Manfred Jung (M Jung)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 69

Top Venues

Journal of medicinal chemistry

International journal of molecular sciences

Nature communications

ChemMedChem

University of Freiburg

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Freiburg

Germany

Professor for Pharmaceutical Chemistry, www.jungm.de :: Institute of Pharmaceutical Sciences

Publications

Johannes Seitz, Marina Auth, Tony Prinz, Mirjam Hau, Pavlos Tzortzoglou, Johannes Schulz-Fincke, Karin Schmidtkunz, Adina A Baniahmad, Dominica Willmann, Eric Metzger, Lutz Hein, Sebastian Preissl, Roland Schüle, Manfred Jung
Soft drug inhibitors for the epigenetic targets lysine-specific demethylase 1 and histone deacetylases. Archiv der Pharmazie (2024)
Sheng Wang, Sebastian O Klein, Sylvia Urban, Maximillian Staudt, Nicolas P F Barthes, Dominica Willmann, Johannes Bacher, Manuela Sum, Helena Bauer, Ling Peng, Georg A Rennar, Christian Gratzke, Katrin M Schüle, Lin Zhang, Oliver Einsle, Holger Greschik, Calum MacLeod, Christopher G Thomson, Manfred Jung, Eric Metzger, Roland Schuele
Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity. Nature communications 15 (1) (2024)
Arianna Colcerasa, Florian Friedrich, Jelena Melesina, Patrick Moser, Anja Vogelmann, Pavlos Tzortzoglou, Emilia Neuwirt, Manuela Sum, Dina Robaa, Lin Zhang, Elizabeth Ramos-Morales, Christophe Romier, Oliver Einsle, Eric Metzger, Roland Schüle, Olaf Groß, Wolfgang Sippl, Manfred Jung
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD + -Dependent Lysine Deacylase Sirtuin 2. Journal of medicinal chemistry 67 (12) (2024)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Vicki Gamble, Kwang-Su Park, Vincent Fagan, Fengling Li, Irene Chau, Masoud Vedadi, Cheryl H Arrowsmith, Paul Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor. Journal of medicinal chemistry 67 (7) (2024)
Arianna Colcerasa, Florian Friedrich, Jelena Melesina, Patrick Moser, Anja Vogelmann, Pavlos Tzortzoglou, Emilia Neuwirt, Manuela Sum, Dina Robaa, Lin Zhang, Elizabeth Ramos-Morales, Christophe Romier, Oliver Einsle, Eric Metzger, Roland Schüle, Olaf Groß, Wolfgang Sippl, Manfred Jung
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD + -Dependent Lysine Deacylase Sirtuin 2. Journal of medicinal chemistry (2024)
Sheng Wang, Sebastian O Klein, Sylvia Urban, Maximillian Staudt, Nicolas P F Barthes, Dominica Willmann, Johannes Bacher, Manuela Sum, Helena Bauer, Ling Peng, Georg A Rennar, Christian Gratzke, Katrin M Schüle, Lin Zhang, Oliver Einsle, Holger Greschik, Calum MacLeod, Christopher G Thomson, Manfred Jung, Eric Metzger, Roland Schuele
Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity. Nature communications 15 (1) (2024)
Sheng Wang, Sebastian O Klein, Sylvia Urban, Maximillian Staudt, Nicolas P F Barthes, Dominica Willmann, Johannes Bacher, Manuela Sum, Helena Bauer, Ling Peng, Georg A Rennar, Christian Gratzke, Katrin M Schüle, Lin Zhang, Oliver Einsle, Holger Greschik, Calum MacLeod, Christopher G Thomson, Manfred Jung, Eric Metzger, Roland Schuele
Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity. Nature communications 15 (1) (2024)
Arianna Colcerasa, Florian Friedrich, Jelena Melesina, Patrick Moser, Anja Vogelmann, Pavlos Tzortzoglou, Emilia Neuwirt, Manuela Sum, Dina Robaa, Lin Zhang, Elizabeth Ramos-Morales, Christophe Romier, Oliver Einsle, Eric Metzger, Roland Schüle, Olaf Groß, Wolfgang Sippl, Manfred Jung
Structure-Activity Studies of 1,2,4-Oxadiazoles for the Inhibition of the NAD + -Dependent Lysine Deacylase Sirtuin 2. Journal of medicinal chemistry 67 (12) (2024)
