Derek A Pratt (Derek Pratt)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 55

Top Topics

Amyotrophic Lateral Sclerosis

Hydrogen Peroxide

Top Venues

Journal of the American Chemical Society

The Journal of organic chemistry

Angewandte Chemie (International ed. in English)

This page only lists publications with an associated author ORCID identifier.

Publications

Cheng Yang, Luke A Farmer, Elvis C McFee, Rahul Kant Jha, Stephen Maldonado, Derek A Pratt, Corey R J Stephenson
Attenuating N-Oxyl Decomposition for Improved Hydrogen Atom Transfer Catalysts. Angewandte Chemie (International ed. in English) 63 (21) (2024)
Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira Dos Santos, Palina S Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M Lorenz, Viktoria Kunz, Helene Nehring, Thamara Nishida Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G Doll, Emily L Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri Miyamoto, Ann Marie Wehman, Thiago C Genaro-Mattos, Karoly Mirnics, Lokender Kumar, Judith Klein-Seetharaman, Svenja Meierjohann, Isabel Weigand, Matthias Kroiss, Georg W Bornkamm, Fernando Gomes, Luis Eduardo Soares Netto, Manjima B Sathian, David B Konrad, Douglas F Covey, Bernhard Michalke, Kurt Bommert, Ralf Christian Bargou, Ana J Garcia-Saez, Derek A Pratt, Maria Fedorova, Flavia Carla Meotti, Marcus Conrad, José Pedro Friedmann Angeli
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature 626 (7998) (2024)
Luke A Farmer, Derek A Pratt
Non-Tertiary Alkyl Substituents Enhance High-Temperature Radical Trapping by Phenothiazine and Phenoxazine Antioxidants. The Journal of organic chemistry 89 (9) (2024)
Luke A Farmer, Derek A Pratt
Non-Tertiary Alkyl Substituents Enhance High-Temperature Radical Trapping by Phenothiazine and Phenoxazine Antioxidants. The Journal of organic chemistry (2024)
Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira Dos Santos, Palina S Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M Lorenz, Viktoria Kunz, Helene Nehring, Thamara Nishida Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G Doll, Emily L Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri Miyamoto, Ann Marie Wehman, Thiago C Genaro-Mattos, Karoly Mirnics, Lokender Kumar, Judith Klein-Seetharaman, Svenja Meierjohann, Isabel Weigand, Matthias Kroiss, Georg W Bornkamm, Fernando Gomes, Luis Eduardo Soares Netto, Manjima B Sathian, David B Konrad, Douglas F Covey, Bernhard Michalke, Kurt Bommert, Ralf Christian Bargou, Ana J Garcia-Saez, Derek A Pratt, Maria Fedorova, Flavia Carla Meotti, Marcus Conrad, José Pedro Friedmann Angeli
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature 626 (7998) (2024)
Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira Dos Santos, Palina S Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M Lorenz, Viktoria Kunz, Helene Nehring, Thamara Nishida Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G Doll, Emily L Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri Miyamoto, Ann Marie Wehman, Thiago C Genaro-Mattos, Karoly Mirnics, Lokender Kumar, Judith Klein-Seetharaman, Svenja Meierjohann, Isabel Weigand, Matthias Kroiss, Georg W Bornkamm, Fernando Gomes, Luis Eduardo Soares Netto, Manjima B Sathian, David B Konrad, Douglas F Covey, Bernhard Michalke, Kurt Bommert, Ralf Christian Bargou, Ana J Garcia-Saez, Derek A Pratt, Maria Fedorova, Flavia Carla Meotti, Marcus Conrad, José Pedro Friedmann Angeli
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature 626 (7998) (2024)
Cheng Yang, Luke A Farmer, Elvis C McFee, Rahul Kant Jha, Stephen Maldonado, Derek A Pratt, Corey R J Stephenson
Attenuating N-Oxyl Decomposition for Improved Hydrogen Atom Transfer Catalysts. Angewandte Chemie (International ed. in English) (2024)
Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira Dos Santos, Palina S Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M Lorenz, Viktoria Kunz, Helene Nehring, Thamara Nishida Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G Doll, Emily L Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri Miyamoto, Ann Marie Wehman, Thiago C Genaro-Mattos, Karoly Mirnics, Lokender Kumar, Judith Klein-Seetharaman, Svenja Meierjohann, Isabel Weigand, Matthias Kroiss, Georg W Bornkamm, Fernando Gomes, Luis Eduardo Soares Netto, Manjima B Sathian, David B Konrad, Douglas F Covey, Bernhard Michalke, Kurt Bommert, Ralf Christian Bargou, Ana J Garcia-Saez, Derek A Pratt, Maria Fedorova, Flavia Carla Meotti, Marcus Conrad, José Pedro Friedmann Angeli
