Cheng Luo

ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 83

Top Venues

Journal of medicinal chemistry

Nature communications

Signal transduction and targeted therapy

ACS chemical biology

Shanghai Institute of Materia Medica

Shanghai Institute of Materia Medica Chinese Academy of Sciences (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Shanghai Institute of Materia Medica Jul 01 2004

China

Professor/Ph.D. :: Drug Discovery and Design Center

Wistar Institute/Upenn - Mar 27 2008

China

Postdoctoral Fellow

Education History

Shanghai Institute of Materia Medica Chinese Academy of Sciences

China

PHD

Fudan University

China

MSC

Fuzhou University

China

BSC

Publications

Zhihao Liu, Min Lin, Chenyu Liu, Xin Chen, Qian Chen, Xinyu Li, Xiaoyan Wu, Yahui Wang, Lei Wang, Fan Yang, Cheng Luo, Jia Jin, Fei Ye
Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma. Journal of medicinal chemistry 67 (8) (2024)
Huimin Zhang, Dounan Xu, Hongchan Huang, Hao Jiang, Linghao Hu, Liping Liu, Ge Sun, Jing Gao, Yuanqing Li, Cuicui Xia, Shijie Chen, Hu Zhou, Xiang-Qian Kong, Mingliang Wang, Cheng Luo
Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase. ACS chemical biology (2024)
Zhihao Liu, Min Lin, Chenyu Liu, Xin Chen, Qian Chen, Xinyu Li, Xiaoyan Wu, Yahui Wang, Lei Wang, Fan Yang, Cheng Luo, Jia Jin, Fei Ye
Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma. Journal of medicinal chemistry (2024)
Huimin Zhang, Dounan Xu, Hongchan Huang, Hao Jiang, Linghao Hu, Liping Liu, Ge Sun, Jing Gao, Yuanqing Li, Cuicui Xia, Shijie Chen, Hu Zhou, Xiang-Qian Kong, Mingliang Wang, Cheng Luo
Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase. ACS chemical biology 19 (4) (2024)
Zhenfei Zhou, Siqi Huang, Shijie Fan, Xueyuan Li, Chengyu Wang, Wanlin Yu, Daohai Du, Yuanyuan Zhang, Kaixian Chen, Wei Fu, Cheng Luo
Structure-Based Design and Discovery of a Potent and Cell-Active LC3A/B Covalent Inhibitor. Journal of medicinal chemistry 67 (14) (2024)
Huimin Zhang, Dounan Xu, Hongchan Huang, Hao Jiang, Linghao Hu, Liping Liu, Ge Sun, Jing Gao, Yuanqing Li, Cuicui Xia, Shijie Chen, Hu Zhou, Xiang-Qian Kong, Mingliang Wang, Cheng Luo
Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase. ACS chemical biology 19 (4) (2024)
Zemin Zhang, Yuanqing Li, Jie Yang, Jiacheng Li, Xiongqiang Lin, Ting Liu, Shiling Yang, Jin Lin, Shengyu Xue, Jiamin Yu, Cailing Tang, Ziteng Li, Liping Liu, Zhengzheng Ye, Ya-Nan Deng, Zhihai Li, Kaixian Chen, Hong Ding, Cheng Luo, Hua Lin
Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex. Nature communications 15 (1) (2024)
Yuying Suo, Daohai Du, Chao Chen, Hongwen Zhu, Xiongjun Wang, Nixue Song, Dayun Lu, Yaxi Yang, Jiacheng Li, Jun Wang, Zhongyuan Luo, Bing Zhou, Cheng Luo, Hu Zhou
Uncovering PROTAC Sensitivity and Efficacy by Multidimensional Proteome Profiling: A Case for STAT3. Journal of medicinal chemistry (2024)
Hui Qian, Chen-Hong Ding, Fang Liu, Shi-Jie Chen, Chen-Kai Huang, Meng-Chao Xiao, Xia-Lu Hong, Ming-Chen Wang, Fang-Zhi Yan, Kai Ding, Ya-Lu Cui, Bai-Nan Zheng, Jin Ding, Cheng Luo, Xin Zhang, Wei-Fen Xie
SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors. Signal transduction and targeted therapy 9 (1) (2024)
Zemin Zhang, Yuanqing Li, Jie Yang, Jiacheng Li, Xiongqiang Lin, Ting Liu, Shiling Yang, Jin Lin, Shengyu Xue, Jiamin Yu, Cailing Tang, Ziteng Li, Liping Liu, Zhengzheng Ye, Ya-Nan Deng, Zhihai Li, Kaixian Chen, Hong Ding, Cheng Luo, Hua Lin
Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex. Nature communications 15 (1) (2024)
Huimin Zhang, Dounan Xu, Hongchan Huang, Hao Jiang, Linghao Hu, Liping Liu, Ge Sun, Jing Gao, Yuanqing Li, Cuicui Xia, Shijie Chen, Hu Zhou, Xiang-Qian Kong, Mingliang Wang, Cheng Luo
Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase. ACS chemical biology 19 (4) (2024)
Zemin Zhang, Yuanqing Li, Jie Yang, Jiacheng Li, Xiongqiang Lin, Ting Liu, Shiling Yang, Jin Lin, Shengyu Xue, Jiamin Yu, Cailing Tang, Ziteng Li, Liping Liu, Zhengzheng Ye, Ya-Nan Deng, Zhihai Li, Kaixian Chen, Hong Ding, Cheng Luo, Hua Lin
Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex. Nature communications 15 (1) (2024)
Huimin Zhang, Dounan Xu, Hongchan Huang, Hao Jiang, Linghao Hu, Liping Liu, Ge Sun, Jing Gao, Yuanqing Li, Cuicui Xia, Shijie Chen, Hu Zhou, Xiang-Qian Kong, Mingliang Wang, Cheng Luo
Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase. ACS chemical biology 19 (4) (2024)
Zhipeng Yu, Yi Chu Liang, Stefania Berton, Liping Liu, Jiaqi Zou, Lu Chen, Zhongliang Xu, Cheng Luo, Jim Sun, Weibo Yang
Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy. Journal of medicinal chemistry (2024)
Zhipeng Yu, Yi Chu Liang, Stefania Berton, Liping Liu, Jiaqi Zou, Lu Chen, Zhongliang Xu, Cheng Luo, Jim Sun, Weibo Yang
Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy. Journal of medicinal chemistry 67 (14) (2024)
Zhipeng Yu, Yi Chu Liang, Stefania Berton, Liping Liu, Jiaqi Zou, Lu Chen, Zhongliang Xu, Cheng Luo, Jim Sun, Weibo Yang
Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy. Journal of medicinal chemistry 67 (14) (2024)
Zhenfei Zhou, Siqi Huang, Shijie Fan, Xueyuan Li, Chengyu Wang, Wanlin Yu, Daohai Du, Yuanyuan Zhang, Kaixian Chen, Wei Fu, Cheng Luo
Structure-Based Design and Discovery of a Potent and Cell-Active LC3A/B Covalent Inhibitor. Journal of medicinal chemistry (2024)
Zemin Zhang, Yuanqing Li, Jie Yang, Jiacheng Li, Xiongqiang Lin, Ting Liu, Shiling Yang, Jin Lin, Shengyu Xue, Jiamin Yu, Cailing Tang, Ziteng Li, Liping Liu, Zhengzheng Ye, Ya-Nan Deng, Zhihai Li, Kaixian Chen, Hong Ding, Cheng Luo, Hua Lin
Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex. Nature communications 15 (1) (2024)
Yingjie Chang, Huahui Guo, Xue Li, Liangyi Zong, Jiale Wei, Zhihai Li, Cheng Luo, Xinying Yang, Hao Fang, Xiang-Qian Kong, Xuben Hou
Development of a First-in-Class DNMT1/HDAC Inhibitor with Improved Therapeutic Potential and Potentiated Antitumor Immunity. Journal of medicinal chemistry (2024)
