Anna Orlova

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 97

Top Venues

International journal of molecular sciences

Pharmaceutics

Cancers

Scientific reports

Uppsala Universitet Farmaceutiska fakulteten

Uppsala Universitet Medicinska fakulteten (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Uppsala Universitet Farmaceutiska fakulteten Jul 01 2011

Sweden

PI :: Preclinical PET Platform

Education History

Uppsala Universitet Medicinska fakulteten Jan 01 1999 - Apr 27 2003

Sweden

PHD :: Biomedical Radiation Sciences

Publications

Panagiotis Kanellopoulos, Adam Mattsson, Ayman Abouzayed, Karim Obeid, Berthold A Nock, Vladimir Tolmachev, Theodosia Maina, Anna Orlova
Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology. EJNMMI radiopharmacy and chemistry 9 (1) (2024)
Mariia S Larkina, Ruslan Varvashenya, Feruza Yuldasheva, Evgenii Plotnikov, Ekaterina Bezverkhniaia, Maria Tretyakova, Roman Zelchan, Alexey Schulga, Elena Konovalova, Anzhelika Vorobyeva, Mikhail Belousov, Anna Orlova, Vladimir Tolmachev, Sergey Deyev
Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the 99m Tc-Based Imaging of HER2-Expressing Malignant Tumors. Molecular pharmaceutics 21 (4) (2024)
Mariia S Larkina, Ruslan Varvashenya, Feruza Yuldasheva, Evgenii Plotnikov, Ekaterina Bezverkhniaia, Maria Tretyakova, Roman Zelchan, Alexey Schulga, Elena Konovalova, Anzhelika Vorobyeva, Mikhail Belousov, Anna Orlova, Vladimir Tolmachev, Sergey Deyev
Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the 99m Tc-Based Imaging of HER2-Expressing Malignant Tumors. Molecular pharmaceutics 21 (4) (2024)
Ábel Nagy, Ayman Abouzayed, Panagiotis Kanellopoulos, Fredrika Landmark, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova, Amelie Eriksson Karlström
Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery. ACS omega 9 (34) (2024)
Aleksei E Machulkin, Stanislav A Petrov, Vitalina Bodenko, Mariia S Larkina, Evgenii Plotnikov, Feruza Yuldasheva, Maria Tretyakova, Ekaterina Bezverkhniaia, Nikolay Yu Zyk, Elena Stasyuk, Roman Zelchan, Alexander G Majouga, Vladimir Tolmachev, Anna Orlova, Elena K Beloglazkina, Mekhman S Yusubov
Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with 177 Lu. ACS pharmacology & translational science 7 (5) (2024)
Ekaterina A Bezverkhniaia, Panagiotis Kanellopoulos, Ulrika Rosenström, Vladimir Tolmachev, Anna Orlova
Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m. International journal of molecular sciences 25 (7) (2024)
Ábel Nagy, Ayman Abouzayed, Panagiotis Kanellopoulos, Fredrika Landmark, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova, Amelie Eriksson Karlström
Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery. ACS omega 9 (34) (2024)
Panagiotis Kanellopoulos, Adam Mattsson, Ayman Abouzayed, Karim Obeid, Berthold A Nock, Vladimir Tolmachev, Theodosia Maina, Anna Orlova
Preclinical evaluation of new GRPR-antagonists with improved metabolic stability for radiotheranostic use in oncology. EJNMMI radiopharmacy and chemistry 9 (1) (2024)
Panagiotis Kanellopoulos, Ekaterina Bezverkhniaia, Ayman Abouzayed, Ulrika Rosenström, Vladimir Tolmachev, Anna Orlova
Two Novel [ 68 Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar 11 ]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer. ACS omega 9 (16) (2024)
Sergey Mikhailovich Deyev, Maryam Oroujeni, Javad Garousi, Torbjörn Gräslund, Ruonan Li, Alia Hani Binti Rosly, Anna Orlova, Elena Konovalova, Alexey A Schulga, Anzhelika Vorobyeva, Vladimir Tolmachev
Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion. International journal of molecular sciences 25 (8) (2024)
