Mohammad Abdel-Halim

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 37

Top Venues

Archiv der Pharmazie

Molecules (Basel, Switzerland)

Pharmaceuticals (Basel, Switzerland)

Journal of medicinal chemistry

German University in Cairo

Universität des Saarlandes (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

German University in Cairo Oct 05 2019

Egypt

Associate Professor :: Pharmaceutical Chemistry

German University in Cairo Oct 01 2013 - Oct 04 2019

Egypt

Lecturer :: Pharmaceuitcal Chemistry

Education History

Universität des Saarlandes Jun 01 2010 - Aug 13 2013

Germany

PHD :: Pharmaceutical and Medicinal Chemistry

Publications

Yara A Abd El-Rahman, Po-Jen Chen, Ahmed K ElHady, Shun-Hua Chen, Hsin-Chieh Lin, Dalia S El-Gamil, Youssef Aboushady, Ashraf H Abadi, Matthias Engel, Mohammad Abdel-Halim
Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity. Future medicinal chemistry 16 (12) (2024)
Hend Khalifa, Sari Rasheed, Jörg Haupenthal, Jennifer Herrmann, Yasmine M Mandour, Ashraf H Abadi, Matthias Engel, Rolf Müller, Anna K H Hirsch, Mohammad Abdel-Halim, Mostafa M Hamed
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents. Archiv der Pharmazie (2024)
Dalia S El-Gamil, Mohamed Y Zaky, Patrick M Maximous, Marwa Sharaky, Ahmed M El-Dessouki, Noura M Riad, Saad Shaaban, Mohammad Abdel-Halim, Ahmed Ali Al-Karmalawy
Exploring chromone-2-carboxamide derivatives for triple-negative breast cancer targeting EGFR, FGFR3, and VEGF pathways: Design, synthesis, and preclinical insights. Drug development research 85 (5) (2024)
Yara A Abd El-Rahman, Po-Jen Chen, Ahmed K ElHady, Shun-Hua Chen, Hsin-Chieh Lin, Dalia S El-Gamil, Youssef Aboushady, Ashraf H Abadi, Matthias Engel, Mohammad Abdel-Halim
Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity. Future medicinal chemistry 16 (12) (2024)
Hend Khalifa, Sari Rasheed, Jörg Haupenthal, Jennifer Herrmann, Yasmine M Mandour, Ashraf H Abadi, Matthias Engel, Rolf Müller, Anna K H Hirsch, Mohammad Abdel-Halim, Mostafa M Hamed
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents. Archiv der Pharmazie 357 (4) (2024)
Yara A Abd El-Rahman, Po-Jen Chen, Ahmed K ElHady, Shun-Hua Chen, Hsin-Chieh Lin, Dalia S El-Gamil, Youssef Aboushady, Ashraf H Abadi, Matthias Engel, Mohammad Abdel-Halim
Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity. Future medicinal chemistry 16 (12) (2024)
Hend Khalifa, Sari Rasheed, Jörg Haupenthal, Jennifer Herrmann, Yasmine M Mandour, Ashraf H Abadi, Matthias Engel, Rolf Müller, Anna K H Hirsch, Mohammad Abdel-Halim, Mostafa M Hamed
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents. Archiv der Pharmazie 357 (4) (2024)
Mohammad Abdel-Halim, Dalia S El-Gamil, Mennatallah A Hammam, Mohamed El-Shazly, Yi-Hsuan Wang, Po-Hsiung Kung, Yu-Cheng Chen, Michal Korinek, Ashraf H Abadi, Matthias Engel, Tsong-Long Hwang
Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways. Journal of enzyme inhibition and medicinal chemistry 39 (1) (2024)
Noha Mostafa, Po-Jen Chen, Sarah S Darwish, Yu-Chieh Su, Ming-Hua Shiao, Gary A Piazza, Ashraf H Abadi, Matthias Engel, Mohammad Abdel-Halim
N -Benzylated 5-Hydroxybenzothiophene-2-carboxamides as Multi-Targeted Clk/Dyrk Inhibitors and Potential Anticancer Agents. Cancers 16 (11) (2024)
Sara Sigler, Mohammad Abdel-Halim, Reem K Fathalla, Luciana Madeira Da Silva, Adam B Keeton, Yulia Y Maxuitenko, Kristy Berry, Gang Zhou, Matthias Engel, Ashraf H Abadi, Gary A Piazza
Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription. Anti-cancer agents in medicinal chemistry (2024)
Habiba G Aboelfotouh, Mennatallah Abdallah, Hend Khalifa, Youssef Aboushady, Ashraf H Abadi, Matthias Engel, Mohammad Abdel-Halim
