Graeme Milligan

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 65

Top Topics

Diabetic Nephropathy

Structural Basis

Top Venues

British journal of pharmacology

Journal of medicinal chemistry

Proceedings of the National Academy of Sciences of the United States of America

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Xiaohan Zhou, Horacio Septien-Gonzalez, Sami Husaini, Richard J Ward, Graeme Milligan, Claudiu C Gradinaru
Diffusion and Oligomerization States of the Muscarinic M 1 Receptor in Live Cells─The Impact of Ligands and Membrane Disruptors. The journal of physical chemistry. B 128 (18) (2024)
Graeme Milligan
Editorial for GPR84 pharmacology. British journal of pharmacology 181 (10) (2024)
Xiaohan Zhou, Horacio Septien-Gonzalez, Sami Husaini, Richard J Ward, Graeme Milligan, Claudiu C Gradinaru
Diffusion and Oligomerization States of the Muscarinic M 1 Receptor in Live Cells─The Impact of Ligands and Membrane Disruptors. The journal of physical chemistry. B (2024)
Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Kunpeng Li, Irina G Tikhonova, Graeme Milligan, Cheng Zhang
Structural basis for the ligand recognition and signaling of free fatty acid receptors. Science advances 10 (2) (2024)
Loukas Ieremias, Mads H Kaspersen, Asmita Manandhar, Katrine Schultz-Knudsen, Christina Ioanna Vrettou, Rina Pokhrel, Christoffer V Heidtmann, Laura Jenkins, Christina Kanellou, Sara Marsango, Yueming Li, Hans Bräuner-Osborne, Elisabeth Rexen Ulven, Graeme Milligan, Trond Ulven
Structure-Activity Relationship Studies and Optimization of 4-Hydroxypyridones as GPR84 Agonists. Journal of medicinal chemistry 67 (5) (2024)
Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Kunpeng Li, Irina G Tikhonova, Graeme Milligan, Cheng Zhang
Structural basis for the ligand recognition and signaling of free fatty acid receptors. Science advances 10 (2) (2024)
Xiaohan Zhou, Horacio Septien-Gonzalez, Sami Husaini, Richard J Ward, Graeme Milligan, Claudiu C Gradinaru
Diffusion and Oligomerization States of the Muscarinic M 1 Receptor in Live Cells─The Impact of Ligands and Membrane Disruptors. The journal of physical chemistry. B 128 (18) (2024)
Graeme Milligan
Editorial for GPR84 pharmacology. British journal of pharmacology (2024)
Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Kunpeng Li, Irina G Tikhonova, Graeme Milligan, Cheng Zhang
Structural basis for the ligand recognition and signaling of free fatty acid receptors. Science advances 10 (2) (2024)
Loukas Ieremias, Mads H Kaspersen, Asmita Manandhar, Katrine Schultz-Knudsen, Christina Ioanna Vrettou, Rina Pokhrel, Christoffer V Heidtmann, Laura Jenkins, Christina Kanellou, Sara Marsango, Yueming Li, Hans Bräuner-Osborne, Elisabeth Rexen Ulven, Graeme Milligan, Trond Ulven
Structure-Activity Relationship Studies and Optimization of 4-Hydroxypyridones as GPR84 Agonists. Journal of medicinal chemistry 67 (5) (2024)
Loukas Ieremias, Mads H Kaspersen, Asmita Manandhar, Katrine Schultz-Knudsen, Christina Ioanna Vrettou, Rina Pokhrel, Christoffer V Heidtmann, Laura Jenkins, Christina Kanellou, Sara Marsango, Yueming Li, Hans Bräuner-Osborne, Elisabeth Rexen Ulven, Graeme Milligan, Trond Ulven
Structure-Activity Relationship Studies and Optimization of 4-Hydroxypyridones as GPR84 Agonists. Journal of medicinal chemistry (2024)
Xiaohan Zhou, Horacio Septien-Gonzalez, Sami Husaini, Richard J Ward, Graeme Milligan, Claudiu C Gradinaru
Diffusion and Oligomerization States of the Muscarinic M 1 Receptor in Live Cells─The Impact of Ligands and Membrane Disruptors. The journal of physical chemistry. B 128 (18) (2024)