Zhenfei Zhou, Siqi Huang, Shijie Fan, Xueyuan Li, Chengyu Wang, Wanlin Yu, Daohai Du, Yuanyuan Zhang, Kaixian Chen, Wei Fu, Cheng Luo
Structure-Based Design and Discovery of a Potent and Cell-Active LC3A/B Covalent Inhibitor. Journal of medicinal chemistry 67 (14) (2024)
Hui Qian, Chen-Hong Ding, Fang Liu, Shi-Jie Chen, Chen-Kai Huang, Meng-Chao Xiao, Xia-Lu Hong, Ming-Chen Wang, Fang-Zhi Yan, Kai Ding, Ya-Lu Cui, Bai-Nan Zheng, Jin Ding, Cheng Luo, Xin Zhang, Wei-Fen Xie
SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors. Signal transduction and targeted therapy 9 (1) (2024)
Yuying Suo, Daohai Du, Chao Chen, Hongwen Zhu, Xiongjun Wang, Nixue Song, Dayun Lu, Yaxi Yang, Jiacheng Li, Jun Wang, Zhongyuan Luo, Bing Zhou, Cheng Luo, Hu Zhou
Uncovering PROTAC Sensitivity and Efficacy by Multidimensional Proteome Profiling: A Case for STAT3. Journal of medicinal chemistry 67 (6) (2024)
Yang Li, Yuyuan Zhu, Fan-Fan Shang, Lin Xu, Defang Jiang, Bin Sun, Lei Zhang, Cheng Luo, Ao Zhang, Hao Zhang, Chunyong Ding
Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells. Journal of medicinal chemistry 67 (9) (2024)
Yuying Suo, Daohai Du, Chao Chen, Hongwen Zhu, Xiongjun Wang, Nixue Song, Dayun Lu, Yaxi Yang, Jiacheng Li, Jun Wang, Zhongyuan Luo, Bing Zhou, Cheng Luo, Hu Zhou
Uncovering PROTAC Sensitivity and Efficacy by Multidimensional Proteome Profiling: A Case for STAT3. Journal of medicinal chemistry 67 (6) (2024)
Zhipeng Yu, Yi Chu Liang, Stefania Berton, Liping Liu, Jiaqi Zou, Lu Chen, Zhongliang Xu, Cheng Luo, Jim Sun, Weibo Yang
Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy. Journal of medicinal chemistry 67 (14) (2024)
Hui Qian, Chen-Hong Ding, Fang Liu, Shi-Jie Chen, Chen-Kai Huang, Meng-Chao Xiao, Xia-Lu Hong, Ming-Chen Wang, Fang-Zhi Yan, Kai Ding, Ya-Lu Cui, Bai-Nan Zheng, Jin Ding, Cheng Luo, Xin Zhang, Wei-Fen Xie
SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors. Signal transduction and targeted therapy 9 (1) (2024)
Hui Qian, Chen-Hong Ding, Fang Liu, Shi-Jie Chen, Chen-Kai Huang, Meng-Chao Xiao, Xia-Lu Hong, Ming-Chen Wang, Fang-Zhi Yan, Kai Ding, Ya-Lu Cui, Bai-Nan Zheng, Jin Ding, Cheng Luo, Xin Zhang, Wei-Fen Xie
SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors. Signal transduction and targeted therapy 9 (1) (2024)
Zhen Wang, Fengying Fan, Zhihai Li, Fei Ye, Qingxia Wang, Rongchao Gao, Jiaxuan Qiu, Yixin Lv, Min Lin, Wenwen Xu, Cheng Luo, Xuekui Yu
Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nature communications 15 (1) (2024)
Zhen Wang, Fengying Fan, Zhihai Li, Fei Ye, Qingxia Wang, Rongchao Gao, Jiaxuan Qiu, Yixin Lv, Min Lin, Wenwen Xu, Cheng Luo, Xuekui Yu
Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nature communications 15 (1) (2024)
Yang Li, Yuyuan Zhu, Fan-Fan Shang, Lin Xu, Defang Jiang, Bin Sun, Lei Zhang, Cheng Luo, Ao Zhang, Hao Zhang, Chunyong Ding
Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells. Journal of medicinal chemistry (2024)
Zhenfei Zhou, Siqi Huang, Shijie Fan, Xueyuan Li, Chengyu Wang, Wanlin Yu, Daohai Du, Yuanyuan Zhang, Kaixian Chen, Wei Fu, Cheng Luo
