Biotechnology progress

Keyphrases

Publications

volume 40, number 3, 2024

Julie Østerby Madsen, Sebastian Olivier Nymann Topalian, Mikkel Fog Jacobsen, Tommy Skovby, Krist V Gernaey, Allan S Myerson, John M Woodley
Raman spectroscopy and one-dimensional convolutional neural network modeling as a real-time monitoring tool for in vitro transaminase-catalyzed synthesis of a pharmaceutically relevant amine precursor. Biotechnology progress 40 (3) (2024)
Valiollah Keshavarz, Maryam Kazemi, Bahman Khalvati, Fateme Zare, Ali Dehshahri, Hossein Sadeghpour
Surface decoration of low molecular weight polyethylenimine (LMW PEI) by phthalated dextrin for improved delivery of interleukin-12 plasmid. Biotechnology progress 40 (3) (2024)
Louis Coplan, Zhe Zhang, Nicole Ragone, John Reeves, Audrey Rodriguez, Aishwarya Shevade, Hanne Bak, Andrew D Tustian
High-yield recombinant adeno-associated viral vector production by multivariate optimization of bioprocess and transfection conditions. Biotechnology progress 40 (3) (2024)
Sun-Hee Kim, Hae-Min Park, Hee-Jin Jeong
Evaluation of PDL1 positive cancer cell-specific binding activity of recombinant anti-PDL1 scFv. Biotechnology progress 40 (3) (2024)
Irina Ramos, Michelle Najera, Eugene Schaefer
Integration of rapid bioburden testing into production quality management systems and process control. Biotechnology progress 40 (3) (2024)
Xiaoyan Tang, Jorge Quiroz, Yixiao Zhang, Jessica Pan, Zhong Lai, Zhimei Du, Ren Liu
A deep-well plate enabled automated high-throughput cell line development platform. Biotechnology progress 40 (3) (2024)
Dominique WuDunn, Andrea Squeri, Jimmy Vu, Ashna Dhingra, Jon Coffman, Ken Lee
Effect of inner diameter, filter length, and pore size on hollow fiber filter fouling during perfusion cell culture. Biotechnology progress 40 (3) (2024)
Valiollah Keshavarz, Maryam Kazemi, Bahman Khalvati, Fateme Zare, Ali Dehshahri, Hossein Sadeghpour
Surface decoration of low molecular weight polyethylenimine (LMW PEI) by phthalated dextrin for improved delivery of interleukin-12 plasmid. Biotechnology progress 40 (3) (2024)
Zion Lee, Jun Wan, Amy Shen, Gavin C Barnard
Gene copy number, gene configuration and LC/HC mRNA ratio impact on antibody productivity and product quality in targeted integration CHO cell lines. Biotechnology progress 40 (3) (2024)
Lina Chakrabarti, James Savery, John Patrick Mpindi, Judith Klover, Lina Li, Jie Zhu
Simplifying stable CHO cell line generation with high probability of monoclonality by using microfluidic dispensing as an alternative to fluorescence activated cell sorting. Biotechnology progress 40 (3) (2024)
Mohammed Raihan Uddin, Xiaolin Chen
Enhancing cell separation in a hybrid spiral dielectrophoretic microchannel: Numerical insights and optimal operating conditions. Biotechnology progress 40 (3) (2024)
Michelle Meagher, Jacob Tamburro, Nanette R Boyle
A custom 3D printed paddlewheel improves growth in flat panel photobioreactor. Biotechnology progress 40 (3) (2024)
Ping Xu, Yu Chuan Ou, Michael Smith, Jim Paulson, Michael A Schmidt, Lakshmi Kandari, Rodney Parsons, Anurag Khetan
Application of fucosylation inhibitors for production of afucosylated antibody. Biotechnology progress 40 (3) (2024)
Tsuyoshi Yamaguchi, Hiroko Ishikawa, Mie Fukuda, Yumi Sugita, Misaki Furuie, Ryuma Nagano, Toshiyuki Suzawa, Koichi Yamamoto, Kaori Wakamatsu
Catechins prevent monoclonal antibody fragmentation during production via fed-batch culture of Chinese hamster ovary cells. Biotechnology progress 40 (3) (2024)
Ujjiti Pandey, Indrani Madhugiri, Chetan Gadgil, Mugdha Gadgil
Leveraging machine learning to dissect role of combinations of amino acids in modulating the effect of zinc on mammalian cell growth. Biotechnology progress 40 (3) (2024)
Jessica Zuponcic, Fernanda Cunha, Grant Springer, Eduardo Ximenes, Michael R Ladisch
Effect of flux and shear rate on E. coli recovery in tangential flow filtration through a single hollow fiber. Biotechnology progress 40 (3) (2024)
Rigumula Wu, Danielle M Kahl, Ronald Kloberdanz, Kushal J Rohilla, Sowmya Balasubramanian
