Weiqiang Lu

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 33

Top Topics

Acute Myeloid Leukemia

Structural Basis

Top Venues

Journal of medicinal chemistry

Science advances

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Haojie Wang, Xinyu Yang, Yan Li, Shuyin Ze, Bo Feng, Yuan Weng, Aoqi Gao, Gaojie Song, Mingyao Liu, Qiong Xie, Yonghui Wang, Weiqiang Lu
Subtle Structural Changes across the Boundary between A 2A R/A 2B R Dual Antagonism and A 2B R Antagonism: A Novel Class of 2-Aminopyrimidine-Based Derivatives. Journal of medicinal chemistry 67 (6) (2024)
Haojie Wang, Xinyu Yang, Yan Li, Shuyin Ze, Bo Feng, Yuan Weng, Aoqi Gao, Gaojie Song, Mingyao Liu, Qiong Xie, Yonghui Wang, Weiqiang Lu
Subtle Structural Changes across the Boundary between A 2A R/A 2B R Dual Antagonism and A 2B R Antagonism: A Novel Class of 2-Aminopyrimidine-Based Derivatives. Journal of medicinal chemistry (2024)
Ruoqing Zeng, Meimiao Fang, Ancheng Shen, Xiaolei Chai, Yumiao Zhao, Mingyao Liu, Lingfeng Zhu, Weiwei Rui, Bo Feng, Liang Hong, Chunyong Ding, Zilan Song, Weiqiang Lu, Ao Zhang
Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[ d ]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD). Journal of medicinal chemistry 67 (5) (2024)
Haojie Wang, Xinyu Yang, Yan Li, Shuyin Ze, Bo Feng, Yuan Weng, Aoqi Gao, Gaojie Song, Mingyao Liu, Qiong Xie, Yonghui Wang, Weiqiang Lu
Subtle Structural Changes across the Boundary between A 2A R/A 2B R Dual Antagonism and A 2B R Antagonism: A Novel Class of 2-Aminopyrimidine-Based Derivatives. Journal of medicinal chemistry 67 (6) (2024)
Ruoqing Zeng, Meimiao Fang, Ancheng Shen, Xiaolei Chai, Yumiao Zhao, Mingyao Liu, Lingfeng Zhu, Weiwei Rui, Bo Feng, Liang Hong, Chunyong Ding, Zilan Song, Weiqiang Lu, Ao Zhang
Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[ d ]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD). Journal of medicinal chemistry (2024)
Ruoqing Zeng, Meimiao Fang, Ancheng Shen, Xiaolei Chai, Yumiao Zhao, Mingyao Liu, Lingfeng Zhu, Weiwei Rui, Bo Feng, Liang Hong, Chunyong Ding, Zilan Song, Weiqiang Lu, Ao Zhang
Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[ d ]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD). Journal of medicinal chemistry 67 (5) (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Chenyu Zhu, Shuyin Ze, Ronghui Zhou, Xinyu Yang, Haojie Wang, Xiaolei Chai, Meimiao Fang, Mingyao Liu, Yonghui Wang, Weiqiang Lu, Qiong Xie
Discovery of Pyridinone Derivatives as Potent, Selective, and Orally Bioavailable Adenosine A 2A Receptor Antagonists for Cancer Immunotherapy. Journal of medicinal chemistry (2023)
Hui Ma, Jiayan Cui, Zehui Liu, Wenqing Fang, Sisi Lu, Shuying Cao, Yuanyuan Zhang, Ji-An Chen, Lixue Lu, Qiong Xie, Yonghui Wang, Ying Huang, Kongfei Li, Hongyan Tong, Jin Huang, Weiqiang Lu
Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia. Oncogene (2023)
Zhiyuan Cheng, Yijie Wang, Yao Zhang, Chan Zhang, Mengru Wang, Wei Wang, Jiacheng He, Yang Wang, Han-Kun Zhang, Qiansen Zhang, Chunyong Ding, Deyan Wu, Linlin Yang, Mingyao Liu, Weiqiang Lu
