NPJ aging and mechanisms of disease

Keyphrases

Publications

volume 7, number 1, 2021

Kristina Bečanović, Muhammad Asghar, Izabella Gadawska, Shiny Sachdeva, David Walker, Eduardo R Lazarowski, Sonia Franciosi, Kevin H J Park, Hélène C F Côté, Blair R Leavitt
Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease. NPJ aging and mechanisms of disease 7 (1) (2021)
Ji Huang, Xiujie Liang, Diogo Ladeiras, Benoît Fellay, Xiu-Fen Ming, Zhihong Yang
Role of tubular epithelial arginase-II in renal inflammaging. NPJ aging and mechanisms of disease 7 (1) (2021)
Joshua S Talboom, M D De Both, M A Naymik, A M Schmidt, C R Lewis, W M Jepsen, A K Håberg, Tatjana Rundek, B E Levin, S Hoscheidt, Y Bolla, R D Brinton, N J Schork, M Hay, C A Barnes, E Glisky, L Ryan, Matthew J Huentelman
Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance. NPJ aging and mechanisms of disease 7 (1) (2021)
Fatin N Zainul Abidin, Helena R R Wells, André Altmann, Sally J Dawson
Hearing difficulty is linked to Alzheimer's disease by common genetic vulnerability, not shared genetic architecture. NPJ aging and mechanisms of disease 7 (1) (2021)
Miguel A Aon, Sonia Cortassa, Magdalena Juhaszova, José Antonio González-Reyes, Miguel Calvo-Rubio, José M Villalba, Andrew D Lachance, Bruce D Ziman, Sarah J Mitchell, Kelsey N Murt, Jessie E C Axsom, Irene Alfaras, Steven L Britton, Lauren G Koch, Rafael de Cabo, Edward G Lakatta, Steven J Sollott
Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan. NPJ aging and mechanisms of disease 7 (1) (2021)
Ha-Neui Kim, Filipa Ponte, Aaron Warren, Rebecca Ring, Srividhya Iyer, Li Han, Maria Almeida
A decrease in NAD+ contributes to the loss of osteoprogenitors and bone mass with aging. NPJ aging and mechanisms of disease 7 (1) (2021)
Tomomi Komura, Mikihiro Yamanaka, Kohji Nishimura, Keita Hara, Yoshikazu Nishikawa
Autofluorescence as a noninvasive biomarker of senescence and advanced glycation end products in Caenorhabditis elegans. NPJ aging and mechanisms of disease 7 (1) (2021)
Chih-Chieh Yu, Ferng-Chang Chang, Yong-Huei Hong, Jian-Chiuan Li, Po-Lin Chen, Chun-Hong Chen, Tzai-Wen Chiu, Tsai-Te Lu, Yun-Ming Wang, Chih-Fei Kao
Assessing the cognitive status of Drosophila by the value-based feeding decision. NPJ aging and mechanisms of disease 7 (1) (2021)
Yankun Lyu, Vipin K Verma, Younjee Lee, Iosif Taleb, Rachit Badolia, Thirupura S Shankar, Christos P Kyriakopoulos, Craig H Selzman, William Caine, Rami Alharethi, Sutip Navankasattusas, Thomas Seidel, Stavros G Drakos, Frank B Sachse
Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart. NPJ aging and mechanisms of disease 7 (1) (2021)
Subhashis Banerjee, Sarbani Ghoshal, Clemence Girardet, Kelly M DeMars, Changjun Yang, Michael L Niehoff, Andrew D Nguyen, Prerana Jayanth, Brittany A Hoelscher, Fenglian Xu, William A Banks, Kim M Hansen, Jinsong Zhang, Eduardo Candelario-Jalil, Susan A Farr, Andrew A Butler
Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice. NPJ aging and mechanisms of disease 7 (1) (2021)
Yachna Jain, Keerthivasan Raanin Chandradoss, Anjoom A V, Jui Bhattacharya, Mohan Lal, Meenakshi Bagadia, Harpreet Singh, Kuljeet Singh Sandhu
Convergent evolution of a genomic rearrangement may explain cancer resistance in hystrico- and sciuromorpha rodents. NPJ aging and mechanisms of disease 7 (1) (2021)
Sophie Vanhunsel, Steven Bergmans, An Beckers, Isabelle Etienne, Jolien Van Houcke, Eve Seuntjens, Lutgarde Arckens, Lies De Groef, Lieve Moons
The killifish visual system as an in vivo model to study brain aging and rejuvenation. NPJ aging and mechanisms of disease 7 (1) (2021)
Le Zong, Mayuri Tanaka-Yano, Bongsoo Park, Hagai Yanai, Ferda T Turhan, Deborah L Croteau, Jane Tian, Evandro Fei Fang, Vilhelm A Bohr, Isabel Beerman
NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm-/- and old mice HSCs. NPJ aging and mechanisms of disease 7 (1) (2021)
