David J Rawlings

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 32

Top Topics

Regulatory T Cells

Acute Lymphoblastic Leukemia

Immune Response

Top Venues

Journal of immunology (Baltimore, Md. : 1950)

The Journal of experimental medicine

bioRxiv : the preprint server for biology

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Malika Hale, Kennidy K Takehara, Christopher D Thouvenel, Dina A Moustafa, Andrea Repele, Mary F Fontana, Jason Netland, Sharon McNamara, Ronald L Gibson, Joanna B Goldberg, David J Rawlings, Marion Pepper
Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice. bioRxiv : the preprint server for biology (2024)
Akhilesh K Singh, Fahd Al Qureshah, Travis Drow, Baidong Hou, David J Rawlings
Activated PI3Kδ Specifically Perturbs Mouse Regulatory T Cell Homeostasis and Function Leading to Immune Dysregulation. Journal of immunology (Baltimore, Md. : 1950) (2024)
Akhilesh K Singh, Fahd Al Qureshah, Travis Drow, Baidong Hou, David J Rawlings
Activated PI3Kδ Specifically Perturbs Mouse Regulatory T Cell Homeostasis and Function Leading to Immune Dysregulation. Journal of immunology (Baltimore, Md. : 1950) (2024)
Akhilesh K Singh, Fahd Al Qureshah, Travis Drow, Baidong Hou, David J Rawlings
Activated PI3Kδ Specifically Perturbs Mouse Regulatory T Cell Homeostasis and Function Leading to Immune Dysregulation. Journal of immunology (Baltimore, Md. : 1950) 213 (2) (2024)
Taylor K Watson, Aaron B I Rosen, Travis Drow, Jacob A Medjo, Matthew A MacQuivey, Yan Ge, H Denny Liggitt, Dane A Grosvenor, Kimberly A Dill-McFarland, Matthew C Altman, Patrick J Concannon, Jane H Buckner, David J Rawlings, Eric J Allenspach
Reduced function of the adaptor SH2B3 promotes T1D via altered gc cytokine-regulated, T cell intrinsic immune tolerance. bioRxiv : the preprint server for biology (2024)
Malika Hale, Kennidy K Takehara, Christopher D Thouvenel, Dina A Moustafa, Andrea Repele, Mary F Fontana, Jason Netland, Sharon McNamara, Ronald L Gibson, Joanna B Goldberg, David J Rawlings, Marion Pepper
Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice. bioRxiv : the preprint server for biology (2024)
Akhilesh K Singh, Fahd Al Qureshah, Travis Drow, Baidong Hou, David J Rawlings
Activated PI3Kδ Specifically Perturbs Mouse Regulatory T Cell Homeostasis and Function Leading to Immune Dysregulation. Journal of immunology (Baltimore, Md. : 1950) 213 (2) (2024)
Akhilesh K Singh, Fahd Al Qureshah, Travis Drow, Baidong Hou, David J Rawlings
Activated PI3Kδ Specifically Perturbs Mouse Regulatory T Cell Homeostasis and Function Leading to Immune Dysregulation. Journal of immunology (Baltimore, Md. : 1950) 213 (2) (2024)
Akhilesh K Singh, Fahd Al Qureshah, Travis Drow, Baidong Hou, David J Rawlings
Activated PI3Kδ Specifically Perturbs Mouse Regulatory T Cell Homeostasis and Function Leading to Immune Dysregulation. Journal of immunology (Baltimore, Md. : 1950) 213 (2) (2024)
Rene Yu-Hong Cheng, Joseph de Rutte, Cade Ellis K Ito, Andee R Ott, Lucie Bosler, Wei-Ying Kuo, Jesse Liang, Brian E Hall, David J Rawlings, Dino Di Carlo, Richard C James
SEC-seq: association of molecular signatures with antibody secretion in thousands of single human plasma cells. Nature communications 14 (1) (2023)
