Effectiveness and tolerability of dolutegravir and abacavir/lamivudine administered as two separate pills compared to their equivalent single-tablet regimen in a multicentre cohort in Spain.

Inés Suárez-GarcíaBelén AlejosMarta Ruiz-AlgueróCristina García YuberoCristina MorenoEnrique BernalLaura Pérez-IsZuriñe ZuberoMiguel Alberto de Zárraga FernándezGloria Samperiz AbadInmaculada Jarrínnull null

Published in: Journal of the International AIDS Society (2021)

In naïve individuals, the effectiveness and tolerability at 24 weeks of DTG plus ABC/3TC administered as two separate pills, either as branded or generic ABC/3TC, was similar to the STR DTG/ABC/3TC. Switching the STR DTG/ABC/3TC to its separate components DTG+(ABC/3TC)g in virologically suppressed individuals did not seem to impair its effectiveness.

Keyphrases

randomized controlled trial
systematic review
hiv infected patients
open label
double blind
hiv infected
antiretroviral therapy
cross sectional