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature (2024)
Cheng Yang, Luke A Farmer, Derek A Pratt, Stephen Maldonado, Corey R J Stephenson
Revisiting the Reactivity of the Dismissed Hydrogen Atom Transfer Catalyst Succinimide- N -oxyl. Journal of the American Chemical Society 146 (18) (2024)
Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira Dos Santos, Palina S Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M Lorenz, Viktoria Kunz, Helene Nehring, Thamara Nishida Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G Doll, Emily L Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri Miyamoto, Ann Marie Wehman, Thiago C Genaro-Mattos, Karoly Mirnics, Lokender Kumar, Judith Klein-Seetharaman, Svenja Meierjohann, Isabel Weigand, Matthias Kroiss, Georg W Bornkamm, Fernando Gomes, Luis Eduardo Soares Netto, Manjima B Sathian, David B Konrad, Douglas F Covey, Bernhard Michalke, Kurt Bommert, Ralf Christian Bargou, Ana J Garcia-Saez, Derek A Pratt, Maria Fedorova, Flavia Carla Meotti, Marcus Conrad, José Pedro Friedmann Angeli
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature (2024)
Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira Dos Santos, Palina S Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M Lorenz, Viktoria Kunz, Helene Nehring, Thamara Nishida Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G Doll, Emily L Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri Miyamoto, Ann Marie Wehman, Thiago C Genaro-Mattos, Karoly Mirnics, Lokender Kumar, Judith Klein-Seetharaman, Svenja Meierjohann, Isabel Weigand, Matthias Kroiss, Georg W Bornkamm, Fernando Gomes, Luis Eduardo Soares Netto, Manjima B Sathian, David B Konrad, Douglas F Covey, Bernhard Michalke, Kurt Bommert, Ralf Christian Bargou, Ana J Garcia-Saez, Derek A Pratt, Maria Fedorova, Flavia Carla Meotti, Marcus Conrad, José Pedro Friedmann Angeli
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature 626 (7998) (2024)
Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira Dos Santos, Palina S Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M Lorenz, Viktoria Kunz, Helene Nehring, Thamara Nishida Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G Doll, Emily L Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri Miyamoto, Ann Marie Wehman, Thiago C Genaro-Mattos, Karoly Mirnics, Lokender Kumar, Judith Klein-Seetharaman, Svenja Meierjohann, Isabel Weigand, Matthias Kroiss, Georg W Bornkamm, Fernando Gomes, Luis Eduardo Soares Netto, Manjima B Sathian, David B Konrad, Douglas F Covey, Bernhard Michalke, Kurt Bommert, Ralf Christian Bargou, Ana J Garcia-Saez, Derek A Pratt, Maria Fedorova, Flavia Carla Meotti, Marcus Conrad, José Pedro Friedmann Angeli
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature (2024)
Cheng Yang, Luke A Farmer, Derek A Pratt, Stephen Maldonado, Corey R J Stephenson
Revisiting the Reactivity of the Dismissed Hydrogen Atom Transfer Catalyst Succinimide- N -oxyl. Journal of the American Chemical Society (2024)
Derek A Pratt
Targeting lipoxygenases to suppress ferroptotic cell death. Proceedings of the National Academy of Sciences of the United States of America 120 (29) (2023)
Melodie Mallais, Carly S Hanson, Melanie Giray, Derek A Pratt
General Approach to Identify, Assess, and Characterize Inhibitors of Lipid Peroxidation and Associated Cell Death. ACS chemical biology 18 (3) (2023)
Zijun Wu, Derek A Pratt
Radical approaches to C-S bonds. Nature reviews. Chemistry (2023)
Zijun Wu, Robynne Vlaming, Michael Donohoe, Derek A Pratt
Interrupted Homolytic Substitution Enables Organoboron Compounds to Inhibit Radical Chain Reactions Rather than Initiate Them. Journal of the American Chemical Society 146 (1) (2023)
Melodie Mallais, Carly S Hanson, Melanie Giray, Derek A Pratt
General Approach to Identify, Assess, and Characterize Inhibitors of Lipid Peroxidation and Associated Cell Death. ACS chemical biology (2023)