Structure-Based Design and Discovery of a Potent and Cell-Active LC3A/B Covalent Inhibitor. Journal of medicinal chemistry 67 (14) (2024)
Mingyu Wang, Rongkun Lin, Jiacheng Li, Yuying Suo, Jing Gao, Liping Liu, Liyuan Zhou, Yicheng Ni, Ziqun Yang, Jie Zheng, Jin Lin, Hu Zhou, Cheng Luo, Hua Lin
Discovery of LL-K8-22 : A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex. Journal of medicinal chemistry (2023)
Yu Bai, Zheyi Liu, Yuanqing Li, Heng Zhao, Can Lai, Shan Zhao, Kaixian Chen, Cheng Luo, Xueming Yang, Fang-Jun Wang
Structural Mass Spectrometry Probes the Inhibitor-Induced Allosteric Activation of CDK12/CDK13-Cyclin K Dissociation. Journal of the American Chemical Society (2023)
Jing Gao, Jie Yang, Shengyu Xue, Hong Ding, Hua Lin, Cheng Luo
A patent review of PRMT5 inhibitors to treat cancer (2018 - present). Expert opinion on therapeutic patents (2023)
Linghao Hu, Huiyun Li, Junlin Qin, Dan Yang, Jieming Liu, Xiaomin Luo, Jingkun Ma, Cheng Luo, Fei Ye, Yubo Zhou, Jia Li, Mingliang Wang
Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader. Journal of medicinal chemistry (2023)
Bo Liu, Xueni Yu, Liping Liu, Lei Wang, Jie Wang, Qianqian Huang, Zhongliang Xu, Cheng Luo, Liguang Lou, Wei Huang, Weibo Yang
Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance. Journal of medicinal chemistry (2023)
Jian-Hua Chen, Xuemin Jian, Siyu Deng, Zengyi Ma, Xuefei Shou, Yue Shen, Qilin Zhang, Zhijian Song, Zhi-Qiang Li, Hong Peng, Cheng Peng, Min Chen, Cheng Luo, Dan Zhao, Zhao Ye, Ming Shen, Yichao Zhang, Juan Zhou, Aamir Fahira, Yongfei Wang, Shiqi Li, Zhaoyun Zhang, Hongying Ye, Yiming Li, Jiawei Shen, Hong Chen, Feng Tang, Zhenwei Yao, Zhifeng Shi, Chunjui Chen, Lu Xie, Ye Wang, Chaowei Fu, Ying Mao, Liangfu Zhou, Daming Gao, Hai Yan, Yao Zhao, Chuanxin Huang, Yong-Yong Shi
Author Correction: Identification of recurrent USP48 and BRAF mutations in Cushing's disease. Nature communications 14 (1) (2023)
Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal transduction and targeted therapy 8 (1) (2023)
Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal transduction and targeted therapy 8 (1) (2023)
Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal transduction and targeted therapy 8 (1) (2023)
Bo Liu, Xueni Yu, Liping Liu, Lei Wang, Jie Wang, Qianqian Huang, Zhongliang Xu, Cheng Luo, Liguang Lou, Wei Huang, Weibo Yang
Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance. Journal of medicinal chemistry 66 (4) (2023)
Bo Liu, Xueni Yu, Liping Liu, Lei Wang, Jie Wang, Qianqian Huang, Zhongliang Xu, Cheng Luo, Liguang Lou, Wei Huang, Weibo Yang
Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance. Journal of medicinal chemistry 66 (4) (2023)
Ruina Wang, Lei Xiao, Jianbo Pan, Guangsen Bao, Yunmei Zhu, Di Zhu, Jun Wang, Chengfeng Pei, Qinfeng Ma, Xian Fu, Ziruoyu Wang, Mengdi Zhu, Guoxiang Wang, Ling Gong, Qiuping Tong, Min Jiang, Junchi Hu, Miao He, Yun Wang, Tiejun Li, Chunmin Liang, Wei Li, Chunmei Xia, Zengxia Li, Dengke K Ma, Min-Jia Tan, Jun Yan Liu, Wei Jiang, Cheng Luo, Biao Yu, Yongjun Dang