N 1 -Benzoylated 5-(4-pyridinyl)indazole-based kinase inhibitors: Attaining haspin and Clk4 selectivity via modulation of the benzoyl substituents. Archiv der Pharmazie 357 (6) (2024)
Habiba G Aboelfotouh, Mennatallah Abdallah, Hend Khalifa, Youssef Aboushady, Ashraf H Abadi, Matthias Engel, Mohammad Abdel-Halim
N 1 -Benzoylated 5-(4-pyridinyl)indazole-based kinase inhibitors: Attaining haspin and Clk4 selectivity via modulation of the benzoyl substituents. Archiv der Pharmazie (2024)
Hend Khalifa, Sari Rasheed, Jörg Haupenthal, Jennifer Herrmann, Yasmine M Mandour, Ashraf H Abadi, Matthias Engel, Rolf Müller, Anna K H Hirsch, Mohammad Abdel-Halim, Mostafa M Hamed
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents. Archiv der Pharmazie 357 (4) (2024)
Dalia S El-Gamil, Mohamed Y Zaky, Patrick M Maximous, Marwa Sharaky, Ahmed M El-Dessouki, Noura M Riad, Saad Shaaban, Mohammad Abdel-Halim, Ahmed Ali Al-Karmalawy
Exploring chromone-2-carboxamide derivatives for triple-negative breast cancer targeting EGFR, FGFR3, and VEGF pathways: Design, synthesis, and preclinical insights. Drug development research 85 (5) (2024)
Noha Mostafa, Po-Jen Chen, Sarah S Darwish, Yu-Chieh Su, Ming-Hua Shiao, Gary A Piazza, Ashraf H Abadi, Matthias Engel, Mohammad Abdel-Halim
N -Benzylated 5-Hydroxybenzothiophene-2-carboxamides as Multi-Targeted Clk/Dyrk Inhibitors and Potential Anticancer Agents. Cancers 16 (11) (2024)
Lina Ammar, Hung-Yu Lin, Shou-Ping Shih, Tsen-Ni Tsai, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Ashraf H Abadi
Novel 9-Benzylaminoacridine Derivatives as Dual Inhibitors of Phosphodiesterase 5 and Topoisomerase II for the Treatment of Colon Cancer. Molecules (Basel, Switzerland) 28 (2) (2023)
Lina Ammar, Hung-Yu Lin, Shou-Ping Shih, Tsen-Ni Tsai, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Ashraf H Abadi
Novel 9-Benzylaminoacridine Derivatives as Dual Inhibitors of Phosphodiesterase 5 and Topoisomerase II for the Treatment of Colon Cancer. Molecules (Basel, Switzerland) 28 (2) (2023)
Youssef Y Helmi, Niklas Papenkordt, Georg Rennar, Florence Gbahou, Ahmed K El-Hady, Nedjma Labani, Karin Schmidtkunz, Stefan Boettcher, Ralf Jockers, Mohammad Abdel-Halim, Manfred Jung, Darius P Zlotos
Melatonin-vorinostat hybrid ligands show higher histone deacetylase and cancer cell growth inhibition than vorinostat. Archiv der Pharmazie (2023)
Lina Ammar, Hung-Yu Lin, Shou-Ping Shih, Tsen-Ni Tsai, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Ashraf H Abadi
Novel 9-Benzylaminoacridine Derivatives as Dual Inhibitors of Phosphodiesterase 5 and Topoisomerase II for the Treatment of Colon Cancer. Molecules (Basel, Switzerland) 28 (2) (2023)
Lina Ammar, Hung-Yu Lin, Shou-Ping Shih, Tsen-Ni Tsai, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Ashraf H Abadi
Novel 9-Benzylaminoacridine Derivatives as Dual Inhibitors of Phosphodiesterase 5 and Topoisomerase II for the Treatment of Colon Cancer. Molecules (Basel, Switzerland) 28 (2) (2023)
Ahmed K ElHady, Dalia S El-Gamil, Mohammad Abdel-Halim, Ashraf H Abadi
Advancements in Phosphodiesterase 5 Inhibitors: Unveiling Present and Future Perspectives. Pharmaceuticals (Basel, Switzerland) 16 (9) (2023)
Lina Ammar, Hung-Yu Lin, Shou-Ping Shih, Tsen-Ni Tsai, Yu-Ting Syu, Mohammad Abdel-Halim, Tsong-Long Hwang, Ashraf H Abadi
Novel 9-Benzylaminoacridine Derivatives as Dual Inhibitors of Phosphodiesterase 5 and Topoisomerase II for the Treatment of Colon Cancer. Molecules (Basel, Switzerland) 28 (2) (2023)
Suzan Fangary, Mohammad Abdel-Halim, Reem K Fathalla, Raghda Hassan, Noha Farag, Matthias Engel, Samar Mansour, Salma N Tammam
Nanoparticle Fraught Liposomes: A Platform for Increased Antibiotic Selectivity in Multidrug Resistant Bacteria. Molecular pharmaceutics 19 (9) (2022)
