Jennifer A Roth (Jennifer Roth)

ORCID

Publication Activity (10 Years)

Years Active: 2021-2024
Publications (10 Years): 57

Top Venues

Nature

Nature cancer

Nature communications

Cancer research

This page only lists publications with an associated author ORCID identifier.

Publications

Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Álvaro Curiel-García, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert A Anders, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature 629 (8013) (2024)
Noha A M Shendy, Melissa Bikowitz, Logan H Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M Delahunty, Sarah Robinson, Vanshita Goel, Matthew G Rees, Melissa A Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A Roth, Yingzhe Wang, Burgess B Freeman, Brent A Orr, Brian J Abraham, Martine F Roussel, Ernst K Schonbrunn, Jun Qi, Adam D Durbin
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nature communications 15 (1) (2024)
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer A Roth, Matthew G Rees, Melissa A Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature (2024)
Julien Dilly, Megan T Hoffman, Laleh Abbassi, Ziyue Li, Francesca Paradiso, Brendan D Parent, Connor J Hennessey, Alexander C Jordan, Micaela Morgado, Shatavisha Dasgupta, Giselle A Uribe, Annan Yang, Kevin S Kapner, Felix P Hambitzer, Li Qiang, Hanrong Feng, Jacob Geisberg, Junning Wang, Kyle E Evans, Hengyu Lu, Aislyn Schalck, Ningping Feng, Anastasia M Lopez, Christopher A Bristow, Michael P Kim, Kimal I Rajapakshe, Vahid Bahrambeigi, Jennifer A Roth, Kavita Garg, Paola A Guerrero, Ben Z Stanger, Simona Cristea, Scott W Lowe, Timour Baslan, Eliezer Van Allen, Joseph D Mancias, Emily Chan, Abraham Anderson, Yuliya V Katlinskaya, Alex K Shalek, David S Hong, Shubham Pant, Jill Hallin, Kenna Anderes, Peter Olson, Timothy P Heffernan, Seema Chugh, James G Christensen, Anirban Maitra, Brian M Wolpin, Srivatsan Raghavan, Jonathan Andrew Nowak, Peter S Winter, Stephanie K Dougan, Andrew J Aguirre
Mechanisms of resistance to oncogenic KRAS inhibition in pancreatic cancer. Cancer discovery (2024)
Grace H Hwang, Maria F Pazyra-Murphy, Hyuk-Soo Seo, Sirano Dhe-Paganon, Sylwia A Stopka, Marina DiPiazza, Nizhoni Sutter, Thomas W Gero, Alison Volkert, Lincoln Ombelets, Georgia A Dittemore, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Nathalie Y R Agar, David A Scott, Rosalind A Segal
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma. Cancer research 84 (6) (2024)
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Álvaro Curiel-García, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert A Anders, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature 629 (8013) (2024)
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Álvaro Curiel-García, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert A Anders, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature 629 (8013) (2024)
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Álvaro Curiel-García, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert A Anders, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature 629 (8013) (2024)
Liang Chang, Nancy Y Jung, Adel Atari, Diego J Rodriguez, Devishi Kesar, Tian-Yu Song, Matthew G Rees, Melissa A Ronan, Ruitong Li, Paloma A Ruiz, Saireudee Chaturantabut, Takahiro Ito, Laurens M van Tienen, Yuen-Yi Tseng, Jennifer A Roth, William R Sellers
Author Correction: Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities. Nature genetics (2024)
Ulrike Rauh, Guo Wei, Michael Serrano-Wu, Georgios Kosmidis, Stefan Kaulfuss, Franziska Siegel, Kai Thede, James McFarland, Christopher T Lemke, Nicolas Werbeck, Katrin Nowak-Reppel, Sabine Pilari, Stephan Menz, Matthias Ocker, Weiqun Zhang, Kyle Davis, Guillaume Poncet-Montange, Jennifer A Roth, Douglas S Daniels, Virendar K Kaushik, Brian Hubbard, Karl Ziegelbauer, Todd R Golub