Karim Obeid, Panagiotis Kanellopoulos, Ayman Abouzayed, Adam Mattsson, Vladimir Tolmachev, Berthold A Nock, Theodosia Maina, Anna Orlova
GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics. Pharmaceutics 16 (4) (2024)
Aleksei E Machulkin, Stanislav A Petrov, Vitalina Bodenko, Mariia S Larkina, Evgenii Plotnikov, Feruza Yuldasheva, Maria Tretyakova, Ekaterina Bezverkhniaia, Nikolay Yu Zyk, Elena Stasyuk, Roman Zelchan, Alexander G Majouga, Vladimir Tolmachev, Anna Orlova, Elena K Beloglazkina, Mekhman S Yusubov
Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with 177 Lu. ACS pharmacology & translational science 7 (5) (2024)
Roman Zelchan, Vladimir Chernov, Anna Medvedeva, Anastasia Rybina, Olga Bragina, Elizaveta Mishina, Mariia S Larkina, Ruslan Varvashenya, Anastasia Fominykh, Alexey A Schulga, Elena Konovalova, Anzhelika Vorobyeva, Anna Orlova, Liubov Alexandrovna Tashireva, Sergey Mikhailovich Deyev, Vladimir Tolmachev
Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [ 99m Tc]Tc(CO) 3 -(HE) 3 -Ec1 for Visualization of EpCAM-Expressing Lung Cancer. Cancers 16 (16) (2024)
Roman Zelchan, Vladimir Chernov, Anna Medvedeva, Anastasia Rybina, Olga Bragina, Elizaveta Mishina, Mariia S Larkina, Ruslan Varvashenya, Anastasia Fominykh, Alexey A Schulga, Elena Konovalova, Anzhelika Vorobyeva, Anna Orlova, Liubov Alexandrovna Tashireva, Sergey Mikhailovich Deyev, Vladimir Tolmachev
Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [ 99m Tc]Tc(CO) 3 -(HE) 3 -Ec1 for Visualization of EpCAM-Expressing Lung Cancer. Cancers 16 (16) (2024)
Ekaterina A Bezverkhniaia, Panagiotis Kanellopoulos, Ulrika Rosenström, Vladimir Tolmachev, Anna Orlova
Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m. International journal of molecular sciences 25 (7) (2024)
Sergey Mikhailovich Deyev, Maryam Oroujeni, Javad Garousi, Torbjörn Gräslund, Ruonan Li, Alia Hani Binti Rosly, Anna Orlova, Elena Konovalova, Alexey A Schulga, Anzhelika Vorobyeva, Vladimir Tolmachev
Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion. International journal of molecular sciences 25 (8) (2024)
Panagiotis Kanellopoulos, Ekaterina Bezverkhniaia, Ayman Abouzayed, Ulrika Rosenström, Vladimir Tolmachev, Anna Orlova
Two Novel [ 68 Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar 11 ]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer. ACS omega 9 (16) (2024)
Sergey Mikhailovich Deyev, Maryam Oroujeni, Javad Garousi, Torbjörn Gräslund, Ruonan Li, Alia Hani Binti Rosly, Anna Orlova, Elena Konovalova, Alexey A Schulga, Anzhelika Vorobyeva, Vladimir Tolmachev
Preclinical Evaluation of HER2-Targeting DARPin G3: Impact of Albumin-Binding Domain (ABD) Fusion. International journal of molecular sciences 25 (8) (2024)
Karim Obeid, Panagiotis Kanellopoulos, Ayman Abouzayed, Adam Mattsson, Vladimir Tolmachev, Berthold A Nock, Theodosia Maina, Anna Orlova
GRPR-Antagonists Carrying DOTAGA-Chelator via Positively Charged Linkers: Perspectives for Prostate Cancer Theranostics. Pharmaceutics 16 (4) (2024)
Ekaterina A Bezverkhniaia, Panagiotis Kanellopoulos, Ulrika Rosenström, Vladimir Tolmachev, Anna Orlova
Influence of Molecular Design on the Tumor Targeting and Biodistribution of PSMA-Binding Tracers Labeled with Technetium-99m. International journal of molecular sciences 25 (7) (2024)
Kristina Westerlund, Maryam Oroujeni, Maxime Gestin, Jacob Clinton, Alia Hani Rosly, Hanna Tano, Anzhelika Vorobyeva, Anna Orlova, Amelie Eriksson Karlström, Vladimir Tolmachev
Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting. ACS pharmacology & translational science 7 (5) (2024)