Cheng Yang, Sahil Arora, Stephen Maldonado, Derek A Pratt, Corey R J Stephenson
The design of PINO-like hydrogen-atom-transfer catalysts. Nature reviews. Chemistry (2023)
Dmitry D Saraev, Zijun Wu, Hye-Young H Kim, Ned A Porter, Derek A Pratt
Intramolecular H-Atom Transfers in Alkoxyl Radical Intermediates Underlie the Apparent Oxidation of Lipid Hydroperoxides by Fe(II). ACS chemical biology (2023)
Melodie Mallais, Carly S Hanson, Melanie Giray, Derek A Pratt
General Approach to Identify, Assess, and Characterize Inhibitors of Lipid Peroxidation and Associated Cell Death. ACS chemical biology 18 (3) (2023)
Zijun Wu, Robynne Vlaming, Michael Donohoe, Derek A Pratt
Interrupted Homolytic Substitution Enables Organoboron Compounds to Inhibit Radical Chain Reactions Rather than Initiate Them. Journal of the American Chemical Society (2023)
Carly S Hanson, Michael Donohoe, Derek A Pratt
Enhancement of Diarylamine Antioxidant Activity by Molybdenum Dithiocarbamates. The Journal of organic chemistry (2023)
Zijun Wu, Vinayak S Khodade, Jean-Philippe R Chauvin, Deborah Rodriguez, John P Toscano, Derek A Pratt
Hydropersulfides Inhibit Lipid Peroxidation and Protect Cells from Ferroptosis. Journal of the American Chemical Society 144 (34) (2022)
Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian G Doll, Wulf Tonnus, Palina S Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-Ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K Geissler, Kiyotaka Nakagawa, Takaaki K Abe, Maria Fedorova, Bettina Proneth, Derek A Pratt, Marcus Conrad
A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature 608 (7924) (2022)
Luke A Farmer, Zijun Wu, Jia-Fei Poon, Omkar Zilka, Svenja M Lorenz, Stephanie Huehn, Bettina Proneth, Marcus Conrad, Derek A Pratt
Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death. Journal of the American Chemical Society 144 (32) (2022)
Wulf Tonnus, Claudia Meyer, Christian Steinebach, Alexia Belavgeni, Anne von Mässenhausen, Nadia Zamora Gonzalez, Francesca Maremonti, Florian Gembardt, Nina Himmerkus, Markus Latk, Sophie Locke, Julian Marschner, Wenjun Li, Spencer Short, Sebastian Doll, Irina Ingold, Bettina Proneth, Christoph Daniel, Nazanin Kabgani, Rafael Kramann, Stephen Motika, Paul J Hergenrother, Stefan R Bornstein, Christian Hugo, Jan Ulrich Becker, Kerstin Amann, Hans-Joachim Anders, Daniel Kreisel, Derek A Pratt, Michael Gütschow, Marcus Conrad, Andreas Linkermann
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury. Nature communications 12 (1) (2021)
Julian Helberg, Derek A Pratt
Autoxidation vs. antioxidants - the fight for forever. Chemical Society reviews 50 (13) (2021)
Cheng Yang, Luke A Farmer, Derek A Pratt, Stephen Maldonado, Corey R J Stephenson
Mechanism of Electrochemical Generation and Decomposition of Phthalimide-N-oxyl. Journal of the American Chemical Society 143 (27) (2021)
Megan Conlon, Carson D Poltorack, Giovanni C Forcina, David A Armenta, Melodie Mallais, Marcos A Perez, Alex Wells, Alexis Kahanu, Leslie Magtanong, Jennifer L Watts, Derek A Pratt, Scott J Dixon
A compendium of kinetic modulatory profiles identifies ferroptosis regulators. Nature chemical biology 17 (6) (2021)
Jia-Fei Poon, Luke A Farmer, Evan A Haidasz, Derek A Pratt
Temperature-dependence of radical-trapping activity of phenoxazine, phenothiazine and their aza-analogues clarifies the way forward for new antioxidant design. Chemical science 12 (33) (2021)
Zijun Wu, Derek A Pratt
A Divergent Strategy for Site-Selective Radical Disulfuration of Carboxylic Acids with Trisulfide-1,1-Dioxides. Angewandte Chemie (International ed. in English) 60 (28) (2021)
Ron Shah, Jia-Fei Poon, Evan A Haidasz, Derek A Pratt
Temperature-Dependent Effects of Alkyl Substitution on Diarylamine Antioxidant Reactivity. The Journal of organic chemistry 86 (9) (2021)
Omkar Zilka, Jia-Fei Poon, Derek A Pratt
Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death. Journal of the American Chemical Society 143 (45) (2021)
Jia-Fei Poon, Omkar Zilka, Derek A Pratt
Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived Peroxyl Radicals and Hydroperoxyl Radicals. Journal of the American Chemical Society 142 (33) (2020)