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models. Nature cancer (2024)
Noha A M Shendy, Melissa Bikowitz, Logan H Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M Delahunty, Sarah Robinson, Vanshita Goel, Matthew G Rees, Melissa A Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A Roth, Yingzhe Wang, Burgess B Freeman, Brent A Orr, Brian J Abraham, Martine F Roussel, Ernst K Schonbrunn, Jun Qi, Adam D Durbin
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nature communications 15 (1) (2024)
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Álvaro Curiel-García, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert A Anders, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature (2024)
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Álvaro Curiel-García, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert A Anders, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature 629 (8013) (2024)
Weicheng Li, Enrique M Garcia-Rivera, Dylan C Mitchell, Joel M Chick, Micah Maetani, John M Knapp, Geoffrey M Matthews, Ryosuke Shirasaki, Ricardo Matos de Simoes, Vasanthi S Viswanathan, John L Pulice, Matthew G Rees, Jennifer A Roth, Steven P Gygi, Constantine S Mitsiades, Cigall Kadoch, Stuart L Schreiber, Jonathan M L Ostrem
Highly specific intracellular ubiquitination of a small molecule. bioRxiv : the preprint server for biology (2024)
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer A Roth, Matthew G Rees, Melissa A Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature (2024)
Brian Belmontes, Katherine K Slemmons, Chun Su, Siyuan Liu, Antonia N Policheni, Jodi Moriguchi, Hong Tan, Fang Xie, Daniel Andrew Aiello, Yajing Yang, Raul Lazaro, Famke Aeffner, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Mikkel Vestergaard, Sanne Cowland, Jan Andersson, Ian Sarvary, Qing Chen, Pooja Sharma, Patricia Lopez, Nuria A Tamayo, Liping H Pettus, Sudipa Ghimire-Rijal, Susmith Mukund, Jennifer R Allen, Jason DeVoss, Angela Coxon, Jordi Rodon Ahnert, François Ghiringhelli, Nicolas Penel, Hans Prenen, Sanne Glad, Chen-Hua Chuang, Kiana Keyvanjah, Danielle M Townsley, John R Butler, Matthew P Bourbeau, Sean Caenepeel, Paul E Hughes
AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients With MTAP-Deleted Cancers. Cancer discovery (2024)
Noha A M Shendy, Melissa Bikowitz, Logan H Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M Delahunty, Sarah Robinson, Vanshita Goel, Matthew G Rees, Melissa A Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A Roth, Yingzhe Wang, Burgess B Freeman, Brent A Orr, Brian J Abraham, Martine F Roussel, Ernst K Schonbrunn, Jun Qi, Adam D Durbin
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nature communications 15 (1) (2024)
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer A Roth, Matthew G Rees, Melissa A Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature (2024)
Ulrike Rauh, Guo Wei, Michael Serrano-Wu, Georgios Kosmidis, Stefan Kaulfuss, Franziska Siegel, Kai Thede, James McFarland, Christopher T Lemke, Nicolas Werbeck, Katrin Nowak-Reppel, Sabine Pilari, Stephan Menz, Matthias Ocker, Weiqun Zhang, Kyle Davis, Guillaume Poncet-Montange, Jennifer A Roth, Douglas S Daniels, Virendar K Kaushik, Brian Hubbard, Karl Ziegelbauer, Todd R Golub
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models. Nature cancer (2024)
Noha A M Shendy, Melissa Bikowitz, Logan H Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M Delahunty, Sarah Robinson, Vanshita Goel, Matthew G Rees, Melissa A Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A Roth, Yingzhe Wang, Burgess B Freeman, Brent A Orr, Brian J Abraham, Martine F Roussel, Ernst K Schonbrunn, Jun Qi, Adam D Durbin
