Chris Whitfield

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 34

Top Topics

Escherichia Coli

Multidrug Resistant

Quality Control

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

Nature chemical biology

The Journal of biological chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Steven D Kelly, Mikel Jason Allas, Lawrence D Goodridge, Todd L Lowary, Chris Whitfield
Structure, biosynthesis and regulation of the T1 antigen, a phase-variable surface polysaccharide conserved in many Salmonella serovars. Nature communications 15 (1) (2024)
Steven D Kelly, Nam Ha Duong, Jeremy T Nothof, Todd L Lowary, Chris Whitfield
Three-component systems represent a common pathway for extracytoplasmic addition of pentofuranose sugars into bacterial glycans. Proceedings of the National Academy of Sciences of the United States of America 121 (21) (2024)
Christa Litschko, Valerio Di Domenico, Julia Schulze, Sizhe Li, Olga G Ovchinnikova, Thijs Voskuilen, Andrea Bethe, Javier O Cifuente, Alberto Marina, Insa Budde, Tim A Mast, Małgorzata Sulewska, Monika Berger, Falk F R Büttner, Todd L Lowary, Chris Whitfield, Jeroen D C Codée, Mario Schubert, Marcelo E Guerin, Timm Fiebig
Transition transferases prime bacterial capsule polymerization. Nature chemical biology (2024)
Steven D Kelly, Nam Ha Duong, Jeremy T Nothof, Todd L Lowary, Chris Whitfield
Three-component systems represent a common pathway for extracytoplasmic addition of pentofuranose sugars into bacterial glycans. Proceedings of the National Academy of Sciences of the United States of America 121 (21) (2024)
Steven D Kelly, Nam Ha Duong, Jeremy T Nothof, Todd L Lowary, Chris Whitfield
Three-component systems represent a common pathway for extracytoplasmic addition of pentofuranose sugars into bacterial glycans. Proceedings of the National Academy of Sciences of the United States of America 121 (21) (2024)
Steven D Kelly, Nam Ha Duong, Jeremy T Nothof, Todd L Lowary, Chris Whitfield
Three-component systems represent a common pathway for extracytoplasmic addition of pentofuranose sugars into bacterial glycans. Proceedings of the National Academy of Sciences of the United States of America 121 (21) (2024)
Steven D Kelly, Mikel Jason Allas, Lawrence D Goodridge, Todd L Lowary, Chris Whitfield
Structure, biosynthesis and regulation of the T1 antigen, a phase-variable surface polysaccharide conserved in many Salmonella serovars. Nature communications 15 (1) (2024)
Steven D Kelly, Mikel Jason Allas, Lawrence D Goodridge, Todd L Lowary, Chris Whitfield
Structure, biosynthesis and regulation of the T1 antigen, a phase-variable surface polysaccharide conserved in many Salmonella serovars. Nature communications 15 (1) (2024)
Steven D Kelly, Mikel Jason Allas, Lawrence D Goodridge, Todd L Lowary, Chris Whitfield
Structure, biosynthesis and regulation of the T1 antigen, a phase-variable surface polysaccharide conserved in many Salmonella serovars. Nature communications 15 (1) (2024)
Lindsey A Carfrae, Kenneth Rachwalski, Shawn French, Rodion Gordzevich, Laura Seidel, Caressa N Tsai, Megan M Tu, Craig R MacNair, Olga G Ovchinnikova, Bradley R Clarke, Chris Whitfield, Eric D Brown
Inhibiting fatty acid synthesis overcomes colistin resistance. Nature microbiology (2023)
Olga G Ovchinnikova, Logan P Treat, Tanisha Teelucksingh, Bradley R Clarke, Taryn A Miner, Chris Whitfield, Kimberly A Walker, Virginia L Miller
Hypermucoviscosity Regulator RmpD Interacts with Wzc and Controls Capsular Polysaccharide Chain Length. mBio (2023)
Steven D Kelly, Olga G Ovchinnikova, Fabian Müller, Michael Steffen, Martin Braun, Ryan P Sweeney, Michael Kowarik, Rainer Follador, Todd L Lowary, Fabio Serventi, Chris Whitfield
Identification of a second glycoform of the clinically prevalent O1 antigen from Klebsiella pneumoniae . Proceedings of the National Academy of Sciences of the United States of America 120 (29) (2023)
Steven D Kelly, Danielle M Williams, Jeremy T Nothof, Taeok Kim, Todd L Lowary, Matthew S Kimber, Chris Whitfield
The biosynthetic origin of ribofuranose in bacterial polysaccharides. Nature chemical biology 18 (5) (2022)
Taylor J B Forrester, Olga G Ovchinnikova, Zhixiong Li, Elena N Kitova, Jeremy T Nothof, Akihiko Koizumi, John S Klassen, Todd L Lowary, Chris Whitfield, Matthew S Kimber
Author Correction: The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step. Nature communications 13 (1) (2022)
Taylor J B Forrester, Olga G Ovchinnikova, Zhixiong Li, Elena N Kitova, Jeremy T Nothof, Akihiko Koizumi, John S Klassen, Todd L Lowary, Chris Whitfield, Matthew S Kimber
The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step. Nature communications 13 (1) (2022)
Taylor J B Forrester, Olga G Ovchinnikova, Zhixiong Li, Elena N Kitova, Jeremy T Nothof, Akihiko Koizumi, John S Klassen, Todd L Lowary, Chris Whitfield, Matthew S Kimber
Author Correction: The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step. Nature communications 13 (1) (2022)