Natural product P57 induces hypothermia through targeting pyridoxal kinase. Nature communications 14 (1) (2023)
Hongru Tao, Chen Jin, Liyuan Zhou, Zhenzhong Deng, Xiao Li, Wenzhen Dang, Shijie Fan, Bing Li, Fei Ye, JunYan Lu, Xiang-Qian Kong, Chuanpeng Liu, Cheng Luo, Yuanyuan Zhang
PRMT1 inhibition activates the interferon pathway to potentiate antitumor immunity and enhance checkpoint blockade efficacy in melanoma. Cancer research (2023)
Bo Liu, Xueni Yu, Liping Liu, Lei Wang, Jie Wang, Qianqian Huang, Zhongliang Xu, Cheng Luo, Liguang Lou, Wei Huang, Weibo Yang
Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance. Journal of medicinal chemistry 66 (4) (2023)
Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal transduction and targeted therapy 8 (1) (2023)
Heng Xu, Hongfang Zhao, Chunyong Ding, Defang Jiang, Zijie Zhao, Yang Li, Xiaoyu Ding, Jing Gao, Hu Zhou, Cheng Luo, Guoqiang Chen, Ao Zhang, Ying Xu, Hao Zhang
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal transduction and targeted therapy 8 (1) (2023)
Xiaotong Diao, Fei Ye, Meina Zhang, Xintong Ren, Xiaoxu Tian, Jingping Lu, Xiangnan Sun, Zeng Hou, Xiaoyu Chen, Fengwei Li, Jingjing Zhuang, Hong Ding, Chao Peng, Fraydoon Rastinejad, Cheng Luo, Da-Lei Wu
Identification of oleoylethanolamide as an endogenous ligand for HIF-3α. Nature communications 13 (1) (2022)
Liping Liu, Rui Zhu, Jiacheng Li, Yuan Pei, Shuangshuang Wang, Pan Xu, Mingyu Wang, Yu Wen, Hao Zhang, Daohai Du, Hong Ding, Hualiang Jiang, Kaixian Chen, Bing Zhou, Li-Fang Yu, Cheng Luo
Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). Journal of medicinal chemistry 65 (3) (2022)
Jiacheng Li, Ting Liu, Yuanli Song, Mingyu Wang, Liping Liu, Hongwen Zhu, Qi Li, Jin Lin, Hualiang Jiang, Kaixian Chen, Kehao Zhao, Mingliang Wang, Hu Zhou, Hua Lin, Cheng Luo
Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer. Journal of medicinal chemistry 65 (16) (2022)
De-Bing Pu, Si-Qi Guo, Dong-Xuan Ni, Jing Lin, Jun-Bo Gao, Xiao-Ning Li, Rui-Han Zhang, Xiao-Li Li, Cheng Luo, Shi-Jie Chen, Wei-Lie Xiao
Spiroarborin, an ent -Clerodane Homodimer from Callicarpa arborea as an Inhibitor of the Eleven-Nineteen Leukemia (ENL) Protein by Targeting the YEATS Domain. Journal of natural products 85 (2) (2022)
Tonghai Liu, Wenjia Shi, Yiluan Ding, Qiqi Wu, Bei Zhang, Naixia Zhang, Mingliang Wang, Daohai Du, Hao Zhang, Bo Han, De-An Guo, Jie Zheng, Qi Li, Cheng Luo
(-)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase. ACS medicinal chemistry letters 13 (11) (2022)
Xiao Li, Lun Zhang, Jing Xu, Chenyu Liu, Xiaojian Zhang, Amr Abbas Abdelmoneim, Qian Zhang, Jiaqi Ke, Yingnan Zhang, Lei Wang, Fan Yang, Cheng Luo, Jia Jin, Fei Ye
Identification, Synthesis, and Biological Evaluations of Potent Inhibitors Targeting Type I Protein Arginine Methyltransferases. Journal of chemical information and modeling 62 (3) (2022)
