Daniel J Siegwart

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 45

Top Topics

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Advanced materials (Deerfield Beach, Fla.)

Nature nanotechnology

Science (New York, N.Y.)

This page only lists publications with an associated author ORCID identifier.

Publications

Yehui Sun, Sumanta Chatterjee, Xizhen Lian, Zachary Traylor, Sandhya R Sattiraju, Yufen Xiao, Sean A Dilliard, Yun-Chieh Sung, Minjeong Kim, Sang M Lee, Stephen Moore, Xu Wang, Di Zhang, Shiying Wu, Pratima Basak, Jialu Wang, Jing Liu, Rachel J Mann, David F LePage, Weihong Jiang, Shadaan Abid, Mirko Hennig, Anna Martinez, Brandon A Wustman, David J Lockhart, Raksha Jain, Ronald A Conlon, Mitchell L Drumm, Craig A Hodges, Daniel J Siegwart
In vivo editing of lung stem cells for durable gene correction in mice. Science (New York, N.Y.) 384 (6701) (2024)
Yehui Sun, Sumanta Chatterjee, Xizhen Lian, Zachary Traylor, Sandhya R Sattiraju, Yufen Xiao, Sean A Dilliard, Yun-Chieh Sung, Minjeong Kim, Sang M Lee, Stephen Moore, Xu Wang, Di Zhang, Shiying Wu, Pratima Basak, Jialu Wang, Jing Liu, Rachel J Mann, David F LePage, Weihong Jiang, Shadaan Abid, Mirko Hennig, Anna Martinez, Brandon A Wustman, David J Lockhart, Raksha Jain, Ronald A Conlon, Mitchell L Drumm, Craig A Hodges, Daniel J Siegwart
In vivo editing of lung stem cells for durable gene correction in mice. Science (New York, N.Y.) 384 (6701) (2024)
Amogh Vaidya, Stephen Moore, Sumanta Chatterjee, Erick Guerrero, Minjeong Kim, Lukas Farbiak, Sean A Dilliard, Daniel J Siegwart
Expanding RNAi to Kidneys, Lungs, and Spleen via Selective ORgan Targeting (SORT) siRNA Lipid Nanoparticles. Advanced materials (Deerfield Beach, Fla.) 36 (35) (2024)
Xizhen Lian, Sumanta Chatterjee, Yehui Sun, Sean A Dilliard, Stephen Moore, Yufen Xiao, Xiaoyan Bian, Kohki Yamada, Yun-Chieh Sung, Rachel M Levine, Kalin Mayberry, Samuel John, Xiaoye Liu, Caroline Smith, Lindsay T Johnson, Xu Wang, Cheng Cheng Zhang, David R Liu, Gregory A Newby, Mitchell J Weiss, Jonathan S Yen, Daniel J Siegwart
Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells. Nature nanotechnology (2024)
Yehui Sun, Sumanta Chatterjee, Xizhen Lian, Zachary Traylor, Sandhya R Sattiraju, Yufen Xiao, Sean A Dilliard, Yun-Chieh Sung, Minjeong Kim, Sang M Lee, Stephen Moore, Xu Wang, Di Zhang, Shiying Wu, Pratima Basak, Jialu Wang, Jing Liu, Rachel J Mann, David F LePage, Weihong Jiang, Shadaan Abid, Mirko Hennig, Anna Martinez, Brandon A Wustman, David J Lockhart, Raksha Jain, Ronald A Conlon, Mitchell L Drumm, Craig A Hodges, Daniel J Siegwart
In vivo editing of lung stem cells for durable gene correction in mice. Science (New York, N.Y.) 384 (6701) (2024)
Xizhen Lian, Sumanta Chatterjee, Yehui Sun, Sean A Dilliard, Stephen Moore, Yufen Xiao, Xiaoyan Bian, Kohki Yamada, Yun-Chieh Sung, Rachel M Levine, Kalin Mayberry, Samuel John, Xiaoye Liu, Caroline Smith, Lindsay T Johnson, Xu Wang, Cheng Cheng Zhang, David R Liu, Gregory A Newby, Mitchell J Weiss, Jonathan S Yen, Daniel J Siegwart
Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells. Nature nanotechnology (2024)
Amogh Vaidya, Stephen Moore, Sumanta Chatterjee, Erick Guerrero, Minjeong Kim, Lukas Farbiak, Sean A Dilliard, Daniel J Siegwart
Expanding RNAi to Kidneys, Lungs, and Spleen via Selective ORgan Targeting (SORT) siRNA Lipid Nanoparticles. Advanced materials (Deerfield Beach, Fla.) 36 (35) (2024)
Xizhen Lian, Sumanta Chatterjee, Yehui Sun, Sean A Dilliard, Stephen Moore, Yufen Xiao, Xiaoyan Bian, Kohki Yamada, Yun-Chieh Sung, Rachel M Levine, Kalin Mayberry, Samuel John, Xiaoye Liu, Caroline Smith, Lindsay T Johnson, Xu Wang, Cheng Cheng Zhang, David R Liu, Gregory A Newby, Mitchell J Weiss, Jonathan S Yen, Daniel J Siegwart
Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells. Nature nanotechnology (2024)
Amogh Vaidya, Stephen Moore, Sumanta Chatterjee, Erick Guerrero, Minjeong Kim, Lukas Farbiak, Sean A Dilliard, Daniel J Siegwart
Expanding RNAi to Kidneys, Lungs, and Spleen via Selective ORgan Targeting (SORT) siRNA Lipid Nanoparticles. Advanced materials (Deerfield Beach, Fla.) (2024)
