Ao Zhang

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 58

Top Venues

Journal of medicinal chemistry

EMBO molecular medicine

The Journal of organic chemistry

Organic letters

Shanghai Institute of Materia Medica Chinese Academy of Sciences

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Shanghai Institute of Materia Medica Chinese Academy of Sciences Mar 01 2006

China

Professor :: Medicinal Chemistry

Publications

Ruoqing Zeng, Meimiao Fang, Ancheng Shen, Xiaolei Chai, Yumiao Zhao, Mingyao Liu, Lingfeng Zhu, Weiwei Rui, Bo Feng, Liang Hong, Chunyong Ding, Zilan Song, Weiqiang Lu, Ao Zhang
Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[ d ]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD). Journal of medicinal chemistry 67 (5) (2024)
Mingjie Chen, Shuyue Lei, Zihua Zhou, Meng Wang, Chunlan Feng, Xiao-Ling Gao, Chunyong Ding, Zilan Song, Wei Tang, Ao Zhang
Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3'-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury. Journal of medicinal chemistry (2024)
Yang Li, Yuyuan Zhu, Fan-Fan Shang, Lin Xu, Defang Jiang, Bin Sun, Lei Zhang, Cheng Luo, Ao Zhang, Hao Zhang, Chunyong Ding
Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells. Journal of medicinal chemistry 67 (9) (2024)
Mingjie Chen, Shuyue Lei, Zihua Zhou, Meng Wang, Chunlan Feng, Xiao-Ling Gao, Chunyong Ding, Zilan Song, Wei Tang, Ao Zhang
Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3'-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury. Journal of medicinal chemistry 67 (8) (2024)
Ruoqing Zeng, Meimiao Fang, Ancheng Shen, Xiaolei Chai, Yumiao Zhao, Mingyao Liu, Lingfeng Zhu, Weiwei Rui, Bo Feng, Liang Hong, Chunyong Ding, Zilan Song, Weiqiang Lu, Ao Zhang
Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[ d ]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD). Journal of medicinal chemistry (2024)
Ruoqing Zeng, Meimiao Fang, Ancheng Shen, Xiaolei Chai, Yumiao Zhao, Mingyao Liu, Lingfeng Zhu, Weiwei Rui, Bo Feng, Liang Hong, Chunyong Ding, Zilan Song, Weiqiang Lu, Ao Zhang
Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[ d ]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD). Journal of medicinal chemistry 67 (5) (2024)
Yang Li, Yuyuan Zhu, Fan-Fan Shang, Lin Xu, Defang Jiang, Bin Sun, Lei Zhang, Cheng Luo, Ao Zhang, Hao Zhang, Chunyong Ding
Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells. Journal of medicinal chemistry (2024)
Xuanzheng Xiao, Juanjuan Feng, Jing Ma, Xinting Xia, Xiaogu Liu, Jian Zhang, Chunyong Ding, Xiufeng Pang, Ao Zhang
Design, Synthesis, and Pharmacological Evaluation of Multisubstituted Pyrido[4,3- d ]pyrimidine Analogues Bearing Deuterated Methylene Linkers as Potent KRAS G12D Inhibitors. Journal of medicinal chemistry (2023)
Li-Min Wang, Pingyuan Wang, Xiao-Min Chen, Hui Yang, Shan-Shan Song, Zilan Song, Li Jia, Hua-Dong Chen, Xu-Bin Bao, Ne Guo, Xia-Juan Huan, Yong Xi, Yan-Yan Shen, Xin-Ying Yang, Yi Su, Yi-Ming Sun, Ying-Lei Gao, Yi Chen, Jian Ding, Jing-Yu Lang, Ze-Hong Miao, Ao Zhang, Jin-Xue He
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance. EMBO molecular medicine 15 (3) (2023)
Lei Sun, Haibo Zhang, Huihui Zhang, Xinyi Lou, Zhiming Wang, Yaxian Wu, Xinyi Yang, Daijie Chen, Beining Guo, Ao Zhang, Feng Qian
Staphylococcal virulence factor HlgB targets the endoplasmic-reticulum-resident E3 ubiquitin ligase AMFR to promote pneumonia. Nature microbiology (2023)
Hairong Tang, Aisong Yu, Li Xing, Xiaoyu Chen, Huaqian Ding, Hong Yang, Zilan Song, Qiongyu Shi, Meiyu Geng, Xun Huang, Ao Zhang
Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors. Journal of medicinal chemistry 66 (2) (2023)
Li-Min Wang, Pingyuan Wang, Xiao-Min Chen, Hui Yang, Shan-Shan Song, Zilan Song, Li Jia, Hua-Dong Chen, Xu-Bin Bao, Ne Guo, Xia-Juan Huan, Yong Xi, Yan-Yan Shen, Xin-Ying Yang, Yi Su, Yi-Ming Sun, Ying-Lei Gao, Yi Chen, Jian Ding, Jing-Yu Lang, Ze-Hong Miao, Ao Zhang, Jin-Xue He
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance. EMBO molecular medicine 15 (3) (2023)
Li-Min Wang, Pingyuan Wang, Xiao-Min Chen, Hui Yang, Shan-Shan Song, Zilan Song, Li Jia, Hua-Dong Chen, Xu-Bin Bao, Ne Guo, Xia-Juan Huan, Yong Xi, Yan-Yan Shen, Xin-Ying Yang, Yi Su, Yi-Ming Sun, Ying-Lei Gao, Yi Chen, Jian Ding, Jing-Yu Lang, Ze-Hong Miao, Ao Zhang, Jin-Xue He
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance. EMBO molecular medicine 15 (3) (2023)
Lei Sun, Haibo Zhang, Huihui Zhang, Xinyi Lou, Zhiming Wang, Yaxian Wu, Xinyi Yang, Daijie Chen, Beining Guo, Ao Zhang, Feng Qian
Staphylococcal virulence factor HlgB targets the endoplasmic-reticulum-resident E3 ubiquitin ligase AMFR to promote pneumonia. Nature microbiology 8 (1) (2023)
Li-Min Wang, Pingyuan Wang, Xiao-Min Chen, Hui Yang, Shan-Shan Song, Zilan Song, Li Jia, Hua-Dong Chen, Xu-Bin Bao, Ne Guo, Xia-Juan Huan, Yong Xi, Yan-Yan Shen, Xin-Ying Yang, Yi Su, Yi-Ming Sun, Ying-Lei Gao, Yi Chen, Jian Ding, Jing-Yu Lang, Ze-Hong Miao, Ao Zhang, Jin-Xue He
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance. EMBO molecular medicine 15 (3) (2023)
Lei Sun, Haibo Zhang, Huihui Zhang, Xinyi Lou, Zhiming Wang, Yaxian Wu, Xinyi Yang, Daijie Chen, Beining Guo, Ao Zhang, Feng Qian
Staphylococcal virulence factor HlgB targets the endoplasmic-reticulum-resident E3 ubiquitin ligase AMFR to promote pneumonia. Nature microbiology 8 (1) (2023)
Chang-Yun Shi, Xiao-Qu Chen, Ruoqing Zeng, Heng Lu, Zhoulong Fan, Ao Zhang
Ruthenium-Catalyzed Ligand-Enabled Regiodivergent Difluoroallylation of Aryl C-H Bonds. Organic letters (2023)
Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal transduction and targeted therapy 8 (1) (2023)
Hairong Tang, Aisong Yu, Li Xing, Xiaoyu Chen, Huaqian Ding, Hong Yang, Zilan Song, Qiongyu Shi, Meiyu Geng, Xun Huang, Ao Zhang
Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors. Journal of medicinal chemistry (2023)
Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal transduction and targeted therapy 8 (1) (2023)
Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal transduction and targeted therapy 8 (1) (2023)
Hairong Tang, Aisong Yu, Li Xing, Xiaoyu Chen, Huaqian Ding, Hong Yang, Zilan Song, Qiongyu Shi, Meiyu Geng, Xun Huang, Ao Zhang
Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors. Journal of medicinal chemistry 66 (2) (2023)
Li-Min Wang, Pingyuan Wang, Xiao-Min Chen, Hui Yang, Shan-Shan Song, Zilan Song, Li Jia, Hua-Dong Chen, Xu-Bin Bao, Ne Guo, Xia-Juan Huan, Yong Xi, Yan-Yan Shen, Xin-Ying Yang, Yi Su, Yi-Ming Sun, Ying-Lei Gao, Yi Chen, Jian Ding, Jing-Yu Lang, Ze-Hong Miao, Ao Zhang, Jin-Xue He
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance. EMBO molecular medicine (2023)
Hairong Tang, Aisong Yu, Li Xing, Xiaoyu Chen, Huaqian Ding, Hong Yang, Zilan Song, Qiongyu Shi, Meiyu Geng, Xun Huang, Ao Zhang
Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors. Journal of medicinal chemistry 66 (2) (2023)
Lei Sun, Haibo Zhang, Huihui Zhang, Xinyi Lou, Zhiming Wang, Yaxian Wu, Xinyi Yang, Daijie Chen, Beining Guo, Ao Zhang, Feng Qian
Staphylococcal virulence factor HlgB targets the endoplasmic-reticulum-resident E3 ubiquitin ligase AMFR to promote pneumonia. Nature microbiology 8 (1) (2023)
Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal transduction and targeted therapy 8 (1) (2023)
Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal transduction and targeted therapy 8 (1) (2023)
Chenghu Xie, Bo Liu, Zilan Song, Ye Yang, Mengdi Dai, Yinglei Gao, Yujia Yao, Chunyong Ding, Jing Ai, Ao Zhang
Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors. Journal of medicinal chemistry (2023)
Lei Sun, Haibo Zhang, Huihui Zhang, Xinyi Lou, Zhiming Wang, Yaxian Wu, Xinyi Yang, Daijie Chen, Beining Guo, Ao Zhang, Feng Qian
Staphylococcal virulence factor HlgB targets the endoplasmic-reticulum-resident E3 ubiquitin ligase AMFR to promote pneumonia. Nature microbiology 8 (1) (2023)
Li-Min Wang, Pingyuan Wang, Xiao-Min Chen, Hui Yang, Shan-Shan Song, Zilan Song, Li Jia, Hua-Dong Chen, Xu-Bin Bao, Ne Guo, Xia-Juan Huan, Yong Xi, Yan-Yan Shen, Xin-Ying Yang, Yi Su, Yi-Ming Sun, Ying-Lei Gao, Yi Chen, Jian Ding, Jing-Yu Lang, Ze-Hong Miao, Ao Zhang, Jin-Xue He
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance. EMBO molecular medicine 15 (3) (2023)
Xiao-Qu Chen, Heng Lu, Chuan-Xin Chen, Ruoqing Zeng, Dong-Yu Wang, Chang-Yun Shi, Ao Zhang
Palladium-Catalyzed gem -Difluoroallylation Reaction between Aryltributyltin and Bromodifluoromethylated Alkenes. The Journal of organic chemistry 87 (5) (2022)
Jie Li, Yao Wu, Jiaoying Wang, Xiaoxuan Xu, Ao Zhang, Yaping Li, Zhiwen Zhang
Macrophage Membrane-Coated Nano-Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function. ACS nano 17 (1) (2022)
Jie Li, Yao Wu, Jiaoying Wang, Xiaoxuan Xu, Ao Zhang, Yaping Li, Zhiwen Zhang
Macrophage Membrane-Coated Nano-Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function. ACS nano (2022)
Jie Li, Yao Wu, Jiaoying Wang, Xiaoxuan Xu, Ao Zhang, Yaping Li, Zhiwen Zhang
Macrophage Membrane-Coated Nano-Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function. ACS nano 17 (1) (2022)
Heng Lu, Ruo-Xuan Xiao, Chang-Yun Shi, Zi-Lan Song, Hou-Wen Lin, Ao Zhang
Synthesis of aryldifluoromethyl aryl ethers via nickel-catalyzed suzuki cross-coupling between aryloxydifluoromethyl bromides and boronic acids. Communications chemistry 5 (1) (2022)
Heng Lu, Ruo-Xuan Xiao, Chang-Yun Shi, Zi-Lan Song, Hou-Wen Lin, Ao Zhang
Synthesis of aryldifluoromethyl aryl ethers via nickel-catalyzed suzuki cross-coupling between aryloxydifluoromethyl bromides and boronic acids. Communications chemistry 5 (1) (2022)
Jie Li, Yao Wu, Jiaoying Wang, Xiaoxuan Xu, Ao Zhang, Yaping Li, Zhiwen Zhang
Macrophage Membrane-Coated Nano-Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function. ACS nano 17 (1) (2022)
Jie Li, Yao Wu, Jiaoying Wang, Xiaoxuan Xu, Ao Zhang, Yaping Li, Zhiwen Zhang
Macrophage Membrane-Coated Nano-Gemcitabine Promotes Lymphocyte Infiltration and Synergizes AntiPD-L1 to Restore the Tumoricidal Function. ACS nano 17 (1) (2022)
Ancheng Shen, Mingjie Chen, Qingxuan Chen, Zhiguo Liu, Ao Zhang
Recent advances in the development of STING inhibitors: an updated patent review. Expert opinion on therapeutic patents 32 (11) (2022)
Hairong Tang, Ruoqing Zeng, Ende He, Isabella Zhang, Chunyong Ding, Ao Zhang
Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators. Journal of medicinal chemistry 65 (9) (2022)
Zilan Song, Xiyuan Wang, Yan Zhang, Wangting Gu, Ancheng Shen, Chunyong Ding, Han Li, Ruoxuan Xiao, Meiyu Geng, Zuoquan Xie, Ao Zhang
Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists. Journal of medicinal chemistry 64 (3) (2021)
Zilan Song, Bo Liu, Xia Peng, Wangting Gu, Yiming Sun, Li Xing, Yi Xu, Meiyu Geng, Jing Ai, Ao Zhang
Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage. Journal of medicinal chemistry 64 (22) (2021)
Jing Tan, Bing Wu, Tingting Chen, Chen Fan, Jiannan Zhao, Chaodong Xiong, Chunlan Feng, Ruoxuan Xiao, Chunyong Ding, Wei Tang, Ao Zhang
Synthesis and Pharmacological Evaluation of Tetrahydro-γ-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase. Journal of medicinal chemistry 64 (11) (2021)
Chaodong Xiong, Lina Zhou, Jing Tan, Shanshan Song, Xubin Bao, Ning Zhang, Huaqian Ding, Jiannan Zhao, Jin-Xue He, Ze-Hong Miao, Ao Zhang
Development of Potent NEDD8-Activating Enzyme Inhibitors Bearing a Pyrimidotriazole Scaffold. Journal of medicinal chemistry 64 (9) (2021)
Heng Lu, Dong-Yu Wang, Ao Zhang
Visible Light-Promoted Phosphine-Catalyzed Difluoroalkylation of Arenes and Heterocycles. The Journal of organic chemistry 85 (2) (2020)
Jiabin Ni, Bekzod Nishonov, Azizbek Pardaev, Ao Zhang
Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones. The Journal of organic chemistry 84 (21) (2019)
Jian-Nan Zhao, Muzaffar Kayumov, Dong-Yu Wang, Ao Zhang
Transition-Metal-Free Aryl-Heteroatom Bond Formation via C-S Bond Cleavage. Organic letters 21 (18) (2019)
Chunyong Ding, Fengyang Wang, Yijing Dang, Zhiai Xu, Lingling Li, Yi Lai, Haijun Yu, Yi Luo, Ruimin Huang, Ao Zhang, Wen Zhang
Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity. Analytical chemistry 91 (24) (2019)
Zhoulong Fan, Heng Lu, Ao Zhang
PMes3-Promoted Ruthenium-Catalyzed Meta C-H Nitration of 6-Arylpurines. The Journal of organic chemistry 83 (6) (2018)
Chunyong Ding, Qianting Tian, Jie Li, Mingkun Jiao, Shanshan Song, Yingqing Wang, Zehong Miao, Ao Zhang
Structural Modification of Natural Product Tanshinone I Leading to Discovery of Novel Nitrogen-Enriched Derivatives with Enhanced Anticancer Profile and Improved Drug-like Properties. Journal of medicinal chemistry 61 (3) (2018)
Yu Xue, Peiran Song, Zilan Song, Aoli Wang, Linjiang Tong, Meiyu Geng, Jian Ding, Qing-Song Liu, Liping Sun, Hua Xie, Ao Zhang
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrimido[5,4- b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors. Journal of medicinal chemistry 61 (10) (2018)
Heng Lu, Zhoulong Fan, Chaodong Xiong, Ao Zhang
Highly Stereoselective Assembly of Polycyclic Molecules from 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation. Organic letters 20 (10) (2018)
Jiabin Ni, Yu Xue, Liping Sun, Ao Zhang
Cu-Mediated Sulfonyl Radical-Enabled 5- exo-trig Cyclization of Alkenyl Aldehydes: Access to Sulfonylmethyl 1 H-Indenes. The Journal of organic chemistry 83 (8) (2018)
Fengyang Wang, Shujuan Yu, Zhiai Xu, Lingling Li, Yijing Dang, Xiaowei Xu, Yi Luo, Zhen Cheng, Haijun Yu, Wen Zhang, Ao Zhang, Chunyong Ding
Acid-Promoted D-A-D Type Far-Red Fluorescent Probe with High Photostability for Lysosomal Nitric Oxide Imaging. Analytical chemistry 90 (13) (2018)
Gang Liu, Wenjing Huang, Juan Wang, Xiaohua Liu, Jun Yang, Yu Zhang, Yong Geng, Wenfu Tan, Ao Zhang
Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription. Journal of medicinal chemistry 60 (19) (2017)
Jiabin Ni, Hongchuan Zhao, Ao Zhang
Manganese(I)-Catalyzed C-H 3,3-Difluoroallylation of Pyridones and Indoles. Organic letters 19 (12) (2017)
Zhoulong Fan, Jie Li, Heng Lu, Dong-Yu Wang, Chao Wang, Masanobu Uchiyama, Ao Zhang
Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries. Organic letters 19 (12) (2017)
Jie Li, Yu Xue, Zhoulong Fan, Chunyong Ding, Ao Zhang
Difluorination of Furonaphthoquinones. The Journal of organic chemistry 82 (14) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Ao Zhang