Sheng Wang, Sebastian O Klein, Sylvia Urban, Maximillian Staudt, Nicolas P F Barthes, Dominica Willmann, Johannes Bacher, Manuela Sum, Helena Bauer, Ling Peng, Georg A Rennar, Christian Gratzke, Katrin M Schüle, Lin Zhang, Oliver Einsle, Holger Greschik, Calum MacLeod, Christopher G Thomson, Manfred Jung, Eric Metzger, Roland Schuele
Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity. Nature communications 15 (1) (2024)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Vicki Gamble, Kwang-Su Park, Vincent Fagan, Fengling Li, Irene Chau, Masoud Vedadi, Cheryl H Arrowsmith, Paul Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor. Journal of medicinal chemistry 67 (7) (2024)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Vicki Gamble, Kwang-Su Park, Vincent Fagan, Fengling Li, Irene Chau, Masoud Vedadi, Cheryl H Arrowsmith, Paul Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor. Journal of medicinal chemistry (2024)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Vicki Gamble, Kwang-Su Park, Vincent Fagan, Fengling Li, Irene Chau, Masoud Vedadi, Cheryl H Arrowsmith, Paul Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor. Journal of medicinal chemistry 67 (7) (2024)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Vicki Gamble, Kwang-Su Park, Vincent Fagan, Fengling Li, Irene Chau, Masoud Vedadi, Cheryl H Arrowsmith, Paul Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor. Journal of medicinal chemistry 67 (7) (2024)
Sebastian O Klein, Adina A Baniahmad, Manfred Jung
Photoreductive β-aminoalkylation with amino acids affords functionalized γ-aminoketones for nucleoside mimics. Chemical communications (Cambridge, England) (2023)
Sebastian O Klein, Adina A Baniahmad, Manfred Jung
Photoreductive β-aminoalkylation with amino acids affords functionalized γ-aminoketones for nucleoside mimics. Chemical communications (Cambridge, England) 59 (14) (2023)
Matthes Zessin, Marat Meleshin, Sebastian Hilscher, Cordelia Schiene-Fischer, Cyril Barinka, Manfred Jung, Mike Schutkowski
Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines. International journal of molecular sciences 24 (8) (2023)
Sebastian O Klein, Adina A Baniahmad, Manfred Jung
Photoreductive β-aminoalkylation with amino acids affords functionalized γ-aminoketones for nucleoside mimics. Chemical communications (Cambridge, England) 59 (14) (2023)
Matthes Zessin, Marat Meleshin, Sebastian Hilscher, Cordelia Schiene-Fischer, Cyril Barinka, Manfred Jung, Mike Schutkowski
Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines. International journal of molecular sciences 24 (8) (2023)
Mohamed Abdelsalam, Mariia Zmyslia, Karin Schmidtkunz, Anita Vecchio, Sebastian Hilscher, Hany S Ibrahim, Mike Schutkowski, Manfred Jung, Claudia Jessen-Trefzer, Wolfgang Sippl
Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells. Archiv der Pharmazie (2023)
Laura Sinatra, Anja Vogelmann, Florian Friedrich, Margarita A Tararina, Emilia Neuwirt, Arianna Colcerasa, Philipp König, Lara Toy, Talha Z Yesiloglu, Sebastian Hilscher, Lena Gaitzsch, Niklas Papenkordt, Shiyang Zhai, Lin Zhang, Christophe Romier, Oliver Einsle, Wolfgang Sippl, Mike Schutkowski, Olaf Gross, Gerd Bendas, David W Christianson, Finn K Hansen, Manfred Jung, Matthias Schiedel
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. Journal of medicinal chemistry (2023)
Youssef Y Helmi, Niklas Papenkordt, Georg Rennar, Florence Gbahou, Ahmed K El-Hady, Nedjma Labani, Karin Schmidtkunz, Stefan Boettcher, Ralf Jockers, Mohammad Abdel-Halim, Manfred Jung, Darius P Zlotos
Melatonin-vorinostat hybrid ligands show higher histone deacetylase and cancer cell growth inhibition than vorinostat. Archiv der Pharmazie (2023)
Michael Kohr, Niklas Papenkordt, Manfred Jung, Uli Kazmaier
