Christopher T Lemke

Publication Activity (10 Years)

Years Active: 2023-2024
Publications (10 Years): 11

Top Topics

Crystal Structure

Anti Inflammatory

Top Venues

Cancer discovery

Proceedings of the National Academy of Sciences of the United States of America

This page only lists publications with an associated author ORCID identifier.

Publications

Douglas A Rubinson, Noritaka Tanaka, Ferran Fece de la Cruz, Kevin S Kapner, Michael H Rosenthal, Bryanna L Norden, Haley Barnes, Sara Ehnstrom, Alvin A Morales-Giron, Lauren K Brais, Christopher T Lemke, Andrew J Aguirre, Ryan B Corcoran
Sotorasib is a pan-RASG12C inhibitor capable of driving clinical response in NRASG12C cancers. Cancer discovery (2024)
Ulrike Rauh, Guo Wei, Michael Serrano-Wu, Georgios Kosmidis, Stefan Kaulfuss, Franziska Siegel, Kai Thede, James McFarland, Christopher T Lemke, Nicolas Werbeck, Katrin Nowak-Reppel, Sabine Pilari, Stephan Menz, Matthias Ocker, Weiqun Zhang, Kyle Davis, Guillaume Poncet-Montange, Jennifer A Roth, Douglas S Daniels, Virendar K Kaushik, Brian Hubbard, Karl Ziegelbauer, Todd R Golub
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models. Nature cancer (2024)
Ulrike Rauh, Guo Wei, Michael Serrano-Wu, Georgios Kosmidis, Stefan Kaulfuss, Franziska Siegel, Kai Thede, James McFarland, Christopher T Lemke, Nicolas Werbeck, Katrin Nowak-Reppel, Sabine Pilari, Stephan Menz, Matthias Ocker, Weiqun Zhang, Kyle Davis, Guillaume Poncet-Montange, Jennifer A Roth, Douglas S Daniels, Virendar K Kaushik, Brian Hubbard, Karl Ziegelbauer, Todd R Golub
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models. Nature cancer (2024)
Douglas A Rubinson, Noritaka Tanaka, Ferran Fece de la Cruz, Kevin S Kapner, Michael H Rosenthal, Bryanna L Norden, Haley Barnes, Sara Ehnstrom, Alvin A Morales-Giron, Lauren K Brais, Christopher T Lemke, Andrew J Aguirre, Ryan B Corcoran
Sotorasib is a pan-RASG12C inhibitor capable of driving clinical response in NRASG12C cancers. Cancer discovery (2024)
Douglas A Rubinson, Noritaka Tanaka, Ferran Fece de la Cruz, Kevin S Kapner, Michael H Rosenthal, Bryanna L Norden, Haley Barnes, Sara Ehnstrom, Alvin A Morales-Giron, Lauren K Brais, Christopher T Lemke, Andrew J Aguirre, Ryan B Corcoran
Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers. Cancer discovery 14 (5) (2024)
Douglas A Rubinson, Noritaka Tanaka, Ferran Fece de la Cruz, Kevin S Kapner, Michael H Rosenthal, Bryanna L Norden, Haley Barnes, Sara Ehnstrom, Alvin A Morales-Giron, Lauren K Brais, Christopher T Lemke, Andrew J Aguirre, Ryan B Corcoran
Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers. Cancer discovery 14 (5) (2024)
Douglas A Rubinson, Noritaka Tanaka, Ferran Fece de la Cruz, Kevin S Kapner, Michael H Rosenthal, Bryanna L Norden, Haley Barnes, Sara Ehnstrom, Alvin A Morales-Giron, Lauren K Brais, Christopher T Lemke, Andrew J Aguirre, Ryan B Corcoran
Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers. Cancer discovery 14 (5) (2024)
