Long Non-Coding RNA and Breast Cancer.
Tianzhu ZhangHui HuGe YanTangwei WuShuiyi LiuWeiqun ChenYong NingZhongxin LuPublished in: Technology in cancer research & treatment (2020)
Breast cancer, one of the most common diseases among women, is regarded as a heterogeneous and complicated disease that remains a major public health concern. Recently, owing to the development of next-generation sequencing technologies, long non-coding RNAs have received extensive attention. Numerous studies reveal that long non-coding RNAs are playing important roles in tumor development. Although the biological function and molecular mechanisms of long non-coding RNAs remain enigmatic, recent researchers have demonstrated that an array of long non-coding RNAs express abnormally in cancers, including breast cancer. Herein, we summarized the latest literature about long non-coding RNAs in breast cancer, with a particular focus on the multiple molecular roles of regulatory long non-coding RNAs that regulate cell proliferation, invasion, metastasis, and apoptosis.
Keyphrases
- long non coding rna
- poor prognosis
- public health
- cell proliferation
- breast cancer risk
- oxidative stress
- systematic review
- transcription factor
- gene expression
- genome wide
- endoplasmic reticulum stress
- polycystic ovary syndrome
- cell death
- signaling pathway
- skeletal muscle
- high throughput
- copy number
- mass spectrometry
- single molecule
- global health