Warren Anderson, Fariba Barahmand-Pour-Whitman, Carla J Greenbaum, Karen Cerosaletti, Jane H Buckner, David J Rawlings
PTPN22 R620W gene editing in T cells enhances low avidity TCR responses. eLife 12 (2023)
Malika Hale, Jason Netland, Yu Chen, Christopher D Thouvenel, Katherine Nabel Smith, Lucille M Rich, Elizabeth R Vanderwall, Marcos C Miranda, Julie Eggenberger, Linhui Hao, Michael J Watson, Charles C Mundorff, Lauren B Rodda, Neil P King, Miklos M Guttman, Michael Gale, Jonathan Abraham, Jason S Debley, Marion Pepper, David J Rawlings
IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2. The Journal of experimental medicine 219 (9) (2022)
Michelle L Christian, Michael J Dapp, Samuel C Scharffenberger, Hank Jones, Chaozhong Song, Lisa M Frenkel, Anthony Krumm, James I Mullins, David J Rawlings
CRISPR/Cas9-Mediated Insertion of HIV Long Terminal Repeat within BACH2 Promotes Expansion of T Regulatory-like Cells. Journal of immunology (Baltimore, Md. : 1950) 208 (7) (2022)
Soo Jung Yang, Akhilesh K Singh, Travis Drow, Tori Tappen, Yuchi Honaker, Fariba Barahmand-Pour-Whitman, Carla J Greenbaum, Karen Cerosaletti, Kelsey Mauk, Yufei Xiang, Jessica Smith, Emma Mortensen, Peter J Cook, David J Rawlings, Iram Khan, Denny Liggitt, David J Rawlings, Jane H Buckner
Pancreatic islet-specific engineered T regs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models. Science translational medicine 14 (665) (2022)
Jonathan Woods, Sarah E Pemberton, Andrea D Largent, Kristy Chiang, H Denny Liggitt, Mohamed Oukka, David J Rawlings, Shaun W Jackson
Cutting Edge: Systemic Autoimmunity in Murine STAT3 Gain-of-Function Syndrome Is Characterized by Effector T Cell Expansion in the Absence of Overt Regulatory T Cell Dysfunction. Journal of immunology (Baltimore, Md. : 1950) 209 (6) (2022)
Rene Yu-Hong Cheng, King L Hung, Tingting Zhang, Claire M Stoffers, Andee R Ott, Emmaline R Suchland, Nathan D Camp, Iram F Khan, Swati Singh, Ying-Jen Yang, David J Rawlings, Richard C James
Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo. Nature communications 13 (1) (2022)
Geoff P O'Donoghue, Lukasz J Bugaj, Warren Anderson, Kyle G Daniels, David J Rawlings, Wendell A Lim
T cells selectively filter oscillatory signals on the minutes timescale. Proceedings of the National Academy of Sciences of the United States of America 118 (9) (2021)
Fahd Al Qureshah, Sara Sagadiev, Christopher D Thouvenel, Shuozhi Liu, Zhaolin Hua, Baidong Hou, Mridu Acharya, Richard C James, David J Rawlings
Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress. The Journal of experimental medicine 218 (12) (2021)
Holly M Jacobs, Tanvi Arkatkar, Samuel W Du, Nicole E Scharping, Jonathan Woods, Quan-Zhen Li, Kelly L Hudkins, Charles E Alpers, David J Rawlings, Shaun W Jackson
TACI haploinsufficiency protects against BAFF-driven humoral autoimmunity in mice. European journal of immunology 51 (9) (2021)
Kerri R Thomas, Eric J Allenspach, Nathan D Camp, Michelle N Wray-Dutra, Socheath Khim, Anna Zielinska-Kwiatkowska, Andrew E Timms, Joseph P Loftus, H Denny Liggitt, Katia Georgopoulos, Sarah K Tasian, Richard C James, David J Rawlings
Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice. Leukemia (2021)
Kristy Chiang, Andrea D Largent, Tanvi Arkatkar, Christopher D Thouvenel, Samuel W Du, Natali M Shumlak, Jonathan Woods, Quan-Zhen Li, Yifan Liu, Baidong Hou, David J Rawlings, Shaun W Jackson