Yang Wang, Wenjie Yuan, Siqi Guo, Qiqi Li, Xiaomei Chen, Cheng Li, Qianying Liu, Lei Sun, Zhenguo Chen, Zhenghong Yuan, Cheng Luo, Shijie Chen, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang
A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments. Nature communications 13 (1) (2022)
Yixuan Lei, Panyu Fei, Bin Song, Wenjia Shi, Cheng Luo, Dahai Luo, Dan Li, Wei Chen, Jie Zheng
A loosened gating mechanism of RIG-I leads to autoimmune disorders. Nucleic acids research 50 (10) (2022)
Fei Zhu, Sijie Yang, Fan Wang Meng, Yuxiang Zheng, Xin Ku, Cheng Luo, Guang Hu, Zhongjie Liang
Leveraging Protein Dynamics to Identify Functional Phosphorylation Sites using Deep Learning Models. Journal of chemical information and modeling 62 (14) (2022)
Daohai Du, Dandan Xu, Licheng Zhu, Giulia Stazi, Clemens Zwergel, Yanli Liu, Zhongyuan Luo, Yuanqing Li, Yuanyuan Zhang, Kongkai Zhu, Yiluan Ding, Jingqiu Liu, Shijie Fan, Kaiyan Zhao, Naixia Zhang, Xiangqian Kong, Hualiang Jiang, Kaixian Chen, Kehao Zhao, Sergio Valente, Jinrong Min, Wenhu Duan, Cheng Luo
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. Journal of medicinal chemistry 64 (12) (2021)
Senhao Xiao, Siqi Guo, Jie Han, Yanli Sun, Mingchen Wang, Yantao Chen, Xueyu Fang, Feng Yang, Yajuan Mu, Liang Zhang, Yiluan Ding, Naixia Zhang, Hualiang Jiang, Kaixian Chen, Kehao Zhao, Cheng Luo, Shijie Chen
High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases. Nucleic acids research (2021)
Youyi Zhang, Fei Ye, Tongtong Zhang, Shiyun Lv, Liping Zhou, Daohai Du, He Lin, Fei Guo, Cheng Luo, Shu-Jia Zhu
Structural basis of ketamine action on human NMDA receptors. Nature 596 (7871) (2021)
Shijie Fan, Liyan Yue, Wei Wan, Yuanyuan Zhang, Bidong Zhang, Chinatsu Otomo, Quanfu Li, Tingting Lin, Junchi Hu, Pan Xu, Mingrui Zhu, Hongru Tao, Zhifeng Chen, Lianchun Li, Hong Ding, Zhiyi Yao, Junyan Lu, Yi Wen, Naixia Zhang, Minjia Tan, Kaixian Chen, Yuli Xie, Takanori Otomo, Bing Zhou, Hualiang Jiang, Yongjun Dang, Cheng Luo
Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angewandte Chemie (International ed. in English) 60 (50) (2021)
Qidi Kong, Wei Pan, Heng Xu, Yaru Xue, Bin Guo, Xin Meng, Cheng Luo, Ting Wang, Shuhua Zhang, Yushe Yang
Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens. Journal of medicinal chemistry 64 (12) (2021)
Huimin Zhang, Jixiao He, Guang Hu, Fei Zhu, Hao Jiang, Jing Gao, Hu Zhou, Hua Lin, Yingjuan Wang, Kaixian Chen, Fanwang Meng, Minghong Hao, Kehao Zhao, Cheng Luo, Zhongjie Liang
Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family. Journal of medicinal chemistry 64 (20) (2021)
Tian Lu, Haibo Lu, Zhe Duan, Jun Wang, Jie Han, Senhao Xiao, HuanHuan Chen, Hao Jiang, Yu Chen, Feng Yang, Qi Li, Dongying Chen, Jin Lin, Bo Li, Hualiang Jiang, Kaixian Chen, Wen Chao Lu, Hua Lin, Cheng Luo
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain. Journal of medicinal chemistry 64 (16) (2021)
Stuart J Conway, Paola Arimondo, Cheryl H Arrowsmith, Jian Jin, Cheng Luo, Nicholas A Meanwell, Wendy B Young, Gunda I Georg, Shaomeng Wang
Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers. Journal of medicinal chemistry 63 (21) (2020)
Yaxi Yang, Rukang Zhang, Zhaojun Li, Lianghe Mei, Shili Wan, Hong Ding, Zhifeng Chen, Jing Xing, Huijin Feng, Jie Han, Hualiang Jiang, Mingyue Zheng, Cheng Luo, Bing Zhou
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors. Journal of medicinal chemistry 63 (3) (2020)
Zizhou Li, Senhao Xiao, Yaxi Yang, Chao Chen, Tian Lu, Zhifeng Chen, Hualiang Jiang, Shijie Chen, Cheng Luo, Bing Zhou
Discovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitors. Journal of medicinal chemistry 63 (8) (2020)
Fan Wang Meng, Zhongjie Liang, Kehao Zhao, Cheng Luo
Drug design targeting active posttranslational modification protein isoforms. Medicinal research reviews 41 (3) (2020)
Ze Dong, Zhen Wang, Zhong-Qiang Guo, Shouzhe Gong, Tao Zhang, Jiang Liu, Cheng Luo, Hualiang Jiang, Cai-Guang Yang
Structure-Activity Relationship of SPOP Inhibitors against Kidney Cancer. Journal of medicinal chemistry 63 (9) (2020)
Zhiqiang Li, Xinzhi Li, Ming-Bo Su, Li-Xin Gao, Yu-Bo Zhou, Bingchuan Yuan, Xilin Lyu, Ziqin Yan, Chujiao Hu, Hao Zhang, Cheng Luo, Zheng Chen, Jia Li, Yujun Zhao
Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo. Journal of medicinal chemistry 63 (8) (2020)
Ze Dong, Zhen Wang, Zhong-Qiang Guo, Shouzhe Gong, Tao Zhang, Jiang Liu, Cheng Luo, Hualiang Jiang, Cai-Guang Yang
Correction to Structure-Activity Relationship of SPOP Inhibitors against Kidney Cancer. Journal of medicinal chemistry 64 (1) (2020)
Zhongya Sun, Hao Zhang, Yuanyuan Zhang, Liping Liao, Wen Zhou, Fengcai Zhang, Fulin Lian, Jing Huang, Pan Xu, Rukang Zhang, Wenchao Lu, Mingrui Zhu, Hongru Tao, Feng Yang, Hong Ding, Shijie Chen, Liyan Yue, Bing Zhou, Naixia Zhang, Minjia Tan, Hualiang Jiang, Kaixian Chen, Bo Liu, Chuanpeng Liu, Yongjun Dang, Cheng Luo
Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 7 (14) (2020)
Xi Xu, Zijian Kuang, Jie Han, Ying Meng, Lei Li, Hongyu Luan, Pengfei Xu, Jubo Wang, Cheng Luo, Hong Ding, Zhiyu Li, Jinlei Bian
Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors. Journal of medicinal chemistry 62 (21) (2019)
Tianran Fu, Liping Liu, Qing-Lin Yang, Yuxin Wang, Pan Xu, Lin Zhang, Shien Liu, Qing Dai, Quanjiang Ji, Guo-Liang Xu, Chuan He, Cheng Luo, Liang Zhang
Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine. Chemical science 10 (31) (2019)
Hongru Tao, Jun Wang, Wen Chao Lu, Rukang Zhang, Yiqian Xie, Yu-Chih Liu, Rongfeng Liu, Liyan Yue, Kaixian Chen, Hualiang Jiang, Yuanyuan Zhang, Xiaohui Xu, Cheng Luo
Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening. RSC advances 9 (9) (2019)
Chenghui Shi, Yinyong Zhang, Ting Wang, Wenchao Lu, Shuhua Zhang, Bin Guo, Qian Chen, Cheng Luo, Xianli Zhou, Yushe Yang
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria. Journal of medicinal chemistry 62 (6) (2019)
Fei Ye, Xiangqian Kong, Hao Zhang, Yan Liu, Zhiyuan Shao, Jia Jin, Yi Cai, Rukang Zhang, Linjuan Li, Yang W Zhang, Yu-Chih Liu, Chenhua Zhang, Wenbing Xie, Kunqian Yu, Hong Ding, Kehao Zhao, Shijie Chen, Hualiang Jiang, Stephen B Baylin, Cheng Luo