Kristina Westerlund, Maryam Oroujeni, Maxime Gestin, Jacob Clinton, Alia Hani Rosly, Hanna Tano, Anzhelika Vorobyeva, Anna Orlova, Amelie Eriksson Karlström, Vladimir Tolmachev
Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting. ACS pharmacology & translational science 7 (5) (2024)
Fanny Lundmark, Ayman Abouzayed, Sara Sophie Rinne, Vasiliy Timofeev, Nadezhda Sipkina, Maria Naan, Anastasia Kirichenko, Maria Vasyutina, Daria Ryzhkova, Vladimir Tolmachev, Ulrika Rosenström, Anna Orlova
Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [ 68 Ga]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation. Cancers 15 (2) (2023)
Ayman Abouzayed, Jesper Borin, Fanny Lundmark, Anastasiya Rybina, Sophia Hober, Roman Zelchan, Vladimir Tolmachev, Vladimir Chernov, Anna Orlova
The GRPR Antagonist [ 99m Tc]Tc-maSSS-PEG 2 -RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity. Diagnostics (Basel, Switzerland) 13 (9) (2023)
Tianqi Xu, Alexey A Schulga, Elena Konovalova, Sara Sophie Rinne, Hongchao Zhang, Olga Vorontsova, Anna Orlova, Sergey Mikhailovich Deyev, Vladimir Tolmachev, Anzhelika Vorobyeva
Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model. International journal of molecular sciences 24 (3) (2023)
Ekaterina A Bezverkhniaia, Panagiotis Kanellopoulos, Ayman Abouzayed, Mariia S Larkina, Maryam Oroujeni, Anzhelika Vorobyeva, Ulrika Rosenström, Vladimir Tolmachev, Anna Orlova
Preclinical Evaluation of a Novel High-Affinity Radioligand [ 99m Tc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA). International journal of molecular sciences 24 (24) (2023)
Yongsheng Liu, Tianqi Xu, Anzhelika Vorobyeva, Annika Loftenius, Vitalina Bodenko, Anna Orlova, Fredrik Y Frejd, Vladimir Tolmachev
Radionuclide Therapy of HER2-Expressing Xenografts Using [ 177 Lu]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab. Cancers 15 (9) (2023)
Lutfi A Hasnowo, Maria S Larkina, Evgenii V Plotnikov, Vitalina Bodenko, Feruza Yuldasheva, Elena Stasyuk, Stanislav A Petrov, Nikolai Y Zyk, Aleksei E Machulkin, Nikolai I Vorozhtsov, Elena K Beloglazkina, Valentine G Nenajdenko, Vladimir Tolmachev, Anna Orlova, Alexander G Majouga, Mekhman S Yusubov
Synthesis, 123 I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures. International journal of molecular sciences 24 (15) (2023)
Ekaterina A Bezverkhniaia, Panagiotis Kanellopoulos, Ayman Abouzayed, Mariia S Larkina, Maryam Oroujeni, Anzhelika Vorobyeva, Ulrika Rosenström, Vladimir Tolmachev, Anna Orlova
Preclinical Evaluation of a Novel High-Affinity Radioligand [ 99m Tc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA). International journal of molecular sciences 24 (24) (2023)
Tianqi Xu, Alexey A Schulga, Elena Konovalova, Sara Sophie Rinne, Hongchao Zhang, Olga Vorontsova, Anna Orlova, Sergey Mikhailovich Deyev, Vladimir Tolmachev, Anzhelika Vorobyeva
Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model. International journal of molecular sciences 24 (3) (2023)
Ayman Abouzayed, Jesper Borin, Fanny Lundmark, Anastasiya Rybina, Sophia Hober, Roman Zelchan, Vladimir Tolmachev, Vladimir Chernov, Anna Orlova
The GRPR Antagonist [ 99m Tc]Tc-maSSS-PEG 2 -RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity. Diagnostics (Basel, Switzerland) 13 (9) (2023)
Fanny Lundmark, Ayman Abouzayed, Sara Sophie Rinne, Vasiliy Timofeev, Nadezhda Sipkina, Maria Naan, Anastasia Kirichenko, Maria Vasyutina, Daria Ryzhkova, Vladimir Tolmachev, Ulrika Rosenström, Anna Orlova
Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [ 68 Ga]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation. Cancers 15 (2) (2023)
