Adrian D Hobson (Adrian Hobson)

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 28

Top Venues

RSC medicinal chemistry

Journal of medicinal chemistry

Science translational medicine

Analytical methods : advancing methods and applications

Abbvie Bioresearch Center

University of Sheffield (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Abbvie Bioresearch Center Nov 02 1992

United States

Senior Research Fellow :: Global Biologics - ADC

Education History

University of Sheffield Sep 01 1989 - Oct 31 1992

United Kingdom

PHD :: Chemistry

University of Sheffield

United Kingdom

BSC :: Chemistry

Publications

Zhou Xu, Zhongyuan Wang, Xiaona Shi, Rui Ding, Li Han, Xueping Yang, Hongmei Zhang, Adrian D Hobson
Impact of atropisomerism on a non-steroidal glucocorticoid receptor agonist. RSC medicinal chemistry 15 (7) (2024)
Christopher C Marvin, Adrian D Hobson, Michael J McPherson, Martin E Hayes, Meena V Patel, Diana L Schmidt, Tongmei Li, John T Randolph, Agnieszka K Bischoff, Julia Fitzgibbons, Lu Wang, Lu Wang, Axel Hernandez, Ying Jia, Christian A Goess, Shaughn H Bryant, Suzanne L Mathieu, Jianwen Xu
Anti-TNF Thioester Glucocorticoid Antibody-Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model. Journal of medicinal chemistry (2024)
Adrian D Hobson
The medicinal chemistry evolution of antibody-drug conjugates. RSC medicinal chemistry 15 (3) (2024)
Ling C Santora, Adrian D Hobson, Lu Wang, Kan X Wu
Impact of drug-linker on method selection for analytical characterization and purification of antibody-drug conjugates. Analytical methods : advancing methods and applications (2024)
Michael J McPherson, Adrian D Hobson, Axel Hernandez, Christopher C Marvin, Wendy Waegell, Christian Goess, Jason Z Oh, Dan Shi, Martin E Hayes, Lu Wang, Lu Wang, Diana Schmidt, Zhi Wang, Victoria Pitney, Kimberley McCarthy, Ying Jia, Ce Wang, Bit Na Kang, Shaughn Bryant, Suzanne Mathieu, Melanie C Ruzek, Julie Parmentier, Ronilda R D'Cunha, Yinuo Pang, Lucy Phillips, Nathan J Brown, Jianwen Xu, Candace Graff, Yu Tian, Kenton L Longenecker, Wei Qiu, Haizhong Zhu, Wei Liu, Pingping Zheng, Yingtao Bi, Robert Stoffel
An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases. Science translational medicine 16 (739) (2024)
Adrian D Hobson, Haizhong Zhu, Wei Qiu, Russell A Judge, Kenton Longenecker
Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties. RSC medicinal chemistry 15 (3) (2024)
Adrian D Hobson
The medicinal chemistry evolution of antibody-drug conjugates. RSC medicinal chemistry 15 (3) (2024)
Christopher C Marvin, Adrian D Hobson, Michael J McPherson, Martin E Hayes, Meena V Patel, Diana L Schmidt, Tongmei Li, John T Randolph, Agnieszka K Bischoff, Julia Fitzgibbons, Lu Wang, Lu Wang, Axel Hernandez, Ying Jia, Christian A Goess, Shaughn H Bryant, Suzanne L Mathieu, Jianwen Xu
Anti-TNF Thioester Glucocorticoid Antibody-Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model. Journal of medicinal chemistry 67 (11) (2024)
