Drug development research

Keyphrases

Publications

volume 85, number 4, 2024

Junbing He, Wanbing Qin, Shusong Jiang, Yao Lin, Yingying Lin, Ruoxuan Yang, Mingwei Xu, Qinghua Liu
Oxymatrine attenuates sepsis-induced inflammation and organ injury via inhibition of HMGB1/RAGE/NF-κB signaling pathway. Drug development research 85 (4) (2024)
Wael A A Fadaly, Yaseen A M M Elshaier, Fares E M Ali, Ali H El-Bahrawy, Khaled R A Abdellatif, Mohamed T M Nemr
Vicinal diaryl pyrazole with tetrazole/urea scaffolds as selective angiotensin converting enzyme-1/cyclooxygenase-2 inhibitors: Design, synthesis, anti-hypertensive, anti-fibrotic, and anti-inflammatory. Drug development research 85 (4) (2024)
Abrar Ahmad Zargar
Vedolizumab in the treatment of Crohn's disease: A promising therapeutic approach. Drug development research 85 (4) (2024)
Xiangyu Chen, Binghua Sun, Shuai Li
Downregulation of HIGD1B induces mitochondria-mediated apoptosis in gastric cancer cells by inactivating Akt and ERK pathways. Drug development research 85 (4) (2024)
Abrar Ahmad Zargar
Vedolizumab in the treatment of Crohn's disease: A promising therapeutic approach. Drug development research 85 (4) (2024)
Junbing He, Wanbing Qin, Shusong Jiang, Yao Lin, Yingying Lin, Ruoxuan Yang, Mingwei Xu, Qinghua Liu
Oxymatrine attenuates sepsis-induced inflammation and organ injury via inhibition of HMGB1/RAGE/NF-κB signaling pathway. Drug development research 85 (4) (2024)
Selen Gozde Kaya, Gokcen Eren, Alberto Massarotti, Filiz Bakar-Ates, Erva Ozkan, Mahmut Gozelle, Yesim Ozkan
2-(Methyl(phenyl)amino)-N-(phenyloxyphenyl)acetamide structural motif representing a framework for selective SIRT2 inhibition. Drug development research 85 (4) (2024)