Discovery of 2 H -Indazole-3-carboxamide Derivatives as Novel Potent Prostanoid EP4 Receptor Antagonists for Colorectal Cancer Immunotherapy. Journal of medicinal chemistry (2023)
Ying Chen, Jinyi Zhang, Yuan Weng, Yueming Xu, Weiqiang Lu, Wei Liu, Mingyao Liu, Tian Hua, Gaojie Song
Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Science advances 8 (51) (2022)
Wei Wang, Jiacheng He, Jun-Jie Yang, Chan Zhang, Zhiyuan Cheng, Yao Zhang, Qiansen Zhang, Pei-Li Wang, Shuowen Tang, Xin Wang, Mingyao Liu, Weiqiang Lu, Han-Kun Zhang
Scaffold Hopping Strategy to Identify Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy. Journal of medicinal chemistry 65 (11) (2022)
Chunyang Yi, Jiacheng He, Dan Huang, Yumiao Zhao, Chan Zhang, Xiyun Ye, Ying Huang, Ruth Nussinov, Junke Zheng, Mingyao Liu, Weiqiang Lu
Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia. Cell death & disease 13 (11) (2022)
Ying Chen, Jinyi Zhang, Yuan Weng, Yueming Xu, Weiqiang Lu, Wei Liu, Mingyao Liu, Tian Hua, Gaojie Song
Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Science advances 8 (51) (2022)
Ying Chen, Jinyi Zhang, Yuan Weng, Yueming Xu, Weiqiang Lu, Wei Liu, Mingyao Liu, Tian Hua, Gaojie Song
Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Science advances 8 (51) (2022)
Ying Chen, Jinyi Zhang, Yuan Weng, Yueming Xu, Weiqiang Lu, Wei Liu, Mingyao Liu, Tian Hua, Gaojie Song
Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Science advances 8 (51) (2022)
Fazhi Yu, Chenyu Zhu, Shuyin Ze, Haojie Wang, Xinyu Yang, Mingyao Liu, Qiong Xie, Weiqiang Lu, Yonghui Wang
Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8 H )-one Derivatives as Novel Potent Adenosine A 2A Receptor Antagonists for Cancer Immunotherapy. Journal of medicinal chemistry 65 (5) (2022)
Wenhao Jiang, Yunyun Jin, Shiwei Zhang, Yi Ding, Konglin Huo, Junjie Yang, Lei Zhao, Baoning Nian, Tao P Zhong, Weiqiang Lu, Hankun Zhang, Xu Cao, Karan Mehul Shah, Ning Wang, Mingyao Liu, Jian Luo
PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis. Bone research 10 (1) (2022)
Ying Chen, Jinyi Zhang, Yuan Weng, Yueming Xu, Weiqiang Lu, Wei Liu, Mingyao Liu, Tian Hua, Gaojie Song
Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Science advances 8 (51) (2022)
Ying Chen, Jinyi Zhang, Yuan Weng, Yueming Xu, Weiqiang Lu, Wei Liu, Mingyao Liu, Tian Hua, Gaojie Song
Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex. Science advances 8 (51) (2022)
Yunyun Jin, Qianqian Liu, Peng Chen, Siyuan Zhao, Wenhao Jiang, Fanhua Wang, Peng Li, Yuanjin Zhang, Weiqiang Lu, Tao P Zhong, Xinran Ma, Xin Wang, Alison Gartland, Ning Wang, Karan Mehul Shah, Hankun Zhang, Xu Cao, Lei Yang, Mingyao Liu, Jian Luo
A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration. Cell discovery 8 (1) (2022)
Ji-An Chen, Hui Ma, Zehui Liu, Jinlong Tian, Sisi Lu, Wenqing Fang, Shuyin Ze, Weiqiang Lu, Qiong Xie, Jin Huang, Yonghui Wang
Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. Journal of medicinal chemistry 65 (1) (2021)