Holger Babbe, Thomas B Sundberg, Mark S Tichenor, Mark Seierstad, Genesis Bacani, James Berstler, Wenying Chai, Leon Chang, De Michael Chung, Kevin Coe, Bernard Collins, Michael F Finley, Alexander Guletsky, Christopher T Lemke, Puiying A Mak, Ashok Mathur, Eduardo V Mercado-Marin, Shailesh Metkar, Donald D Raymond, Marie-Laure Rives, Michele Rizzolio, Paul L Shaffer, Russell Smith, Jacqueline Smith, Ruth A Steele, Helena Steffens, Javier Suarez, Gaochao Tian, Nathan Majewski, Laurie P Volak, Jianmei Wei, Prerak T Desai, Luvena L Ong, Tatiana Koudriakova, Steven D Goldberg, Gavin Hirst, Virendar K Kaushik, Tatiana Ort, Nilufer Seth, Daniel B Graham, Scott Plevy, Jennifer D Venable, Ramnik J Xavier, Jennifer E Towne
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Holger Babbe, Thomas B Sundberg, Mark S Tichenor, Mark Seierstad, Genesis Bacani, James Berstler, Wenying Chai, Leon Chang, De Michael Chung, Kevin Coe, Bernard Collins, Michael F Finley, Alexander Guletsky, Christopher T Lemke, Puiying A Mak, Ashok Mathur, Eduardo V Mercado-Marin, Shailesh Metkar, Donald D Raymond, Marie-Laure Rives, Michele Rizzolio, Paul L Shaffer, Russell Smith, Jacqueline Smith, Ruth A Steele, Helena Steffens, Javier Suarez, Gaochao Tian, Nathan Majewski, Laurie P Volak, Jianmei Wei, Prerak T Desai, Luvena L Ong, Tatiana Koudriakova, Steven D Goldberg, Gavin Hirst, Virendar K Kaushik, Tatiana Ort, Nilufer Seth, Daniel B Graham, Scott Plevy, Jennifer D Venable, Ramnik J Xavier, Jennifer E Towne
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Holger Babbe, Thomas B Sundberg, Mark S Tichenor, Mark Seierstad, Genesis Bacani, James Berstler, Wenying Chai, Leon Chang, De Michael Chung, Kevin Coe, Bernard Collins, Michael F Finley, Alexander Guletsky, Christopher T Lemke, Puiying A Mak, Ashok Mathur, Eduardo V Mercado-Marin, Shailesh Metkar, Donald D Raymond, Marie-Laure Rives, Michele Rizzolio, Paul L Shaffer, Russell Smith, Jacqueline Smith, Ruth A Steele, Helena Steffens, Javier Suarez, Gaochao Tian, Nathan Majewski, Laurie P Volak, Jianmei Wei, Prerak T Desai, Luvena L Ong, Tatiana Koudriakova, Steven D Goldberg, Gavin Hirst, Virendar K Kaushik, Tatiana Ort, Nilufer Seth, Daniel B Graham, Scott Plevy, Jennifer D Venable, Ramnik J Xavier, Jennifer E Towne
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)
Holger Babbe, Thomas B Sundberg, Mark S Tichenor, Mark Seierstad, Genesis Bacani, James Berstler, Wenying Chai, Leon Chang, De Michael Chung, Kevin Coe, Bernard Collins, Michael F Finley, Alexander Guletsky, Christopher T Lemke, Puiying A Mak, Ashok Mathur, Eduardo V Mercado-Marin, Shailesh Metkar, Donald D Raymond, Marie-Laure Rives, Michele Rizzolio, Paul L Shaffer, Russell Smith, Jacqueline Smith, Ruth A Steele, Helena Steffens, Javier Suarez, Gaochao Tian, Nathan Majewski, Laurie P Volak, Jianmei Wei, Prerak T Desai, Luvena L Ong, Tatiana Koudriakova, Steven D Goldberg, Gavin Hirst, Virendar K Kaushik, Tatiana Ort, Nilufer Seth, Daniel B Graham, Scott Plevy, Jennifer D Venable, Ramnik J Xavier, Jennifer E Towne
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America 121 (1) (2023)