Chewei Anderson Chang, Ethan Emberley, Aloma L D'Souza, Weilong Zhao, Cormac Cosgrove, Karen Parrish, Diya Mitra, Elmer Payson, Anatol Oleksijew, Paul Ellis, Luis Rodriguez, Ryan Duggan, Cara Hrusch, Loren Lasko, Wissam Assaily, Pingping Zheng, Wei Liu, Axel Hernandez, Kimberley McCarthy, Zhaomei Zhang, Geunbae Rha, Zhensheng Cao, Yingchun Li, Olivia Perng, Jos Campbell, Gloria Zhang, Tyler Curran, Milan Bruncko, Christopher C Marvin, Adrian D Hobson, Michael J McPherson, Tamar Uziel, Marybeth A Pysz, Xi Zhao, Alex Bankovich, Joel Hayflick, Michael McDevitt, Kevin J Freise, Susan Morgan-Lappe, James W Purcell
ABBV-319: a CD19-targeting glucocorticoid receptor modulator antibody-drug conjugate therapy for B-cell malignancies. Blood 144 (7) (2024)
Adrian D Hobson, Haizhong Zhu, Wei Qiu, Russell A Judge, Kenton Longenecker
Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties. RSC medicinal chemistry 15 (3) (2024)
Michael J McPherson, Adrian D Hobson, Axel Hernandez, Christopher C Marvin, Wendy Waegell, Christian Goess, Jason Z Oh, Dan Shi, Martin E Hayes, Lu Wang, Lu Wang, Diana Schmidt, Zhi Wang, Victoria Pitney, Kimberley McCarthy, Ying Jia, Ce Wang, Bit Na Kang, Shaughn Bryant, Suzanne Mathieu, Melanie C Ruzek, Julie Parmentier, Ronilda R D'Cunha, Yinuo Pang, Lucy Phillips, Nathan J Brown, Jianwen Xu, Candace Graff, Yu Tian, Kenton L Longenecker, Wei Qiu, Haizhong Zhu, Wei Liu, Pingping Zheng, Yingtao Bi, Robert Stoffel
An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases. Science translational medicine 16 (739) (2024)
Ling C Santora, Adrian D Hobson, Lu Wang, Kan X Wu
Impact of drug-linker on method selection for analytical characterization and purification of antibody-drug conjugates. Analytical methods : advancing methods and applications 16 (22) (2024)
Zhou Xu, Zhongyuan Wang, Xiaona Shi, Rui Ding, Li Han, Xueping Yang, Hongmei Zhang, Adrian D Hobson
Impact of atropisomerism on a non-steroidal glucocorticoid receptor agonist. RSC medicinal chemistry 15 (7) (2024)
Chewei Anderson Chang, Ethan Emberley, Aloma L D'Souza, Weilong Zhao, Cormac Cosgrove, Karen E Parrish, Diya Mitra, Elmer Payson, Anatol Oleksijew, Paul Ellis, Luis Rodriguez, Ryan Duggan, Cara Hrusch, Loren Lasko, Wissam Assaily, Pingping Zheng, Wei Liu, Axel Hernandez, Kimberley McCarthy, Zhaomei Zhang, Geunbae Rha, Zhensheng Cao, Yingchun Li, Olivia Perng, Jos Campbell, Gloria Zhang, Tyler Scott Curran, Milan Bruncko, Christopher C Marvin, Adrian D Hobson, Michael J McPherson, Tamar Uziel, Marybeth A Pysz, Xi Zhao, Alexander Bankovich, Joel Hayflick, Michael McDevitt, Kevin J Freise, Susan Morgan-Lappe, James W Purcell
ABBV-319: A CD19-targeting glucocorticoid receptor modulator antibody-drug conjugate therapy for B-cell malignancies. Blood (2024)
Michael J McPherson, Adrian D Hobson, Axel Hernandez, Christopher C Marvin, Wendy Waegell, Christian Goess, Jason Z Oh, Dan Shi, Martin E Hayes, Lu Wang, Lu Wang, Diana Schmidt, Zhi Wang, Victoria Pitney, Kimberley McCarthy, Ying Jia, Ce Wang, Bit Na Kang, Shaughn Bryant, Suzanne Mathieu, Melanie C Ruzek, Julie Parmentier, Ronilda R D'Cunha, Yinuo Pang, Lucy Phillips, Nathan J Brown, Jianwen Xu, Candace Graff, Yu Tian, Kenton L Longenecker, Wei Qiu, Haizhong Zhu, Wei Liu, Pingping Zheng, Yingtao Bi, Robert Stoffel