Sarah S Darwish, Po-Jen Chen, Mostafa M Hamed, Reem A Wagdy, Shun-Hua Chen, Ashraf H Abadi, Mohammad Abdel-Halim, Tsong-Long Hwang, Matthias Engel
Development of (4-Phenylamino)quinazoline Alkylthiourea Derivatives as Novel NF-κB Inhibitors. Pharmaceuticals (Basel, Switzerland) 15 (7) (2022)
Jehad Hamdy, Nouran Emadeldin, Mostafa M Hamed, Efseveia Frakolaki, Sotirios Katsamakas, Niki Vassilaki, Grigoris Zoidis, Anna Katharina Herta Hirsch, Mohammad Abdel-Halim, Ashraf H Abadi
Design and Synthesis of Novel Bis-Imidazolyl Phenyl Butadiyne Derivatives as HCV NS5A Inhibitors. Pharmaceuticals (Basel, Switzerland) 15 (5) (2022)
Reem K Fathalla, Wolfgang Fröhner, Chantal D Bader, Patrick D Fischer, Charlotte Dahlem, Deep Chatterjee, Sebastian Mathea, Alexandra K Kiemer, Haribabu Arthanari, Rolf Müller, Mohammad Abdel-Halim, Christian Ducho, Matthias Engel
Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA. Journal of medicinal chemistry 65 (21) (2022)
Ahmed K ElHady, Dalia S El-Gamil, Ashraf H Abadi, Mohammad Abdel-Halim, Matthias Engel
An overview of cdc2-like kinase 1 (Clk1) inhibitors and their therapeutic indications. Medicinal research reviews (2022)
Hani Mohammed Hafez, Mohammad Abdel-Halim, Ahmed M Hemdan, Mennatallah A Hammam
Kinetic degradation study for the first licensed anti-influenza polymerase inhibitor, baloxavir marboxil, using high-performance liquid chromatography-mass spectrometry. Journal of separation science 45 (14) (2022)
Sarah H Megahed, Mohammad Abdel-Halim, Amr Hefnawy, Heba Handoussa, Boris Mizaikoff, Nesrine Abdelrehim E L Gohary
Molecularly Imprinted Solid Phase Extraction Strategy for Quinic Acid. Polymers 14 (16) (2022)
Ahmed K ElHady, Dalia S El-Gamil, Po-Jen Chen, Tsong-Long Hwang, Ashraf H Abadi, Mohammad Abdel-Halim, Matthias Engel
5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency. Molecules (Basel, Switzerland) 26 (4) (2021)
Salma Elshamy, Amira Abdel Motaal, Mohammad Abdel-Halim, Dalia Medhat, Heba Handoussa
Potential neuroprotective activity of Mentha longifolia L. in aluminum chloride-induced rat model of Alzheimer's disease. Journal of food biochemistry 45 (4) (2021)
Mohammad Abdel-Halim, Sara Sigler, Nora A S Racheed, Amr Hefnawy, Reem K Fathalla, Mennatallah A Hammam, Ahmed Maher, Yulia Maxuitenko, Adam B Keeton, Rolf Wolfgang Hartmann, Matthias Engel, Gary A Piazza, Ashraf H Abadi
From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity. Journal of medicinal chemistry 64 (8) (2021)
Youssef Aboushady, Moustafa Gabr, Ahmed K ElHady, Mohamed Salah, Ashraf H Abadi, Gerrit Wilms, Walter Becker, Mohammad Abdel-Halim, Matthias Engel
Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases. ACS chemical neuroscience 12 (22) (2021)
Ebaa M El-Hossary, Mohammad Abdel-Halim, Eslam S Ibrahim, Sheila Marie Pimentel-Elardo, Justin R Nodwell, Heba Handoussa, Miada F Abdelwahab, Gerhard Bringmann, Usama Ramadan Abdelmohsen
Natural Products Repertoire of the Red Sea. Marine drugs 18 (9) (2020)
Mohammad Abdel-Halim, Ashraf H Abadi, Matthias Engel
Design and synthesis of novel 1,3,5-triphenyl pyrazolines as potential anti-inflammatory agents through allosteric inhibition of protein kinase Czeta (PKCζ). MedChemComm 9 (6) (2018)
Mohamed Salah, Mohammad Abdel-Halim, Matthias Engel
Design and synthesis of conformationally constraint Dyrk1A inhibitors by creating an intramolecular H-bond involving a benzothiazole core. MedChemComm 9 (6) (2018)
Ahmed K ElHady, Mohammad Abdel-Halim, Ashraf H Abadi, Matthias Engel
Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins. Journal of medicinal chemistry 60 (13) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Mohammad Abdel-Halim