RSC medicinal chemistry

Keyphrases

Publications

volume 15, number 8, 2024

Ana Teresa Silva, Isabel Oliveira, Denise Maria F A Duarte, Diana Moita, Miguel Prudncio, Fátima Nogueira, Ricardo Ferraz, Eduardo Figueira Marques, Paula A C Gomes
"Seasoning" antimalarial drugs' action: chloroquine bile salts as novel triple-stage antiplasmodial hits. RSC medicinal chemistry 15 (8) (2024)
Vojtech Chmil, Natálie Živná, Marcela Milanová, Alžběta Filipová, Jaroslav Pejchal, Lukáš Prchal, Darina Muthná, Vít Řeháček, Martina Řezáčová, Jan Marek, Jakub Grepl, Radim Havelek
Second-generation piperazine derivatives as promising radiation countermeasures. RSC medicinal chemistry 15 (8) (2024)
Sanaa K Bardaweel, Rola AlOmari, Rima Hajjo
Integrating computational and experimental chemical biology revealed variable anticancer activities of phosphodiesterase isoenzyme 5 inhibitors (PDE5i) in lung cancer. RSC medicinal chemistry 15 (8) (2024)
Théo Frazier, Pauline Murail, Arthur Boulangé, Nazim Chalane, Francis Giraud, Alain Artola, Radhouane Dallel, Fabrice Anizon, Pascale Moreau
Synthesis of diversely substituted pyridin-2(1 H )-ones and in vivo evaluation of their anti-allodynic effect on cutaneous inflammatory mechanical allodynia. RSC medicinal chemistry 15 (8) (2024)
Ajay Kishor Kushawaha, Arvind Kumar Jaiswal, Jay Gupta, Sarita Katiyar, Alisha Ansari, Hemlata Bhatt, Sandeep K Sharma, Abhijit Deb Choudhury, Rabi Sankar Bhatta, Bhupendra N Singh, Koneni V Sashidhara
Antitubercular evaluation of dihydropyridine-triazole conjugates: design, synthesis, in vitro screening, SAR and in silico ADME predictions. RSC medicinal chemistry 15 (8) (2024)
Satsawat Visansirikul, Suthira Yanaso, Yingrak Boondam, Kanjanawadee Prasittisa, Brompoj Prutthiwanasan, Sumet Chongruchiroj, Kittisak Sripha
Discovery of novel coumarin triazolyl and phenoxyphenyl triazolyl derivatives targeting amyloid beta aggregation-mediated oxidative stress and neuroinflammation for enhanced neuroprotection. RSC medicinal chemistry 15 (8) (2024)
Aishvarya Tandon, Anna Santura, Herbert Waldmann, Axel Pahl, Paul Czodrowski
Identification of lysosomotropism using explainable machine learning and morphological profiling cell painting data. RSC medicinal chemistry 15 (8) (2024)
Axel Pahl, Oleksandr O Grygorenko, Ivan S Kondratov, Herbert Waldmann
Identification of readily available pseudo-natural products. RSC medicinal chemistry 15 (8) (2024)
Gurpreet Singh, Rajveer Singh, Vikram Deep Monga, Sidharth Mehan
Thiazolidine-2,4-dione hybrids as dual alpha-amylase and alpha-glucosidase inhibitors: design, synthesis, in vitro and in vivo anti-diabetic evaluation. RSC medicinal chemistry 15 (8) (2024)
Ji-Chao Guo, Shi-Hui Deng, Shu-Min Zhou, Xuan Zhou, Jiajia Du, Si-Han Zhou, Qi-Hua Zhao, Zhong-Yan Cai, Xiaoxia Ren, Ming-Jin Xie
Responsive ZIF-90 nanocomposite material: targeted delivery of 10-hydroxycamptothecine to enhance the therapeutic effect of colon cancer (HCT116) cells. RSC medicinal chemistry 15 (8) (2024)
