Bioorganic chemistry

Keyphrases

Publications

volume 153, 2024

Felipe Escobar-Montaño, Ricardo Gómez-Oliva, Abdellah Ezzanad, Sonia Vázquez de Górgolas, David Zorrilla, Antonio J Macías-Sánchez, José M Botubol-Ares, Pedro Nunez-Abades, Carmen Castro, Rosa Durán-Patrón, Rosario Hernández-Galán
Effect of lathyrane-type diterpenoids in neural stem cell physiology: Microbial transformations, molecular docking and dynamics studies. Bioorganic chemistry 153 (2024)
Dorota Żelaszczyk, Aneta Chmiel, Agnieszka Gunia-Krzyżak, Henryk Marona, Paweł Krzyżek, Kinga Dworak, Iwona Skiba-Kurek, Elżbieta Karczewska, Justyna Popiół, Elżbieta Pękala, Paweł Żmudzki, Magdalena Ziąbka, Karolina Klesiewicz
Antibacterial and antibiofilm agents in the group of xanthone derivatives with piperazine moiety active against drug-resistant Helicobacter pylori strains. Bioorganic chemistry 153 (2024)
Moataz Dowaidar
Synthetic biology of metabolic cycles for Enhanced CO 2 capture and Sequestration. Bioorganic chemistry 153 (2024)
Yaping Song, Jie Gao, Yunxiao Wang, Hongyun Cui, Dandan Wang, Xihao Chang, Xianhai Lv
Evaluation of the antifungal activity of novel bis-pyrazole carboxamide derivatives and preliminary investigation of the mechanism. Bioorganic chemistry 153 (2024)
Yanning Xu, Peiyun Yu, Jiao Liang, Yuting Chen, Chunyan Yang, Chen Xia, Junlin Deng, Li Hai, Jian Chen, Yong Wu
Synthesis and bioactivity evaluation of glycosylated resveratrol derivatives as antioxidative neuroprotection agents against cerebral Ischemia-Reperfusion injury. Bioorganic chemistry 153 (2024)
Xiangdan Cuan, Xingying Yang, Jinxian Wang, Jun Sheng, Xuanjun Wang, Yanping Huang
Discovery of flavonoid-containing compound Lupalbigenin as anti-NSCLC cancer agents via suppression of EGFR and ERK1/2 pathway. Bioorganic chemistry 153 (2024)
Sakesh Kumar, Sumit K Rastogi, Subrata Roy, Kajal Sharma, Santosh Kumar, Debalina Maity, Diwan Chand, Sachin Vishwakarma, Jiaur R Gayen, Kinshuk R Srivastava, Ravindra Kumar, Prem N Yadav
Discovery and structure - activity relationships of 2,4,5-trimethoxyphenyl pyrimidine derivatives as selective D5 receptor partial agonists. Bioorganic chemistry 153 (2024)
Sukanya Sukanya, Aina Bellver-Sanchis, Bhanwar Singh Choudhary, Sunil Kumar, Belén Pérez, Antón Leandro Martínez Rodríguez, Jose Brea, Christian Griñán-Ferré, Ruchi Malik
Design, synthesis, and biological evaluation of tetrahydropyrimidine analogue as GSK-3β/Aβ aggregation inhibitor and anti-Alzheimer's agent. Bioorganic chemistry 153 (2024)
Sasithorn Decharuangsilp, Uthai Arwon, Marie Hoarau, Jarunee Vanichtanankul, Thanaya Saeyang, Tararat Jantra, Roonglawan Rattanajak, Ratthiya Thiabma, Nawarat Sooksai, Darin Kongkasuriyachai, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong
Flexible 2,4-diaminopyrimidine bearing a butyrolactone as Plasmodium falciparum dihydrofolate reductase inhibitors. Bioorganic chemistry 153 (2024)
Tazeen Fatima, Zeeshan Fatima, Muriel Billamboz, Saif Hameed
Exploring the antifungal potential of novel carbazate derivatives as promising drug candidates against emerging superbug, Candida auris. Bioorganic chemistry 153 (2024)
Manmohan Sharma, Marco L Lolli, Vivek K Vyas
A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 2: Non-DSM compounds. Bioorganic chemistry 153 (2024)
Wagdy M Eldehna, Maha-Hamadien Abdulla, Mohamed S Nafie, Ahmed E Elsawi, Salsabil Ayman, Mai I Shahin, Noura S Alhassan, Ahmad M Zubaidi, Hazem A Ghabbour, Mahmoud Elaasser, Ahmed A Al-Karmalawy, Hatem A Abdel-Aziz