Cutting Edge: A Threshold of B Cell Costimulatory Signals Is Required for Spontaneous Germinal Center Formation in Autoimmunity. Journal of immunology (Baltimore, Md. : 1950) 207 (9) (2021)
Eric J Allenspach, Nicholas J Shubin, Karen Cerosaletti, Carmen Mikacenic, Jacquelyn A Gorman, Matthew A MacQuivey, Aaron B I Rosen, Andrew E Timms, Michelle N Wray-Dutra, Kerri Niino, H Denny Liggitt, Mark M Wurfel, Jane H Buckner, Adrian M Piliponsky, David J Rawlings
The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis. Journal of immunology (Baltimore, Md. : 1950) 207 (11) (2021)
Olivier Humbert, Stefan Radtke, Clare Samuelson, Ray R Carrillo, Anai M Perez, Sowmya S Reddy, Christopher Lux, Sowmya Pattabhi, Lauren E Schefter, Olivier Negre, Ciaran M Lee, Gang Bao, Jennifer E Adair, Christopher W Peterson, David J Rawlings, Andrew M Scharenberg, Hans-Peter Kiem
Therapeutically relevant engraftment of a CRISPR-Cas9-edited HSC-enriched population with HbF reactivation in nonhuman primates. Science translational medicine 11 (503) (2020)
Warren Anderson, Jerill Thorpe, S Alice Long, David J Rawlings
Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells. Journal of immunology (Baltimore, Md. : 1950) 203 (12) (2019)
Samuel W Du, Tanvi Arkatkar, Fahd Al Qureshah, Holly M Jacobs, Christopher D Thouvenel, Kristy Chiang, Andrea D Largent, Quan-Zhen Li, Baidong Hou, David J Rawlings, Shaun W Jackson
Functional Characterization of CD11c+ Age-Associated B Cells as Memory B Cells. Journal of immunology (Baltimore, Md. : 1950) 203 (11) (2019)
Samuel W Du, Holly M Jacobs, Tanvi Arkatkar, David J Rawlings, Shaun W Jackson
Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells. Journal of immunology (Baltimore, Md. : 1950) 201 (11) (2018)
Michelle N Wray-Dutra, Fahd Al Qureshah, Genita Metzler, Mohamed Oukka, Richard G James, David J Rawlings
Activated PIK3CD drives innate B cell expansion yet limits B cell-intrinsic immune responses. The Journal of experimental medicine 215 (10) (2018)
Michelle N Wray-Dutra, Raghav Chawla, Kerri R Thomas, Brenda J Seymour, Tanvi Arkatkar, Karen M Sommer, Socheath Khim, Cole Trapnell, Richard G James, David J Rawlings
Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation. The Journal of experimental medicine 215 (9) (2018)
Tanvi Arkatkar, Samuel W Du, Holly M Jacobs, Elizabeth M Dam, Baidong Hou, Jane H Buckner, David J Rawlings, Shaun W Jackson
B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity. The Journal of experimental medicine 214 (11) (2017)
Genita Metzler, Xuezhi Dai, Christopher D Thouvenel, Socheath Khim, Tania Habib, Jane H Buckner, David J Rawlings
The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire. Journal of immunology (Baltimore, Md. : 1950) 199 (7) (2017)
Holly M Jacobs, Christopher D Thouvenel, Sarah Leach, Tanvi Arkatkar, Genita Metzler, Nicole E Scharping, Nikita S Kolhatkar, David J Rawlings, Shaun W Jackson
Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells. Journal of immunology (Baltimore, Md. : 1950) 196 (9) (2016)
Shaun W Jackson, Nicole E Scharping, Holly M Jacobs, Shari Wang, Alan Chait, David J Rawlings
Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation. Journal of immunology (Baltimore, Md. : 1950) 197 (12) (2016)