Vladimir Chernov, Anastasiya Rybina, Roman Zelchan, Anna Medvedeva, Olga Bragina, Nadejda Lushnikova, Artem Doroshenko, Evgeniy Usynin, Liubov Alexandrovna Tashireva, Sergey Vtorushin, Ayman Abouzayed, Sara Sophie Rinne, Jens Sörensen, Vladimir Tolmachev, Anna Orlova
Phase I Trial of [ 99m Tc]Tc-maSSS-PEG 2 -RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors. Cancers 15 (6) (2023)
Vladimir Chernov, Anastasiya Rybina, Roman Zelchan, Anna Medvedeva, Olga Bragina, Nadejda Lushnikova, Artem Doroshenko, Evgeniy Usynin, Liubov Alexandrovna Tashireva, Sergey Vtorushin, Ayman Abouzayed, Sara Sophie Rinne, Jens Sörensen, Vladimir Tolmachev, Anna Orlova
Phase I Trial of [ 99m Tc]Tc-maSSS-PEG 2 -RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors. Cancers 15 (6) (2023)
Yongsheng Liu, Tianqi Xu, Anzhelika Vorobyeva, Annika Loftenius, Vitalina Bodenko, Anna Orlova, Fredrik Y Frejd, Vladimir Tolmachev
Radionuclide Therapy of HER2-Expressing Xenografts Using [ 177 Lu]Lu-ABY-027 Affibody Molecule Alone and in Combination with Trastuzumab. Cancers 15 (9) (2023)
Ayman Abouzayed, Panagiotis Kanellopoulos, Alisa Gorislav, Vladimir Tolmachev, Theodosia Maina, Berthold A Nock, Anna Orlova
Preclinical Characterization of a Stabilized Gastrin-Releasing Peptide Receptor Antagonist for Targeted Cancer Theranostics. Biomolecules 13 (7) (2023)
Tianqi Xu, Alexey A Schulga, Elena Konovalova, Sara Sophie Rinne, Hongchao Zhang, Olga Vorontsova, Anna Orlova, Sergey Mikhailovich Deyev, Vladimir Tolmachev, Anzhelika Vorobyeva
Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model. International journal of molecular sciences 24 (3) (2023)
Vladimir Tolmachev, Vitalina Bodenko, Maryam Oroujeni, Sergey Mikhailovich Deyev, Elena Konovalova, Alexey A Schulga, Sarah Lindbo, Sophia Hober, Olga Bragina, Anna Orlova, Anzhelika Vorobyeva
Direct In Vivo Comparison of 99m Tc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy. International journal of molecular sciences 23 (23) (2022)
Javad Garousi, Tianqi Xu, Yongsheng Liu, Olga Vorontsova, Sophia Hober, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund, Anzhelika Vorobyeva
Experimental HER2-Targeted Therapy Using ADAPT6-ABD-mcDM1 in Mice Bearing SKOV3 Ovarian Cancer Xenografts: Efficacy and Selection of Companion Imaging Counterpart. Pharmaceutics 14 (8) (2022)
Tianqi Xu, Jie Zhang, Maryam Oroujeni, Maria S Tretyakova, Vitalina Bodenko, Mikhail V Belousov, Anna Orlova, Vladimir Tolmachev, Anzhelika Vorobyeva, Torbjörn Gräslund
Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2. Pharmaceutics 14 (3) (2022)
Vladimir Tolmachev, Vitalina Bodenko, Maryam Oroujeni, Sergey Mikhailovich Deyev, Elena Konovalova, Alexey A Schulga, Sarah Lindbo, Sophia Hober, Olga Bragina, Anna Orlova, Anzhelika Vorobyeva
Direct In Vivo Comparison of 99m Tc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy. International journal of molecular sciences 23 (23) (2022)
Vladimir Tolmachev, Vitalina Bodenko, Maryam Oroujeni, Sergey Mikhailovich Deyev, Elena Konovalova, Alexey A Schulga, Sarah Lindbo, Sophia Hober, Olga Bragina, Anna Orlova, Anzhelika Vorobyeva
Direct In Vivo Comparison of 99m Tc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy. International journal of molecular sciences 23 (23) (2022)
Maryam Oroujeni, Ekaterina A Bezverkhniaia, Tianqi Xu, Yongsheng Liu, Evgenii V Plotnikov, Ida Karlberg, Eva Ryer, Anna Orlova, Vladimir Tolmachev, Fredrik Y Frejd
Evaluation of an Affibody-Based Binder for Imaging of Immune Check-Point Molecule B7-H3. Pharmaceutics 14 (9) (2022)
Vladimir Tolmachev, Vitalina Bodenko, Maryam Oroujeni, Sergey Mikhailovich Deyev, Elena Konovalova, Alexey A Schulga, Sarah Lindbo, Sophia Hober, Olga Bragina, Anna Orlova, Anzhelika Vorobyeva