Unveiling the anticancer potential of novel spirooxindole-tethered pyrazolopyridine derivatives. Bioorganic chemistry 153 (2024)
Aanchal Khanna, Nitish Kumar, Rupali Rana, null Jyoti, Anchal Sharma, null Muskan, Harmandeep Kaur, Preet Mohinder Singh Bedi
Fluoroquinolones tackling antimicrobial resistance: Rational design, mechanistic insights and comparative analysis of norfloxacin vs ciprofloxacin derivatives. Bioorganic chemistry 153 (2024)
Xin Guo, Peiyao Zhang, Miaomiao Chen, Taiqing Li, Cancan Hou, Xinyue Que, Li Xu, Zhenghong Zhou, Qingmin Wang, Ziwen Wang
Synthesis, structural modification, and biological activity of a novel bisindole alkaloid iheyamine A. Bioorganic chemistry 153 (2024)
Rayees Ahmad Naikoo, Ritu Painuli, Zaheen Akhter, Parvinder Pal Singh
Cannabinoid receptor 2 (CB2) modulators: A patent review (2016-2024). Bioorganic chemistry 153 (2024)
Gaochao Lv, Xin Hu, Nan Zhang, Junyi Zhu, Xiaoqing Gao, Hongjie Xi, Ying Peng, Quan Xie, Ling Qiu, Jianguo Lin
Synthesis and immunotherapy efficacy of a PD-L1 small-molecule inhibitor combined with its 131 I-iodide labelled isostructural compound. Bioorganic chemistry 153 (2024)
Wagdy M Eldehna, Haytham O Tawfik, Maha-Hamadien Abdulla, Mohamed S Nafie, Heba Aref, Moataz A Shaldam, Noura S Alhassan, Omar Al Obeed, Zainab M Elsayed, Hatem A Abdel-Aziz
Identification of indole-grafted pyrazolopyrimidine and pyrazolopyridine derivatives as new anti-cancer agents: Synthesis, biological assessments, and molecular modeling insights. Bioorganic chemistry 153 (2024)
Pan Wu, Xiaoxia Liang, Han Wang, Zhenyu Wang, Yan Niu, Zhenghua Dong, Lizi Yin, Changliang He, Funeng Xu, Haohuan Li, Huaqiao Tang
Structurally diverse design and synthesis of novel 2-phenylindole amide derivatives with anti-canine breast cancer activity. Bioorganic chemistry 153 (2024)
Basma S Ali, Anber F Mohammed, Benson M Kariuki, Raafat El-Awady, Hajjaj H M Abdu-Allah
Tetrahydrocarbazoles incorporating 5-arylidene-4-thiazolinones as potential antileukemia and antilymphoma targeting tyrosine kinase and tubulin polymerase enzymes: Design, synthesis, structural, biological and molecular docking studies. Bioorganic chemistry 153 (2024)
Neetika Kumari, Manisha Chaudhary, Pamita Awasthi
Sulfonyl-acetohydrazide derivatives as juvenile hormone mimics to be insect growth regulators. Bioorganic chemistry 153 (2024)
Sunidhi Patil, Shankar G Alegaon, Shankar Gharge, Shriram D Ranade, Nayeem A Khatib
Molecular hybridization, synthesis, in vitro α-glucosidase inhibition, in vivo antidiabetic activity and computational studies of isatin based compounds. Bioorganic chemistry 153 (2024)
Guangrui Fan, Xiongfei Luo, Yibo Shi, Yingru Wang, Luhua Ji, Yuwen Gong, Engaung Yang, Chaohu Chen, Shu Cui, Hui Ding, Zhijun Zhang, Juan Wang, Yingqian Liu, Zhiping Wang
FL118: A potential bladder cancer therapeutic compound targeting H2A.X identified through library screening. Bioorganic chemistry 153 (2024)
Xudong Wu, Jiachen Zhang, Rongrong Liu, Yixiang Sun, Zixuan Gao, Guoqi Zhang, Zirui Luo, Kejian Li, Qiaohua Qin, Nian Liu, Haoyu Zhang, Xin Su, Dongmei Zhao, Maosheng Cheng
Design, synthesis and bioactivity evaluation of triazole antifungal drugs with phenylthiophene structure. Bioorganic chemistry 153 (2024)
Gopalakrishnan Venkatesan, Chong Yong Ping, Hong Chen, S Perumal, Aneesh V Karkhanis, Giorgia Pastorin
Design, synthesis, molecular docking, and evaluation of sulfonyl quinazoline analogues as promising liver cancer drugs. Bioorganic chemistry 153 (2024)