Mary Sravani Galla, Nitika Sharma, Priyanka Mishra, Nagula Shankaraiah
Recent insights of PROTAC developments in inflammation-mediated and autoimmune targets: a critical review. RSC medicinal chemistry 15 (8) (2024)
Li-Er Deng, Yuzhi Qiu, Yana Zeng, Jiafeng Zou, Abhinav Kumar, Ying Pan, Alireza Nezamzadeh-Ejhieh, Jian-Qiang Liu, Xingyan Liu
Current and promising applications of MOF composites in the healing of diabetes wounds. RSC medicinal chemistry 15 (8) (2024)
Ana Teresa Silva, Isabel Oliveira, Denise Maria F A Duarte, Diana Moita, Miguel Prudncio, Fátima Nogueira, Ricardo Ferraz, Eduardo Figueira Marques, Paula A C Gomes
"Seasoning" antimalarial drugs' action: chloroquine bile salts as novel triple-stage antiplasmodial hits. RSC medicinal chemistry 15 (8) (2024)
Xiaoyi Li, Cheng Lu, Wenxia Du, Qiuping Zou, Ruirui Wang, Chunyan Hu, Yanping Li, Yi Zhang, Zewei Mao
Development of new dehydrocostuslactone derivatives for treatment of atopic dermatitis via inhibition of the NF-κB signaling pathway. RSC medicinal chemistry 15 (8) (2024)
Asmita Choithramani, Rudradip Das, Gourav Bothra, Priyanka Patel Vatsa, Venkatesh Muthukumar, Bombothu Kavya Sai Bhuvana, Saumya Kapoor, Deepshika Moola, Moumita Ghosh Chowdhury, Amit Mandoli, Amit Shard
Targeted suppression of oral squamous cell carcinoma by pyrimidine-tethered quinoxaline derivatives. RSC medicinal chemistry 15 (8) (2024)
Xiaoyi Li, Cheng Lu, Wenxia Du, Qiuping Zou, Ruirui Wang, Chunyan Hu, Yanping Li, Yi Zhang, Zewei Mao
Development of new dehydrocostuslactone derivatives for treatment of atopic dermatitis via inhibition of the NF-κB signaling pathway. RSC medicinal chemistry 15 (8) (2024)
Bharti Devi, Kailash Jangid, Vijay Kumar, Tania Arora, Naveen Kumar, Ashish Ranjan Dwivedi, Jyoti Parkash, Vinod Kumar
Phenylstyrylpyrimidine derivatives as potential multipotent therapeutics for Alzheimer's disease. RSC medicinal chemistry 15 (8) (2024)
Asmita Choithramani, Rudradip Das, Gourav Bothra, Priyanka Patel Vatsa, Venkatesh Muthukumar, Bombothu Kavya Sai Bhuvana, Saumya Kapoor, Deepshika Moola, Moumita Ghosh Chowdhury, Amit Mandoli, Amit Shard
Targeted suppression of oral squamous cell carcinoma by pyrimidine-tethered quinoxaline derivatives. RSC medicinal chemistry 15 (8) (2024)
Eman O Osman, Nadia A Khalil, Alaa Magdy, Yara El-Dash
New pyrazole-pyridazine hybrids as selective COX-2 inhibitors: design, synthesis, molecular docking, in silico studies and investigation of their anti-inflammatory potential by evaluation of TNF-α, IL-6, PGE-2 and NO in LPS-induced RAW264.7 macrophages. RSC medicinal chemistry 15 (8) (2024)
Alonzo Gonzalez-Gonzalez, Oscar Sánchez-Sánchez, Baojie Wan, Scott G Franzblau, Isidro Palos, José Carlos Espinoza-Hicks, Adriana Moreno-Rodríguez, Ana Verónica Martínez-Vázquez, Edgar E Lara-Ramírez, Eyra Ortiz-Pérez, Alma D Paz-González, Gildardo Rivera