Amogh Vaidya, Stephen Moore, Sumanta Chatterjee, Erick Guerrero, Minjeong Kim, Lukas Farbiak, Sean A Dilliard, Daniel J Siegwart
Expanding RNAi to Kidneys, Lungs, and Spleen via Selective ORgan Targeting (SORT) siRNA Lipid Nanoparticles. Advanced materials (Deerfield Beach, Fla.) (2024)
Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart
In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma. Proceedings of the National Academy of Sciences of the United States of America 120 (52) (2023)
Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart
In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma. Proceedings of the National Academy of Sciences of the United States of America 120 (52) (2023)
Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart
In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma. Proceedings of the National Academy of Sciences of the United States of America 120 (52) (2023)
Tuo Wei, Yehui Sun, Qiang Cheng, Sumanta Chatterjee, Zachary Traylor, Lindsay T Johnson, Melissa L Coquelin, Jialu Wang, Michael J Torres, Xizhen Lian, Xu Wang, Yufen Xiao, Craig A Hodges, Daniel J Siegwart
Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models. Nature communications 14 (1) (2023)
Zhaoming Chen, Yang Tian, Jieyu Yang, Fapu Wu, Senyao Liu, Wenwen Cao, Weijia Xu, Tao Hu, Daniel J Siegwart, Hu Xiong
Modular Design of Biodegradable Ionizable Lipids for Improved mRNA Delivery and Precise Cancer Metastasis Delineation In Vivo. Journal of the American Chemical Society (2023)
Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart
In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma. Proceedings of the National Academy of Sciences of the United States of America 120 (52) (2023)
Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart
In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma. Proceedings of the National Academy of Sciences of the United States of America 120 (52) (2023)
Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart
In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma. Proceedings of the National Academy of Sciences of the United States of America 120 (52) (2023)
Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart
In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma. Proceedings of the National Academy of Sciences of the United States of America 120 (52) (2023)
Sean A Dilliard, Daniel J Siegwart
Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs. Nature reviews. Materials (2023)
Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart
In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma. Proceedings of the National Academy of Sciences of the United States of America 120 (52) (2023)
Sean A Dilliard, Daniel J Siegwart
Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs. Nature reviews. Materials (2023)
Xu Wang, Shuai Liu, Yehui Sun, Xueliang Yu, Sang M Lee, Qiang Cheng, Tuo Wei, Junyu Gong, Joshua Robinson, Di Zhang, Xizhen Lian, Pratima Basak, Daniel J Siegwart
Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery. Nature protocols (2022)
Lindsay T Johnson, Di Zhang, Kejin Zhou, Sang M Lee, Shuai Liu, Sean A Dilliard, Lukas Farbiak, Sumanta Chatterjee, Yu-Hsuan Lin, Daniel J Siegwart
Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model. Molecular pharmaceutics 19 (11) (2022)
Sean A Dilliard, Daniel J Siegwart
Disrupting off-target Cas9 activity in the liver. Nature biomedical engineering 6 (2) (2022)
Ester Álvarez-Benedicto, Lukas Farbiak, Martha Márquez Ramírez, Xu Wang, Lindsay T Johnson, Osamah Mian, Erick D Guerrero, Daniel J Siegwart
Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA). Biomaterials science 10 (2) (2022)
Di Zhang, Guoxun Wang, Xueliang Yu, Tuo Wei, Lukas Farbiak, Lindsay T Johnson, Alan Mark Taylor, Jiazhu Xu, Yi Hong, Hao Zhu, Daniel J Siegwart
Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy. Nature nanotechnology 17 (7) (2022)
Ming-Hsiu Yang, Jamie L Russell, Yuto Mifune, Ying Wang, Hexin Shi, Eva Marie Y Moresco, Daniel J Siegwart, Bruce Beutler, Dale L Boger
Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response. Journal of medicinal chemistry 65 (13) (2022)
Sean A Dilliard, Qiang Cheng, Daniel J Siegwart
On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles. Proceedings of the National Academy of Sciences of the United States of America 118 (52) (2022)
Lukas Farbiak, Qiang Cheng, Tuo Wei, Ester Álvarez-Benedicto, Lindsay T Johnson, Sang Lee, Daniel J Siegwart
All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo. Advanced materials (Deerfield Beach, Fla.) 33 (30) (2021)
Sang M Lee, Qiang Cheng, Xueliang Yu, Shuai Liu, Lindsay T Johnson, Daniel J Siegwart
A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo. Angewandte Chemie (International ed. in English) 60 (11) (2021)
Shuai Liu, Qiang Cheng, Tuo Wei, Xueliang Yu, Lindsay T Johnson, Lukas Farbiak, Daniel J Siegwart
Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing. Nature materials 20 (5) (2021)
Lian Xue, Yunfeng Yan, Petra Kos, Xiaoping Chen, Daniel J Siegwart
PEI fluorination reduces toxicity and promotes liver-targeted siRNA delivery. Drug delivery and translational research 11 (1) (2021)
Shuai Liu, Xu Wang, Xueliang Yu, Qiang Cheng, Lindsay T Johnson, Sumanta Chatterjee, Di Zhang, Sang M Lee, Yehui Sun, Ting-Chih Lin, John L Liu, Daniel J Siegwart
Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes. Journal of the American Chemical Society (2021)
Xueliang Yu, Shuai Liu, Qiang Cheng, Tuo Wei, Sang Lee, Di Zhang, Daniel J Siegwart
Lipid-Modified Aminoglycosides for mRNA Delivery to the Liver. Advanced healthcare materials 9 (7) (2020)
Qiang Cheng, Tuo Wei, Lukas Farbiak, Lindsay T Johnson, Sean A Dilliard, Daniel J Siegwart
Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing. Nature nanotechnology 15 (4) (2020)
Tuo Wei, Qiang Cheng, Lukas Farbiak, Daniel G Anderson, Robert S Langer, Daniel J Siegwart
Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing. ACS nano 14 (8) (2020)
Kejin Zhou, Lindsay T Johnson, Hu Xiong, Sergio Barrios, Jonathan T Minnig, Yunfeng Yan, Bethanie Abram, Xueliang Yu, Daniel J Siegwart
Hydrophobic Domain Structure of Linear-Dendritic Poly(ethylene glycol) Lipids Affects RNA Delivery of Lipid Nanoparticles. Molecular pharmaceutics 17 (5) (2020)
Tuo Wei, Qiang Cheng, Yi-Li Min, Eric N Olson, Daniel J Siegwart
Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing. Nature communications 11 (1) (2020)
Jason B Miller, Petra Kos, Victor Tieu, Kejin Zhou, Daniel J Siegwart
Development of Cationic Quaternary Ammonium Sulfonamide Amino Lipids for Nucleic Acid Delivery. ACS applied materials & interfaces 10 (3) (2018)
Hu Xiong, Kejin Zhou, Yunfeng Yan, Jason B Miller, Daniel J Siegwart
Tumor-Activated Water-Soluble Photosensitizers for Near-Infrared Photodynamic Cancer Therapy. ACS applied materials & interfaces 10 (19) (2018)
Qiang Cheng, Tuo Wei, Yuemeng Jia, Lukas Farbiak, Kejin Zhou, Shuyuan Zhang, Yonglong Wei, Hao Zhu, Daniel J Siegwart
Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I. Advanced materials (Deerfield Beach, Fla.) 30 (52) (2018)
Yunfeng Yan, Hu Xiong, Xinyi Zhang, Qiang Cheng, Daniel J Siegwart
Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers. Biomacromolecules 18 (12) (2017)
Hu Xiong, Hao Zuo, Yunfeng Yan, Gino Occhialini, Kejin Zhou, Yihong Wan, Daniel J Siegwart
High-Contrast Fluorescence Detection of Metastatic Breast Cancer Including Bone and Liver Micrometastases via Size-Controlled pH-Activatable Water-Soluble Probes. Advanced materials (Deerfield Beach, Fla.) 29 (29) (2017)
Jason B Miller, Shuyuan Zhang, Petra Kos, Hu Xiong, Kejin Zhou, Sofya S Perelman, Hao Zhu, Daniel J Siegwart
Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA. Angewandte Chemie (International ed. in English) 56 (4) (2016)
Linwei Wu, Liem H Nguyen, Kejin Zhou, T Yvanka de Soysa, Lin Li, Jason B Miller, Jianmin Tian, Joseph Locker, Shuyuan Zhang, Gen Shinoda, Marc T Seligson, Lauren R Zeitels, Asha Acharya, Sam C Wang, Joshua T Mendell, Xiaoshun He, Jinsuke Nishino, Sean J Morrison, Daniel J Siegwart, George Q Daley, Ng Shyh-Chang, Hao Zhu
Precise let-7 expression levels balance organ regeneration against tumor suppression. eLife 4 (2015)