Douglas J Kojetin

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 26

Top Venues

bioRxiv : the preprint server for biology

Nature communications

Journal of medicinal chemistry

eLife

Scripps Florida

North Carolina State University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Scripps Florida

United States

Associate Professor :: Integrative Structural and Computational Biology

Education History

North Carolina State University

United States

PHD :: Biochemistry

Publications

Brian MacTavish, Di Zhu, Jinsai Shang, Qianzhen Shao, Zhongyue J Yang, Theodore M Kamenecka, Douglas J Kojetin
Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states. bioRxiv : the preprint server for biology (2024)
Stephen Zorc, Paola Munoz-Tello, Timothy O'Leary, Xiaoyu Yu, Mithun Nag, Althea Hansel-Harris, Stefano Forli, Patrick R Griffin, Douglas J Kojetin, Raktim N Roy, Michalina Janiszewska
Structural insights into IMP2 dimerization and RNA binding. bioRxiv : the preprint server for biology (2024)
Christopher C Williams, Jonathan Chuck, Paola Munoz-Tello, Douglas J Kojetin
A tethering mechanism underlies Pin1-catalyzed proline cis-trans isomerization at a noncanonical site. bioRxiv : the preprint server for biology (2024)
Stephen Zorc, Paola Munoz-Tello, Timothy O'Leary, Xiaoyu Yu, Mithun Nag Karadi Giridhar, Althea Hansel-Harris, Stefano Forli, Patrick R Griffin, Douglas J Kojetin, Raktim N Roy, Michalina Janiszewska
Structural insights into IMP2 dimerization and RNA binding. bioRxiv : the preprint server for biology (2024)
Brian MacTavish, Di Zhu, Jinsai Shang, Qianzhen Shao, Zhongyue J Yang, Theodore M Kamenecka, Douglas J Kojetin
Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states. bioRxiv : the preprint server for biology (2024)
Brian MacTavish, Di Zhu, Jinsai Shang, Qianzhen Shao, Zhongyue J Yang, Theodore M Kamenecka, Douglas J Kojetin
Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states. bioRxiv : the preprint server for biology (2024)
Jinsai Shang, Douglas J Kojetin
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ. bioRxiv : the preprint server for biology (2024)
Jinsai Shang, Douglas J Kojetin
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ. bioRxiv : the preprint server for biology (2024)
Christopher C Williams, Jonathan Chuck, Paola Munoz-Tello, Douglas J Kojetin
A tethering mechanism underlies Pin1-catalyzed proline cis-trans isomerization at a noncanonical site. bioRxiv : the preprint server for biology (2024)
Jinsai Shang, Douglas J Kojetin
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ. bioRxiv : the preprint server for biology (2024)
Yuanjun He, Di Zhu, Kevin Greenman, Claudia Ruiz, Jinsai Shang, Qun Lu, Douglas J Kojetin, Robert Drakas, Michael D Cameron, Mike Lizarzaburu, Laura A Solt, Theodore M Kamenecka
Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 ( 34 ) for Autoimmune Disorders. Journal of medicinal chemistry (2023)
Xiaoyu Yu, Jinsai Shang, Douglas J Kojetin
Molecular basis of ligand-dependent Nurr1-RXRα activation. eLife 12 (2023)
Dilani G Gamage, Kamran Melikov, Paola Munoz-Tello, Tanner J Wherley, Leah C Focke, Evgenia Leikina, Elliana Huffman, Jiajie Diao, Douglas J Kojetin, Vikram Prasad, Leonid V Chernomordik, Douglas P Millay
Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion. Proceedings of the National Academy of Sciences of the United States of America 119 (38) (2022)
Nelson E Bruno, Jerome C Nwachukwu, Sathish Srinivasan, Charles C Nettles, Tina Izard, Zhuang Jin, Jason Nowak, Michael D Cameron, Siddaraju V Boregowda, Donald G Phinney, Olivier Elemento, Xu Liu, Eric A Ortlund, Rene Houtman, Diana A Stavreva, Gordon L Hager, Theodore M Kamenecka, Douglas J Kojetin, Kendall W Nettles
Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling. Nature chemical biology 17 (3) (2021)
Mei Lan Chen, Xiangsheng Huang, Hongtao Wang, Courtney Hegner, Yujin Liu, Jinsai Shang, Amber Eliason, Huitian Diao, HaJeung Park, Blake Frey, Guohui Wang, Sarah A Mosure, Laura A Solt, Douglas J Kojetin, Alex Rodriguez-Palacios, Deborah A Schady, Casey T Weaver, Matthew E Pipkin, David D Moore, Mark S Sundrud
CAR directs T cell adaptation to bile acids in the small intestine. Nature 593 (7857) (2021)
Paola Munoz-Tello, Hua Lin, Pasha Khan, Ian Mitchelle S de Vera, Theodore M Kamenecka, Douglas J Kojetin
Correction to Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1. Journal of medicinal chemistry 64 (8) (2021)
Sarah A Mosure, Timothy S Strutzenberg, Jinsai Shang, Paola Munoz-Tello, Laura A Solt, Patrick R Griffin, Douglas J Kojetin
Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ. Science advances 7 (5) (2021)
Paola Munoz-Tello, Hua Lin, Pasha Khan, Ian Mitchelle S de Vera, Theodore M Kamenecka, Douglas J Kojetin
Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1. Journal of medicinal chemistry 63 (24) (2020)
Jinsai Shang, Sarah A Mosure, Jie Zheng, Richard Brust, Jared Bass, Ashley Nichols, Laura A Solt, Patrick R Griffin, Douglas J Kojetin
A molecular switch regulating transcriptional repression and activation of PPARγ. Nature communications 11 (1) (2020)
Sarah A Mosure, Jinsai Shang, Jerome Eberhardt, Richard Brust, Jie Zheng, Patrick R Griffin, Stefano Forli, Douglas J Kojetin
Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone. Journal of medicinal chemistry 62 (4) (2019)
Jinsai Shang, Richard Brust, Sarah A Mosure, Jared Bass, Paola Munoz-Tello, Hua Lin, Travis S Hughes, Miru Tang, Qingfeng Ge, Theodore M Kamenekca, Douglas J Kojetin
Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ. eLife 7 (2018)
Richard Brust, Jinsai Shang, Jakob Fuhrmann, Sarah A Mosure, Jared Bass, Andrew Cano, Zahra Heidari, Ian M Chrisman, Michelle D Nemetchek, Anne-Laure Blayo, Patrick R Griffin, Theodore M Kamenecka, Travis S Hughes, Douglas J Kojetin
A structural mechanism for directing corepressor-selective inverse agonism of PPARγ. Nature communications 9 (1) (2018)
Ian M Chrisman, Michelle D Nemetchek, Ian Mitchelle S de Vera, Jinsai Shang, Zahra Heidari, Yanan Long, Hermes Reyes-Caballero, Rodrigo Galindo-Murillo, Thomas E Cheatham, Anne-Laure Blayo, Youseung Shin, Jakob Fuhrmann, Patrick R Griffin, Theodore M Kamenecka, Douglas J Kojetin, Travis S Hughes
Defining a conformational ensemble that directs activation of PPARγ. Nature communications 9 (1) (2018)
Dipak N Patil, Erumbi S Rangarajan, Scott J Novick, Bruce D Pascal, Douglas J Kojetin, Patrick R Griffin, Tina Izard, Kirill A Martemyanov
Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex. eLife 7 (2018)
William H Hudson, Ian Mitchelle S de Vera, Jerome C Nwachukwu, Emily R Weikum, Austin G Herbst, Qin Yang, David L Bain, Kendall W Nettles, Douglas J Kojetin, Eric A Ortlund
Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements. Nature communications 9 (1) (2018)
Richard Brust, Hua Lin, Jakob Fuhrmann, Alice Asteian, Theodore M Kamenecka, Douglas J Kojetin
Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor. ACS chemical biology 12 (4) (2017)

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Publication Activity (10 Years)

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Douglas J Kojetin