Direct In Vivo Comparison of 99m Tc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy. International journal of molecular sciences 23 (23) (2022)
Yongsheng Liu, Shengze Yu, Tianqi Xu, Vitalina Bodenko, Anna Orlova, Maryam Oroujeni, Sara Sophie Rinne, Vladimir Tolmachev, Anzhelika Vorobyeva, Torbjörn Gräslund
Preclinical Evaluation of a New Format of 68 Ga- and 111 In-Labeled Affibody Molecule Z IGF-1R:4551 for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT. Pharmaceutics 14 (7) (2022)
Sara Sophie Rinne, Wen Yin, Anna Mestre Borras, Ayman Abouzayed, Charles Dahlsson Leitao, Anzhelika Vorobyeva, John Löfblom, Stefan Ståhl, Anna Orlova, Torbjörn Gräslund
Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules. Biomedicines 10 (6) (2022)
Yongsheng Liu, Rezan Güler, Yunqi Liao, Anzhelika Vorobyeva, Olof Widmark, Theodorus J Meuleman, Anna Baierl, Leendert J van den Bos, Robert Naasz, Vitalina Bodenko, Anna Orlova, Caroline Ekblad, Vladimir Tolmachev, Fredrik Y Frejd
Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis. Pharmaceutics 14 (11) (2022)
Vladimir Tolmachev, Vitalina Bodenko, Maryam Oroujeni, Sergey Mikhailovich Deyev, Elena Konovalova, Alexey A Schulga, Sarah Lindbo, Sophia Hober, Olga Bragina, Anna Orlova, Anzhelika Vorobyeva
Direct In Vivo Comparison of 99m Tc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy. International journal of molecular sciences 23 (23) (2022)
Fanny Lundmark, Gustav Olanders, Sara Sophie Rinne, Ayman Abouzayed, Anna Orlova, Ulrika Rosenström
Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands. Pharmaceutics 14 (5) (2022)
Yongsheng Liu, Anzhelika Vorobyeva, Anna Orlova, Mark W Konijnenberg, Tianqi Xu, Olga Bragina, Annika Loftenius, Erica Rosander, Fredrik Y Frejd, Vladimir Tolmachev
Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule 188 Re-ZHER2:41071. Pharmaceutics 14 (5) (2022)
Mei Li, Roman Zelchan, Anna Orlova
The Performance of FDA-Approved PET Imaging Agents in the Detection of Prostate Cancer. Biomedicines 10 (10) (2022)
Maryam Oroujeni, Sara Sophie Rinne, Anzhelika Vorobyeva, Annika Loftenius, Joachim Feldwisch, Per Jonasson, Vladimir Chernov, Anna Orlova, Fredrik Y Frejd, Vladimir Tolmachev
Preclinical Evaluation of 99mTc-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake. International journal of molecular sciences 22 (5) (2021)
Maryam Oroujeni, Hanna Tano, Anzhelika Vorobyeva, Yongsheng Liu, Olga Vorontsova, Tianqi Xu, Kristina Westerlund, Anna Orlova, Vladimir Tolmachev, Amelie Eriksson Karlström
Affibody-mediated PNA-based pretargeted co-treatment improves survival of trastuzumab-treated mice bearing HER2-expressing xenografts. Journal of nuclear medicine : official publication, Society of Nuclear Medicine (2021)
Sergey Mikhailovich Deyev, Tianqi Xu, Yongsheng Liu, Alexey A Schulga, Elena Konovalova, Javad Garousi, Sara Sophie Rinne, Mariia S Larkina, Haozhong Ding, Torbjörn Gräslund, Anna Orlova, Vladimir Tolmachev, Anzhelika Vorobyeva
Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1. Cancers 13 (14) (2021)
Hanna Tano, Maryam Oroujeni, Anzhelika Vorobyeva, Kristina Westerlund, Yongsheng Liu, Tianqi Xu, Daniel Vasconcelos, Anna Orlova, Amelie Eriksson Karlström, Vladimir Tolmachev
Comparative Evaluation of Novel 177Lu-Labeled PNA Probes for Affibody-Mediated PNA-Based Pretargeting. Cancers 13 (3) (2021)
Tianqi Xu, Anzhelika Vorobyeva, Alexey A Schulga, Elena Konovalova, Olga Vorontsova, Haozhong Ding, Torbjörn Gräslund, Liubov Alexandrovna Tashireva, Anna Orlova, Vladimir Tolmachev, Sergey Mikhailovich Deyev
Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model. Cancers 13 (16) (2021)