volume 85, number 5, 2024

Dalia S El-Gamil, Mohamed Y Zaky, Patrick M Maximous, Marwa Sharaky, Ahmed M El-Dessouki, Noura M Riad, Saad Shaaban, Mohammad Abdel-Halim, Ahmed Ali Al-Karmalawy
Exploring chromone-2-carboxamide derivatives for triple-negative breast cancer targeting EGFR, FGFR3, and VEGF pathways: Design, synthesis, and preclinical insights. Drug development research 85 (5) (2024)
Zainah Al-Qahtani, Hayder M Al-Kuraishy, Naif H Ali, Yasser Hosny Ali Elewa, Gaber El-Saber Batiha
Kynurenine pathway in type 2 diabetes: Role of metformin. Drug development research 85 (5) (2024)
Yasaman Kiani Doustvaghe, Azadeh Haeri, Mahsa Mollapour Sisakht, Mohammad Amir Amirkhani, Hossein Vatanpour
Recombinant human epidermal growth factor-loaded liposomes and transferosomes for dermal delivery: Development, characterization, and cytotoxicity evaluation. Drug development research 85 (5) (2024)
Abu Sufiyan Chhipa, Ayush Sharma, Srashti Verma, Snehal S Patel
Therapeutic effects of tilorone on mammary carcinogenesis through downregulation of pro-inflammatory cytokines and oxidative stress. Drug development research 85 (5) (2024)
Farag E S Mosa, Mohammed A Alqahtani, Mahmoud A El-Ghiaty, Jason R B Dyck, Khaled Barakat, Ayman O S Ei-Kadi
Identification of aryl hydrocarbon receptor allosteric antagonists from clinically approved drugs. Drug development research 85 (5) (2024)
Xingyi Du, Xingxing Yang, Jianyuan Zhao, Jinyan Zhang, Jiahui Yu, Ling Ma, Weina Zhang, Shan Cen, Xuhong Ren, Xinhua He
Design of novel broad-spectrum antiviral nucleoside analogues using natural bases ring-opening strategy. Drug development research 85 (5) (2024)
Yasaman Kiani Doustvaghe, Azadeh Haeri, Mahsa Mollapour Sisakht, Mohammad Amir Amirkhani, Hossein Vatanpour
Recombinant human epidermal growth factor-loaded liposomes and transferosomes for dermal delivery: Development, characterization, and cytotoxicity evaluation. Drug development research 85 (5) (2024)
Xiaowen Wang, Linyu Su, Chong Niu, Xiao Li, Ruijie Wang, Bo Li, Sha Liu, Yuwen Xu
Targeted degradation of KRAS protein in non-small cell lung cancer: Therapeutic strategies using liposomal PROTACs with enhanced cellular uptake and pharmacokinetic profiles. Drug development research 85 (5) (2024)
Jane Tchekalarova, Daniela Pechlivanova, Miroslav Rangelov, Nadezda Todorova, Tsveta Stoyanova, Borislav Assenov, Petar Todorov
A novel cinnamic and caffeic acid-conjugated peptide analogs with anticonvulsant and analgesic potency: Comparative analyses of trans/cis isomers. Drug development research 85 (5) (2024)
Chuankun Li, Ruichun Li, Yuan Wang, Haitao Jiang
Inhibition of the TCF12/VSIG4 axis by palbociclib diminishes the proliferation and migration of glioma cells and decreases the M2 polarization of glioma-associated microglia. Drug development research 85 (5) (2024)
Xiaowen Wang, Linyu Su, Chong Niu, Xiao Li, Ruijie Wang, Bo Li, Sha Liu, Yuwen Xu
Targeted degradation of KRAS protein in non-small cell lung cancer: Therapeutic strategies using liposomal PROTACs with enhanced cellular uptake and pharmacokinetic profiles. Drug development research 85 (5) (2024)
Fatih Tok, Nimet Baltaş, Burçin İrem Abas, Gizem Tatar Yılmaz, Süleyman Kaya, Bedia Koçyiğit-Kaymakçıoğlu, Özge Çevik
Design, synthesis, molecular modeling, in vitro evaluation of novel piperidine-containing hydrazone derivatives as cholinesterase inhibitors. Drug development research 85 (5) (2024)
Xinke Chen, Lijuan Ouyang, Ning Ke, Lianhong Pi, Xiyuan Zhou