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nature communications 15 (1) (2024)
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer A Roth, Matthew G Rees, Melissa A Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature 629 (8013) (2024)
Weicheng Li, Enrique M Garcia-Rivera, Dylan C Mitchell, Joel M Chick, Micah Maetani, John M Knapp, Geoffrey M Matthews, Ryosuke Shirasaki, Ricardo Matos de Simoes, Vasanthi S Viswanathan, John L Pulice, Matthew G Rees, Jennifer A Roth, Steven P Gygi, Constantine S Mitsiades, Cigall Kadoch, Stuart L Schreiber, Jonathan M L Ostrem
Highly specific intracellular ubiquitination of a small molecule. bioRxiv : the preprint server for biology (2024)
Grace H Hwang, Maria F Pazyra-Murphy, Hyuk-Soo Seo, Sirano Dhe-Paganon, Sylwia A Stopka, Marina DiPiazza, Nizhoni Sutter, Thomas W Gero, Alison Volkert, Lincoln Ombelets, Georgia A Dittemore, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Nathalie Y R Agar, David A Scott, Rosalind A Segal
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma. Cancer research 84 (6) (2024)
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Álvaro Curiel-García, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert A Anders, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature 629 (8013) (2024)
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer A Roth, Matthew G Rees, Melissa A Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature 629 (8013) (2024)
Grace H Hwang, Maria F Pazyra-Murphy, Hyuk-Soo Seo, Sirano Dhe-Paganon, Sylwia A Stopka, Marina DiPiazza, Nizhoni Sutter, Thomas W Gero, Alison Volkert, Lincoln Ombelets, Georgia A Dittemore, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Nathalie Y R Agar, David A Scott, Rosalind A Segal
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma. Cancer research 84 (6) (2024)
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer A Roth, Matthew G Rees, Melissa A Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature (2024)
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Álvaro Curiel-García, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert A Anders, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature 629 (8013) (2024)
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer A Roth, Matthew G Rees, Melissa A Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature (2024)
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Álvaro Curiel-García, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert A Anders, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature (2024)
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Álvaro Curiel-García, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert A Anders, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature 629 (8013) (2024)
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer A Roth, Matthew G Rees, Melissa A Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature 629 (8013) (2024)
Noha A M Shendy, Melissa Bikowitz, Logan H Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M Delahunty, Sarah Robinson, Vanshita Goel, Matthew G Rees, Melissa A Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A Roth, Yingzhe Wang, Burgess B Freeman, Brent A Orr, Brian J Abraham, Martine F Roussel, Ernst K Schonbrunn, Jun Qi, Adam D Durbin
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition. Nature communications 15 (1) (2024)
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer A Roth, Matthew G Rees, Melissa A Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature 629 (8013) (2024)
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer A Roth, Matthew G Rees, Melissa A Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature 629 (8013) (2024)