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. ACS chemical biology 13 (3) (2018)
Jian-Hua Chen, Xuemin Jian, Siyu Deng, Zengyi Ma, Xuefei Shou, Yue Shen, Qilin Zhang, Zhijian Song, Zhi-Qiang Li, Hong Peng, Cheng Peng, Min Chen, Cheng Luo, Dan Zhao, Zhao Ye, Ming Shen, Yichao Zhang, Juan Zhou, Aamir Fahira, Yongfei Wang, Shiqi Li, Zhaoyun Zhang, Hongying Ye, Yiming Li, Jiawei Shen, Hong Chen, Feng Tang, Zhenwei Yao, Zhifeng Shi, Chunjui Chen, Lu Xie, Ye Wang, Chaowei Fu, Ying Mao, Liangfu Zhou, Daming Gao, Hai Yan, Yao Zhao, Chuanxin Huang, Yong-Yong Shi
Identification of recurrent USP48 and BRAF mutations in Cushing's disease. Nature communications 9 (1) (2018)
Fei Ye, Weiyao Zhang, Xiaoqing Ye, Jia Jin, Zhengbing Lv, Cheng Luo
Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays. Journal of chemical information and modeling 58 (5) (2018)
Jing Xing, Wenchao Lu, Rongfeng Liu, Yulan Wang, Yiqian Xie, Hao Zhang, Zhe Shi, Hao Jiang, Yu-Chih Liu, Kaixian Chen, Hualiang Jiang, Cheng Luo, Mingyue Zheng
Machine-Learning-Assisted Approach for Discovering Novel Inhibitors Targeting Bromodomain-Containing Protein 4. Journal of chemical information and modeling 57 (7) (2017)
Ruifeng Mao, Jingwei Shao, Kongkai Zhu, Yuanyuan Zhang, Hong Ding, Chenhua Zhang, Zhe Shi, Hualiang Jiang, Dequn Sun, Wenhu Duan, Cheng Luo
Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. Journal of medicinal chemistry 60 (14) (2017)
Chen Wang, Hao Jiang, Jia Jin, Yiqian Xie, Zhifeng Chen, Hao Zhang, Fulin Lian, Yu-Chih Liu, Chenhua Zhang, Hong Ding, Shijie Chen, Naixia Zhang, Yuanyuan Zhang, Hualiang Jiang, Kaixian Chen, Fei Ye, Zhiyi Yao, Cheng Luo
Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation. Journal of medicinal chemistry 60 (21) (2017)
Zhifeng Chen, Hao Zhang, Shien Liu, Yiqian Xie, Hao Jiang, Wenchao Lu, Heng Xu, Liyan Yue, Yuanyuan Zhang, Hong Ding, Mingyue Zheng, Kunqian Yu, Kaixian Chen, Hualiang Jiang, Cheng Luo
Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay. MedChemComm 8 (6) (2017)
Junyi Ju, Aiping Chen, Yexuan Deng, Ming Liu, Ying Wang, Yadong Wang, Min Nie, Chao Wang, Hong Ding, Bing Yao, Tao Gui, Xinyu Li, Zhen Xu, Chi Ma, Yong Song, Marc Kvansakul, Ke Zen, Chen-Yu Zhang, Cheng Luo, Ming Fang, David C S Huang, C David Allis, Renxiang Tan, Changjiang Kathy Zeng, Jiwu Wei, Quan Zhao
NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression. Nature communications 8 (1) (2017)
Jing Wang, Cheng Luo, Changliang Shan, Qiancheng You, Junyan Lu, Shannon Elf, Yu Zhou, Yi Wen, Jan L Vinkenborg, Jun Fan, Heebum Kang, Ruiting Lin, Dali Han, Yuxin Xie, Jason Karpus, Shijie Chen, Shisheng Ouyang, Chihao Luan, Naixia Zhang, Hong Ding, Maarten Merkx, Hong Liu, Jing Chen, Hualiang Jiang, Chuan He
Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nature chemistry 7 (12) (2015)

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Cheng Luo