Expanding the chemical space of ester of quinoxaline-7-carboxylate 1,4-di- N -oxide derivatives as potential antitubercular agents. RSC medicinal chemistry 15 (8) (2024)
Itisha Chummun, Andrea Gómez-Llonín, Archana Bhaw-Luximon
From traditional medicine to nanomedicine: potential of Ginkgo biloba extracts in treating inflammatory skin diseases. RSC medicinal chemistry 15 (8) (2024)
Doretta Cuffaro, Tina Burkhard, Bianca Laura Bernardoni, Riccardo Di Leo, Xiaohan Zhang, Salvatore Galati, Tiziano Tuccinardi, Marco Macchia, Armando Rossello, Salvatore Santamaria, Rens de Groot, Elisa Nuti
Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors. RSC medicinal chemistry 15 (8) (2024)
Mary Sravani Galla, Nitika Sharma, Priyanka Mishra, Nagula Shankaraiah
Recent insights of PROTAC developments in inflammation-mediated and autoimmune targets: a critical review. RSC medicinal chemistry 15 (8) (2024)
Lucia M Chávez-López, Gabriela I Carballo-López, Karina Del Carmen Lugo-Ibarra, Ana B Castro-Ceseña
A comprehensive framework for managing metabolic dysfunction-associated steatotic liver disease: analyzing novel risk factors and advances in nanotechnology-based treatments and diagnosis. RSC medicinal chemistry 15 (8) (2024)
Arnab Chowdhury, Nitesh Mani Tripathi, Rohit Jadav, Vinod Gour, Parva Purohit, Anupam Bandyopadhyay
On-resin synthesis of Lanreotide epimers and studies of their structure-activity relationships. RSC medicinal chemistry 15 (8) (2024)
Mohammad Shahidul Islam, Refaah M Al-Jassas, Abdullah Mohammed Al-Majid, Matti Haukka, Mohamed S Nafie, Marwa M Abu-Serie, Mohamed Teleb, Amira F El-Yazbi, Abdul Majeed Abdullah Alayyaf, Assem Barakat, Marwa M Shaaban
Exploiting spirooxindoles for dual DNA targeting/CDK2 inhibition and simultaneous mitigation of oxidative stress towards selective NSCLC therapy; synthesis, evaluation, and molecular modelling studies. RSC medicinal chemistry 15 (8) (2024)
Cecilia Romanò, Hao Jiang, Sahar Tahvili, Peng Wei, Ulrik B Keiding, Gael Clergeaud, Sarah Line Skovbakke, Anne Louise Blomberg, Lise Hafkenscheid, Jonas Rosager Henriksen, Thomas L Andresen, Steffen Goletz, Anders E Hansen, Dennis Christensen, Mads Hartvig Clausen
Chemical synthesis and immunological evaluation of cancer vaccines based on ganglioside antigens and α-galactosylceramide. RSC medicinal chemistry 15 (8) (2024)
Sanaa K Bardaweel, Rola AlOmari, Rima Hajjo
Integrating computational and experimental chemical biology revealed variable anticancer activities of phosphodiesterase isoenzyme 5 inhibitors (PDE5i) in lung cancer. RSC medicinal chemistry 15 (8) (2024)
Eman O Osman, Nadia A Khalil, Alaa Magdy, Yara El-Dash
New pyrazole-pyridazine hybrids as selective COX-2 inhibitors: design, synthesis, molecular docking, in silico studies and investigation of their anti-inflammatory potential by evaluation of TNF-α, IL-6, PGE-2 and NO in LPS-induced RAW264.7 macrophages. RSC medicinal chemistry 15 (8) (2024)