Grace H Hwang, Maria F Pazyra-Murphy, Hyuk-Soo Seo, Sirano Dhe-Paganon, Sylwia A Stopka, Marina DiPiazza, Nizhoni Sutter, Thomas W Gero, Alison Volkert, Lincoln Ombelets, Georgia A Dittemore, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Nathalie Y R Agar, David A Scott, Rosalind A Segal
A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma. Cancer research 84 (6) (2024)
Urszula N Wasko, Jingjing Jiang, Tanner C Dalton, Álvaro Curiel-García, A Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A Sastra, Carmine F Palermo, Marie C Hasselluhn, Amanda R Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B Kemp, Cynthia Clendenin, Rina Sor, William P Vostrejs, Priya S Hibshman, Amber M Amparo, Connor Hennessey, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D Socci, Laura E Herring, Natalie K Barker, Junning Wang, James M Cleary, Brian M Wolpin, John A Chabot, Michael D Kluger, Gulam A Manji, Kenneth Y Tsai, Miroslav Sekulic, Stephen M Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A M Smith, Matthew Holderfield, David Wildes, Scott W Lowe, Michael A Badgley, Andrew J Aguirre, Robert A Anders, Ben Z Stanger, Timour Baslan, Channing J Der, Mallika Singh, Kenneth P Olive
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature 629 (8013) (2024)
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E Knox, Jennifer E Klomp, Jennifer A Roth, Matthew G Rees, Melissa A Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamaria, Andrew J Aguirre, Andrew M Waters, Channing J Der, Chiara Ambrogio, Zhengping Wang, Adrian L Gill, Elena S Koltun, Jacqueline A M Smith, David Wildes, Mallika Singh
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature 629 (8013) (2024)
Marc Payton, Brian Belmontes, Kelly Hanestad, Jodi Moriguchi, Kui Chen, John D McCarter, Grace Chung, Maria Stefania Ninniri, Jan Sun, Raffi Manoukian, Stuart Chambers, Seok-Man Ho, Robert J M Kurzeja, Katheryne Z Edson, Upendra P Dahal, Tian Wu, Sharon Wannberg, Pedro J Beltran, Jude Canon, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Sheroy Minocherhomji, Matthew P Bourbeau, Jennifer R Allen, Angela Coxon, Nuria A Tamayo, Paul E Hughes
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nature cancer 5 (1) (2023)
Christina K Baumgartner, Hakimeh Ebrahimi-Nik, Arvin Iracheta-Vellve, Keith M Hamel, Kira E Olander, Thomas G R Davis, Kathleen A McGuire, Geoff T Halvorsen, Omar I Avila, Chirag H Patel, Sarah Y Kim, Ashwin V Kammula, Audrey J Muscato, Kyle Halliwill, Prasanthi Geda, Kelly L Klinge, Zhaoming Xiong, Ryan Duggan, Liang Mu, Mitchell D Yeary, James C Patti, Tyler M Balon, Rebecca Mathew, Carey Backus, Domenick E Kennedy, Angeline Chen, Kenton Longenecker, Joseph T Klahn, Cara L Hrusch, Navasona Krishnan, Charles W Hutchins, Jax P Dunning, Marinka Bulic, Payal Tiwari, Kayla J Colvin, Cun Lan Chuong, Ian C Kohnle, Matthew G Rees, Andrew Boghossian, Melissa A Ronan, Jennifer A Roth, Meng-Ju Wu, Juliette S M T Suermondt, Nelson H Knudsen, Collins K Cheruiyot, Debattama R Sen, Gabriel K Griffin, Todd R Golub, Nabeel El-Bardeesy, Joshua H Decker, Yi Yang, Magali Guffroy, Stacey Fossey, Patricia Trusk, Im-Meng Sun, Yue Liu, Wei Qiu, Qi Sun, Marcia N Paddock, Elliot P Farney, Mark A Matulenko, Clay Beauregard, Jennifer M Frost, Kathleen B Yates, Philip R Kym, Robert T Manguso
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature (2023)
Owen S Skinner, Joan Blanco-Fernández, Russell P Goodman, Akinori Kawakami, Hongying Shen, Lajos V Kemény, Lena Joesch-Cohen, Matthew G Rees, Jennifer A Roth, David E Fisher, Vamsi K Mootha, Alexis A Jourdain
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions. Nature metabolism (2023)