Total synthesis and biological evaluation of histone deacetylase inhibitor WF-3161. Organic & biomolecular chemistry (2023)
Matthes Zessin, Marat Meleshin, Sebastian Hilscher, Cordelia Schiene-Fischer, Cyril Barinka, Manfred Jung, Mike Schutkowski
Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines. International journal of molecular sciences 24 (8) (2023)
Vivien Ngo, Bernd K Fleischmann, Manfred Jung, Lutz Hein, Achim Lother
Histone Deacetylase 6 Inhibitor JS28 Prevents Pathological Gene Expression in Cardiac Myocytes. Journal of the American Heart Association 11 (12) (2022)
Daniel Herp, Johannes Ridinger, Dina Robaa, Stephen A Shinsky, Karin Schmidtkunz, Talha Z Yesiloglu, Theresa Bayer, Raphael R Steimbach, Corey J Herbst-Gervasoni, Annika Merz, Christophe Romier, Peter Sehr, Nikolas Gunkel, Aubry K Miller, David W Christianson, Ina Oehme, Wolfgang Sippl, Manfred Jung
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement. Chembiochem : a European journal of chemical biology 23 (14) (2022)
A Vogelmann, Matthias Schiedel, N Wössner, A Merz, D Herp, S Hammelmann, A Colcerasa, G Komaniecki, J Y Hong, M Sum, E Metzger, E Neuwirt, L Zhang, O Einsle, O Groß, R Schüle, Hening Lin, Wolfgang Sippl, Manfred Jung
Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration. RSC chemical biology 3 (4) (2022)
Salma Darwish, Ehab Ghazy, Tino Heimburg, Daniel Herp, Patrik Zeyen, Rabia Salem-Altintas, Johannes Ridinger, Dina Robaa, Karin Schmidtkunz, Frank Erdmann, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme, Wolfgang Sippl
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity. International journal of molecular sciences 23 (14) (2022)
Eleonora Diamanti, María Méndez, Tatjana Ross, Christian A Kuttruff, Julien Lefranc, Franca-Maria Klingler, Franz von Nussbaum, Manfred Jung, Alexander Titz
Frontiers in Medicinal Chemistry 2022 Goes Virtual. ChemMedChem 17 (21) (2022)
Anja Vogelmann, Manfred Jung, Finn K Hansen, Matthias Schiedel
Comparison of Cellular Target Engagement Methods for the Tubulin Deacetylases Sirt2 and HDAC6: NanoBRET, CETSA, Tubulin Acetylation, and PROTACs. ACS pharmacology & translational science 5 (2) (2022)
Salma Darwish, Tino Heimburg, Johannes Ridinger, Daniel Herp, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme, Wolfgang Sippl
Synthesis, Biochemical, and Cellular Evaluation of HDAC6 Targeting Proteolysis Targeting Chimeras. Methods in molecular biology (Clifton, N.J.) 2589 (2022)
Lars Kaiser, Isabel Quint, Rene Csuk, Manfred Jung, Hans-Peter Deigner
Lineage-Selective Disturbance of Early Human Hematopoietic Progenitor Cell Differentiation by the Commonly Used Plasticizer Di-2-ethylhexyl Phthalate via Reactive Oxygen Species: Fatty Acid Oxidation Makes the Difference. Cells 10 (10) (2021)
Chenyang Lan, Anja Stulz, Nicolas P F Barthes, Susan Lauw, Pavel Salavei, Manfred Jung, Heiko Heerklotz, Maximilian H Ulbrich
Designed membrane protein heterodimers and control of their affinity by binding domain and membrane linker properties. Nanoscale (2021)
Janina Schreiber, Nastassia Liaukouskaya, Lars Fuhrmann, Alexander-Thomas Hauser, Manfred Jung, Tobias B Huber, Nicola Wanner
BET Proteins Regulate Expression of Osr1 in Early Kidney Development. Biomedicines 9 (12) (2021)
Lars Fuhrmann, Saskia Lindner, Alexander-Thomas Hauser, Clemens Höse, Oliver Kretz, Clemens D Cohen, Maja T Lindenmeyer, Wolfgang Sippl, Manfred Jung, Tobias B Huber, Nicola Wanner
Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development. International journal of molecular sciences 22 (8) (2021)
