Dwight V Nissley

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 29

Top Topics

Molecular Dynamics Simulations

Endoplasmic Reticulum

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Analytical chemistry

Communications biology

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Gabriel Cornilescu, Lakshman Bindu, Louise M Sternicki, Fa-An Chao, William K Gillette, Nicole Fer, John Colombus, Jean Castillo, Pedro Andrade Bonilla, Que N Van, Erik Larsen, Min Hong, William Burgan, Thomas Turbyville, Dwight V Nissley, Miaomiao Liu, Ronald J Quinn, Frantz L Jean-Francois
Natural Product Graveoline Modulates Kirsten Rat Sarcoma Viral Oncogene Homologue (KRAS) Membrane Association: Insights from Advanced Spectroscopic Studies. ACS pharmacology & translational science 7 (7) (2024)
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Stephanie R T Widmeyer, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry (2024)
Gabriel Cornilescu, Lakshman Bindu, Louise M Sternicki, Fa-An Chao, William K Gillette, Nicole Fer, John Colombus, Jean Castillo, Pedro Andrade Bonilla, Que N Van, Erik Larsen, Min Hong, William Burgan, Thomas Turbyville, Dwight V Nissley, Miaomiao Liu, Ronald J Quinn, Frantz L Jean-Francois
Natural Product Graveoline Modulates Kirsten Rat Sarcoma Viral Oncogene Homologue (KRAS) Membrane Association: Insights from Advanced Spectroscopic Studies. ACS pharmacology & translational science 7 (7) (2024)
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Grace M Scheidemantle, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry 96 (13) (2024)
Lorenzo I Finci, Mayukh Chakrabarti, Gulcin Gulten, Joseph Finney, Carissa Grose, Tara Fox, Renbin Yang, Dwight V Nissley, Frank McCormick, Dominic Esposito, Trent E Balius, Dhirendra K Simanshu
Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Communications biology 7 (1) (2024)
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Grace M Scheidemantle, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry 96 (13) (2024)
Lorenzo I Finci, Mayukh Chakrabarti, Gulcin Gulten, Joseph Finney, Carissa Grose, Tara Fox, Renbin Yang, Dwight V Nissley, Frank McCormick, Dominic Esposito, Trent E Balius, Dhirendra K Simanshu
Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Communications biology 7 (1) (2024)
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Grace M Scheidemantle, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry 96 (13) (2024)
Lorenzo I Finci, Mayukh Chakrabarti, Gulcin Gulten, Joseph Finney, Carissa Grose, Tara Fox, Renbin Yang, Dwight V Nissley, Frank McCormick, Dominic Esposito, Trent E Balius, Dhirendra K Simanshu
Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Communications biology 7 (1) (2024)
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Grace M Scheidemantle, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry 96 (13) (2024)
Matthew J Whitley, Timothy H Tran, Megan Rigby, Ming Yi, Srisathiyanarayanan Dharmaiah, Timothy J Waybright, Nitya Ramakrishnan, Shelley Perkins, Troy Taylor, Simon Messing, Dominic Esposito, Dwight V Nissley, Frank McCormick, Andrew G Stephen, Thomas J Turbyville, Gabriel Cornilescu, Dhirendra K Simanshu
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties. Science advances 10 (7) (2024)
Matthew J Whitley, Timothy H Tran, Megan Rigby, Ming Yi, Srisathiyanarayanan Dharmaiah, Timothy J Waybright, Nitya Ramakrishnan, Shelley Perkins, Troy Taylor, Simon Messing, Dominic Esposito, Dwight V Nissley, Frank McCormick, Andrew G Stephen, Thomas J Turbyville, Gabriel Cornilescu, Dhirendra K Simanshu
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties. Science advances 10 (7) (2024)