Taylor J B Forrester, Olga G Ovchinnikova, Zhixiong Li, Elena N Kitova, Jeremy T Nothof, Akihiko Koizumi, John S Klassen, Todd L Lowary, Chris Whitfield, Matthew S Kimber
Author Correction: The retaining β-Kdo glycosyltransferase WbbB uses a double-displacement mechanism with an intermediate adduct rearrangement step. Nature communications 13 (1) (2022)
Caitlin Sande, Chris Whitfield
Correction for Sande and Whitfield, "Capsules and Extracellular Polysaccharides in Escherichia coli and Salmonella". EcoSal Plus (2022)
Caitlin Sande, Chris Whitfield
Capsules and Extracellular Polysaccharides in Escherichia coli and Salmonella. EcoSal Plus 9 (2) (2021)
Yun Yang, Jiwei Liu, Bradley R Clarke, Laura Seidel, Jani Reddy Bolla, Philip N Ward, Peijun Zhang, Carol V Robinson, Chris Whitfield, James H Naismith
The molecular basis of regulation of bacterial capsule assembly by Wzc. Nature communications 12 (1) (2021)
Bradley R Clarke, Olga G Ovchinnikova, Ryan P Sweeney, Evelyn R Kamski-Hennekam, Russel Gitalis, Evan Mallette, Steven D Kelly, Todd L Lowary, Matthew S Kimber, Chris Whitfield
A bifunctional O-antigen polymerase structure reveals a new glycosyltransferase family. Nature chemical biology 16 (4) (2020)
Chris Whitfield, Danielle M Williams, Steven D Kelly
Lipopolysaccharide O-antigens-bacterial glycans made to measure. The Journal of biological chemistry 295 (31) (2020)
Samantha S Wear, Brittany A Hunt, Bradley R Clarke, Chris Whitfield
Analysis of the Topology and Active-Site Residues of WbbF, a Putative O-Polysaccharide Synthase from Salmonella enterica Serovar Borreze. Journal of bacteriology 202 (5) (2020)
Caitlin Sande, Catrien Bouwman, Elisabeth Kell, Nicholas N Nickerson, Sharookh B Kapadia, Chris Whitfield
Structural and Functional Variation in Outer Membrane Polysaccharide Export (OPX) Proteins from the Two Major Capsule Assembly Pathways Present in Escherichia coli. Journal of bacteriology 201 (14) (2019)
Evan Mann, Steven D Kelly, M Sameer Al-Abdul-Wahid, Bradley R Clarke, Olga G Ovchinnikova, Bin Liu, Chris Whitfield
Substrate recognition by a carbohydrate-binding module in the prototypical ABC transporter for lipopolysaccharide O-antigen from Escherichia coli O9a. The Journal of biological chemistry 294 (41) (2019)
Liam Doyle, Olga G Ovchinnikova, Katharine Myler, Evan Mallette, Bo-Shun Huang, Todd L Lowary, Matthew S Kimber, Chris Whitfield
Biosynthesis of a conserved glycolipid anchor for Gram-negative bacterial capsules. Nature chemical biology 15 (6) (2019)
Sean D Liston, Stephen A McMahon, Audrey Le Bas, Michael D L Suits, James H Naismith, Chris Whitfield
Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides. Proceedings of the National Academy of Sciences of the United States of America 115 (21) (2018)
Danielle M Williams, Olga G Ovchinnikova, Akihiko Koizumi, Iain L Mainprize, Matthew S Kimber, Todd L Lowary, Chris Whitfield
Single polysaccharide assembly protein that integrates polymerization, termination, and chain-length quality control. Proceedings of the National Academy of Sciences of the United States of America 114 (7) (2017)
Jonathan M Stokes, Craig R MacNair, Bushra Ilyas, Shawn French, Jean-Philippe Côté, Catrien Bouwman, Maya A Farha, Arthur O Sieron, Chris Whitfield, Brian K Coombes, Eric D Brown
Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance. Nature microbiology 2 (2017)
Jingyu Diao, Catrien Bouwman, Donghong Yan, Jing Kang, Anand K Katakam, Peter Liu, Homer Pantua, Alexander R Abbas, Nicholas N Nickerson, Cary Austin, Mike Reichelt, Wendy Sandoval, Min Xu, Chris Whitfield, Sharookh B Kapadia
Peptidoglycan Association of Murein Lipoprotein Is Required for KpsD-Dependent Group 2 Capsular Polysaccharide Expression and Serum Resistance in a Uropathogenic Escherichia coli Isolate. mBio 8 (3) (2017)
Olga G Ovchinnikova, Liam Doyle, Bo-Shun Huang, Matthew S Kimber, Todd L Lowary, Chris Whitfield
Biochemical Characterization of Bifunctional 3-Deoxy-β-d-manno-oct-2-ulosonic Acid (β-Kdo) Transferase KpsC from Escherichia coli Involved in Capsule Biosynthesis. The Journal of biological chemistry 291 (41) (2016)
Olga G Ovchinnikova, Evan Mallette, Akihiko Koizumi, Todd L Lowary, Matthew S Kimber, Chris Whitfield
Bacterial β-Kdo glycosyltransferases represent a new glycosyltransferase family (GT99). Proceedings of the National Academy of Sciences of the United States of America 113 (22) (2016)
Sean D Liston, Olga G Ovchinnikova, Chris Whitfield
Unique lipid anchor attaches Vi antigen capsule to the surface of Salmonella enterica serovar Typhi. Proceedings of the National Academy of Sciences of the United States of America 113 (24) (2016)
Evan Mann, Evan Mallette, Bradley R Clarke, Matthew S Kimber, Chris Whitfield
The Klebsiella pneumoniae O12 ATP-binding Cassette (ABC) Transporter Recognizes the Terminal Residue of Its O-antigen Polysaccharide Substrate. The Journal of biological chemistry 291 (18) (2016)