Christian M Grimm (Christian Grimm)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 38

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Cell death & disease

PloS one

Cells

Ludwig-Maximilians-Universitat Munchen

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Ludwig-Maximilians-Universitat Munchen Dec 01 2011 - Oct 31 2018

Germany

Group leader :: Chemistry and Pharmacy

Publications

Lora L Martucci, Jean-Marie Launay, Natsuko Kawakami, Cécile Sicard, Nathalie Desvignes, Mbarka Dakouane-Giudicelli, Barbara Spix, Maude Têtu, Franck-Olivier Gilmaire, Sloane Paulcan, Jacques Callebert, Cyrille Vaillend, Franz Bracher, Christian M Grimm, Philippe Fossier, Sabine de la Porte, Hirotaka Sakamoto, John F Morris, Antony Galione, Sylvie Granon, José-Manuel Cancela
Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Lora L Martucci, Jean-Marie Launay, Natsuko Kawakami, Cécile Sicard, Nathalie Desvignes, Mbarka Dakouane-Giudicelli, Barbara Spix, Maude Têtu, Franck-Olivier Gilmaire, Sloane Paulcan, Jacques Callebert, Cyrille Vaillend, Franz Bracher, Christian M Grimm, Philippe Fossier, Sabine de la Porte, Hirotaka Sakamoto, John F Morris, Antony Galione, Sylvie Granon, José-Manuel Cancela
Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Lora L Martucci, Jean-Marie Launay, Natsuko Kawakami, Cécile Sicard, Nathalie Desvignes, Mbarka Dakouane-Giudicelli, Barbara Spix, Maude Têtu, Franck-Olivier Gilmaire, Sloane Paulcan, Jacques Callebert, Cyrille Vaillend, Franz Bracher, Christian M Grimm, Philippe Fossier, Sabine de la Porte, Hirotaka Sakamoto, John F Morris, Antony Galione, Sylvie Granon, José-Manuel Cancela
Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Lora L Martucci, Jean-Marie Launay, Natsuko Kawakami, Cécile Sicard, Nathalie Desvignes, Mbarka Dakouane-Giudicelli, Barbara Spix, Maude Têtu, Franck-Olivier Gilmaire, Sloane Paulcan, Jacques Callebert, Cyrille Vaillend, Franz Bracher, Christian M Grimm, Philippe Fossier, Sabine de la Porte, Hirotaka Sakamoto, John F Morris, Antony Galione, Sylvie Granon, José-Manuel Cancela
Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Lora L Martucci, Jean-Marie Launay, Natsuko Kawakami, Cécile Sicard, Nathalie Desvignes, Mbarka Dakouane-Giudicelli, Barbara Spix, Maude Têtu, Franck-Olivier Gilmaire, Sloane Paulcan, Jacques Callebert, Cyrille Vaillend, Franz Bracher, Christian M Grimm, Philippe Fossier, Sabine de la Porte, Hirotaka Sakamoto, John F Morris, Antony Galione, Sylvie Granon, José-Manuel Cancela
Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Ryo Saito, Qianru Mu, Yu Yuan, Marcos Rubio-Alarcón, Maria Eznarriaga, Pingwei Zhao, Gihan Gunaratne, Sushil Kumar, Marco Keller, Franz Bracher, Christian M Grimm, Eugen Brailoiu, Jonathan S Marchant, Taufiq Rahman, Sandip Patel
Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes. Science signaling 16 (799) (2023)
Lora L Martucci, Jean-Marie Launay, Natsuko Kawakami, Cécile Sicard, Nathalie Desvignes, Mbarka Dakouane-Giudicelli, Barbara Spix, Maude Têtu, Franck-Olivier Gilmaire, Sloane Paulcan, Jacques Callebert, Cyrille Vaillend, Franz Bracher, Christian M Grimm, Philippe Fossier, Sabine de la Porte, Hirotaka Sakamoto, John F Morris, Antony Galione, Sylvie Granon, José-Manuel Cancela
Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion. Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Mengnan Xu, Xi Zoë Zhong, Peng Huang, Dawid Jaślan, Pingping Wang, Xue Sun, Eva-Maria Weiden, Yassine El Hiani, Christian M Grimm, Xian-Ping Dong
TRPML3/BK complex promotes autophagy and bacterial clearance by providing a positive feedback regulation of mTOR via PI3P. Proceedings of the National Academy of Sciences of the United States of America 120 (34) (2023)
Barbara Spix, Andrew J Castiglioni, Natalie N Remis, Emma N Flores, Philipp Wartenberg, Amanda Wyatt, Ulrich Boehm, Thomas Gudermann, Martin Biel, Jaime García-Añoveros, Christian M Grimm
Whole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands. PloS one 17 (12) (2022)
Belén Fernández, Pablo Olmedo, Fernando Gil, Elena Fdez, Yahaira Naaldijk, Pilar Rivero-Ríos, Franz Bracher, Christian M Grimm, Grant C Churchill, Sabine Hilfiker
Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB. Cell death & disease 13 (12) (2022)
Sandra Prat Castro, Veronika Kudrina, Dawid Jaślan, Julia Böck, Anna Scotto Rosato, Christian M Grimm
Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue! Cells 11 (18) (2022)
Barbara Spix, Andrew J Castiglioni, Natalie N Remis, Emma N Flores, Philipp Wartenberg, Amanda Wyatt, Ulrich Boehm, Thomas Gudermann, Martin Biel, Jaime García-Añoveros, Christian M Grimm
Whole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands. PloS one 17 (12) (2022)
Nouf N Laqtom, Wentao Dong, Uche N Medoh, Andrew L Cangelosi, Vimisha Dharamdasani, Sze Ham Chan, Tenzin Kunchok, Caroline A Lewis, Ivonne Heinze, Rachel Tang, Christian M Grimm, An N Dang Do, Forbes D Porter, Alessandro Ori, David M Sabatini, Monther Abu-Remaileh
CLN3 is required for the clearance of glycerophosphodiesters from lysosomes. Nature 609 (7929) (2022)
Belén Fernández, Pablo Olmedo, Fernando Gil, Elena Fdez, Yahaira Naaldijk, Pilar Rivero-Ríos, Franz Bracher, Christian M Grimm, Grant C Churchill, Sabine Hilfiker
Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB. Cell death & disease 13 (12) (2022)
Belén Fernández, Pablo Olmedo, Fernando Gil, Elena Fdez, Yahaira Naaldijk, Pilar Rivero-Ríos, Franz Bracher, Christian M Grimm, Grant C Churchill, Sabine Hilfiker
Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB. Cell death & disease 13 (12) (2022)
Barbara Spix, Elisabeth S Butz, Cheng-Chang Chen, Anna Scotto Rosato, Rachel Tang, Aicha Jeridi, Veronika Kudrina, Eva Plesch, Philipp Wartenberg, Elisabeth Arlt, Daria Briukhovetska, Meshal Ansari, Gizem Günes Günsel, Thomas M Conlon, Amanda Wyatt, Sandra Wetzel, Daniel Teupser, Lesca M Holdt, Fabien Ectors, Ingrid Boekhoff, Ulrich Boehm, Jaime García-Añoveros, Paul Saftig, Martin A Giera, Sebastian Kobold, Herbert B Schiller, Susanna Zierler, Thomas Gudermann, Christian Wahl-Schott, Franz Bracher, Ali Oender Yildirim, Martin Biel, Christian M Grimm
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. Nature communications 13 (1) (2022)
Barbara Spix, Andrew J Castiglioni, Natalie N Remis, Emma N Flores, Philipp Wartenberg, Amanda Wyatt, Ulrich Boehm, Thomas Gudermann, Martin Biel, Jaime García-Añoveros, Christian M Grimm
