Patrick R Griffin

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 38

Top Topics

Estrogen Receptor

Magnetic Nanoparticles

Structural Basis

Breast Cancer Cells

Top Venues

Nature communications

ACS chemical biology

Science advances

Science (New York, N.Y.)

This page only lists publications with an associated author ORCID identifier.

Publications

Matthew D Mann, Min Wang, Josephine C Ferreon, Michael P Suess, Antrix Jain, Anna Malovannaya, Bruce D Pascal, Raj Kumar, Dean P Edwards, Patrick R Griffin
Structural proteomics defines a sequential priming mechanism for the progesterone receptor. bioRxiv : the preprint server for biology (2024)
Rebecca L Frkic, Jordan L Pederick, Aimee J Horsfall, Blagojce Jovcevski, Elise E Crame, Wioleta Kowalczyk, Tara Louise Pukala, Mi Ra Chang, Jie Zheng, Anne-Laure Blayo, Andrew D Abell, Theodore M Kamenecka, Joshua S Harbort, Jeffery R Harmer, Patrick R Griffin, John B Bruning
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles. ACS chemical biology 18 (5) (2023)
Rebecca L Frkic, Jordan L Pederick, Aimee J Horsfall, Blagojce Jovcevski, Elise E Crame, Wioleta Kowalczyk, Tara Louise Pukala, Mi Ra Chang, Jie Zheng, Anne-Laure Blayo, Andrew D Abell, Theodore M Kamenecka, Joshua S Harbort, Jeffery R Harmer, Patrick R Griffin, John B Bruning
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles. ACS chemical biology 18 (5) (2023)
Timothy R O'Leary, Deepa Balasubramaniam, Kristin Hughes, Denisa Foster, Jeffrey Boyles, Kristina Coleman, Patrick R Griffin
Hydrogen-Deuterium Exchange Epitope Mapping of Glycosylated Epitopes Enabled by Online Immobilized Glycosidase. Analytical chemistry (2023)
Rebecca L Frkic, Jordan L Pederick, Aimee J Horsfall, Blagojce Jovcevski, Elise E Crame, Wioleta Kowalczyk, Tara Louise Pukala, Mi Ra Chang, Jie Zheng, Anne-Laure Blayo, Andrew D Abell, Theodore M Kamenecka, Joshua S Harbort, Jeffery R Harmer, Patrick R Griffin, John B Bruning
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles. ACS chemical biology (2023)
Rebecca L Frkic, Jordan L Pederick, Aimee J Horsfall, Blagojce Jovcevski, Elise E Crame, Wioleta Kowalczyk, Tara Louise Pukala, Mi Ra Chang, Jie Zheng, Anne-Laure Blayo, Andrew D Abell, Theodore M Kamenecka, Joshua S Harbort, Jeffery R Harmer, Patrick R Griffin, John B Bruning
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles. ACS chemical biology 18 (5) (2023)
Mi Ra Chang, Patrick R Griffin
RORβ modulates a gene program that is protective against articular cartilage damage. PloS one 17 (10) (2022)
Edmond R Watson, Scott J Novick, Mary E Matyskiela, Philip P Chamberlain, Andres H de la Peña, Jin-Yi Zhu, Eileen Tran, Patrick R Griffin, Ingrid E Wertz, Gabriel C Lander
Molecular glue CELMoD compounds are regulators of cereblon conformation. Science (New York, N.Y.) 378 (6619) (2022)
Ruchi Yadav, Valentine V Courouble, Sanjay Kumar Dey, Jerry Joe E K Harrison, Jennifer Timm, Jesse B Hopkins, Ryan L Slack, Stefan G Sarafianos, Francesc Xavier Ruiz, Patrick R Griffin, Eddy Arnold
Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro. Science advances 8 (49) (2022)
Daniel Adu-Ampratwum, Yuhan Pan, Pratibha C Koneru, Janet Antwi, Ashley C Hoyte, Jacques J Kessl, Patrick R Griffin, Mamuka Kvaratskhelia, Joanna E Burdette, Ross C Larue
Identification and Optimization of a Novel HIV-1 Integrase Inhibitor. ACS omega 7 (5) (2022)
Guochao Wei, Naseer Iqbal, Valentine V Courouble, Ashwanth C Francis, Parmit Kumar Singh, Arpa Hudait, Arun S Annamalai, Stephanie M Bester, Szu-Wei Huang, Nikoloz Shkriabai, Lorenzo Briganti, Reed Haney, Vineet N KewalRamani, Gregory A Voth, Alan N Engelman, Gregory B Melikyan, Patrick R Griffin, Francisco Asturias, Mamuka Kvaratskhelia
Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection. Nature communications 13 (1) (2022)
Ruchi Yadav, Valentine V Courouble, Sanjay Kumar Dey, Jerry Joe E K Harrison, Jennifer Timm, Jesse B Hopkins, Ryan L Slack, Stefan G Sarafianos, Francesc Xavier Ruiz, Patrick R Griffin, Eddy Arnold
Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro. Science advances 8 (49) (2022)
Michael L Cato, Jeffery L Cornelison, Racheal M Spurlin, Valentine V Courouble, Anamika B Patel, Autumn R Flynn, Alyssa M Johnson, C Denise Okafor, Filipp Frank, Emma H D'Agostino, Patrick R Griffin, Nathan T Jui, Eric A Ortlund
Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket. Journal of medicinal chemistry 65 (9) (2022)
Ruchi Yadav, Valentine V Courouble, Sanjay Kumar Dey, Jerry Joe E K Harrison, Jennifer Timm, Jesse B Hopkins, Ryan L Slack, Stefan G Sarafianos, Francesc Xavier Ruiz, Patrick R Griffin, Eddy Arnold
Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro. Science advances 8 (49) (2022)
Valentine V Courouble, Sanjay Kumar Dey, Ruchi Yadav, Jennifer Timm, Jerry Joe E K Harrison, Francesc X Ruiz, Eddy Arnold, Patrick R Griffin
Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics. Journal of the American Society for Mass Spectrometry 32 (7) (2021)
Dipak N Patil, Shikha Singh, Thibaut Laboute, Timothy S Strutzenberg, Xingyu Qiu, Di Wu, Scott J Novick, Carol V Robinson, Patrick R Griffin, John F Hunt, Tina Izard, Appu K Singh, Kirill A Martemyanov
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex. Science (New York, N.Y.) (2021)
Jian Min, Jerome C Nwachukwu, Charles K Min, Jacqline W Njeri, Sathish Srinivasan, Erumbi S Rangarajan, Charles C Nettles, Valeria Sanabria Guillen, Yvonne S Ziegler, Shunchao Yan, Kathryn E Carlson, Yingwei Hou, Sung Hoon Kim, Scott J Novick, Bruce D Pascal, Rene Houtman, Patrick R Griffin, Tina Izard, Benita S Katzenellenbogen, John A Katzenellenbogen, Kendall W Nettles
Dual-mechanism estrogen receptor inhibitors. Proceedings of the National Academy of Sciences of the United States of America 118 (35) (2021)
Laszlo Radnai, Matthew Surman, Madalyn Hafenbreidel, Erica J Young, Rebecca F Stremel, Li Lin, Bilel Bdiri, Paolo Pasetto, Xiaomin Jin, Mackenzie Geedy, Joni-Rae Partridge, Aagam Patel, Michael Conlon, James R Sellers, Michael D Cameron, Gavin Rumbaugh, Patrick R Griffin, Theodore M Kamenecka, Courtney A Miller
Discovery of Selective Inhibitors for In Vitro and In Vivo Interrogation of Skeletal Myosin II. ACS chemical biology 16 (11) (2021)
Hua Lin, Kfir Sharabi, Li Lin, Claudia Ruiz, Di Zhu, Michael D Cameron, Scott J Novick, Patrick R Griffin, Pere Puigserver, Theodore M Kamenecka
Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production. Journal of medicinal chemistry 64 (2) (2021)
Sarah A Mosure, Timothy S Strutzenberg, Jinsai Shang, Paola Munoz-Tello, Laura A Solt, Patrick R Griffin, Douglas J Kojetin
Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ. Science advances 7 (5) (2021)
Mia Shin, Edmond R Watson, Albert S Song, Jeffrey T Mindrebo, Scott J Novick, Patrick R Griffin, R Luke Wiseman, Gabriel C Lander
Structures of the human LONP1 protease reveal regulatory steps involved in protease activation. Nature communications 12 (1) (2021)
Shanwen Zhang, Qian Ren, Scott J Novick, Timothy S Strutzenberg, Patrick R Griffin, Huan Bao
One-step construction of circularized nanodiscs using SpyCatcher-SpyTag. Nature communications 12 (1) (2021)
Litao Sun, Na Wei, Bernhard Kuhle, David Blocquel, Scott J Novick, Zaneta Matuszek, Huihao Zhou, Weiwei He, Jingjing Zhang, Thomas Weber, Rita Horvath, Philippe Latour, Tao Pan, Paul Schimmel, Patrick R Griffin, Xiang-Lei Yang
CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS. Proceedings of the National Academy of Sciences of the United States of America 118 (13) (2021)
Yan Yan, Somnath Mukherjee, Kaleeckal G Harikumar, Timothy S Strutzenberg, X Edward Zhou, Kelly Suino-Powell, Ting-Hai Xu, Ryan D Sheldon, Jared Lamp, Joseph S Brunzelle, Katarzyna Radziwon, Abigail E Ellis, Scott J Novick, Irving E Vega, Russell G Jones, Laurence J Miller, H Eric Xu, Patrick R Griffin, Anthony A Kossiakoff, Karsten Melcher
Structure of an AMPK complex in an inactive, ATP-bound state. Science (New York, N.Y.) 373 (6553) (2021)