Feixiong Cheng, Junfei Zhao, Yang Wang, Weiqiang Lu, Zehui Liu, Yadi Zhou, William R Martin, Ruisheng Wang, Jin Huang, Tong Hao, Hong Yue, Jing Ma, Yuan Hou, Jessica A Castrillon, Jiansong Fang, Justin D Lathia, Ruth A Keri, Felice C Lightstone, Elliott Marshall Antman, Raúl Rabadán, David E Hill, Charis Eng, Marc Vidal, Joseph Loscalzo
Comprehensive characterization of protein-protein interactions perturbed by disease mutations. Nature genetics 53 (3) (2021)
Shihong Peng, Pan Hu, Yu-Tian Xiao, Weiqiang Lu, Dandan Guo, Shixiu Hu, Jiayi Xie, Minna Wang, Weiwei Yu, Jun-Jie Yang, Huang Chen, Xiaomin Zhang, Yasheng Zhu, Ye Wang, Yue Yang, Guanghui Zhu, Sujun Chen, Jian Wang, Bo Zhang, Weidong Chen, Huangan Wu, Zhenliang Sun, Tao Ding, Hankun Zhang, Zhengfang Yi, Mingyao Liu, Shancheng Ren
Single-cell analysis reveals EP4 as a target for restoring T cell infiltration and sensitizing prostate cancer to immunotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Bei-Er Jiang, Xingwu Jiang, Qiansen Zhang, Qiuwen Liang, Zi-Liang Qiu, Xiang-Bai Sun, Jun-Jie Yang, Si Chen, Chunyang Yi, Xiaolei Chai, Mingyao Liu, Li-Fang Yu, Weiqiang Lu, Han-Kun Zhang
From a Designer Drug to the Discovery of Selective Cannabinoid Type 2 Receptor Agonists with Favorable Pharmacokinetic Profiles for the Treatment of Systemic Sclerosis. Journal of medicinal chemistry 64 (1) (2020)
Weiqiang Lu, Weiwei Yu, Jiacheng He, Wenjuan Liu, Junjie Yang, Xianhua Lin, Yuanjin Zhang, Xin Wang, Wenhao Jiang, Jian Luo, Qiansen Zhang, Huaiyu Yang, Shihong Peng, Zhengfang Yi, Shancheng Ren, Jing Chen, Stefan Siwko, Ruth Nussinov, Feixiong Cheng, Han-Kun Zhang, Mingyao Liu
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer. EMBO molecular medicine 13 (1) (2020)
Chunyang Yi, Xiaolong Li, Si Chen, Mingyao Liu, Weiqiang Lu, Xiyun Ye
Natural product corynoline suppresses melanoma cell growth through inducing oxidative stress. Phytotherapy research : PTR 34 (10) (2020)
Ping Liao, Yunguang Qiu, Yiqing Mo, Jie Fu, Zhenpeng Song, Lu Huang, Suwen Bai, Yang Wang, Jia-Jie Zhu, Fuyun Tian, Zhuo Chen, Nanfang Pan, Er-Yi Sun, Linghui Yang, Xi Lan, Yinbin Chen, Dongping Huang, Peihua Sun, Lifen Zhao, Dehua Yang, Weiqiang Lu, Tingting Yang, Junjie Xiao, Wei-Guang Li, Zhaobing Gao, Bing Shen, Qiansen Zhang, Jin Liu, Hualiang Jiang, Ruo-Tian Jiang, Huaiyu Yang
Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models. Science translational medicine 11 (519) (2020)
Jun-Jie Yang, Wei-Wei Yu, Long-Long Hu, Wen-Juan Liu, Xian-Hua Lin, Wei Wang, Qiansen Zhang, Pei-Li Wang, Shuo-Wen Tang, Xin Wang, Mingyao Liu, Weiqiang Lu, Han-Kun Zhang
Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy. Journal of medicinal chemistry 63 (2) (2020)
Feixiong Cheng, Weiqiang Lu, Chuang Liu, Jiansong Fang, Yuan Hou, Diane E Handy, Ruisheng Wang, Yuzheng Zhao, Yi Yang, Jin Huang, David E Hill, Marc Vidal, Charis Eng, Joseph Loscalzo
A genome-wide positioning systems network algorithm for in silico drug repurposing. Nature communications 10 (1) (2019)