Yongsheng Liu, Anzhelika Vorobyeva, Tianqi Xu, Anna Orlova, Annika Loftenius, Theresa Bengtsson, Per Jonasson, Vladimir Tolmachev, Fredrik Y Frejd
Comparative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody® Molecules 177Lu-ABY-271 and 177Lu-ABY-027: Impact of DOTA Position on ABD Domain. Pharmaceutics 13 (6) (2021)
Sara Sophie Rinne, Charles Dahlsson Leitao, Ayman Abouzayed, Anzhelika Vorobyeva, Vladimir Tolmachev, Stefan Ståhl, John Löfblom, Anna Orlova
HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers. Cancers 13 (19) (2021)
Maryam Oroujeni, Tianqi Xu, Katherine Gagnon, Sara S Rinne, Jan Weis, Javad Garousi, Ken G Andersson, John Löfblom, Anna Orlova, Vladimir Tolmachev
The Use of a Non-Conventional Long-Lived Gallium Radioisotope 66Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR:2377 Affibody Molecule. Pharmaceutics 13 (2) (2021)
Haozhong Ding, Tianqi Xu, Jie Zhang, Vladimir Tolmachev, Maryam Oroujeni, Anna Orlova, Torbjörn Gräslund, Anzhelika Vorobyeva
Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution. Pharmaceutics 13 (3) (2021)
Wen Yin, Tianqi Xu, Mohamed Altai, Maryam Oroujeni, Jie Zhang, Anzhelika Vorobyeva, Olga Vorontsova, Sergey V Vtorushin, Vladimir Tolmachev, Torbjörn Gräslund, Anna Orlova
The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy. Pharmaceutics 13 (11) (2021)
Sara Sophie Rinne, Anna Orlova, Vladimir Tolmachev
PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology. International journal of molecular sciences 22 (7) (2021)
Javad Garousi, Haozhong Ding, Emma von Witting, Tianqi Xu, Anzhelika Vorobyeva, Maryam Oroujeni, Anna Orlova, Sophia Hober, Torbjörn Gräslund, Vladimir Tolmachev
Targeting HER2 Expressing Tumors with a Potent Drug Conjugate Based on an Albumin Binding Domain-Derived Affinity Protein. Pharmaceutics 13 (11) (2021)
Ayman Abouzayed, Sara S Rinne, Hamideh Sabahnoo, Jens Sörensen, Vladimir Chernov, Vladimir Tolmachev, Anna Orlova
Preclinical Evaluation of 99mTc-Labeled GRPR Antagonists maSSS/SES-PEG2-RM26 for Imaging of Prostate Cancer. Pharmaceutics 13 (2) (2021)
Olga Bragina, Vladimir Chernov, Alexey A Schulga, Elena V Konovalova, Eugeniy Garbukov, Anzhelika Vorobyeva, Anna Orlova, Liubov Alexandrovna Tashireva, Jens Sorensen, Roman Zelchan, Anna Medvedeva, Sergey Mikhailovich Deyev, Vladimir Tolmachev
Phase I trial of 99mTc-(HE)3-G3, a DARPin-based probe for imaging of HER2 expression in breast cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine (2021)
Sara S Rinne, Ayman Abouzayed, Katherine Gagnon, Vladimir Tolmachev, Anna Orlova
66Ga-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [66Ga]Ga-NOTA-PEG2-RM26. Scientific reports 11 (1) (2021)
Sara S Rinne, Tianqi Xu, Charles Dahlsson Leitao, Stefan Ståhl, John Löfblom, Anna Orlova, Vladimir Tolmachev, Anzhelika Vorobyeva
Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules. International journal of molecular sciences 21 (4) (2020)
Tianqi Xu, Haozhong Ding, Anzhelika Vorobyeva, Maryam Oroujeni, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund
Drug Conjugates Based on a Monovalent Affibody Targeting Vector Can Efficiently Eradicate HER2 Positive Human Tumors in an Experimental Mouse Model. Cancers 13 (1) (2020)
Anzhelika Vorobyeva, Ekaterina A Bezverkhniaia, Elena Konovalova, Alexey A Schulga, Javad Garousi, Olga Vorontsova, Ayman Abouzayed, Anna Orlova, Sergey Mikhailovich Deyev, Vladimir Tolmachev
Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1. Molecules (Basel, Switzerland) 25 (20) (2020)
Ayman Abouzayed, Hanna Tano, Ábel Nagy, Sara Sophie Rinne, Fadya Wadeea, Sharmishtaa Kumar, Kristina Westerlund, Vladimir Tolmachev, Amelie Eriksson Karlström, Anna Orlova
Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer. Pharmaceutics 12 (10) (2020)
Sara S Rinne, Charles Dahlsson Leitao, Zahra Saleh-Nihad, Bogdan Mitran, Vladimir Tolmachev, Stefan Ståhl, John Löfblom, Anna Orlova
Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules. International journal of molecular sciences 21 (6) (2020)
Anzhelika Vorobyeva, Elena Konovalova, Tianqi Xu, Alexey A Schulga, Mohamed Altai, Javad Garousi, Sara S Rinne, Anna Orlova, Vladimir Tolmachev, Sergey Deyev
Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1. International journal of molecular sciences 21 (9) (2020)
Vladimir Tolmachev, Anna Orlova
Affibody Molecules as Targeting Vectors for PET Imaging. Cancers 12 (3) (2020)
Haozhong Ding, Mohamed Altai, Wen Yin, Sarah Lindbo, Hao Liu, Javad Garousi, Tianqi Xu, Anna Orlova, Vladimir Tolmachev, Sophia Hober, Torbjörn Gräslund
HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution. Pharmaceutics 12 (4) (2020)
Christina Baun, Bogdan Mitran, Sara Sophie Rinne, Johan Hygum Dam, Birgitte Brinkmann Olsen, Vladimir Tolmachev, Anna Orlova, Helge Thisgaard
Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer. Molecules (Basel, Switzerland) 25 (24) (2020)
Charles Dahlsson Leitao, Sara S Rinne, Mohamed Altai, Olga Vorontsova, Finn Dunås, Per Jonasson, Vladimir Tolmachev, John Löfblom, Stefan Ståhl, Anna Orlova
Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model. Pharmaceutics 12 (6) (2020)
Fanny Lundmark, Ayman Abouzayed, Bogdan Mitran, Sara S Rinne, Zohreh Varasteh, Mats Larhed, Vladimir Tolmachev, Ulrika Rosenström, Anna Orlova
Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model. Pharmaceutics 12 (7) (2020)
Charles Dahlsson Leitao, Sara S Rinne, Bogdan Mitran, Anzhelika Vorobyeva, Ken G Andersson, Vladimir Tolmachev, Stefan Ståhl, John Löfblom, Anna Orlova
Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of 68Ga-Labeled Tracers. International journal of molecular sciences 20 (5) (2019)
Sara S Rinne, Charles Dahlsson Leitao, Bogdan Mitran, Tarek Z Bass, Ken G Andersson, Vladimir Tolmachev, Stefan Ståhl, John Löfblom, Anna Orlova
Optimization of HER3 expression imaging using affibody molecules: Influence of chelator for labeling with indium-111. Scientific reports 9 (1) (2019)
Ayman Abouzayed, Cheng-Bin Yim, Bogdan Mitran, Sara S Rinne, Vladimir Tolmachev, Mats Larhed, Ulrika Rosenström, Anna Orlova
Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer. Pharmaceutics 11 (7) (2019)
Maryam Oroujeni, Ayman Abouzayed, Fanny Lundmark, Bogdan Mitran, Anna Orlova, Vladimir Tolmachev, Ulrika Rosenström
Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart. Pharmaceutics 11 (8) (2019)
Sara S Rinne, Charles Dahlsson Leitao, Joshua Gentry, Bogdan Mitran, Ayman Abouzayed, Vladimir Tolmachev, Stefan Ståhl, John Löfblom, Anna Orlova
Increase in negative charge of 68Ga/chelator complex reduces unspecific hepatic uptake but does not improve imaging properties of HER3-targeting affibody molecules. Scientific reports 9 (1) (2019)
Bogdan Mitran, Helge Thisgaard, Sara Rinne, Johan Hygum Dam, Frishta Azami, Vladimir Tolmachev, Anna Orlova, Ulrika Rosenström
Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26. Scientific reports 9 (1) (2019)
Javad Garousi, Fokko J Huizing, Anzhelika Vorobyeva, Bogdan Mitran, Ken G Andersson, Charles Dahlsson Leitao, Fredrik Y Frejd, John Löfblom, Johan Bussink, Anna Orlova, Sandra Heskamp, Vladimir Tolmachev
Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts. Scientific reports 9 (1) (2019)