Owen S Skinner, Joan Blanco-Fernández, Russell P Goodman, Akinori Kawakami, Hongying Shen, Lajos V Kemény, Lena Joesch-Cohen, Matthew G Rees, Jennifer A Roth, David E Fisher, Vamsi K Mootha, Alexis A Jourdain
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions. Nature metabolism (2023)
Joana Reis, Christoph Gorgulla, Marta Massari, Sara Marchese, Sergio Valente, Beatrice Noce, Lorenzo Basile, Ricarda Törner, Huel Cox, Thibault Viennet, Moon Hee Yang, Melissa A Ronan, Matthew G Rees, Jennifer A Roth, Lucia Capasso, Angela Nebbioso, Lucia Altucci, Antonello Mai, Haribabu Arthanari, Andrea Mattevi
Targeting ROS production through inhibition of NADPH oxidases. Nature chemical biology (2023)
Marc Payton, Brian Belmontes, Kelly Hanestad, Jodi Moriguchi, Kui Chen, John D McCarter, Grace Chung, Maria Stefania Ninniri, Jan Sun, Raffi Manoukian, Stuart Chambers, Seok-Man Ho, Robert J M Kurzeja, Katheryne Z Edson, Upendra P Dahal, Tian Wu, Sharon Wannberg, Pedro J Beltran, Jude Canon, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Sheroy Minocherhomji, Matthew P Bourbeau, Jennifer R Allen, Angela Coxon, Nuria A Tamayo, Paul E Hughes
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nature cancer 5 (1) (2023)
Marc Payton, Brian Belmontes, Kelly Hanestad, Jodi Moriguchi, Kui Chen, John D McCarter, Grace Chung, Maria Stefania Ninniri, Jan Sun, Raffi Manoukian, Stuart Chambers, Seok-Man Ho, Robert J M Kurzeja, Katheryne Z Edson, Upendra P Dahal, Tian Wu, Sharon Wannberg, Pedro J Beltran, Jude Canon, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Sheroy Minocherhomji, Matthew P Bourbeau, Jennifer R Allen, Angela Coxon, Nuria A Tamayo, Paul E Hughes
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nature cancer 5 (1) (2023)
Damon A Hofman, Jorge Ruiz-Orera, Ian Yannuzzi, Rakesh Murugesan, Adam Brown, Karl R Clauser, Alexandra-Larisa Condurat, Jip T van Dinter, Sem A G Engels, Amy Goodale, Jasper van der Lugt, Tanaz Abid, Li Wang, Kevin N Zhou, Jayne Vogelzang, Keith L Ligon, Timothy N Phoenix, Jennifer A Roth, David E Root, Norbert Hübner, Todd R Golub, Pratiti Bandopadhayay, Sebastiaan van Heesch, John R Prensner
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma. bioRxiv : the preprint server for biology (2023)
Marc Payton, Brian Belmontes, Kelly Hanestad, Jodi Moriguchi, Kui Chen, John D McCarter, Grace Chung, Maria Stefania Ninniri, Jan Sun, Raffi Manoukian, Stuart Chambers, Seok-Man Ho, Robert J M Kurzeja, Katheryne Z Edson, Upendra P Dahal, Tian Wu, Sharon Wannberg, Pedro J Beltran, Jude Canon, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Sheroy Minocherhomji, Matthew P Bourbeau, Jennifer R Allen, Angela Coxon, Nuria A Tamayo, Paul E Hughes
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nature cancer (2023)
Liang Chang, Nancy Y Jung, Adel Atari, Diego J Rodriguez, Devishi Kesar, Tian-Yu Song, Matthew G Rees, Melissa A Ronan, Ruitong Li, Paloma A Ruiz, Saireudee Chaturantabut, Takahiro Ito, Laurens M van Tienen, Yuen-Yi Tseng, Jennifer A Roth, William R Sellers
Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities. Nature genetics (2023)
Prahalathan Pichavaram, Carolyn M Jablonowski, Jie Fang, Andrew M Fleming, Hyea Jin Gil, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Christopher L Morton, Gerard P Zambetti, Andrew M Davidoff, Jun J Yang, Andrew Jackson Murphy
Oncogenic cells of renal embryonic lineage sensitive to the small molecule inhibitor QC6352 display depletion of KDM4 levels and disruption of ribosome biogenesis. Molecular cancer therapeutics (2023)