Albert T Lam, Xiao-Nan Zhang, Valentine V Courouble, Timothy S Strutzenberg, Hua Pei, Bangyan L Stiles, Stan G Louie, Patrick R Griffin, Yong Zhang
A Bifunctional NAD+ for Profiling Poly-ADP-Ribosylation-Dependent Interacting Proteins. ACS chemical biology 16 (2) (2021)
Jie Zheng, Timothy S Strutzenberg, Adrian Reich, Venkatasubramanian Dharmarajan, Bruce D Pascal, Gogce C Crynen, Scott J Novick, Ruben D Garcia-Ordonez, Patrick R Griffin
Comparative Analysis of Cleavage Specificities of Immobilized Porcine Pepsin and Nepenthesin II under Hydrogen/Deuterium Exchange Conditions. Analytical chemistry 92 (16) (2020)
Wallace H Liu, Jie Zheng, Jessica L Feldman, Mark A Klein, Vyacheslav I Kuznetsov, Craig L Peterson, Patrick R Griffin, John M Denu
Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6. Nature communications 11 (1) (2020)
Stephanie M Bester, Guochao Wei, Haiyan Zhao, Daniel Adu-Ampratwum, Naseer Iqbal, Valentine V Courouble, Ashwanth C Francis, Arun S Annamalai, Parmit Kumar Singh, Nikoloz Shkriabai, Peter van Blerkom, James H Morrison, Eric M Poeschla, Alan N Engelman, Gregory B Melikyan, Patrick R Griffin, Joanna E Burdette, Francisco J Asturias, Mamuka Kvaratskhelia
Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science (New York, N.Y.) 370 (6514) (2020)
Jinsai Shang, Sarah A Mosure, Jie Zheng, Richard Brust, Jared Bass, Ashley Nichols, Laura A Solt, Patrick R Griffin, Douglas J Kojetin
A molecular switch regulating transcriptional repression and activation of PPARγ. Nature communications 11 (1) (2020)
Jinsai Shang, Richard Brust, Patrick R Griffin, Theodore M Kamenecka, Douglas J Kojetin
Quantitative structural assessment of graded receptor agonism. Proceedings of the National Academy of Sciences of the United States of America 116 (44) (2019)
Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin
Correction: HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists. eLife 8 (2019)
Sarah A Mosure, Jinsai Shang, Jerome Eberhardt, Richard Brust, Jie Zheng, Patrick R Griffin, Stefano Forli, Douglas J Kojetin
Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone. Journal of medicinal chemistry 62 (4) (2019)
Mi Ra Chang, Anthony Ciesla, Timothy S Strutzenberg, Scott J Novick, Yuanjun He, Ruben D Garcia-Ordonez, Rebecca L Frkic, John B Bruning, Theodore M Kamenecka, Patrick R Griffin
Unique Polypharmacology Nuclear Receptor Modulator Blocks Inflammatory Signaling Pathways. ACS chemical biology 14 (5) (2019)
James E Longbotham, Cynthia M Chio, Venkatasubramanian Dharmarajan, Michael J Trnka, Idelisse Ortiz Torres, Devrishi Goswami, Karen Ruiz, Alma L Burlingame, Patrick R Griffin, Danica Galonić Fujimori
Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling. Nature communications 10 (1) (2019)
Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin
HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists. eLife 8 (2019)
Zahra Heidari, Ian M Chrisman, Michelle D Nemetchek, Scott J Novick, Anne-Laure Blayo, Trey Patton, Desiree E Mendes, Philippe Diaz, Theodore M Kamenecka, Patrick R Griffin, Travis S Hughes
Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ. Nature communications 10 (1) (2019)
Sean W Fanning, Rinath Jeselsohn, Venkatasubramanian Dharmarajan, Christopher G Mayne, Mostafa Karimi, Gilles Buchwalter, René Houtman, Weiyi Toy, Colin E Fowler, Ross Han, Muriel Lainé, Kathryn E Carlson, Teresa A Martin, Jason Nowak, Jerome C Nwachukwu, David J Hosfield, Sarat Chandarlapaty, Emad Tajkhorshid, Kendall W Nettles, Patrick R Griffin, Yang Shen, John A Katzenellenbogen, Myles A Brown, Geoffrey L Greene
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. eLife 7 (2018)
Jie Zheng, Chen Wang, Mi Ra Chang, Swapnil C Devarkar, Brandon Schweibenz, Gogce C Crynen, Ruben D Garcia-Ordonez, Bruce D Pascal, Scott J Novick, Smita S Patel, Joseph Marcotrigiano, Patrick R Griffin
HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity. Nature communications 9 (1) (2018)