Graeme Milligan
Editorial for GPR84 pharmacology. British journal of pharmacology 181 (10) (2024)
Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Kunpeng Li, Irina G Tikhonova, Graeme Milligan, Cheng Zhang
Structural basis for the ligand recognition and signaling of free fatty acid receptors. Science advances 10 (2) (2024)
Xiaohan Zhou, Horacio Septien-Gonzalez, Sami Husaini, Richard J Ward, Graeme Milligan, Claudiu C Gradinaru
Diffusion and Oligomerization States of the Muscarinic M 1 Receptor in Live Cells─The Impact of Ligands and Membrane Disruptors. The journal of physical chemistry. B 128 (18) (2024)
Xiaohan Zhou, Horacio Septien-Gonzalez, Sami Husaini, Richard J Ward, Graeme Milligan, Claudiu C Gradinaru
Diffusion and Oligomerization States of the Muscarinic M 1 Receptor in Live Cells─The Impact of Ligands and Membrane Disruptors. The journal of physical chemistry. B 128 (18) (2024)
Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Kunpeng Li, Irina G Tikhonova, Graeme Milligan, Cheng Zhang
Structural basis for the ligand recognition and signaling of free fatty acid receptors. Science advances 10 (2) (2024)
Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Kunpeng Li, Irina G Tikhonova, Graeme Milligan, Cheng Zhang
Structural basis for the ligand recognition and signaling of free fatty acid receptors. Science advances 10 (2) (2024)
Sara Marsango, Graeme Milligan
Regulation of the pro-inflammatory G protein-coupled receptor GPR84. British journal of pharmacology (2023)
Sara Marsango, Graeme Milligan
Regulation of the pro-inflammatory G protein-coupled receptor GPR84. British journal of pharmacology (2023)
Mausam Kalita, Jun Hyung Park, Renesmee Chenting Kuo, Samira Hayee, Sara Marsango, Valentina Straniero, Israt S Alam, Angelie Rivera-Rodriguez, Mallesh Pandrala, Mackenzie L Carlson, Samantha T Reyes, Isaac M Jackson, Lorenzo Suigo, Audrey Luo, Sydney C Nagy, Ermanno Valoti, Graeme Milligan, Frezghi Habte, Bin Shen, Michelle L James
PET Imaging of Innate Immune Activation Using 11 C Radiotracers Targeting GPR84. JACS Au 3 (12) (2023)
Sara Marsango, Graeme Milligan
Regulation of the pro-inflammatory G protein-coupled receptor GPR84. British journal of pharmacology (2023)
Xuan Zhang, Yujing Wang, Shreyas Supekar, Xu Cao, Jingkai Zhou, Jessica Dang, Siqi Chen, Laura Jenkins, Sara Marsango, Xiu Li, Guibing Liu, Graeme Milligan, Mingye Feng, Hao Fan, Weimin Gong, Cheng Zhang
Pro-phagocytic function and structural basis of GPR84 signaling. Research square (2023)
Mausam Kalita, Jun Hyung Park, Renesmee Chenting Kuo, Samira Hayee, Sara Marsango, Valentina Straniero, Israt S Alam, Angelie Rivera-Rodriguez, Mallesh Pandrala, Mackenzie L Carlson, Samantha T Reyes, Isaac M Jackson, Lorenzo Suigo, Audrey Luo, Sydney C Nagy, Ermanno Valoti, Graeme Milligan, Frezghi Habte, Bin Shen, Michelle L James
PET Imaging of Innate Immune Activation Using 11 C Radiotracers Targeting GPR84. JACS Au 3 (12) (2023)
Alice Valentini, Katrine Schultz-Knudsen, Anders Højgaard Hansen, Argyro Tsakoumagkou, Laura Jenkins, Henriette B Christensen, Asmita Manandhar, Graeme Milligan, Trond Ulven, Elisabeth Rexen Ulven
Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists. Journal of medicinal chemistry 66 (9) (2023)
Alice Valentini, Katrine Schultz-Knudsen, Anders Højgaard Hansen, Argyro Tsakoumagkou, Laura Jenkins, Henriette B Christensen, Asmita Manandhar, Graeme Milligan, Trond Ulven, Elisabeth Rexen Ulven
Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists. Journal of medicinal chemistry 66 (9) (2023)
Alice Valentini, Katrine Schultz-Knudsen, Anders Højgaard Hansen, Argyro Tsakoumagkou, Laura Jenkins, Henriette B Christensen, Asmita Manandhar, Graeme Milligan, Trond Ulven, Elisabeth Rexen Ulven
Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists. Journal of medicinal chemistry 66 (9) (2023)
Natasja Barki, Laura Jenkins, Sara Marsango, Domonkos Dedeo, Daniele Bolognini, Louis Dwomoh, Aisha M Abdelmalik, Margaret Nilsen, Manon Stoffels, Falko Nagel, Stefan Schulz, Andrew B Tobin, Graeme Milligan
Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner. eLife 12 (2023)
Alice Valentini, Katrine Schultz-Knudsen, Anders Højgaard Hansen, Argyro Tsakoumagkou, Laura Jenkins, Henriette B Christensen, Asmita Manandhar, Graeme Milligan, Trond Ulven, Elisabeth Rexen Ulven
Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists. Journal of medicinal chemistry (2023)
Xuan Zhang, Yujing Wang, Shreyas Supekar, Xu Cao, Jingkai Zhou, Jessica Dang, Siqi Chen, Laura Jenkins, Sara Marsango, Xiu Li, Guibing Liu, Graeme Milligan, Mingye Feng, Hao Fan, Weimin Gong, Cheng Zhang
Pro-phagocytic function and structural basis of GPR84 signaling. Research square (2023)
Sara Marsango, Graeme Milligan
Regulation of the pro-inflammatory G protein-coupled receptor GPR84. British journal of pharmacology (2023)
Sara Marsango, Graeme Milligan
Regulation of the pro-inflammatory G protein-coupled receptor GPR84. British journal of pharmacology (2023)
Xuan Zhang, Yujing Wang, Shreyas Supekar, Xu Cao, Jingkai Zhou, Jessica Dang, Siqi Chen, Laura Jenkins, Sara Marsango, Xiu Li, Guibing Liu, Graeme Milligan, Mingye Feng, Hao Fan, Weimin Gong, Cheng Zhang
Pro-phagocytic function and structural basis of GPR84 signaling. Nature communications 14 (1) (2023)
Xuan Zhang, Yujing Wang, Shreyas Supekar, Xu Cao, Jingkai Zhou, Jessica Dang, Siqi Chen, Laura Jenkins, Sara Marsango, Xiu Li, Guibing Liu, Graeme Milligan, Mingye Feng, Hao Fan, Weimin Gong, Cheng Zhang
Pro-phagocytic function and structural basis of GPR84 signaling. Research square (2023)
Sai Pranathi Meda Venkata, Hainan Li, Liping Xu, Jia Yi Koh, Huong Nguyen, Morgan Minjares, Chunying Li, Anjaneyulu Kowluru, Graeme Milligan, Jie-Mei Wang
Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, David I Hughes, Trond Ulven, Brian D Hudson, Elisabeth Rexen Ulven, Niek Dekker, Andrew B Tobin, Graeme Milligan
Chemogenetics defines a short-chain fatty acid receptor gut-brain axis. eLife 11 (2022)
Sai Pranathi Meda Venkata, Hainan Li, Liping Xu, Jia Yi Koh, Huong Nguyen, Morgan Minjares, Chunying Li, Anjaneyulu Kowluru, Graeme Milligan, Jie-Mei Wang
Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Sai Pranathi Meda Venkata, Hainan Li, Liping Xu, Jia Yi Koh, Huong Nguyen, Morgan Minjares, Chunying Li, Anjaneyulu Kowluru, Graeme Milligan, Jie-Mei Wang
Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Sara Marsango, Laura Jenkins, John D Pediani, Sophie J Bradley, Richard J Ward, Sarah Hesse, Gabriel Biener, Michael R Stoneman, Andrew B Tobin, Valerica Raicu, Graeme Milligan
The M 1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Proceedings of the National Academy of Sciences of the United States of America 119 (24) (2022)
Sai Pranathi Meda Venkata, Hainan Li, Liping Xu, Jia Yi Koh, Huong Nguyen, Morgan Minjares, Chunying Li, Anjaneyulu Kowluru, Graeme Milligan, Jie-Mei Wang
Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Miriam Scarpa, Colin Molloy, Laura Jenkins, Bethany Strellis, Rebecca F Budgett, Sarah Hesse, Louis Dwomoh, Sara Marsango, Gonzalo S Tejeda, Mario Rossi, Zeshan Ahmed, Graeme Milligan, Brian D Hudson, Andrew B Tobin, Sophie J Bradley
Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America 118 (50) (2022)
Sai Pranathi Meda Venkata, Hainan Li, Liping Xu, Jia Yi Koh, Huong Nguyen, Morgan Minjares, Chunying Li, Anjaneyulu Kowluru, Graeme Milligan, Jie-Mei Wang
Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Amit Mahindra, Laura Jenkins, Sara Marsango, Mark Huggett, Margaret Huggett, Lindsay Robinson, Jonathan Gillespie, Muralikrishnan Rajamanickam, Angus Morrison, Stuart McElroy, Irina G Tikhonova, Graeme Milligan, Andrew G Jamieson
Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists. Journal of medicinal chemistry 65 (16) (2022)
Birgit Caspar, Pietro Cocchiara, Armelle Melet, Kristof Van Emelen, Annegret Van der Aa, Graeme Milligan, Jean-Philippe Herbeuval
CXCR4 as a novel target in immunology: moving away from typical antagonists. Future drug discovery 4 (2) (2022)
Sai Pranathi Meda Venkata, Hainan Li, Liping Xu, Jia Yi Koh, Huong Nguyen, Morgan Minjares, Chunying Li, Anjaneyulu Kowluru, Graeme Milligan, Jie-Mei Wang
Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Rudi Prihandoko, Davinder Kaur, Coen H Wiegman, Elisa Alvarez-Curto, Chantal Donovan, Latifa Chachi, Trond Ulven, Martha R Tyas, Eloise Euston, Zhaoyang Dong, Abdulrahman Ghali M Alharbi, Richard Y Kim, Jack G Lowe, Philip M Hansbro, Kian Fan Chung, Christopher E Brightling, Graeme Milligan, Andrew B Tobin
Pathophysiological regulation of lung function by the free fatty acid receptor FFA4. Science translational medicine 12 (557) (2021)
Li-Chiung Lin, Tezz Quon, Susanna Engberg, Amanda E Mackenzie, Andrew B Tobin, Graeme Milligan
G Protein-Coupled Receptor GPR35 Suppresses Lipid Accumulation in Hepatocytes. ACS pharmacology & translational science 4 (6) (2021)
Laura Jenkins, Sara Marsango, Sarah Mancini, Zobaer Al Mahmud, Angus Morrison, Stuart P McElroy, Kirstie A Bennett, Matt Barnes, Andrew B Tobin, Irina G Tikhonova, Graeme Milligan
Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84. ACS pharmacology & translational science 4 (5) (2021)
Annemarie Boleij, Payam Fathi, William Dalton, Ben Park, Xinqun Wu, David Huso, Jawara Allen, Sepideh Besharati, Robert A Anders, Franck Housseau, Amanda E Mackenzie, Laura Jenkins, Graeme Milligan, Shaoguang Wu, Cynthia L Sears
G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis. Communications biology 4 (1) (2021)
Frédéric Labéguère, Sonia Dupont, Luke Alvey, Florilène Soulas, Gregory Newsome, Amynata Tirera, Vanessa Quenehen, Thi Thu Trang Mai, Pierre Deprez, Roland Blanqué, Line Oste, Sandrine Le Tallec, Steve De Vos, Annick Hagers, Ann Vandevelde, Luc Nelles, Nele Vandervoort, Katja Conrath, Thierry Christophe, Ellen van der Aar, Emanuelle Wakselman, Didier Merciris, Céline Cottereaux, Cécile da Costa, Laurent Saniere, Philippe Clement-Lacroix, Laura Jenkins, Graeme Milligan, Stephen Fletcher, Reginald Brys, Romain Gosmini
Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial. Journal of medicinal chemistry 63 (22) (2020)
Sara Marsango, Natasja Barki, Laura Jenkins, Andrew B Tobin, Graeme Milligan
Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84. British journal of pharmacology (2020)
Maria Marti-Solano, Stephanie E Crilly, Duccio Malinverni, Christian Munk, Matthew Harris, Abigail Pearce, Tezz Quon, Amanda E Mackenzie, Xusheng Wang, Junmin Peng, Andrew B Tobin, Graham Ladds, Graeme Milligan, David E Gloriam, Manojkumar A Puthenveedu, M Madan Babu
Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses. Nature (2020)
Maria Marti-Solano, Stephanie E Crilly, Duccio Malinverni, Christian Munk, Matthew Harris, Abigail Pearce, Tezz Quon, Amanda E Mackenzie, Xusheng Wang, Junmin Peng, Andrew B Tobin, Graham Ladds, Graeme Milligan, David E Gloriam, Manojkumar A Puthenveedu, M Madan Babu
Combinatorial expression of GPCR isoforms affects signalling and drug responses. Nature 587 (7835) (2020)
Michael R Stoneman, Gabriel Biener, Richard J Ward, John D Pediani, Dammar Badu, Annie Eis, Ionel Popa, Graeme Milligan, Valerica Raicu
A general method to quantify ligand-driven oligomerization from fluorescence-based images. Nature methods 16 (6) (2019)
Daniele Bolognini, Natasja Barki, Adrian J Butcher, Brian D Hudson, Eugenia Sergeev, Colin Molloy, Catherine E Moss, Sophie J Bradley, Christian Le Gouill, Michel Bouvier, Andrew B Tobin, Graeme Milligan
Chemogenetics defines receptor-mediated functions of short chain free fatty acids. Nature chemical biology 15 (5) (2019)
Sarah J Mancini, Zobaer Al Mahmud, Laura Jenkins, Daniele Bolognini, Robert Newman, Matt Barnes, Michelle E Edye, Stephen B McMahon, Andrew B Tobin, Graeme Milligan
On-target and off-target effects of novel orthosteric and allosteric activators of GPR84. Scientific reports 9 (1) (2019)
Nurul A S Binti Mohd Amir, Amanda E Mackenzie, Laura Jenkins, Karim Boustani, Marston C Hillier, Tomoko Tsuchiya, Graeme Milligan, James Edward Pease
Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35. Journal of immunology (Baltimore, Md. : 1950) 201 (2) (2018)
Frederike M Müskens, Richard J Ward, Dominik Herkt, Helmus van de Langemheen, Andrew B Tobin, Rob M J Liskamp, Graeme Milligan
Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein-Coupled Receptors. Molecular pharmacology 95 (2) (2018)
Janice E Drew, Nicole Reichardt, Lynda M Williams, Claus-Dieter Mayer, Alan William Walker, Andrew J Farquharson, Stavroula Kastora, Freda Farquharson, Graeme Milligan, Douglas J Morrison, Thomas Preston, Harry J Flint, Petra Louis
Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition. Scientific reports 8 (1) (2018)
Graeme Milligan
G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35. British journal of pharmacology 175 (13) (2017)
John D Pediani, Richard J Ward, Antoine G Godin, Sara Marsango, Graeme Milligan
Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs. The Journal of biological chemistry 291 (25) (2016)
Daniele Bolognini, Catherine E Moss, Karolina Nilsson, Annika U Petersson, Iona Donnelly, Eugenia Sergeev, Gabriele M König, Evi Kostenis, Mariola Kurowska-Stolarska, Ashley Miller, Niek Dekker, Andrew B Tobin, Graeme Milligan
A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias. The Journal of biological chemistry 291 (36) (2016)
Elisa Alvarez-Curto, Asuka Inoue, Laura Jenkins, Sheikh Zahir Raihan, Rudi Prihandoko, Andrew B Tobin, Graeme Milligan
Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling. The Journal of biological chemistry 291 (53) (2016)
Joan Heller Brown, William A Catterall, P Jeffrey Conn, Stuart G Cull-Candy, Ray Dingledine, T Kendall Harden, Paul A Insel, Graeme Milligan, Stephen F Traynelis
The First 50 Years of Molecular Pharmacology. Molecular pharmacology 88 (1) (2015)
Eugenia Sergeev, Anders Højgaard Hansen, Sunil K Pandey, Amanda E MacKenzie, Brian D Hudson, Trond Ulven, Graeme Milligan
Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands. The Journal of biological chemistry 291 (1) (2015)