Ashraf Brik

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 41

Top Topics

Silver Nanoparticles

Methicillin Resistant Staphylococcus Aureus

Protein Protein

Top Venues

Angewandte Chemie (International ed. in English)

Nature communications

Chemical science

This page only lists publications with an associated author ORCID identifier.

Publications

Yazid Mohamed Souf, Gonxhe Lokaj, Veeresh Kuruva, Yakop Saed, Delphine Raviglione, Ashraf Brik, Annette Nicke, Nicolas Inguimbert, Sebastien Dutertre
Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails. Marine drugs 21 (6) (2023)
Abhishek Saha, Hiroaki Suga, Ashraf Brik
Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes. Accounts of chemical research (2023)
Yazid Mohamed Souf, Gonxhe Lokaj, Veeresh Kuruva, Yakop Saed, Delphine Raviglione, Ashraf Brik, Annette Nicke, Nicolas Inguimbert, Sebastien Dutertre
Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails. Marine drugs 21 (6) (2023)
Nikolaos Parisis, Pablo D Dans, Muhammad Jbara, Balveer Singh, Diane Schausi-Tiffoche, Diego Molina-Serrano, Isabelle Brun Heath, Denisa Hendrychová, Suman Kumar Maity, Diana Camila Buitrago, Rafael Lema, Thiziri Nait Achour, Simona Giunta, Michael Girardot, Nicolas Talarek, Valérie Rofidal, Katerina Danezi, Damien Coudreuse, Marie-Noëlle Prioleau, Robert Feil, Modesto Orozco, Ashraf Brik, Pei-Yun Jenny Wu, Liliana Krasinska, Daniel Fisher
Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair. Nature communications 14 (1) (2023)
Betsegaw Lemma, Di Zhang, Ganga B Vamisetti, Bryan G Wentz, Hiroaki Suga, Ashraf Brik, Jacek Lubkowski, David Fushman
Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation. Nature communications 14 (1) (2023)
Yazid Mohamed Souf, Gonxhe Lokaj, Veeresh Kuruva, Yakop Saed, Delphine Raviglione, Ashraf Brik, Annette Nicke, Nicolas Inguimbert, Sebastien Dutertre
Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails. Marine drugs 21 (6) (2023)
Yves Haufe, Veeresh Kuruva, Ziyana Samanani, Gonxhe Lokaj, Guy Kamnesky, PranavKumar Shadamarshan, Rezvan Shahoei, Dana Katz, Jared M Sampson, Michael Pusch, Ashraf Brik, Annette Nicke, Abba E Leffler
Basic Residues at Position 11 of α-Conotoxin LvIA Influence Subtype Selectivity between α3β2 and α3β4 Nicotinic Receptors via an Electrostatic Mechanism. ACS chemical neuroscience (2023)
Yazid Mohamed Souf, Gonxhe Lokaj, Veeresh Kuruva, Yakop Saed, Delphine Raviglione, Ashraf Brik, Annette Nicke, Nicolas Inguimbert, Sebastien Dutertre
Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails. Marine drugs 21 (6) (2023)
Julia Kriegesmann, Ashraf Brik
Synthesis of ubiquitinated proteins for biochemical and functional analysis. Chemical science 14 (37) (2023)
Abhishek Saha, Shaswati Mandal, Jan Vincent V Arafiles, Jacobo Gómez-González, Christian P R Hackenberger, Ashraf Brik
Structure-Uptake Relationship Study of DABCYL Derivatives Linked to Cyclic Cell-Penetrating Peptides for Live-Cell Delivery of Synthetic Proteins. Angewandte Chemie (International ed. in English) 61 (47) (2022)
Guy Mann, Pradeep Sadhu, Ashraf Brik
Synthetic Proteins behind the Plasma Barrier: Molecular Spies. Accounts of chemical research 55 (15) (2022)
Shaswati Mandal, Ashraf Brik
Probing the cell delivery of synthetic diubiquitin chains. Chemical communications (Cambridge, England) 58 (63) (2022)