Christopher T Turner, Juliana Bolsoni, Matthew R Zeglinski, Hongyan Zhao, Tatjana Ponomarev, Katlyn Richardson, Sho Hiroyasu, Erin Schmid, Anthony Papp, David J Granville
Granzyme B mediates impaired healing of pressure injuries in aged skin. NPJ aging and mechanisms of disease 7 (1) (2021)
Marangelie Criado-Marrero, Niat T Gebru, Lauren A Gould, Danielle M Blazier, Yamile Vidal-Aguiar, Taylor M Smith, Salma S Abdelmaboud, Lindsey B Shelton, Xinming Wang, Jan Dahrendorff, David Beaulieu-Abdelahad, Chad A Dickey, Laura J Blair
FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model. NPJ aging and mechanisms of disease 7 (1) (2021)
Xiaoyu Zhang, Hui Yuan, Jihui Lyu, Xiaoni Meng, Qiuyue Tian, Yuejin Li, Jie Zhang, Xizhu Xu, Jing Su, Haifeng Hou, Dong Li, Baoliang Sun, Wei Wang, You-Xin Wang
Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population. NPJ aging and mechanisms of disease 7 (1) (2021)
Li-Chun Cho, Chih-Chieh Yu, Chih-Fei Kao
Social perception of young adults prolongs the lifespan of aged Drosophila. NPJ aging and mechanisms of disease 7 (1) (2021)
Miwa Nahata, Sachiko Mogami, Hitomi Sekine, Seiichi Iizuka, Naoto Okubo, Naoki Fujitsuka, Hiroshi Takeda
Bcl-2-dependent autophagy disruption during aging impairs amino acid utilization that is restored by hochuekkito. NPJ aging and mechanisms of disease 7 (1) (2021)
Nicholas Holzscheck, Cassandra Falckenhayn, Jörn Söhle, Boris Kristof, Ralf Siegner, André Werner, Janka Schössow, Clemens Jürgens, Henry Völzke, Horst Wenck, Marc Winnefeld, Elke Grönniger, Lars Kaderali
Modeling transcriptomic age using knowledge-primed artificial neural networks. NPJ aging and mechanisms of disease 7 (1) (2021)
Vijay R Varma, H Büşra Lüleci, Anup M Oommen, Sudhir Varma, Chad T Blackshear, Michael E Griswold, Yang An, Jackson A Roberts, Richard O'Brien, Olga Pletnikova, Juan C Troncoso, David A Bennett, Tunahan Çakır, Cristina Legido-Quigley, Madhav Thambisetty
Abnormal brain cholesterol homeostasis in Alzheimer's disease-a targeted metabolomic and transcriptomic study. NPJ aging and mechanisms of disease 7 (1) (2021)
Zhongde Ye, Timothy M Gould, Huimin Zhang, Jun Jin, Cornelia M Weyand, Jorg J Goronzy
The GSK3β-β-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a. NPJ aging and mechanisms of disease 7 (1) (2021)
Mohammed R Shaker, Julio Aguado, Harman Kaur Chaggar, Ernst J Wolvetang
Klotho inhibits neuronal senescence in human brain organoids. NPJ aging and mechanisms of disease 7 (1) (2021)
Dorela D Shuboni-Mulligan, Demarrius L Young, Julianie De La Cruz Minyety, Elizabeth Vera, Jeeva Munasinghe, Andrew J Gall, Mark R Gilbert, Terri S Armstrong, DeeDee K Smart
Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus. NPJ aging and mechanisms of disease 7 (1) (2021)
Nicholas Don-Doncow, Lotte Vanherle, Frank Matthes, Sine Kragh Petersen, Hana Matuskova, Sara Rattik, Anetta Härtlova, Anja Meissner
Simvastatin therapy attenuates memory deficits that associate with brain monocyte infiltration in chronic hypercholesterolemia. NPJ aging and mechanisms of disease 7 (1) (2021)
Diego Marques-Coelho, Lukas da Cruz Carvalho Iohan, Ana Raquel Melo de Farias, Amandine Flaig, null null, Jean-Charles Lambert, Marcos Romualdo Costa
Differential transcript usage unravels gene expression alterations in Alzheimer's disease human brains. NPJ aging and mechanisms of disease 7 (1) (2021)
Kristina Bečanović, Muhammad Asghar, Izabella Gadawska, Shiny Sachdeva, David Walker, Eduardo R Lazarowski, Sonia Franciosi, Kevin H J Park, Hélène C F Côté, Blair R Leavitt
Author Correction: Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease. NPJ aging and mechanisms of disease 7 (1) (2021)
Claudia E Rübe, Caroline Bäumert, Nadine Schuler, Anna Isermann, Zoé Schmal, Matthias Glanemann, Carl Mann, Harry Scherthan
Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis. NPJ aging and mechanisms of disease 7 (1) (2021)