Hebatallah S Ali, Hiba S Al-Amodi, Shaimaa Hamady, Marian M S Roushdy, Amany Helmy Hasanin, Ghada Ellithy, Rasha A Elmansy, Hagir H T Ahmed, Enshrah M E Ahmed, Doaa M A Elzoghby, Hala F M Kamel, Ghida Hassan, Hind A ELsawi, Laila M Farid, Mariam B Abouelkhair, Eman K Habib, Mohamed Esawie, Heba Fikry, Lobna A Saleh, Marwa Matboli
Correction: Rosavin improves insulin resistance and alleviates hepatic and kidney damage via modulating the cGAS-STING pathway and autophagy signaling in HFD/STZ-induced T2DM animals. RSC medicinal chemistry 15 (8) (2024)
Berehe Solomon Girmay, Sileshi Abera Ayele, Syed Azeem Abbas, Su San Jang, Eunhye Jung, Jin Soo Shin, Soo Bong Han, Hyejin Kim
Discovery and structure-activity relationship study of novel isoxazole-based small molecules targeting Zika virus infections. RSC medicinal chemistry 15 (8) (2024)
Itisha Chummun, Andrea Gómez-Llonín, Archana Bhaw-Luximon
From traditional medicine to nanomedicine: potential of Ginkgo biloba extracts in treating inflammatory skin diseases. RSC medicinal chemistry 15 (8) (2024)
Satsawat Visansirikul, Suthira Yanaso, Yingrak Boondam, Kanjanawadee Prasittisa, Brompoj Prutthiwanasan, Sumet Chongruchiroj, Kittisak Sripha
Discovery of novel coumarin triazolyl and phenoxyphenyl triazolyl derivatives targeting amyloid beta aggregation-mediated oxidative stress and neuroinflammation for enhanced neuroprotection. RSC medicinal chemistry 15 (8) (2024)
Alonzo Gonzalez-Gonzalez, Oscar Sánchez-Sánchez, Baojie Wan, Scott G Franzblau, Isidro Palos, José Carlos Espinoza-Hicks, Adriana Moreno-Rodríguez, Ana Verónica Martínez-Vázquez, Edgar E Lara-Ramírez, Eyra Ortiz-Pérez, Alma D Paz-González, Gildardo Rivera
Expanding the chemical space of ester of quinoxaline-7-carboxylate 1,4-di- N -oxide derivatives as potential antitubercular agents. RSC medicinal chemistry 15 (8) (2024)
Vojtech Chmil, Natálie Živná, Marcela Milanová, Alžběta Filipová, Jaroslav Pejchal, Lukáš Prchal, Darina Muthná, Vít Řeháček, Martina Řezáčová, Jan Marek, Jakub Grepl, Radim Havelek
Second-generation piperazine derivatives as promising radiation countermeasures. RSC medicinal chemistry 15 (8) (2024)
Cecilia Romanò, Hao Jiang, Sahar Tahvili, Peng Wei, Ulrik B Keiding, Gael Clergeaud, Sarah Line Skovbakke, Anne Louise Blomberg, Lise Hafkenscheid, Jonas Rosager Henriksen, Thomas L Andresen, Steffen Goletz, Anders E Hansen, Dennis Christensen, Mads Hartvig Clausen
Chemical synthesis and immunological evaluation of cancer vaccines based on ganglioside antigens and α-galactosylceramide. RSC medicinal chemistry 15 (8) (2024)
Arnab Chowdhury, Nitesh Mani Tripathi, Rohit Jadav, Vinod Gour, Parva Purohit, Anupam Bandyopadhyay
On-resin synthesis of Lanreotide epimers and studies of their structure-activity relationships. RSC medicinal chemistry 15 (8) (2024)
Ajay Kishor Kushawaha, Arvind Kumar Jaiswal, Jay Gupta, Sarita Katiyar, Alisha Ansari, Hemlata Bhatt, Sandeep K Sharma, Abhijit Deb Choudhury, Rabi Sankar Bhatta, Bhupendra N Singh, Koneni V Sashidhara