Sergey Deyev, Anzhelika Vorobyeva, Alexey Schulga, Galina Proshkina, Rezan Güler, John Löfblom, Bogdan Mitran, Javad Garousi, Mohamed Altai, Jos Buijs, Vladimir Chernov, Anna Orlova, Vladimir Tolmachev
Comparative Evaluation of Two DARPin Variants: Effect of Affinity, Size, and Label on Tumor Targeting Properties. Molecular pharmaceutics 16 (3) (2019)
Anzhelika Vorobyeva, Alexey A Schulga, Sara S Rinne, Tyran Günther, Anna Orlova, Sergey Deyev, Vladimir Tolmachev
Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging. International journal of molecular sciences 20 (12) (2019)
Bogdan Mitran, Zohreh Varasteh, Ayman Abouzayed, Sara S Rinne, Emmi Puuvuori, Maria De Rosa, Mats Larhed, Vladimir Tolmachev, Anna Orlova, Ulrika Rosenström
Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer. Cancers 11 (9) (2019)
Maria Rosestedt, Ken G Andersson, Sara S Rinne, Charles Dahlsson Leitao, Bogdan Mitran, Anzhelika Vorobyeva, Stefan Ståhl, John Löfblom, Vladimir Tolmachev, Anna Orlova
Improved contrast of affibody-mediated imaging of HER3 expression in mouse xenograft model through co-injection of a trivalent affibody for in vivo blocking of hepatic uptake. Scientific reports 9 (1) (2019)
Anzhelika Vorobyeva, Alexey Schulga, Elena Konovalova, Rezan Güler, John Löfblom, Mattias Sandström, Javad Garousi, Vladimir Chernov, Olga Bragina, Anna Orlova, Vladimir Tolmachev, Sergey M Deyev
Optimal composition and position of histidine-containing tags improves biodistribution of 99mTc-labeled DARPin G3. Scientific reports 9 (1) (2019)
Haozhong Ding, Mohamed Altai, Sara S Rinne, Anzhelika Vorobyeva, Vladimir Tolmachev, Torbjörn Gräslund, Anna Orlova
Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody-DM1 Drug Conjugates. Cancers 11 (8) (2019)
Bogdan Mitran, Sara S Rinne, Mark W Konijnenberg, Theodosia Maina, Berthold A Nock, Mohamed Altai, Anzhelika Vorobyeva, Mats Larhed, Vladimir Tolmachev, Marion de Jong, Ulrika Rosenström, Anna Orlova
Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist 177 Lu-DOTAGA-PEG2 -RM26. International journal of cancer 145 (12) (2019)
Maryam Oroujeni, Javad Garousi, Ken G Andersson, John Löfblom, Bogdan Mitran, Anna Orlova, Vladimir Tolmachev
Preclinical Evaluation of [68Ga]Ga-DFO-ZEGFR:2377: A Promising Affibody-Based Probe for Noninvasive PET Imaging of EGFR Expression in Tumors. Cells 7 (9) (2018)
Anzhelika Vorobyeva, Olga Bragina, Mohamed Altai, Bogdan Mitran, Anna Orlova, Alexey Shulga, Galina Proshkina, Vladimir Chernov, Vladimir Tolmachev, Sergey Deyev
Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors. Contrast media & molecular imaging 2018 (2018)
Mohamed Altai, Charles Dahlsson Leitao, Sara S Rinne, Anzhelika Vorobyeva, Christina Atterby, Stefan Ståhl, Vladimir Tolmachev, John Löfblom, Anna Orlova
Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs. Cells 7 (10) (2018)
Anna Orlova, Tarek Z Bass, Sara S Rinne, Charles Dahlsson Leitao, Maria Rosestedt, Christina Atterby, Lindvi Gudmundsdotter, Fredrik Y Frejd, John Löfblom, Vladimir Tolmachev, Stefan Ståhl
Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab. Molecular pharmaceutics 15 (8) (2018)
Sarah Lindbo, Javad Garousi, Bogdan Mitran, Anzhelika Vorobyeva, Maryam Oroujeni, Anna Orlova, Sophia Hober, Vladimir Tolmachev
Optimized Molecular Design of ADAPT-Based HER2-Imaging Probes Labeled with 111In and 68Ga. Molecular pharmaceutics 15 (7) (2018)
Bogdan Mitran, Helge Thisgaard, Ulrika Rosenström, Johan Hygum Dam, Mats Larhed, Vladimir Tolmachev, Anna Orlova
High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26. Contrast media & molecular imaging 2017 (2017)

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Anna Orlova