Whole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands. PloS one 17 (12) (2022)
Yu Yuan, Dawid Jaślan, Taufiq Rahman, Stephen R Bolsover, Vikas Arige, Larry E Wagner, Carla Abrahamian, Rachel Tang, Marco Keller, Jonas Hartmann, Anna S Rosato, Eva-Maria Weiden, Franz Bracher, David I Yule, Christian M Grimm, Sandip Patel
Segregated cation flux by TPC2 biases Ca 2+ signaling through lysosomes. Nature communications 13 (1) (2022)
Belén Fernández, Pablo Olmedo, Fernando Gil, Elena Fdez, Yahaira Naaldijk, Pilar Rivero-Ríos, Franz Bracher, Christian M Grimm, Grant C Churchill, Sabine Hilfiker
Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB. Cell death & disease 13 (12) (2022)
Franz Geisslinger, Martin Müller, Yu-Kai Chao, Christian M Grimm, Angelika M Vollmar, Karin Bartel
Targeting TPC2 sensitizes acute lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function. Cell death & disease 13 (8) (2022)
Belén Fernández, Pablo Olmedo, Fernando Gil, Elena Fdez, Yahaira Naaldijk, Pilar Rivero-Ríos, Franz Bracher, Christian M Grimm, Grant C Churchill, Sabine Hilfiker
Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB. Cell death & disease 13 (12) (2022)
Barbara Spix, Aicha Jeridi, Meshal Ansari, Ali Önder Yildirim, Herbert B Schiller, Christian M Grimm
Endolysosomal Cation Channels and Lung Disease. Cells 11 (2) (2022)
Wei Xiong Siow, Yaschar Kabiri, Rachel Tang, Yu-Kai Chao, Eva Plesch, Carola Eberhagen, Florian Flenkenthaler, Thomas Fröhlich, Franz Bracher, Christian M Grimm, Martin Biel, Hans Zischka, Angelika M Vollmar, Karin Bartel
Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells. Journal of cell science 135 (6) (2022)
Belén Fernández, Pablo Olmedo, Fernando Gil, Elena Fdez, Yahaira Naaldijk, Pilar Rivero-Ríos, Franz Bracher, Christian M Grimm, Grant C Churchill, Sabine Hilfiker
Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB. Cell death & disease 13 (12) (2022)
Anna Scotto Rosato, Einar K Krogsaeter, Dawid Jaślan, Carla Abrahamian, Sandro Montefusco, Chiara Soldati, Barbara Spix, Maria Teresa Pizzo, Giuseppina Grieco, Julia Böck, Amanda Wyatt, Daniela Wünkhaus, Marcel Passon, Marc Stieglitz, Marco Keller, Guido Hermey, Sandra Markmann, Doris Gruber-Schoffnegger, Susan L Cotman, Ludger Johannes, Dennis Crusius, Ulrich Boehm, Christian Wahl-Schott, Martin Biel, Franz Bracher, Elvira De Leonibus, Elena Polishchuk, Diego Luis Medina, Dominik Paquet, Christian M Grimm
TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease. EMBO molecular medicine 14 (9) (2022)
Barbara Spix, Andrew J Castiglioni, Natalie N Remis, Emma N Flores, Philipp Wartenberg, Amanda Wyatt, Ulrich Boehm, Thomas Gudermann, Martin Biel, Jaime García-Añoveros, Christian M Grimm
Whole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands. PloS one 17 (12) (2022)
Sandip Patel, Yu Yuan, Cheng-Chang Chen, Dawid Jaślan, Gihan S Gunaratne, Christian M Grimm, Taufiq Rahman, Jonathan S Marchant
Electrophysiology of Endolysosomal Two-Pore Channels: A Current Account. Cells 11 (15) (2022)
Julia Böck, Einar K Krogsaeter, Marcel Passon, Yu-Kai Chao, Sapna Sharma, Harald Grallert, Annette Peters, Christian M Grimm
Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect. PLoS genetics 17 (1) (2021)