volume 6, number 1, 2020

Andrea Di Francesco, Youngshim Choi, Michel Bernier, Yingchun Zhang, Alberto Diaz-Ruiz, Miguel A Aon, Krystle Kalafut, Margaux R Ehrlich, Kelsey Murt, Ahmed Ali, Kevin J Pearson, Sophie Levan, Joshua D Preston, Alejandro Martin-Montalvo, Jennifer L Martindale, Kotb Abdelmohsen, Cole R Michel, Diana M Willmes, Christine Henke, Plácido Navas, Jose Manuel Villalba, David Siegel, Myriam Gorospe, Kristofer Fritz, Shyam Biswal, David Ross, Rafael de Cabo
NQO1 protects obese mice through improvements in glucose and lipid metabolism. NPJ aging and mechanisms of disease 6 (1) (2020)
Ashok Mandala, Austin Armstrong, Becky Girresch, Jiyao Zhu, Aruna Chilakala, Sanmathi Chavalmane, Kapil Chaudhary, Pratim Biswas, Judith Ogilvie, Jaya P Gnana-Prakasam
Fenofibrate prevents iron induced activation of canonical Wnt/β-catenin and oxidative stress signaling in the retina. NPJ aging and mechanisms of disease 6 (1) (2020)
Tetsuya Oishi, Daisuke Matsumaru, Nao Ota, Hiroshi Kitamura, Tianxiang Zhang, Yohei Honkura, Yukio Katori, Hozumi Motohashi
Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss. NPJ aging and mechanisms of disease 6 (1) (2020)