Giuseppe Campiani, Caterina Cavella, Jeremy D Osko, Margherita Brindisi, Nicola Relitti, Simone Brogi, A Prasanth Saraswati, Stefano Federico, Giulia Chemi, Samuele Maramai, Gabriele Carullo, Benedikt Jaeger, Alfonso Carleo, Rosaria Benedetti, Federica Sarno, Stefania Lamponi, Paola Rottoli, Elena Bargagli, Carlo Bertucci, Daniele Tedesco, Daniel Herp, Johanna Senger, Giovina Ruberti, Fulvio Saccoccia, Simona Saponara, Beatrice Gorelli, Massimo Valoti, Breandán N Kennedy, Husvinee Sundaramurthi, Stefania Butini, Manfred Jung, Katy M Roach, Lucia Altucci, Peter Bradding, David W Christianson, Sandra Gemma, Antje Prasse
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors. Journal of medicinal chemistry 64 (14) (2021)
Chiara Luise, Dina Robaa, Pierre Regenass, David Maurer, Dmytro Ostrovskyi, Ludwig Seifert, Johannes Bacher, Teresa Burgahn, Tobias Wagner, Johannes Seitz, Holger Greschik, Kwang-Su Park, Yan Xiong, Jian Jin, Roland Schüle, Bernhard Breit, Manfred Jung, Wolfgang Sippl
Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors. International journal of molecular sciences 22 (11) (2021)
Christoph W Grathwol, Nathalie Wössner, Steven Behnisch-Cornwell, Lukas Schulig, Lin Zhang, Oliver Einsle, Manfred Jung, Andreas Link
Activation of Sirtuin 2 Inhibitors Employing Photoswitchable Geometry and Aqueous Solubility. ChemMedChem 15 (15) (2020)
Lars Kaiser, Helga Weinschrott, Isabel Quint, Markus Blaess, Rene Csuk, Manfred Jung, Matthias Kohl, Hans-Peter Deigner
Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways. International journal of molecular sciences 21 (17) (2020)
Martin Hügle, Pierre Regenass, Robin Warstat, Mirjam Hau, Karin Schmidtkunz, Xavier Lucas, Daniel Wohlwend, Oliver Einsle, Manfred Jung, Bernhard Breit, Stefan Günther
4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines. Journal of medicinal chemistry 63 (24) (2020)
Matthias Schiedel, Herwin Daub, Aymelt Itzen, Manfred Jung
Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology. Chembiochem : a European journal of chemical biology 21 (8) (2020)
Matthias Schiedel, Attila Lehotzky, Sandor Szunyogh, Judit Oláh, Sören Hammelmann, Nathalie Wössner, Dina Robaa, Oliver Einsle, Wolfgang Sippl, Judit Ovádi, Manfred Jung
HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2)*. Chembiochem : a European journal of chemical biology 21 (23) (2020)
Eva-Maria Herrlinger, Mirjam Hau, Desiree Melanie Redhaber, Gabriele Greve, Dominica Willmann, Simon Steimle, Michael Müller, Michael Lübbert, Christoph Cornelius Miething, Roland Schuele, Manfred Jung
Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells. Chembiochem : a European journal of chemical biology 21 (16) (2020)
Tugsan Tezil, Manish Chamoli, Che-Ping Ng, Roman P Simon, Victoria J Butler, Manfred Jung, Julie Andersen, Aimee W Kao, Eric Verdin
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. NPJ aging and mechanisms of disease 5 (2019)
Piotr H Małecki, Nicole Rüger, Martin Roatsch, Oxana Krylova, Andreas Link, Manfred Jung, Udo Heinemann, Manfred S Weiss
Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases. ChemMedChem 14 (21) (2019)
Bertrand Lecointre, Remy Narozny, Maria Teresa Borrello, Johanna Senger, Alokta Chakrabarti, Manfred Jung, Martin Marek, Christophe Romier, Jelena Melesina, Wolfgang Sippl, Laurent Bischoff, Arasu Ganesan
Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 373 (1748) (2019)
Christoph W Grathwol, Nathalie Wössner, Sören Swyter, Adam C Smith, Enrico Tapavicza, Robert Klaus Hofstetter, Anja Bodtke, Manfred Jung, Andreas Link
Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors. Beilstein journal of organic chemistry 15 (2019)
Jeremy D Osko, Nicholas J Porter, Poli Adi Narayana Reddy, You-Cai Xiao, Johanna Rokka, Manfred Jung, Jacob M Hooker, Joseph M Salvino, David W Christianson
Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. Journal of medicinal chemistry 63 (1) (2019)
Martin Roatsch, Inga Hoffmann, Martine I Abboud, Rebecca L Hancock, Hanna Tarhonskaya, Kuo-Feng Hsu, Sarah E Wilkins, Tzu-Lan Yeh, Kerstin Lippl, Kerstin Serrer, Isabelle Moneke, Theresa D Ahrens, Dina Robaa, Sandra Wenzler, Nicolas P F Barthes, Henriette Franz, Wolfgang Sippl, Silke Lassmann, Sven Diederichs, Erik Schleicher, Christopher J Schofield, Akane Kawamura, Roland Schüle, Manfred Jung
The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases. ACS chemical biology 14 (8) (2019)
Fulvio Saccoccia, Margherita Brindisi, Roberto Gimmelli, Nicola Relitti, Alessandra Guidi, A Prasanth Saraswati, Caterina Cavella, Simone Brogi, Giulia Chemi, Stefania Butini, Giuliana Papoff, Johanna Senger, Daniel Herp, Manfred Jung, Giuseppe Campiani, Sandra Gemma, Giovina Ruberti
Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents. ACS infectious diseases 6 (1) (2019)
Katharina Vögerl, Nghia Ong, Johanna Senger, Daniel Herp, Karin Schmidtkunz, Martin Marek, Martin Müller, Karin Bartel, Tajith Baba Shaik, Nicholas J Porter, Dina Robaa, David W Christianson, Christophe Romier, Wolfgang Sippl, Manfred Jung, Franz Bracher
Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors. Journal of medicinal chemistry 62 (3) (2019)
Sören Swyter, Matthias Schiedel, Daria Monaldi, Sándor Szunyogh, Attila Lehotzky, Tobias Rumpf, Judit Ovádi, Wolfgang Sippl, Manfred Jung
New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 373 (1748) (2019)
Daria Monaldi, Dante Rotili, Julien Lancelot, Martin Marek, Nathalie Wössner, Alessia Lucidi, Daniela Tomaselli, Elizabeth Ramos-Morales, Christophe Romier, Raymond J Pierce, Antonello Mai, Manfred Jung
Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2). Journal of medicinal chemistry 62 (19) (2019)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Johannes Bacher, Kwang-Su Park, Nicolas Babault, Michael Martini, Vincent Fagan, Fengling Li, Irene Chau, Thomas Christott, David Dilworth, Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H Arrowsmith, Paul E Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). Journal of medicinal chemistry 62 (20) (2019)
Vincent Fagan, Catrine Johansson, Carina Gileadi, Octovia Monteiro, James E Dunford, Reshma Nibhani, Martin Philpott, Jessica Malzahn, Graham Wells, Ruth Faram, Adam P Cribbs, Nadia Halidi, Fengling Li, Irene Chau, Holger Greschik, Srikannathasan Velupillai, Abdellah Allali-Hassani, James Bennett, Thomas Christott, Charline Giroud, Andrew M Lewis, Kilian V M Huber, Nick Athanasou, Chas Bountra, Manfred Jung, Roland Schüle, Masoud Vedadi, Cheryl H Arrowsmith, Yan Xiong, Jian Jin, Oleg Fedorov, Gillian Farnie, Paul E Brennan, Udo Oppermann
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. Journal of medicinal chemistry 62 (20) (2019)
Roman P Simon, Tobias Rumpf, Vaida Linkuviene, Daumantas Matulis, Asifa Akhtar, Manfred Jung
Cofactor Analogues as Active Site Probes in Lysine Acetyltransferases. Journal of medicinal chemistry 62 (5) (2019)
Eric Metzger, Sheng Wang, Sylvia Urban, Dominica Willmann, Andreas Schmidt, Anne Offermann, Anita Allen, Manuela Sum, Nadine Obier, Félicie Cottard, Svenja Ulferts, Bogdan-Tiberius Preca, Bianca Hermann, Jochen Maurer, Holger Greschik, Veit Hornung, Oliver Einsle, Sven Perner, Axel Imhof, Manfred Jung, Roland Schuele
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. Nature structural & molecular biology 26 (5) (2019)
Dina Robaa, Daria Monaldi, Nathalie Wössner, Norio Kudo, Tobias Rumpf, Matthias Schiedel, Minoru Yoshida, Manfred Jung
Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 - New Opportunities, New Questions. Chemical record (New York, N.Y.) 18 (12) (2018)
Nadja A Simeth, Lisa-Marie Altmann, Nathalie Wössner, Elisabeth Bauer, Manfred Jung, Burkhard König
Photochromic Indolyl Fulgimides as Chromo-pharmacophores Targeting Sirtuins. The Journal of organic chemistry 83 (15) (2018)
Martin Marek, Tajith B Shaik, Tino Heimburg, Alokta Chakrabarti, Julien Lancelot, Elizabeth Ramos-Morales, Cyrielle Da Veiga, Dmitrii Kalinin, Jelena Melesina, Dina Robaa, Karin Schmidtkunz, Takayoshi Suzuki, Ralph Holl, Eric Ennifar, Raymond J Pierce, Manfred Jung, Wolfgang Sippl, Christophe Romier
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. Journal of medicinal chemistry 61 (22) (2018)
Kristina King, Alexander-Thomas Hauser, Jelena Melesina, Wolfgang Sippl, Manfred Jung
Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition. Molecules (Basel, Switzerland) 23 (2) (2018)
Conrad V Simoben, Dina Robaa, Alokta Chakrabarti, Karin Schmidtkunz, Martin Marek, Julien Lancelot, Srinivasaraghavan Kannan, Jelena Melesina, Tajith Baba Shaik, Raymond J Pierce, Christophe Romier, Manfred Jung, Wolfgang Sippl
A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing. Molecules (Basel, Switzerland) 23 (3) (2018)
Berin Karaman, Zayan Alhalabi, Sören Swyter, Shetonde O Mihigo, Kerstin Andrae-Marobela, Manfred Jung, Wolfgang Sippl, Fidele Ntie-Kang
Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing. Molecules (Basel, Switzerland) 23 (2) (2018)
Matthias Wünsch, Johanna Senger, Philipp Schultheisz, Sabrina Schwarzbich, Karin Schmidtkunz, Carmela Michalek, Michaela Klaß, Stefanie Goskowitz, Philipp Borchert, Lucas Praetorius, Wolfgang Sippl, Manfred Jung, Norbert Sewald
Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors. ChemMedChem 12 (24) (2017)
Matthias Schiedel, Daniel Herp, Sören Hammelmann, Sören Swyter, Attila Lehotzky, Dina Robaa, Judit Oláh, Judit Ovádi, Wolfgang Sippl, Manfred Jung
Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). Journal of medicinal chemistry 61 (2) (2017)
Katharina Stenzel, Alexandra Hamacher, Finn K Hansen, Christoph G W Gertzen, Johanna Senger, Viktoria Marquardt, Linda Marek, Martin Marek, Christophe Romier, Marc Remke, Manfred Jung, Holger Gohlke, Matthias U Kassack, Thomas Kurz
Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines. Journal of medicinal chemistry 60 (13) (2017)
Viktoria Krieger, Alexandra Hamacher, Christoph G W Gertzen, Johanna Senger, Martijn R H Zwinderman, Martin Marek, Christophe Romier, Frank J Dekker, Thomas Kurz, Manfred Jung, Holger Gohlke, Matthias U Kassack, Finn K Hansen
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups. Journal of medicinal chemistry 60 (13) (2017)
Tino Heimburg, Fiona R Kolbinger, Patrik Zeyen, Ehab Ghazy, Daniel Herp, Karin Schmidtkunz, Jelena Melesina, Tajith Baba Shaik, Frank Erdmann, Matthias Schmidt, Christophe Romier, Dina Robaa, Olaf Witt, Ina Oehme, Manfred Jung, Wolfgang Sippl
Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity. Journal of medicinal chemistry 60 (24) (2017)
M Schiedel, A Fallarero, Chiara Luise, W Sippl, P Vuorela, Manfred Jung
Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). MedChemComm 8 (2) (2017)
Matthias Schiedel, Tobias Rumpf, Berin Karaman, Attila Lehotzky, Stefan Gerhardt, Judit Ovádi, Wolfgang Sippl, Oliver Einsle, Manfred Jung
Structure-Based Development of an Affinity Probe for Sirtuin 2. Angewandte Chemie (International ed. in English) 55 (6) (2016)

Manfred Jung.css-eqlu8i{font-size:small;padding-left:4px;} (M Jung)

Publication Activity (10 Years)

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Manfred Jung (M Jung)