diabetes
- weight loss
- adipose tissue
- skeletal muscle
- meta analyses
- congenital heart disease
- free survival