Study on the role of MYCN in retinoblastoma by inhibiting p53 and activating wnt/βcatenin/Fra-1 signaling pathway by reducing DKK3. Drug development research 85 (5) (2024)
Zohreh Jahanafrooz, Fatemeh Oroojalian, Ahad Mokhtarzadeh, Abbas Rahdar, Ana Maria Diez-Pascual
Nanovaccines: Immunogenic tumor antigens, targeted delivery, and combination therapy to enhance cancer immunotherapy. Drug development research 85 (5) (2024)
Yanzhen Yu, Yunzhen Hu, Huihui Yan, Xin Zeng, Haodong Yang, Lei Xu, Rong Sheng
Discovery of 5-(1-benzyl-1H-imidazol-4-yl)-1,2,4-oxadiazole derivatives as novel RIPK1 inhibitors via structure-based virtual screening. Drug development research 85 (5) (2024)
Chuankun Li, Ruichun Li, Yuan Wang, Haitao Jiang
Inhibition of the TCF12/VSIG4 axis by palbociclib diminishes the proliferation and migration of glioma cells and decreases the M2 polarization of glioma-associated microglia. Drug development research 85 (5) (2024)
Merve Karpuz, Husniye Hande Aydin, Emre Ozgenc, Gulsah Erel-Akbaba, Evren Atlihan-Gundogdu, Zeynep Senyigit
99m Tc-labeled, tofacitinib citrate encapsulated chitosan microspheres loaded in situ gel formulations for intra-articular treatment of rheumatoid arthritis. Drug development research 85 (5) (2024)
Yanzhen Yu, Yunzhen Hu, Huihui Yan, Xin Zeng, Haodong Yang, Lei Xu, Rong Sheng
Discovery of 5-(1-benzyl-1H-imidazol-4-yl)-1,2,4-oxadiazole derivatives as novel RIPK1 inhibitors via structure-based virtual screening. Drug development research 85 (5) (2024)
Farag E S Mosa, Mohammed A Alqahtani, Mahmoud A El-Ghiaty, Jason R B Dyck, Khaled Barakat, Ayman O S Ei-Kadi
Identification of aryl hydrocarbon receptor allosteric antagonists from clinically approved drugs. Drug development research 85 (5) (2024)
Dalia S El-Gamil, Mohamed Y Zaky, Patrick M Maximous, Marwa Sharaky, Ahmed M El-Dessouki, Noura M Riad, Saad Shaaban, Mohammad Abdel-Halim, Ahmed Ali Al-Karmalawy
Exploring chromone-2-carboxamide derivatives for triple-negative breast cancer targeting EGFR, FGFR3, and VEGF pathways: Design, synthesis, and preclinical insights. Drug development research 85 (5) (2024)
Hiba N Alsaad, Baan M Al-Jasani, Ammar A Razzak Mahmood, Lubna H Tahtamouni, Khaled M M Saleh, Mai F AlSakhen, Sana I Kanaan, Salem R Yasin
Novel 1,3,4-oxadiazole derivatives of naproxen targeting EGFR: Synthesis, molecular docking studies, and cytotoxic evaluation. Drug development research 85 (5) (2024)
David Gurwitz, Rachel Steeg
Enriching iPSC research diversity: Harnessing human biobank collections for improved ethnic representation. Drug development research 85 (5) (2024)
Gulseren Turhal, Busra Demirkan, Izel Nermin Baslilar, Nimet Sule Yuncu, Sultan Nacak Baytas, Asuman Demiroglu-Zergeroglu
Preliminary evaluation of antiproliferative and apoptotic activities of novel indolin-2-one derivatives. Drug development research 85 (5) (2024)
Xinke Chen, Lijuan Ouyang, Ning Ke, Lianhong Pi, Xiyuan Zhou
Study on the role of MYCN in retinoblastoma by inhibiting p53 and activating wnt/βcatenin/Fra-1 signaling pathway by reducing DKK3. Drug development research 85 (5) (2024)
Anju Agnes Tom, Vinoth Rajendran, Ahammed Ameen Thottasseri, Koustav Goswami, Souvik Roy, Gopika Gopan, Maheswaran Mani, Tharanikkarasu Kannan
Antiplasmodial action of 4-nitrobenzenesulfonamide chalcones: Design, synthesis, characterisation, in vitro and in silico evaluation against blood stages of Plasmodium falciparum 3D7. Drug development research 85 (5) (2024)
David Gurwitz, Rachel Steeg
Enriching iPSC research diversity: Harnessing human biobank collections for improved ethnic representation. Drug development research 85 (5) (2024)