Guy Mann, Prasad Sulkshane, Pradeep Sadhu, Tamar Ziv, Michael H Glickman, Ashraf Brik
Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1. Molecules (Basel, Switzerland) 27 (15) (2022)
Rajeshwer Vanjari, Deepanjan Panda, Shaswati Mandal, Ganga B Vamisetti, Ashraf Brik
Gold(I)-Mediated Rapid Cyclization of Propargylated Peptides via Imine Formation. Journal of the American Chemical Society 144 (11) (2022)
Guy Mann, Pradeep Sadhu, Ashraf Brik
Multiplexed Delivery of Synthetic (Un)Conjugatable Ubiquitin and SUMO2 Enables Simultaneous Monitoring of Their Localization and Function in Live Cells. Chembiochem : a European journal of chemical biology 23 (11) (2022)
Ganga B Vamisetti, Abhishek Saha, Yichao J Huang, Rajeshwer Vanjari, Guy Mann, Julia Gutbrod, Nabieh Ayoub, Hiroaki Suga, Ashraf Brik
Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair. Nature communications 13 (1) (2022)
Ganga B Vamisetti, Roman Meledin, Mickal Nawatha, Hiroaki Suga, Ashraf Brik
The Development of a Fluorescence-Based Competitive Assay Enabled the Discovery of Dimeric Cyclic Peptide Modulators of Ubiquitin Chains. Angewandte Chemie (International ed. in English) 60 (13) (2021)
Shay Laps, Fatima Atamleh, Guy Kamnesky, Hao Sun, Ashraf Brik
General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins. Nature communications 12 (1) (2021)
Indrajit Sahu, Sachitanand M Mali, Prasad Sulkshane, Cong Xu, Andrey Rozenberg, Roni Morag, Manisha Priyadarsini Sahoo, Sumeet K Singh, Zhanyu Ding, Yifan Wang, Sharleen Day, Yao Cong, Oded Kleifeld, Ashraf Brik, Michael H Glickman
The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag. Nature communications 12 (1) (2021)
Shay Laps, Fatima Atamleh, Guy Kamnesky, Shaked Uzi, Michael M Meijler, Ashraf Brik
Insight on the Order of Regioselective Ultrafast Formation of Disulfide Bonds in (Antimicrobial) Peptides and Miniproteins. Angewandte Chemie (International ed. in English) 60 (45) (2021)
Rajeshwer Vanjari, Emad Eid, Ganga B Vamisetti, Shaswati Mandal, Ashraf Brik
Highly Efficient Cyclization Approach of Propargylated Peptides via Gold(I)-Mediated Sequential C-N, C-O, and C-C Bond Formation. ACS central science 7 (12) (2021)
Guy Mann, Gandhesiri Satish, Prasad Sulkshane, Shaswati Mandal, Michael H Glickman, Ashraf Brik
Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy. Chemical communications (Cambridge, England) 57 (74) (2021)
Shaswati Mandal, Guy Mann, Gandhesiri Satish, Ashraf Brik
Enhanced Live-Cell Delivery of Synthetic Proteins Assisted by Cell-Penetrating Peptides Fused to DABCYL. Angewandte Chemie (International ed. in English) 60 (13) (2021)
Shay Laps, Gandhesiri Satish, Ashraf Brik
Harnessing the power of transition metals in solid-phase peptide synthesis and key steps in the (semi)synthesis of proteins. Chemical Society reviews 50 (4) (2021)
Sara Gutkin, Satish Gandhesiri, Ashraf Brik, Doron Shabat
Synthesis and Evaluation of Ubiquitin-Dioxetane Conjugate as a Chemiluminescent Probe for Monitoring Deubiquitinase Activity. Bioconjugate chemistry 32 (10) (2021)
Muhammad Jbara, Emad Eid, Ashraf Brik
Gold(I)-Mediated Decaging or Cleavage of Propargylated Peptide Bond in Aqueous Conditions for Protein Synthesis and Manipulation. Journal of the American Chemical Society 142 (18) (2020)