Demonstration of a robust high cell density transient CHO platform yielding mAb titers of up to 2 g/L without medium exchange. Biotechnology progress 40 (3) (2024)
Jinxin Gao, Laurie B Hazeltine, Neal Stroud, Ning Liu, Yao-Ming Huang
Development of bioreactor scale-down model using orthogonal projections to latent structures method and CO 2 supplementation. Biotechnology progress 40 (3) (2024)
Kim B Kuchemüller, Ralf Pörtner, Johannes Möller
Implementation of mDoE-methods to a microcarrier-based expansion processes for mesenchymal stem cells. Biotechnology progress 40 (3) (2024)
Valiollah Keshavarz, Maryam Kazemi, Bahman Khalvati, Fateme Zare, Ali Dehshahri, Hossein Sadeghpour
Surface decoration of low molecular weight polyethylenimine (LMW PEI) by phthalated dextrin for improved delivery of interleukin-12 plasmid. Biotechnology progress 40 (3) (2024)
Lina Chakrabarti, James Savery, John Patrick Mpindi, Judith Klover, Lina Li, Jie Zhu
Simplifying stable CHO cell line generation with high probability of monoclonality by using microfluidic dispensing as an alternative to fluorescence activated cell sorting. Biotechnology progress 40 (3) (2024)
Louis Coplan, Zhe Zhang, Nicole Ragone, John Reeves, Audrey Rodriguez, Aishwarya Shevade, Hanne Bak, Andrew D Tustian
High-yield recombinant adeno-associated viral vector production by multivariate optimization of bioprocess and transfection conditions. Biotechnology progress 40 (3) (2024)
Tsuyoshi Yamaguchi, Hiroko Ishikawa, Mie Fukuda, Yumi Sugita, Misaki Furuie, Ryuma Nagano, Toshiyuki Suzawa, Koichi Yamamoto, Kaori Wakamatsu
Catechins prevent monoclonal antibody fragmentation during production via fed-batch culture of Chinese hamster ovary cells. Biotechnology progress 40 (3) (2024)
Hong Li, Patricia Rose, Patricia Rowicki, Collette Cutler, Jeffrey T McPhee, Claudia Frey, Linda Lemieux, Gerald Pelette, Joo Kok Ang, Ren Liu, Douglas D Richardson
Advancing multiproduct resin reuse for development and clinical manufacturing of an antibody-based therapeutic. Biotechnology progress 40 (3) (2024)
Natália Cristine Dias Dos Santos, Paula Bruzadelle-Vieira, Nádia de Cássia Noronha, Amanda Mizukami-Martins, Maristela Delgado Orellana, Maria Vitória L B Bentley, Dimas Tadeu Covas, Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim
Transitioning from static to suspension culture system for large-scale production of xeno-free extracellular vesicles derived from mesenchymal stromal cells. Biotechnology progress 40 (3) (2024)
Irina Ramos, Michelle Najera, Eugene Schaefer
Integration of rapid bioburden testing into production quality management systems and process control. Biotechnology progress 40 (3) (2024)
Sun-Hee Kim, Hae-Min Park, Hee-Jin Jeong
Evaluation of PDL1 positive cancer cell-specific binding activity of recombinant anti-PDL1 scFv. Biotechnology progress 40 (3) (2024)
Jinxin Gao, Laurie B Hazeltine, Neal Stroud, Ning Liu, Yao-Ming Huang
Development of bioreactor scale-down model using orthogonal projections to latent structures method and CO 2 supplementation. Biotechnology progress 40 (3) (2024)
Zion Lee, Jun Wan, Amy Shen, Gavin C Barnard
Gene copy number, gene configuration and LC/HC mRNA ratio impact on antibody productivity and product quality in targeted integration CHO cell lines. Biotechnology progress 40 (3) (2024)
Natália Cristine Dias Dos Santos, Paula Bruzadelle-Vieira, Nádia de Cássia Noronha, Amanda Mizukami-Martins, Maristela Delgado Orellana, Maria Vitória L B Bentley, Dimas Tadeu Covas, Kamilla Swiech, Kelen Cristina Ribeiro Malmegrim
Transitioning from static to suspension culture system for large-scale production of xeno-free extracellular vesicles derived from mesenchymal stromal cells. Biotechnology progress 40 (3) (2024)
Rigumula Wu, Danielle M Kahl, Ronald Kloberdanz, Kushal J Rohilla, Sowmya Balasubramanian
Demonstration of a robust high cell density transient CHO platform yielding mAb titers of up to 2 g/L without medium exchange. Biotechnology progress 40 (3) (2024)

