Michelle R Arkin (Michelle Arkin)

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 38

Top Topics

Toxoplasma Gondii

Crystal Structure

Endoplasmic Reticulum

Top Venues

Journal of the American Chemical Society

Analytical chemistry

Chembiochem : a European journal of chemical biology

RSC chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Stephanie R T Widmeyer, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry (2024)
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Grace M Scheidemantle, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry 96 (13) (2024)
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Grace M Scheidemantle, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry 96 (13) (2024)
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Grace M Scheidemantle, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry 96 (13) (2024)
Bente A Somsen, Peter J Cossar, Michelle R Arkin, Luc Brunsveld, Christian Ottmann
14-3-3 Protein-Protein Interactions: From Mechanistic Understanding to Their Small-Molecule Stabilization. Chembiochem : a European journal of chemical biology (2024)
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Grace M Scheidemantle, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry 96 (13) (2024)
Bente A Somsen, Peter J Cossar, Michelle R Arkin, Luc Brunsveld, Christian Ottmann
14-3-3 Protein-Protein Interactions: From Mechanistic Understanding to Their Small-Molecule Stabilization. Chembiochem : a European journal of chemical biology 25 (14) (2024)
Bente A Somsen, Peter J Cossar, Michelle R Arkin, Luc Brunsveld, Christian Ottmann
14-3-3 Protein-Protein Interactions: From Mechanistic Understanding to Their Small-Molecule Stabilization. Chembiochem : a European journal of chemical biology 25 (14) (2024)
Robert A D'Ippolito, Dana Rabara, Maria Abreu Blanco, Emily Alberico, Matthew R Drew, Nitya Ramakrishnan, Dara Sontan, Stephanie R T Widmeyer, Grace M Scheidemantle, Simon Messing, David Turner, Michelle R Arkin, Anna E Maciag, Andrew G Stephen, Dominic Esposito, Frank McCormick, Dwight V Nissley, Caroline J DeHart
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Analytical chemistry 96 (13) (2024)
Ziwen Jiang, Yu-Hsuan Kuo, Michelle R Arkin
Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation. Journal of the American Chemical Society (2023)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society 145 (18) (2023)
Takaya Togo, Linh Tram, Laura G Denton, Xochina ElHilali-Pollard, Jun Gu, Jinglei Jiang, Chenglei Liu, Yan Zhao, Yanlong Zhao, Yinzhe Zheng, Yunping Zheng, Jingjing Yang, Panpan Fan, Michelle R Arkin, Harri Härmä, Deqian Sun, Stacie S Canan, Steven E Wheeler, Adam R Renslo
Systematic Study of Heteroarene Stacking Using a Congeneric Set of Molecular Glues for Procaspase-6. Journal of medicinal chemistry (2023)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society 145 (18) (2023)
Bente A Somsen, Rick J C Schellekens, Carlo J A Verhoef, Michelle R Arkin, Christian Ottmann, Peter J Cossar, Luc Brunsveld
Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. Journal of the American Chemical Society (2023)
Dyana N Kenanova, Emira J Visser, Johanna M Virta, Eline Sijbesma, Federica Centorrino, Holly R Vickery, Mengqi Zhong, R Jeffrey Neitz, Luc Brunsveld, Christian Ottmann, Michelle R Arkin
A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. ACS central science 9 (5) (2023)
Gloria Ortiz, James E Longbotham, Sophia L Qin, Meng Yao Zhang, Gregory M Lee, R Jeffrey Neitz, Mark J S Kelly, Michelle R Arkin, Danica Galonić Fujimori
Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening. RSC chemical biology 5 (3) (2023)
Julian R Braxton, Chad R Altobelli, Maxwell R Tucker, Eric Tse, Aye C Thwin, Michelle R Arkin, Daniel R Southworth
The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. bioRxiv : the preprint server for biology (2023)
Ziwen Jiang, Yu-Hsuan Kuo, Michelle R Arkin
Synthetic autophagy receptor. Autophagy (2023)
Markella Konstantinidou, Emira J Visser, Edmee Vandenboorn, Sheng Chen, Priyadarshini Jaishankar, Maurits Overmans, Shubhankar Dutta, R Jeffrey Neitz, Adam R Renslo, Christian Ottmann, Luc Brunsveld, Michelle R Arkin
Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments. Journal of the American Chemical Society (2023)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society 145 (18) (2023)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society (2023)
Gloria Ortiz, James E Longbotham, Sophia L Qin, Meng Yao Zhang, Gregory M Lee, R Jeffrey Neitz, Mark J S Kelly, Michelle R Arkin, Danica Galonić Fujimori
Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening. RSC chemical biology 5 (3) (2023)