Matthew J Whitley, Timothy H Tran, Megan Rigby, Ming Yi, Srisathiyanarayanan Dharmaiah, Timothy J Waybright, Nitya Ramakrishnan, Shelley Perkins, Troy Taylor, Simon Messing, Dominic Esposito, Dwight V Nissley, Frank McCormick, Andrew G Stephen, Thomas J Turbyville, Gabriel Cornilescu, Dhirendra K Simanshu
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties. Science advances 10 (7) (2024)
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Grace M Scheidemantle, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry 96 (13) (2024)
Lorenzo I Finci, Mayukh Chakrabarti, Gulcin Gulten, Joseph Finney, Carissa Grose, Tara Fox, Renbin Yang, Dwight V Nissley, Frank McCormick, Dominic Esposito, Trent E Balius, Dhirendra K Simanshu
Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Communications biology 7 (1) (2024)
Helgi I Ingólfsson, Harsh Bhatia, Fikret Aydin, Tomas Oppelstrup, Cesar A López, Liam G Stanton, Timothy S Carpenter, Sergio Wong, Francesco Di Natale, Xiaohua Zhang, Joseph Y Moon, Christopher B Stanley, Joseph R Chavez, Kien Nguyen, Gautham Dharuman, Violetta Burns, Rebika Shrestha, Debanjan Goswami, Gulcin Gulten, Que N Van, Arvind Ramanathan, Brian Van Essen, Nicolas W Hengartner, Andrew G Stephen, Thomas Turbyville, Peer-Timo Bremer, Sandrasegaram Gnanakaran, James N Glosli, Felice C Lightstone, Dwight V Nissley, Frederick H Streitz
Machine Learning-Driven Multiscale Modeling: Bridging the Scales with a Next-Generation Simulation Infrastructure. Journal of chemical theory and computation (2023)
Fa-An Chao, Albert H Chan, Srisathiyanarayanan Dharmaiah, Charles D Schwieters, Timothy H Tran, Troy Taylor, Nitya Ramakrishnan, Dominic Esposito, Dwight V Nissley, Frank McCormick, Dhirendra K Simanshu, Gabriel Cornilescu
Reduced dynamic complexity allows structure elucidation of an excited state of KRAS G13D . Communications biology 6 (1) (2023)
Lucy C Young, Ruby Goldstein de Salazar, Sae-Won Han, Zi Yi Stephanie Huang, Alan Merk, Matthew Drew, Joseph Darling, Vanessa E Wall, Reinhard Grisshammer, Alice Cheng, Madeline R Allison, Matthew J Sale, Dwight V Nissley, Dominic Esposito, Jana Ognjenovic, Frank McCormick
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Proceedings of the National Academy of Sciences of the United States of America 120 (5) (2023)
Lucy C Young, Ruby Goldstein de Salazar, Sae-Won Han, Zi Yi Stephanie Huang, Alan Merk, Matthew Drew, Joseph Darling, Vanessa E Wall, Reinhard Grisshammer, Alice Cheng, Madeline R Allison, Matthew J Sale, Dwight V Nissley, Dominic Esposito, Jana Ognjenovic, Frank McCormick
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Proceedings of the National Academy of Sciences of the United States of America 120 (5) (2023)
Lucy C Young, Ruby Goldstein de Salazar, Sae-Won Han, Zi Yi Stephanie Huang, Alan Merk, Matthew Drew, Joseph Darling, Vanessa E Wall, Reinhard Grisshammer, Alice Cheng, Madeline R Allison, Matthew J Sale, Dwight V Nissley, Dominic Esposito, Jana Ognjenovic, Frank McCormick
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Proceedings of the National Academy of Sciences of the United States of America 120 (5) (2023)
Lucy C Young, Ruby Goldstein de Salazar, Sae-Won Han, Zi Yi Stephanie Huang, Alan Merk, Matthew Drew, Joseph Darling, Vanessa E Wall, Reinhard Grisshammer, Alice Cheng, Madeline R Allison, Matthew J Sale, Dwight V Nissley, Dominic Esposito, Jana Ognjenovic, Frank McCormick
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Proceedings of the National Academy of Sciences of the United States of America 120 (5) (2023)