volume 40, number 4, 2024

Takao Ito, Herb Lutz, Lihan Tan, Bin Wang, Janice Tan, Masum Patel, Lance Chen, Yuki Tsunakawa, Byunghyun Park, Subhasis Banerjee
Host cell proteins in monoclonal antibody processing: Control, detection, and removal. Biotechnology progress 40 (4) (2024)
Solomon Isu, Lilia Vinskus, Derek Silva, Kristina Cunningham, Thomas Elich, Patricia Greenhalgh, Adam Sokolnicki, Bala Raghunath
Leveraging bioanalytical characterization of fractionated monoclonal antibody pools to identify aggregation-prone and less filterable proteoforms during virus filtration. Biotechnology progress 40 (4) (2024)
Kevin Brower, Kelly Wiltberger, Claudia Berdugo, Allen Bosley, Elizabeth Goodrich, Valerie Pferdeort, Eugene Schaefer
Process development and characterization for integrated continuous bioprocesses-Highlights from N-mAb. Biotechnology progress 40 (4) (2024)
Kevin Brower, Kelly Wiltberger, Claudia Berdugo, Allen Bosley, Elizabeth Goodrich, Valerie Pferdeort, Eugene Schaefer
Process development and characterization for integrated continuous bioprocesses-Highlights from N-mAb. Biotechnology progress 40 (4) (2024)
Md Sadique Hasan, Chad Sundberg, Elias Gilotte, Xudong Ge, Yordan Kostov, Govind Rao
Bioburden detection on surface and water samples in a rapid, ultra-sensitive and high-throughput manner. Biotechnology progress 40 (4) (2024)
Shu Fang, Dillon J Sinanan, Marc H Perez, Raúl G Cruz-Quintero, Sachin R Jadhav
Development of a high-throughput scale-down model in Ambr® 250 HT for plasmid DNA fermentation processes. Biotechnology progress 40 (4) (2024)
Catarina P G Neves, Jonathan L Coffman, Suzanne S Farid
Evaluating end-to-end continuous antibody manufacture with column-free capture alternatives from economic, environmental, and robustness perspectives. Biotechnology progress 40 (4) (2024)
James Flynn, Laura Breen, Shankara Narayanan, Michael Butler
Measurement and control of foam generation in a mammalian cell culture. Biotechnology progress 40 (4) (2024)
Danni Ying, Guofeng Zhang, Huimin Huang, Wen-Song Tan, Haibo Cai
Optimizing glutamine concentration enhances ex vivo expansion of natural killer cells through improved redox status. Biotechnology progress 40 (4) (2024)
Jing Guo, Steven J Traylor, Mohamed Agoub, Weixin Jin, Helen Hua, R Bertrum Diemer, Xuankuo Xu, Sanchayita Ghose, Zheng Jian Li, Abraham M Lenhoff
Modeling scalability of impurity precipitation in downstream biomanufacturing. Biotechnology progress 40 (4) (2024)
Darrick Shen, Shyam Panjwani, Konstantinos Spetsieris
Digital application for drug product potency target evaluation in biopharmaceutical manufacturing. Biotechnology progress 40 (4) (2024)
Da Zhang, Sumith Ranil Wickramasinghe, Andrew L Zydney, John P Smelko, Abdullah Loman, April Wheeler, Xianghong Qian
Proteomic analysis of host cell protein fouling during bioreactor harvesting. Biotechnology progress 40 (4) (2024)
Abigail King, Yiwei Zhao, Alexandru Lazar, Margeaux Capron, Niranjan Thiruvur, Xinrong Liu
Methods comparison of two-dimensional gel electrophoresis for host cell protein characterization. Biotechnology progress 40 (4) (2024)
G Karagülle, Murat Telli
Effects of green light supplementation with red and blue combinations of LED light spectrums on the growth and transcriptional response of Haematococcus pluvialis. Biotechnology progress 40 (4) (2024)
Yawen Tang, Jianlin Xu, Mengmeng Xu, Zhuangrong Huang, Johanna Santos, Qin He, Michael Borys, Anurag Khetan
Fed-batch performance profiles for mAb production using different intensified N - 1 seed strategies are CHO cell-line dependent. Biotechnology progress 40 (4) (2024)
Fatma Zehra Erkoc-Biradli, Berkay Erenay, Alp Ozgun, Hayriye Öztatlı, Ferda Işık, Utku Ateş, Rıfat Rasier, Bora Garipcan
Mesenchymal stem cells derived-exosomes enhanced amniotic membrane extract promotes corneal keratocyte proliferation. Biotechnology progress 40 (4) (2024)
Venkatesh Natarajan, Neil Soice, Johanna Mullen, David Bull
GMP implementation of a hybrid continuous manufacturing process for a recombinant non-mAb protein-A case study. Biotechnology progress 40 (4) (2024)
Leon P Pybus, Charles Heise, Tibor Nagy, Carmen Heeran, Terri Dover, John Raven, Junichi Kori, Graeme Burton, Hiroshi Sakuyama, Benjamin Hastings, Michelle Lyons, Shinichi Nakai, Jonathan Haigh
A modular and multi-functional purification strategy that enables a common framework for manufacturing scale integrated and continuous biomanufacturing. Biotechnology progress 40 (4) (2024)
Howard R G Clarke, Anke Mayer-Bartschmid, Chenxing Zheng, Elizabeth Masterjohn, Falguni Patel, Mark Moffat, Qingxiang Wei, Ren Liu, Robyn Emmins, Simon Fischer, Stephanie Rieder, Thomas Kelly
When will we have a clone? An industry perspective on the typical CLD timeline. Biotechnology progress 40 (4) (2024)