Mohamed K Elgohary, Mahmoud S Elkotamy, Tarfah Al-Warhi, Wagdy M Eldehna, Hatem A Abdel-Aziz
Development of new LSM-83177 analogues as anti-tumor agents against colorectal cancer targeting p53-MDM2 interaction. Bioorganic chemistry 153 (2024)
Jun Cao, José Ignacio Veytia-Bucheli, Lina Liang, Johan Wouters, Isabella Silva-Rosero, Julie Bussmann, Charles Gauthier, Xavier De Bolle, Marie-Christine Groleau, Eric Déziel, Stéphane P Vincent
Exploring fluorinated heptose phosphate analogues as inhibitors of HldA and HldE, key enzymes in the biosynthesis of lipopolysaccharide. Bioorganic chemistry 153 (2024)
Emel Pelit, Aliye Gediz Erturk, Melek Gul
1,3-Naphthoxazine derivatives: Synthesis, in silico pharmacokinetic studies, antioxidant and photoprotective properties. Bioorganic chemistry 153 (2024)
Gabriela Tataringa, Cristina Tuchilus, Mukhtar Ahmed, Sumeer Ahmed, Ajmal R Bhat, Taibi Ben Hadda, Ana-Maria Zbancioc, Khairi M Fahelelbom
Discovery of new molecular hybrid derivatives with coumarin scaffold bearing pyrazole/oxadiazole moieties: Molecular docking, POM analyses, in silico pharmacokinetics and in vitro antimicrobial evaluation with identification of potent antitumor pharmacophore sites. Bioorganic chemistry 153 (2024)
Xiaojiang Wang, Yan Lu, Meixia Li, Xiao Xia, Can Jin, Kan Ding, Daofeng Chen
Structural characterization and Bacteroides proliferation promotion activity of a novel homogeneous arabinoglucuronoxylan from Commelina communis L. Bioorganic chemistry 153 (2024)
Jing-Dian Li, Shou-Lun He, Guang-Hui Wang, Jun-Jie Chen, Xiang-Zhong Liu, Tian-Qi Wang, Mi Zhou, Chun-Chun Du, Hai-Feng Chen, Wen-Jing Tian
Filicinic acid based meroterpenoids from Hypericum elodeoides and their anti-Alzheimer's disease effects. Bioorganic chemistry 153 (2024)
Zhuo Li, Wenjia Tan, Xinru Li, YaJun Wang, Zetao Dang, Zhaoxia Zhang, Shuwen Guan, Shoujun Zhu, Feng Li, Ming Zhang
Unlocking lysosomal acidity to activate membranolytic module for accurately cancer theranostics. Bioorganic chemistry 153 (2024)
Jiaqin Tang, Xin Tie, Shumeng Zhi, Zhizhong Wang, Qipeng Zhao, Zhuo Qu, Guangyuan Lu, Qin Li, Yanran Wu, Ying Shi
Discovery of novel 5-phenyl-1H-pyrrole-2-carboxylic acids as Keap1-Nrf2 inhibitors for acute lung injury treatment. Bioorganic chemistry 153 (2024)
Yanzhi Zhang, Jinxin Jiang, Hao Ding, Qiannan Li, Yibei Xiao, Haiying Sun
Development of novel imipridone derivatives with potent anti-cancer activities as human caseinolytic peptidase P (hClpP) activators. Bioorganic chemistry 153 (2024)
Jie Peng, Hongyan Liu, Yujing Liu, Jingqian Liu, Qianlong Zhao, Wenjia Liu, Haoqian Niu, Haoyu Xue, Jie Sun, Jingde Wu
HDAC6 mediates tumorigenesis during mitosis and the development of targeted deactivating agents. Bioorganic chemistry 153 (2024)
Jinling Zhang, Peng Jiang, Shuping Wang, Mengmeng Li, Zhichao Hao, Wei Guan, Juan Pan, Jiatong Wu, Yiqiang Zhang, Hua Li, Lixia Chen, Bingyou Yang, Yan Liu
Recent advances in the natural product analogues for the treatment of neurodegenerative diseases. Bioorganic chemistry 153 (2024)
Henan Zhang, Changsheng Chen, Jingjun Han, Shuaishuai Wang, Qingwen Jia, Peixue Ling, Shuang Li, Junqiang Fang
Hyaluronan and Glucose Dual-targeting Probe: Synthesis and Application. Bioorganic chemistry 153 (2024)
Samar Sami Alkafaas, Sohila A Khedr, Sara Samy ElKafas, Wael Hafez, Samah A Loutfy, Mohamed Sakran, Nenad Janković