Cesar A López, Xiaohua Zhang, Fikret Aydin, Rebika Shrestha, Que N Van, Christopher B Stanley, Timothy S Carpenter, Kien Nguyen, Lara A Patel, De Chen, Violetta Burns, Nicolas W Hengartner, Tyler J E Reddy, Harsh Bhatia, Francesco Di Natale, Timothy H Tran, Albert H Chan, Dhirendra K Simanshu, Dwight V Nissley, Frederick H Streitz, Andrew G Stephen, Thomas J Turbyville, Felice C Lightstone, Sandrasegaram Gnanakaran, Helgi I Ingólfsson, Chris Neale
Asynchronous Reciprocal Coupling of Martini 2.2 Coarse-Grained and CHARMM36 All-Atom Simulations in an Automated Multiscale Framework. Journal of chemical theory and computation 18 (8) (2022)
Daniel A Bonsor, Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing, Lorenzo I Finci, Dwight V Nissley, Frank McCormick, Dominic Esposito, Pablo Rodriguez-Viciana, Andrew G Stephen, Dhirendra K Simanshu
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Nature structural & molecular biology 29 (10) (2022)
Helgi I Ingólfsson, Chris Neale, Timothy S Carpenter, Rebika Shrestha, César A López, Timothy H Tran, Tomas Oppelstrup, Harsh Bhatia, Liam G Stanton, Xiaohua Zhang, Shiv Sundram, Francesco Di Natale, Animesh Agarwal, Gautham Dharuman, Sara I L Kokkila Schumacher, Thomas Turbyville, Gulcin Gulten, Que N Van, Debanjan Goswami, Frantz Jean-Francois, Constance Agamasu, De Chen, Jeevapani J Hettige, Timothy Travers, Sumantra Sarkar, Michael P Surh, Yue Yang, Adam Moody, Shusen Liu, Brian C Van Essen, Arthur F Voter, Arvind Ramanathan, Nicolas W Hengartner, Dhirendra K Simanshu, Andrew G Stephen, Peer-Timo Bremer, Sandrasegaram Gnanakaran, James N Glosli, Felice C Lightstone, Frank McCormick, Dwight V Nissley, Frederick H Streitz
Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins. Proceedings of the National Academy of Sciences of the United States of America 119 (1) (2022)
Fa-An Chao, Srisathiyanarayanan Dharmaiah, Troy Taylor, Simon Messing, William Gillette, Dominic Esposito, Dwight V Nissley, Frank McCormick, Robert Andrew Byrd, Dhirendra K Simanshu, Gabriel Cornilescu
Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics. Journal of the American Chemical Society 144 (9) (2022)
Lick Pui Lai, Nicole Fer, William Burgan, Vanessa E Wall, Bingfang Xu, Daniel Soppet, Dominic Esposito, Dwight V Nissley, Frank McCormick
Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors. Proceedings of the National Academy of Sciences of the United States of America 119 (5) (2022)
Timothy H Tran, Albert H Chan, Lucy C Young, Lakshman Bindu, Chris Neale, Simon Messing, Srisathiyanarayanan Dharmaiah, Troy Taylor, John-Paul Denson, Dominic Esposito, Dwight V Nissley, Andrew G Stephen, Frank McCormick, Dhirendra K Simanshu
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nature communications 12 (1) (2021)
Que N Van, César A López, Marco Tonelli, Troy Taylor, Ben Niu, Christopher B Stanley, Debsindhu Bhowmik, Timothy H Tran, Peter J Frank, Simon Messing, Patrick A Alexander, Daniel Scott, Xiaoying Ye, Matthew Drew, Oleg Chertov, Mathias Lösche, Arvind Ramanathan, Michael L Gross, Nicolas W Hengartner, William M Westler, John L Markley, Dhirendra K Simanshu, Dwight V Nissley, William K Gillette, Dominic Esposito, Frank McCormick, Sandrasegaram Gnanakaran, Frank Heinrich, Andrew G Stephen
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America 117 (39) (2020)
Hong Liang, Huanwen Mu, Frantz Jean-Francois, Bindu Lakshman, Suparna Sarkar-Banerjee, Yinyin Zhuang, Yongpeng Zeng, Weibo Gao, Ana Maria Zaske, Dwight V Nissley, Alemayehu A Gorfe, Wenting Zhao, Yong Zhou
Membrane curvature sensing of the lipid-anchored K-Ras small GTPase. Life science alliance 2 (4) (2019)