Mark A R Raycroft, Jean-Philippe R Chauvin, Matthew S Galliher, Kevin J Romero, Corey R J Stephenson, Derek A Pratt
Quinone methide dimers lacking labile hydrogen atoms are surprisingly excellent radical-trapping antioxidants. Chemical science 11 (22) (2020)
Maximilian Lübbesmeyer, Emily G Mackay, Mark A R Raycroft, Jonas Elfert, Derek A Pratt, Armido Studer
Base-Promoted C-C Bond Activation Enables Radical Allylation with Homoallylic Alcohols. Journal of the American Chemical Society 142 (5) (2020)
Kevin J Romero, Mitchell H Keylor, Markus Griesser, Xu Zhu, Ethan J Strobel, Derek A Pratt, Corey R J Stephenson
Synthesis of Vitisins A and D Enabled by a Persistent Radical Equilibrium. Journal of the American Chemical Society 142 (14) (2020)
Mariluz Soula, Ross A Weber, Omkar Zilka, Hanan Alwaseem, Konnor La, Frederick S Yen, Henrik Molina, Javier Garcia-Bermudez, Derek A Pratt, Kivanç Birsoy
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers. Nature chemical biology 16 (12) (2020)
Zosia A M Zielinski, Derek A Pratt
H-Atom Abstraction vs Addition: Accounting for the Diverse Product Distribution in the Autoxidation of Cholesterol and Its Esters. Journal of the American Chemical Society 141 (7) (2019)
Emily L Schaefer, Nadia Zopyrus, Zosia A M Zielinski, Glenn A Facey, Derek A Pratt
On the Products of Cholesterol Autoxidation in Phospholipid Bilayers and the Formation of Secosterols Derived Therefrom. Angewandte Chemie (International ed. in English) 59 (5) (2019)
Jean-Philippe R Chauvin, Markus Griesser, Derek A Pratt
The antioxidant activity of polysulfides: it's radical! Chemical science 10 (19) (2019)
Marcus Conrad, Derek A Pratt
The chemical basis of ferroptosis. Nature chemical biology 15 (12) (2019)
Markus Griesser, Jean-Philippe R Chauvin, Derek A Pratt
The hydrogen atom transfer reactivity of sulfinic acids. Chemical science 9 (36) (2018)
Kareem A Harrison, Evan A Haidasz, Markus Griesser, Derek A Pratt
Inhibition of hydrocarbon autoxidation by nitroxide-catalyzed cross-dismutation of hydroperoxyl and alkylperoxyl radicals. Chemical science 9 (28) (2018)
Kevin J Romero, Matthew S Galliher, Mark A R Raycroft, Jean-Philippe R Chauvin, Irene Bosque, Derek A Pratt, Corey R J Stephenson
Electrochemical Dimerization of Phenylpropenoids and the Surprising Antioxidant Activity of the Resultant Quinone Methide Dimers. Angewandte Chemie (International ed. in English) 57 (52) (2018)
Markus Griesser, Ron Shah, Antonius T Van Kessel, Omkar Zilka, Evan A Haidasz, Derek A Pratt
The Catalytic Reaction of Nitroxides with Peroxyl Radicals and Its Relevance to Their Cytoprotective Properties. Journal of the American Chemical Society 140 (10) (2018)
Jia-Fei Poon, Derek A Pratt
Recent Insights on Hydrogen Atom Transfer in the Inhibition of Hydrocarbon Autoxidation. Accounts of chemical research 51 (9) (2018)
Evan A Haidasz, Derek A Pratt
Diazaphenoxazines and Diazaphenothiazines: Synthesis of the "Correct" Isomers Reveals They Are Highly Reactive Radical-Trapping Antioxidants. Organic letters 19 (7) (2017)
Zosia A M Zielinski, Derek A Pratt
Lipid Peroxidation: Kinetics, Mechanisms, and Products. The Journal of organic chemistry 82 (6) (2017)
Ron Shah, Kaitlyn Margison, Derek A Pratt
The Potency of Diarylamine Radical-Trapping Antioxidants as Inhibitors of Ferroptosis Underscores the Role of Autoxidation in the Mechanism of Cell Death. ACS chemical biology 12 (10) (2017)
Liwei Zheng, Markus Griesser, Derek A Pratt, Marc M Greenberg
Aminyl Radical Generation via Tandem Norrish Type I Photocleavage, β-Fragmentation: Independent Generation and Reactivity of the 2'-Deoxyadenosin- N6-yl Radical. The Journal of organic chemistry 82 (7) (2017)
Luke A Farmer, Evan A Haidasz, Markus Griesser, Derek A Pratt
Phenoxazine: A Privileged Scaffold for Radical-Trapping Antioxidants. The Journal of organic chemistry 82 (19) (2017)
Jean-Philippe R Chauvin, Markus Griesser, Derek A Pratt
Hydropersulfides: H-Atom Transfer Agents Par Excellence. Journal of the American Chemical Society 139 (18) (2017)
Jean-Philippe R Chauvin, Derek A Pratt
On the Reactions of Thiols, Sulfenic Acids, and Sulfinic Acids with Hydrogen Peroxide. Angewandte Chemie (International ed. in English) 56 (22) (2016)