An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases. Science translational medicine 16 (739) (2024)
Lu Wang, Adrian D Hobson, Paulin L Salomon, Julia Fitzgibbons, Jianwen Xu, Sean McCarthy, Kan Wu, Ying Jia, Axel Hernandez, Xiang Li, Zhou Xu, Zhongyuan Wang, Yajie Yu, Junxian Li, Lin Tao
Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates. RSC medicinal chemistry 15 (2) (2023)
Adrian D Hobson, Jianwen Xu, Christopher C Marvin, Michael J McPherson, Markus Hollmann, Michael Gattner, Kristina Dzeyk, Margaret M Fettis, Agnieszka K Bischoff, Lu Wang, Julia Fitzgibbons, Lu Wang, Paulin Salomon, Axel Hernandez, Ying Jia, Hetal Sarvaiya, Christian A Goess, Suzanne L Mathieu, Ling C Santora
Optimization of Drug-Linker to Enable Long-term Storage of Antibody-Drug Conjugate for Subcutaneous Dosing. Journal of medicinal chemistry (2023)
Adrian D Hobson, Michael J McPherson, Martin E Hayes, Christian Goess, Xiang Li, Jian Zhou, Zhongyuan Wang, Yajie Yu, Jindong Yang, Liang Sun, Qiang Zhang, Pei Qu, Shi Yang, Axel Hernandez, Shaughn H Bryant, Suzanne L Mathieu, Agnieszka K Bischoff, Julia Fitzgibbons, Ling C Santora, Lu Wang, Lu Wang, Margaret M Fettis, Xiaofeng Li, Christopher C Marvin, Zhi Wang, Meena V Patel, Diana L Schmidt, Tongmei Li, John T Randolph, Rodger F Henry, Candace Graff, Yu Tian, Ana L Aguirre, Anurupa Shrestha
Correction to "Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate". Journal of medicinal chemistry (2023)
Adrian D Hobson, Michael J McPherson, Wendy Waegell, Christian A Goess, Robert H Stoffel, Xiang Li, Jian Zhou, Zhongyuan Wang, Yajie Yu, Axel Hernandez, Shaughn H Bryant, Suzanne L Mathieu, Agnieszka K Bischoff, Julia Fitzgibbons, Martyna Pawlikowska, Sujiet Puthenveetil, Ling C Santora, Lu Wang, Lu Wang, Christopher C Marvin, Martin E Hayes, Anurupa Shrestha, Kathy A Sarris, Biqin Li
Correction to "Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody-Drug Conjugate Payloads". Journal of medicinal chemistry (2023)
Lu Wang, Adrian D Hobson, Julia Fitzgibbons, Axel Hernandez, Ying Jia, Zhou Xu, Zhongyuan Wang, Yajie Yu, Xiang Li
Impact of dipeptide on ADC physicochemical properties and efficacy identifies Ala-Ala as the optimal dipeptide. RSC medicinal chemistry 15 (1) (2023)
Adrian D Hobson, Jianwen Xu, Dennie S Welch, Christopher C Marvin, Michael J McPherson, Bradley Gates, Xiaoli Liao, Markus Hollmann, Michael J Gattner, Kristina Dzeyk, Hetal Sarvaiya, Vikram M Shenoy, Margaret M Fettis, Agnieszka K Bischoff, Lu Wang, Ling C Santora, Lu Wang, Julia Fitzgibbons, Paulin Salomon, Axel Hernandez, Ying Jia, Christian A Goess, Suzanne L Mathieu, Shaughn H Bryant, Mary E Larsen, Baoliang Cui, Yu Tian
Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC). Journal of medicinal chemistry (2023)
Christopher C Marvin, Adrian D Hobson, Michael McPherson, Theresa A Dunstan, Thomas R Vargo, Martin E Hayes, Margaret M Fettis, Agnieszka Bischoff, Lu Wang, Lu Wang, Axel Hernandez, Ying Jia, Jason Z Oh, Yu Tian
Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates. Bioconjugate chemistry (2023)
Lu Wang, Adrian D Hobson, Julia Fitzgibbons, Axel Hernandez, Ying Jia, Zhou Xu, Zhongyuan Wang, Yajie Yu, Xiang Li
Impact of dipeptide on ADC physicochemical properties and efficacy identifies Ala-Ala as the optimal dipeptide. RSC medicinal chemistry 15 (1) (2023)
Lu Wang, Adrian D Hobson, Paulin L Salomon, Julia Fitzgibbons, Jianwen Xu, Sean McCarthy, Kan Wu, Ying Jia, Axel Hernandez, Xiang Li, Zhou Xu, Zhongyuan Wang, Yajie Yu, Junxian Li, Lin Tao
Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates. RSC medicinal chemistry 15 (2) (2023)
Adrian D Hobson, Michael J McPherson, Martin E Hayes, Christian Goess, Xiang Li, Jian Zhou, Zhongyuan Wang, Yajie Yu, Jindong Yang, Liang Sun, Qiang Zhang, Pei Qu, Shi Yang, Axel Hernandez, Shaughn H Bryant, Suzanne L Mathieu, Agnieszka K Bischoff, Julia Fitzgibbons, Ling C Santora, Lu Wang, Lu Wang, Margaret M Fettis, Xiaofeng Li, Christopher C Marvin, Zhi Wang, Meena V Patel, Diana L Schmidt, Tongmei Li, John T Randolph, Rodger F Henry, Candace Graff, Yu Tian, Ana L Aguirre, Anurupa Shrestha
Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. Journal of medicinal chemistry 65 (23) (2022)
Adrian D Hobson, Michael J McPherson, Wendy Waegell, Christian A Goess, Robert H Stoffel, Xiang Li, Jian Zhou, Zhongyuan Wang, Yajie Yu, Axel Hernandez, Shaughn H Bryant, Suzanne L Mathieu, Agnieszka K Bischoff, Julia Fitzgibbons, Martyna Pawlikowska, Sujiet Puthenveetil, Ling C Santora, Lu Wang, Lu Wang, Christopher C Marvin, Martin E Hayes, Anurupa Shrestha, Kathy A Sarris, Biqin Li
Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody-Drug Conjugate Payloads. Journal of medicinal chemistry 65 (6) (2022)
Adrian D Hobson, Russell A Judge, Ana L Aguirre, Brian S Brown, Yifang Cui, Ping Ding, Eric Dominguez, Enrico DiGiammarino, David A Egan, Gail M Freiberg, Sujatha M Gopalakrishnan, Christopher M Harris, Marie P Honore, Karen L Kage, Nicolas J Kapecki, Christopher Ling, Junli Ma, Helmut Mack, Mulugeta Mamo, Stefan Maurus, Bradford McRae, Nigel S Moore, Bernhard K Mueller, Reinhold Mueller, Marian T Namovic, Kaushal Patel, Steve D Pratt, C Brent Putman, Kara L Queeney, Kathy K Sarris, Lisa M Schaffter, Vincent Stoll, Anil Vasudevan, Lei Wang, Lu Wang, William Wirthl, Kimberly Yach
Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design. Journal of medicinal chemistry 61 (24) (2018)
Russell A Judge, Anil Vasudevan, Victoria E Scott, Gricelda H Simler, Steve D Pratt, Marian T Namovic, C Brent Putman, Ana Aguirre, Vincent S Stoll, Mulugeta Mamo, Steven I Swann, Steven C Cassar, Connie R Faltynek, Karen L Kage, Janel M Boyce-Rustay, Adrian D Hobson
Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase A as a Structure Surrogate. Chembiochem : a European journal of chemical biology 19 (6) (2018)

Adrian D Hobson.css-eqlu8i{font-size:small;padding-left:4px;} (Adrian Hobson)

Publication Activity (10 Years)

Top Topics

Top Venues

Adrian D Hobson (Adrian Hobson)