volume 85, number 6, 2024

Muhammad Torequl Islam, Raihan Chowdhury, Md Shimul Bhuia, Brototi Chakrabarty, Neloy Kundu, Md Showkot Akbor, Salehin Sheikh, Rokibul Islam Chowdhury, Siddique Akber Ansari, Irfan Aamer Ansari, Md Amirul Islam
Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5-HT 2A and D 2 receptor interaction pathways. Drug development research 85 (6) (2024)
Ming Jin, Kun He, Shuqing Zhen, Yanqiao Wang, Huifang Guo, Hongxia Shen, Fumin Ping
Asiaticoside enhances the effect of propofol on the invasion, ferroptosis and immune escape of bladder cancer. Drug development research 85 (6) (2024)
Sonaly Akter Mukty, Rubel Hasan, Md Shimul Bhuia, Anik Kumar Saha, Umme Sadea Rahman, Mst Muslima Khatun, Sumaya Akter Bithi, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam
Assessment of sedative activity of fraxin: In vivo approach along with receptor binding affinity and molecular interaction with GABAergic system. Drug development research 85 (6) (2024)
Dilara Koc, Kubra Ibis, Peri Besarat, Erden Banoglu, Erkan Kiris
Tirbanibulin (KX2-391) analog KX2-361 inhibits botulinum neurotoxin serotype A mediated SNAP-25 cleavage in pre- and post-intoxication models in cells. Drug development research 85 (6) (2024)
Chen Zhao, Yuan Zeng, Nannan Kang, Yu Liu
A new perspective on antiangiogenic antibody drug resistance: Biomarkers, mechanisms, and strategies in malignancies. Drug development research 85 (6) (2024)
Heba T Abdel-Mohsen, Amira M Nageeb, Iman A Y Ghannam
Diphenyl urea-benzylidene acetohydrazide hybrids as fibroblast growth factor receptor 1 inhibitors and anticancer agents. Drug development research 85 (6) (2024)
Parteek Prasher, Mousmee Sharma
Starch-based "smart" nanomicelles: Potential delivery systems for doxorubicin. Drug development research 85 (6) (2024)
Dan-Dan Shen, Yue-Lin Zhang, Xiang Li, Yi-Ru Bai, Jun-Feng Xiong, Dong-Jie Seng, Yao-Dong Zhang, Hong-Min Liu, Shuo Yuan, Li Yang
The mechanism of action and chemical synthesis of FDA newly approved drug molecules. Drug development research 85 (6) (2024)
Sandip K Baidya, Tarun Patel, Ambati Himaja, Suvankar Banerjee, Sanjib Das, Balaram Ghosh, Tarun Jha, Nilanjan Adhikari
Biphenylsulfonamides as effective MMP-2 inhibitors with promising antileukemic efficacy: Synthesis, in vitro biological evaluation, molecular docking, and MD simulation analysis. Drug development research 85 (6) (2024)
Dilara Koc, Kubra Ibis, Peri Besarat, Erden Banoglu, Erkan Kiris
Tirbanibulin (KX2-391) analog KX2-361 inhibits botulinum neurotoxin serotype A mediated SNAP-25 cleavage in pre- and post-intoxication models in cells. Drug development research 85 (6) (2024)
Hui-Tong Chen, Xing-Yi Yuan, Zhong-Yu Wang, Dong Fan, Xiong-Ming Luo, Jun-Hua Yang, Yu-Xin Ma, Jing Liu, Xin Wang, Zong-Ming Wang
Induction of apoptosis by oridonin in nonfunctioning pituitary adenoma cells. Drug development research 85 (6) (2024)
Heba T Abdel-Mohsen, Amira M Nageeb, Iman A Y Ghannam
Diphenyl urea-benzylidene acetohydrazide hybrids as fibroblast growth factor receptor 1 inhibitors and anticancer agents. Drug development research 85 (6) (2024)
Sweety Mittal, Chandan Kumar, Laxmi Jha, Madhava B Mallia
A thiourea-bridged 99m Tc(CO) 3 -dipicolylamine-2-nitroimidazole complex for targeting tumor hypoxia: Utilizing metabolizable thiourea-bridge to improve pharmacokinetics. Drug development research 85 (6) (2024)
Sandip K Baidya, Tarun Patel, Ambati Himaja, Suvankar Banerjee, Sanjib Das, Balaram Ghosh, Tarun Jha, Nilanjan Adhikari
Biphenylsulfonamides as effective MMP-2 inhibitors with promising antileukemic efficacy: Synthesis, in vitro biological evaluation, molecular docking, and MD simulation analysis. Drug development research 85 (6) (2024)
Mei Mao, Wen Zeng, Yan Zheng, Wen Fan, Yuanrong Yao
Fasudil attenuates syncytin-1-mediated activation of microglia and impairments of motor neurons and motor function in mice. Drug development research 85 (6) (2024)
Chaoyi Liu, Weihua Tian, Dan Lei
GSTO2 ameliorates human neuroblastoma cell apoptosis, inflammation, ferroptosis, and oxidative stress by upregulating GPX4 expression in intracerebral hemorrhage. Drug development research 85 (6) (2024)

volume 85, number 7, 2024

Fawei Zhou, Dezhong Li, Chang Liu, Can Li, Kaili Li, Lu Shi, Fachun Zhou
m6A-activated BACH1 exacerbates ferroptosis by epigenetic suppression HSPB1 in severe acute pancreatitis. Drug development research 85 (7) (2024)