Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies.
Elmar W TobiDiana L Juvinao-QuinteroJustiina RonkainenRaffael OttRossella AlfanoMickaël CanouilMadelon L GeurtsenAmna KhamisLeanne K KüpersIves Y LimPatrice PerronGiancarlo PesceJohanna TuhkanenAnne P StarlingToby AndrewElisabeth BinderRobert CaiazzoJerry K Y ChanRomy GaillardPeter D GluckmanElina KeikkalaNeerja KarnaniSanna MustaniemiTim S NawrotFrançois PattouMichelle PlusquinVioleta RaverdyKok Hian TanEvangelia TzalaKatri RaikkonenChristiane WinklerAnette-Gabriele ZieglerIsabella Annesi-MaesanoLuigi BouchardYap-Seng ChongDana DabeleaJanine F FelixBarbara HeudeVincent W V JaddoeJari LahtiBrigitte ReimannMarja VääräsmäkiAmélie BonnefondPhillippe FroguelSandra HummelEero KajantieMarjo-Riita JarvelinRegine P M Steegers-TheunissenCaitlin G HoweMarie-France HivertSylvain SebertPublished in: Diabetes care (2022)
Maternal hyperglycemia, as reflected by AUCgluc, was associated with lower cord blood DNAm at TXNIP. Associations between DNAm at these CpGs and metabolic traits in subsequent lookup analyses suggest that these may be candidate loci to investigate in future causal and mediation analyses.