Marissa L Calbert, Gurushankar Chandramouly, Clare M Adams, Magali Saez-Ayala, Tatiana Kent, Mrityunjay Tyagi, V S S Abhinav Ayyadevara, Yifan Wang, John J Krais, John Gordon, Jessica Atkins, Monika Maria Toma, Stéphane Betzi, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Aaron R Goldman, Nicole Gorman, Ramkrishna Mitra, Wayne E Childers, Xavier Graña, Tomasz Skorski, Neil Johnson, Christian Hurtz, Xavier Morelli, Christine M Eischen, Richard T Pomerantz
4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress. Molecular cancer therapeutics (2023)
Marc Payton, Brian Belmontes, Kelly Hanestad, Jodi Moriguchi, Kui Chen, John D McCarter, Grace Chung, Maria Stefania Ninniri, Jan Sun, Raffi Manoukian, Stuart Chambers, Seok-Man Ho, Robert J M Kurzeja, Katheryne Z Edson, Upendra P Dahal, Tian Wu, Sharon Wannberg, Pedro J Beltran, Jude Canon, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Sheroy Minocherhomji, Matthew P Bourbeau, Jennifer R Allen, Angela Coxon, Nuria A Tamayo, Paul E Hughes
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nature cancer (2023)
Damon A Hofman, Jorge Ruiz-Orera, Ian Yannuzzi, Rakesh Murugesan, Adam Brown, Karl R Clauser, Alexandra-Larisa Condurat, Jip T van Dinter, Sem A G Engels, Amy Goodale, Jasper van der Lugt, Tanaz Abid, Li Wang, Kevin N Zhou, Jayne Vogelzang, Keith L Ligon, Timothy N Phoenix, Jennifer A Roth, David E Root, Norbert Hübner, Todd R Golub, Pratiti Bandopadhayay, Sebastiaan van Heesch, John R Prensner
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma. bioRxiv : the preprint server for biology (2023)
Marc Payton, Brian Belmontes, Kelly Hanestad, Jodi Moriguchi, Kui Chen, John D McCarter, Grace Chung, Maria Stefania Ninniri, Jan Sun, Raffi Manoukian, Stuart Chambers, Seok-Man Ho, Robert J M Kurzeja, Katheryne Z Edson, Upendra P Dahal, Tian Wu, Sharon Wannberg, Pedro J Beltran, Jude Canon, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Sheroy Minocherhomji, Matthew P Bourbeau, Jennifer R Allen, Angela Coxon, Nuria A Tamayo, Paul E Hughes
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nature cancer 5 (1) (2023)
Marc Payton, Brian Belmontes, Kelly Hanestad, Jodi Moriguchi, Kui Chen, John D McCarter, Grace Chung, Maria Stefania Ninniri, Jan Sun, Raffi Manoukian, Stuart Chambers, Seok-Man Ho, Robert J M Kurzeja, Katheryne Z Edson, Upendra P Dahal, Tian Wu, Sharon Wannberg, Pedro J Beltran, Jude Canon, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Sheroy Minocherhomji, Matthew P Bourbeau, Jennifer R Allen, Angela Coxon, Nuria A Tamayo, Paul E Hughes
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nature cancer 5 (1) (2023)
Natalie Boehnke, Joelle P Straehla, Hannah C Safford, Mustafa Kocak, Matthew G Rees, Melissa A Ronan, Danny Rosenberg, Charles H Adelmann, Raghu R Chivukula, Namita Nabar, Adam G Berger, Nicholas G Lamson, Jaime H Cheah, Hojun Li, Jennifer A Roth, Angela N Koehler, Paula T Hammond
Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery. Science (New York, N.Y.) 377 (6604) (2022)
Mark R Sullivan, Alicia M Darnell, Montana F Reilly, Tenzin Kunchok, Lena Joesch-Cohen, Daniel Rosenberg, Ahmed Ali, Matthew G Rees, Jennifer A Roth, Caroline A Lewis, Matthew G Vander Heiden
Methionine synthase is essential for cancer cell proliferation in physiological folate environments. Nature metabolism 3 (11) (2021)
Qing Li, Baishan Jiang, Jiaye Guo, Hong Shao, Isabella S Del Priore, Qing Chang, Rei Kudo, Zhiqiang Li, Pedram Razavi, Bo Liu, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Katherine Aleisha Donovan, Marta Palafox, Jorge S Reis-Filho, Elisa de Stanchina, Eric S Fischer, Neal X Rosen, Violeta Serra, Andrew Koff, John D Chodera, Nathanael S Gray, Sarat Chandarlapaty
INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors. Cancer discovery (2021)

Jennifer A Roth.css-eqlu8i{font-size:small;padding-left:4px;} (Jennifer Roth)

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Jennifer A Roth (Jennifer Roth)