Targeting JNK kinase inhibitors via molecular docking: A promising strategy to address tumorigenesis and drug resistance. Bioorganic chemistry 153 (2024)
Yu Xia, Hongbo Zhang, Huijie Du, Lei Huang, Chunqiu Yu, Haozhe Wu, Yiwei Zhang, Yungen Xu, Qihua Zhu, Yi Zou
Design, synthesis, and antitumor activity evaluation of 1,2,3-triazole derivatives as potent PD-1/PD-L1 inhibitors. Bioorganic chemistry 153 (2024)
Liangping Li, Zetian Huang, Yuying Huang, Yongkun Li, Xuesong Ma, Pingping Li, Wenqing Du, Hui Wang, Yufei Zhao, Shulan Zeng, Yan Peng, Guohai Zhang
Pomalidomide sensitizes lung cancer cells to TRAIL/CDDP-induced apoptosis via directly targeting electron transfer flavoprotein alpha subunit. Bioorganic chemistry 153 (2024)
Yousef Mirzaei, Ali Hussein Mer, Bahia Fattah Maran, Leila Omidvar, Fatemeh Misamogooe, Zahra Amirkhani, Nafiseh Javaheri Haghighi, Nader Bagheri, Zahra Keshtkaran, Behzad Rezaei, Farshad Bargrizaneh, Saeed Jahandideh, Nesa Barpour, Hosein Shahsavarani, Ahmadreza Bazyari, Meghdad Abdollahpour-Alitappeh
Clinical and preclinical advances in PSMA-Directed Antibody-Drug conjugates (ADCs): Current status and hope for the future. Bioorganic chemistry 153 (2024)
Ayushi Bhatnagar, Gangotri Pemawat
Anticancer and Antibacterial Activeness of Fused Pyrimidines: Newfangled Updates. Bioorganic chemistry 153 (2024)
Youlu Pan, Haifeng Chen, Jingfeng Fu, Jingyu Zhang, Peipei Wang, Runmei Chen, Shuangshuang Geng, Jinxin Che, Xiaowu Dong, Yubo Zhou, Wenhai Huang
Discovery of N-Benzylpiperidinol derivatives as USP7 inhibitors against Hematology. Bioorganic chemistry 153 (2024)
Nan Cai, Xiang Gao, Ling Jia, Yunzhe Liu, Lingwei Zhou, Jinfeng Zhao, Jingping Qu, Yuhan Zhou
3-(2-Trifluoromethyl-3-aryl-4H-chromen-4-yl)-1H-indoles: Mastering anti-inflammation and analgesia while mitigating gastrointestinal side effects. Bioorganic chemistry 153 (2024)
Sílvia Vinhas, Baltazar de Castro, Maria Rangel
Synthesis of 3-hydroxy-4-pyridinone hexadentate chelators, and biophysical evaluation of their affinity towards lipid bilayers. Bioorganic chemistry 153 (2024)
Yingying Jiang, Xiaogang Luo, Zhanpeng Zheng, Shun Wen, Hongwei Gao, Cheng Xu, Min Jiang, Siyuan Wang
Identification of novel RANKL inhibitors through in silico analysis. Bioorganic chemistry 153 (2024)
Marta Makowska, Anna Wardowska, Marta Bauer, Dariusz Wyrzykowski, Izabela Małuch, Emilia Sikorska
Impact of lipidation site on the activity of α-helical antimicrobial peptides. Bioorganic chemistry 153 (2024)
Shuang Chen, Jialiang Suo, Yu Wang, Chenglun Tang, Beiting Ma, Jiaqi Li, Yuyang Hou, Bingrong Yan, Tao Shen, Qi Zhang, Bo Ma
Cordycepin alleviates diabetes mellitus-associated hepatic fibrosis by inhibiting SOX9-mediated Wnt/β-catenin signal axis. Bioorganic chemistry 153 (2024)
Shumei Wang, Zhenzhen Li, Siyue Ma, Shuxin Zhang, Shuxian Guo, Zhao Ma, Lupei Du, Minyong Li
Discovery of novel 20S proteasome subunit β5 PROTAC degraders as potential therapeutics for pharyngeal carcinoma and Bortezomib-resistant multiple myeloma. Bioorganic chemistry 153 (2024)
Manan Kothari, Karthika Kannan, Revathy Sahadevan, Sruthi Vijaya Retnakumar, Camille Chauvin, Jagadeesh Bayry, Sushabhan Sadhukhan
Lipophilic derivatives of EGCG as potent α-amylase and α-glucosidase inhibitors ameliorating oxidative stress and inflammation. Bioorganic chemistry 153 (2024)
Cheng Chen, Yanyan Feng, Chen Zhou, Zhouyan Liu, Ziwei Tang, Ye Zhang, Tong Li, Chenglei Gu, Jichao Chen
Development of natural product-based targeted protein degraders as anticancer agents. Bioorganic chemistry 153 (2024)