volume 6, 2020

Michel Bernier, Dylan Harney, Yen Chin Koay, Antonio Diaz, Abhishek Singh, Devin Wahl, Tamara Pulpitel, Ahmed Ali, Vince Guiterrez, Sarah J Mitchell, Eun-Young Kim, John Mach, Nathan L Price, Miguel A Aon, David G LeCouteur, Victoria Carroll Cogger, Carlos Fernandez-Hernando, John O'Sullivan, Mark Larance, Ana Maria Cuervo, Rafael de Cabo
Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome. NPJ aging and mechanisms of disease 6 (2020)
Joshua Goldberg, Antonio Currais, Gamze Ates, Ling Huang, Maxim Shokhirev, Pamela Maher, David Schubert
Targeting of intracellular Ca2+ stores as a therapeutic strategy against age-related neurotoxicities. NPJ aging and mechanisms of disease 6 (2020)
Carmen Martin-Ruiz, Jedrzej Hoffmann, Evgeniya V Shmeleva, Thomas von Zglinicki, Gavin D Richardson, Lilia Draganova, Rachael Redgrave, Joanna Collerton, Helen Arthur, Bernard D Keavney, Ioakim Spyridopoulos
CMV-independent increase in CD27-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians. NPJ aging and mechanisms of disease 6 (2020)
Weng Kung Peng, Lan Chen, Bernhard Otto Boehm, Jongyoon Han, Tze Ping Loh
Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system. NPJ aging and mechanisms of disease 6 (2020)
Ashok Mandala, Austin Armstrong, Becky Girresch, Jiyao Zhu, Aruna Chilakala, Sanmathi Chavalmane, Kapil Chaudhary, Pratim Biswas, Judith Ogilvie, Jaya P Gnana-Prakasam
Fenofibrate prevents iron induced activation of canonical Wnt/β-catenin and oxidative stress signaling in the retina. NPJ aging and mechanisms of disease 6 (2020)
Mustafa N Okur, Beatrice Mao, Risako Kimura, Scott Haraczy, Tracy Fitzgerald, Kamren Edwards-Hollingsworth, Jane Tian, Wasif Osmani, Deborah L Croteau, Matthew W Kelley, Vilhelm A Bohr
Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome. NPJ aging and mechanisms of disease 6 (2020)
Li Theng Ng, Li Fang Ng, Richard Ming Yi Tang, Diogo Barardo, Barry Halliwell, Philip Keith Moore, Jan Gruber
Lifespan and healthspan benefits of exogenous H2S in C. elegans are independent from effects downstream of eat-2 mutation. NPJ aging and mechanisms of disease 6 (2020)
Fran M Pool, Christina Kiel, Luis Serrano, Philip J Luthert
Repository of proposed pathways and protein-protein interaction networks in age-related macular degeneration. NPJ aging and mechanisms of disease 6 (2020)
Regina Weinmüllner, Barbara Zbiral, Adnan Becirovic, Elena Maria Stelzer, Fabian Nagelreiter, Markus Schosserer, Ingo Lämmermann, Lisa Liendl, Magdalena Lang, Lucia Terlecki-Zaniewicz, Orestis Andriotis, Michael Mildner, Bahar Golabi, Petra Waidhofer-Söllner, Karl Schedle, Gerhard Emsenhuber, Philipp J Thurner, Erwin Tschachler, Florian Gruber, Johannes Grillari
Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging. NPJ aging and mechanisms of disease 6 (2020)
Alexander Frenzel, Hans Binder, Nadja Walter, Kerstin Wirkner, Markus Loeffler, Henry Loeffler-Wirth
The aging human body shape. NPJ aging and mechanisms of disease 6 (2020)
Zhonghe Ke, Denis Firsanov, Brianna Spencer, Andrei Seluanov, Vera Gorbunova
Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice. NPJ aging and mechanisms of disease 6 (2020)
Erik L Hodges, Jessica P Marshall, Nicole M Ashpole
Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice. NPJ aging and mechanisms of disease 6 (2020)

volume 5, 2019

Ilja L Kruglikov, Jan-Bernd Funcke
Caveolin-1 as a pathophysiological factor and target in psoriasis. NPJ aging and mechanisms of disease 5 (2019)
Tugsan Tezil, Manish Chamoli, Che-Ping Ng, Roman P Simon, Victoria J Butler, Manfred Jung, Julie Andersen, Aimee W Kao, Eric Verdin
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. NPJ aging and mechanisms of disease 5 (2019)
Ryoei Uchida, Yoshimasa Saito, Kazuki Nogami, Yohei Kajiyama, Yukana Suzuki, Yasuhiro Kawase, Toshiaki Nakaoka, Toshihide Muramatsu, Masaki Kimura, Hidetsugu Saito
Erratum: Publisher Correction: Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging. NPJ aging and mechanisms of disease 5 (2019)
Sergei Vatolin, Tomas Radivoyevitch, Jaroslaw P Maciejewski
New drugs for pharmacological extension of replicative life span in normal and progeroid cells. NPJ aging and mechanisms of disease 5 (2019)
Jaymie R Voorhees, Matthew T Remy, Claire M Erickson, Laura M Dutca, Daniel J Brat, Andrew A Pieper
Occupational-like organophosphate exposure disrupts microglia and accelerates deficits in a rat model of Alzheimer's disease. NPJ aging and mechanisms of disease 5 (2019)
Maricela Robles-Murguia, Liam C Hunt, David Finkelstein, Yiping Fan, Fabio Demontis
Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system. NPJ aging and mechanisms of disease 5 (2019)
Trevor R Nash, Eileen S Chow, Alexander D Law, Samuel D Fu, Elżbieta Fuszara, Aleksandra Bilska, Piotr Bebas, Doris Kretzschmar, Jadwiga M Giebultowicz
Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila. NPJ aging and mechanisms of disease 5 (2019)

volume 5, 2018

Ryoei Uchida, Yoshimasa Saito, Kazuki Nogami, Yohei Kajiyama, Yukana Suzuki, Yasuhiro Kawase, Toshiaki Nakaoka, Toshihide Muramatsu, Masaki Kimura, Hidetsugu Saito
Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging. NPJ aging and mechanisms of disease 5 (2018)