Julian R Braxton, Chad R Altobelli, Maxwell R Tucker, Eric Tse, Aye C Thwin, Michelle R Arkin, Daniel R Southworth
The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nature structural & molecular biology (2023)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society 145 (18) (2023)
Kurt S Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K Leung, Raymond A Ng, Andrew J Ambrose, Yinyan Tang, Michelle R Arkin, Adam R Renslo
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society 145 (18) (2023)
Panos Theofilas, Antonia M H Piergies, Ian Oh, Yoo Bin Lee, Song Hua Li, Felipe L Pereira, Cathrine Petersen, Alexander J Ehrenberg, Rana A Eser, Andrew J Ambrose, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, Willian W Seeley, Bruce L Miller, Michelle R Arkin, Lea Tenenholz Grinberg
Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: Diagnostic and therapeutic implications. Neuropathology and applied neurobiology 48 (5) (2022)
Yinyan Tang, Amber Kay, Ziwen Jiang, Michelle R Arkin
LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface. Biochemistry 61 (21) (2022)
Megan L Koleske, Gregory McInnes, Julia E H Brown, Neil Thomas, Keino Hutchinson, Marcus Y Chin, Antoine Koehl, Michelle R Arkin, Avner Schlessinger, Renata C Gallagher, Yun S Song, Russ B Altman, Kathleen M Giacomini
Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency. Proceedings of the National Academy of Sciences of the United States of America 119 (46) (2022)
Marcus Y Chin, Kean-Hooi Ang, Julia Davies, Carolina Alquezar, Virginia G Garda, Brendan Rooney, Kun Leng, Martin Edward Kampmann, Michelle R Arkin, Aimee W Kao
Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model. ACS chemical neuroscience 13 (10) (2022)
Ziwen Jiang, Yu-Hsuan Kuo, Mengqi Zhong, Jianchao Zhang, Xin X Zhou, Lijuan Xing, James A Wells, Yanzhuang Wang, Michelle R Arkin
Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein-Protein Interactions. Journal of the American Chemical Society 144 (29) (2022)
Eline Sijbesma, Kenneth K Hallenbeck, Sebastian A Andrei, Reanne R Rust, Joris M C Adriaans, Luc Brunsveld, Michelle R Arkin, Christian Ottmann
Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. ACS medicinal chemistry letters 12 (6) (2021)
Marcus Y Chin, Anand R Patwardhan, Kean-Hooi Ang, Austin L Wang, Carolina Alquezar, Mackenzie Welch, Phi T Nguyen, Michael Grabe, Anna V Molofsky, Michelle R Arkin, Aimee W Kao
Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH. ACS sensors 6 (6) (2021)
Andrew S Mendiola, Jae Kyu Ryu, Sophia Bardehle, Anke Meyer-Franke, Kenny Kean-Hooi Ang, Chris Wilson, Kim M Baeten, Kristina Hanspers, Mario Merlini, Sean Thomas, Mark A Petersen, Alexander G Williams, Reuben Thomas, Victoria A Rafalski, Rosa Meza-Acevedo, Reshmi Tognatta, Zhaoqi Yan, Samuel J Pfaff, Michael R Machado, Catherine Bedard, Pamela E Rios Coronado, Xiqian Jiang, Jin Wang, Michael A Pleiss, Ari J Green, Scott S Zamvil, Alexander R Pico, Benoit G Bruneau, Michelle R Arkin, Katerina Akassoglou
Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nature immunology 21 (5) (2020)
João Leandro, Susmita Khamrui, Hui Wang, Chalada Suebsuwong, Natalia S Nemeria, Khoi Huynh, Moses Moustakim, Cody Secor, May Wang, Tetyana Dodatko, Brandon Stauffer, Christopher G Wilson, Chunli Yu, Michelle R Arkin, Frank Jordan, Roberto Sanchez, Robert J DeVita, Michael B Lazarus, Sander M Houten
Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex. ACS chemical biology 15 (8) (2020)
Steven Chen, Brian M Suzuki, Jakob Dohrmann, Rahul Singh, Michelle R Arkin, Conor R Caffrey
A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery. Communications biology 3 (1) (2020)
Eline Sijbesma, Bente A Somsen, Galen P Miley, Iris A Leijten-van de Gevel, Luc Brunsveld, Michelle R Arkin, Christian Ottmann
Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. ACS chemical biology 15 (12) (2020)
Xavier Guillory, Madita Wolter, Seppe Leysen, João Filipe Neves, Ave Kuusk, Sylvia Genet, Bente Somsen, John Kenneth Morrow, Emma Rivers, Lotte van Beek, Joe Patel, Robert Goodnow, Heike Schoenherr, Nathan Fuller, Qing Cao, Richard G Doveston, Luc Brunsveld, Michelle R Arkin, Paola Castaldi, Helen Boyd, Isabelle Landrieu, Hongming Chen, Christian Ottmann
Fragment-based Differential Targeting of PPI Stabilizer Interfaces. Journal of medicinal chemistry 63 (13) (2020)
Eline Sijbesma, Kenneth K Hallenbeck, Seppe Leysen, Pim J de Vink, Lukasz Skóra, Wolfgang Jahnke, Luc Brunsveld, Michelle R Arkin, Christian Ottmann
Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. Journal of the American Chemical Society 141 (8) (2019)