Ganga B Vamisetti, Gandhesiri Satish, Prasad Sulkshane, Guy Mann, Michael H Glickman, Ashraf Brik
On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins. Journal of the American Chemical Society 142 (46) (2020)
Muna Msallam, Hao Sun, Roman Meledin, Pauline Franz, Ashraf Brik
Examining the role of phosphorylation of p19INK4d in its stability and ubiquitination using chemical protein synthesis. Chemical science 11 (21) (2020)
Emad Eid, Gábor N Boross, Hao Sun, Muna Msallam, Sumeet K Singh, Ashraf Brik
Total Chemical Synthesis of ISGylated-Ubiquitin Hybrid Chain Assisted by Acetamidomethyl Derivatives with Dual Functions. Bioconjugate chemistry 31 (3) (2020)
Guy Mann, Gandhesiri Satish, Roman Meledin, Ganga B Vamisetti, Ashraf Brik
Palladium-Mediated Cleavage of Proteins with Thiazolidine-Modified Backbone in Live Cells. Angewandte Chemie (International ed. in English) 58 (38) (2019)
Hao Sun, Ashraf Brik
The Journey for the Total Chemical Synthesis of a 53 kDa Protein. Accounts of chemical research 52 (12) (2019)
Shay Laps, Hao Sun, Guy Kamnesky, Ashraf Brik
Palladium-Mediated Direct Disulfide Bond Formation in Proteins Containing S-Acetamidomethyl-cysteine under Aqueous Conditions. Angewandte Chemie (International ed. in English) 58 (17) (2019)
Mickal Nawatha, Joseph M Rogers, Steven M Bonn, Ido Livneh, Betsegaw Lemma, Sachitanand M Mali, Ganga B Vamisetti, Hao Sun, Beatrice Bercovich, Yichao Huang, Aaron Ciechanover, David Fushman, Hiroaki Suga, Ashraf Brik
De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains. Nature chemistry 11 (7) (2019)
Roman Meledin, Sachitanand M Mali, Oded Kleifeld, Ashraf Brik
Activity-Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α-Globin-Modulating Deubiquitinase. Angewandte Chemie (International ed. in English) 57 (20) (2018)
Muhammad Jbara, Shay Laps, Michael Morgan, Guy Kamnesky, Guy Mann, Cynthia Wolberger, Ashraf Brik
Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins. Nature communications 9 (1) (2018)
Hao Sun, Roman Meledin, Sachitanand M Mali, Ashraf Brik
Total chemical synthesis of ester-linked ubiquitinated proteins unravels their behavior with deubiquitinases. Chemical science 9 (6) (2018)
Ganga B Vamisetti, Roman Meledin, Pushparathinam Gopinath, Ashraf Brik
Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7. Chembiochem : a European journal of chemical biology 20 (2) (2018)
Sachitanand M Mali, Sumeet K Singh, Emad Eid, Ashraf Brik
Ubiquitin Signaling: Chemistry Comes to the Rescue. Journal of the American Chemical Society 139 (14) (2017)
Pushparathinam Gopinath, Atif Mahammed, Tal Eilon-Shaffer, Mickal Nawatha, Shimrit Ohayon, Doron Shabat, Zeev Gross, Ashraf Brik
Switching Futile para-Quinone to Efficient Reactive Oxygen Species Generator: Ubiquitin-Specific Protease-2 Inhibition, Electrocatalysis, and Quantification. Chembiochem : a European journal of chemical biology 18 (17) (2017)
Muhammad Jbara, Suman Kumar Maity, Ashraf Brik
Palladium in the Chemical Synthesis and Modification of Proteins. Angewandte Chemie (International ed. in English) 56 (36) (2017)
Somasekhar Bondalapati, Emad Eid, Sachitanand M Mali, Cynthia Wolberger, Ashraf Brik
Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags. Chemical science 8 (5) (2017)