Yu Yuan, Bethan S Kilpatrick, Susanne Gerndt, Franz Bracher, Christian M Grimm, Anthony H Schapira, Sandip Patel
The lysosomotrope GPN mobilises Ca2+ from acidic organelles. Journal of cell science 134 (6) (2021)
Carla Abrahamian, Christian M Grimm
Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma. Biomolecules 11 (7) (2021)
Chiara Soldati, Irene Lopez-Fabuel, Luca G Wanderlingh, Marina García Macia, Jlenia Monfregola, Alessandra Esposito, Gennaro Napolitano, Marta Guevara-Ferrer, Anna Scotto Rosato, Einar K Krogsaeter, Dominik Paquet, Christian M Grimm, Sandro Montefusco, Thomas Braulke, Stephan Storch, Sara E Mole, Maria Antonietta De Matteis, Andrea Balabio, Julio L Sampaio, Tristan McKay, Ludger Johannes, Juan Pedro Bolaños, Diego Luis Medina
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype. EMBO molecular medicine 13 (10) (2021)
Yanfen Li, Christian Schön, Cheng-Chang Chen, Zhuo Yang, Raffael Liegl, Elisa Murenu, Benedikt Schworm, Norbert Klugbauer, Christian M Grimm, Christian Wahl-Schott, Stylianos Michalakis, Martin Biel
TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration. Life science alliance 4 (8) (2021)
Susanne Gerndt, Einar Krogsaeter, Sandip Patel, Franz Bracher, Christian M Grimm
Discovery of lipophilic two-pore channel agonists. The FEBS journal 287 (24) (2020)
Elisabeth Arlt, Marco Fraticelli, Volodymyr Tsvilovskyy, Wiebke Nadolni, Andreas Breit, Thomas J O'Neill, Stefanie Resenberger, Gunther Wennemuth, Christian Wahl-Schott, Martin Biel, Christian M Grimm, Marc Freichel, Thomas Gudermann, Norbert Klugbauer, Ingrid Boekhoff, Susanna Zierler
TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity. Proceedings of the National Academy of Sciences of the United States of America 117 (30) (2020)
Dawid Jaślan, Julia Böck, Einar Krogsaeter, Christian M Grimm
Evolutionary Aspects of TRPMLs and TPCs. International journal of molecular sciences 21 (11) (2020)
Cheng-Chang Chen, Einar K Krogsaeter, Elisabeth S Butz, Yanfen Li, Rosa Puertollano, Christian Wahl-Schott, Martin Biel, Christian M Grimm
TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles. Science advances 6 (46) (2020)
Susanne Gerndt, Cheng-Chang Chen, Yu-Kai Chao, Yu Yuan, Sandra Burgstaller, Anna Scotto Rosato, Einar K Krogsaeter, Nicole Urban, Katharina Jacob, Ong Nam Phuong Nguyen, Meghan T Miller, Marco Keller, Angelika M Vollmar, Thomas Gudermann, Susanna Zierler, Johann Schredelseker, Michael Schaefer, Martin Biel, Roland Malli, Christian Wahl-Schott, Franz Bracher, Sandip Patel, Christian M Grimm
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. eLife 9 (2020)
Eva Plesch, Cheng-Chang Chen, Elisabeth Butz, Anna Scotto Rosato, Einar K Krogsaeter, Hua Yinan, Karin Bartel, Marco Keller, Dina Robaa, Daniel Teupser, Lesca M Holdt, Angelika M Vollmar, Wolfgang Sippl, Rosa Puertollano, Diego Medina, Martin Biel, Christian Wahl-Schott, Franz Bracher, Christian M Grimm
Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells. eLife 7 (2018)

Christian M Grimm.css-eqlu8i{font-size:small;padding-left:4px;} (Christian Grimm)

Publication Activity (10 Years)

Top Topics

Top Venues

Christian M Grimm (Christian Grimm)