Antitubercular evaluation of dihydropyridine-triazole conjugates: design, synthesis, in vitro screening, SAR and in silico ADME predictions. RSC medicinal chemistry 15 (8) (2024)

volume 15, number 9, 2024

Rudradip Das, Deep Rohan Chatterjee, Saumya Kapoor, Het Vyas, Amit Shard
Novel sulfonamides unveiled as potent anti-lung cancer agents via tumor pyruvate kinase M2 activation. RSC medicinal chemistry 15 (9) (2024)
Mousumi Deb, Hoshiyar Singh, Diksha Manhas, Utpal Nandi, Santosh K Guru, Parthasarathi Das
Development of di-arylated 1,2,4-triazole-based derivatives as therapeutic agents against breast cancer: synthesis and biological evaluation. RSC medicinal chemistry 15 (9) (2024)
Yingzhen Guan, Michel Nguyen, Anne Robert, Yan Liu, Bernard Meunier
Copper selective 8-aminoquinoline based tetradentate chelators as anticancer agents. RSC medicinal chemistry 15 (9) (2024)
Jieke Gao, Yongli Xie, Jiantao Zhang, Huirong Chen, Yan Zou, Shan Cen, Jin-Ming Zhou
A novel hydrophobic tag leads to the efficient degradation of programmed death-ligand 1. RSC medicinal chemistry 15 (9) (2024)
Avik Maji, Ambati Himaja, Sripathi Nikhitha, Soumitra Rana, Abhik Paul, Ajeya Samanta, Uday Shee, Chhanda Mukhopadhyay, Balaram Ghosh, Tapan Kumar Maity
Synthesis and antiproliferative potency of 1,3,4-thiadiazole and 1,3-thiazolidine-4-one based new binary heterocyclic molecules: in vitro cell-based anticancer studies. RSC medicinal chemistry 15 (9) (2024)
Mathilde Blitek, Xaysongkhame Phongsavanh, Aurelie T Goyenvalle
The bench to bedside journey of tricyclo-DNA antisense oligonucleotides for the treatment of Duchenne muscular dystrophy. RSC medicinal chemistry 15 (9) (2024)
Giovanna Ballarin, Maddalena Biasiotto, Annika Reisbitzer, Marlen Hegels, Michael Bolte, Sybille Krauß, Daria V Berdnikova
A novel aurone RNA CAG binder inhibits the huntingtin RNA-protein interaction. RSC medicinal chemistry 15 (9) (2024)
Rachana S Bhimanwar, Amit Mittal, Snehal Chaudhari, Vikas Sharma
Recent advancements in the structural exploration of TGR5 agonists for diabetes treatment. RSC medicinal chemistry 15 (9) (2024)
Alex Murray, Peter Kilbride, Matthew I Gibson
Trehalose in cryopreservation. Applications, mechanisms and intracellular delivery opportunities. RSC medicinal chemistry 15 (9) (2024)
Yu Deng, Sida Huang, Guanming Jiang, Luyi Zhou, Alireza Nezamzadeh-Ejhieh, Jianqiang Liu, Zhikun Zhou
Current status and prospects of MOFs loaded with H 2 O 2 -related substances for ferroptosis therapy. RSC medicinal chemistry 15 (9) (2024)
Rachael Pirie, Harriet A Stanway-Gordon, Hannah L Stewart, Kirsty L Wilson, Summer Patton, Jack Tyerman, Daniel J Cole, Katherine Fowler, Michael J Waring
An analysis of the physicochemical properties of oral drugs from 2000 to 2022. RSC medicinal chemistry 15 (9) (2024)
Haoyu Zhang, Jinyu Yu, Ziheng Yang, Zhiqiang Guo, Rui Liu, Qiaohua Qin, Yixiang Sun, Nian Liu, Zixuan Gao, Dongmei Zhao, Mao-Sheng Cheng
Structure-based virtual screening discovers novel PKMYT1 inhibitors. RSC medicinal chemistry 15 (9) (2024)