Frances H Arnold (Frances Arnold)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 80

Top Venues

Journal of the American Chemical Society

Angewandte Chemie (International ed. in English)

ACS central science

ACS synthetic biology

California Institute of Technology

University of California Berkeley (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

California Institute of Technology

United States

Linus Pauling Professor of Chemical Engineering, Bioengineering, and Biochemistry :: Division of Chemistry and Chemical Engineering

California Institute of Technology

United States

Director, Donna and Benjamin M. Rosen Bioengineering Center

California Institute of Technology

United States

Dick and Barbara Dickinson Professor of Chemical Engineering, Bioengineering and Biochemistry :: Division of Chemistry and Chemical Engineering

California Institute of Technology

United States

Professor of Chemical Engineering and Biochemistry :: Division of Chemistry and Chemical Engineering

California Institute of Technology

United States

Professor of Chemical Engineering :: Division of Chemistry and Chemical Engineering

California Institute of Technology

United States

Associate Professor of Chemical Engineering :: Division of Chemistry and Chemical Engineering

California Institute of Technology

United States

Assistant Professor of Chemical Engineering :: Division of Chemistry and Chemical Engineering

California Institute of Technology

United States

Visiting Associate :: Division of Chemistry and Chemical Engineering

University of California Berkeley

United States

Research Fellow :: Department of Chemistry

Solar Energy Research Institute

United States

Research Engineer

Education History

University of California Berkeley

United States

PHD :: Chemical Engineering

Princeton University

United States

BSC :: Mechanical and Aerospace Engineering

Publications

Daniel J Wackelin, Runze Mao, Kathleen M Sicinski, Yutao Zhao, Anuvab Das, Kai Chen, Frances H Arnold
Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society 146 (2) (2024)
Patrick J Almhjell, Kadina E Johnston, Nicholas J Porter, Jennifer L Kennemur, Vignesh C Bhethanabotla, Julie Ducharme, Frances H Arnold
The β-subunit of tryptophan synthase is a latent tyrosine synthase. Nature chemical biology 20 (8) (2024)
Kadina E Johnston, Patrick J Almhjell, Ella J Watkins, Grace Liu, Nicholas J Porter, Jason Yang, Frances H Arnold
A combinatorially complete epistatic fitness landscape in an enzyme active site. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Jason Yang, Julie Ducharme, Kadina E Johnston, Francesca-Zhoufan Li, Yisong Yue, Frances H Arnold
Correction to "DeCOIL: Optimization of Degenerate Codon Libraries for Machine Learning-Assisted Protein Engineering". ACS synthetic biology (2024)
Patrick J Almhjell, Kadina E Johnston, Nicholas J Porter, Jennifer L Kennemur, Vignesh C Bhethanabotla, Julie Ducharme, Frances H Arnold
The β-subunit of tryptophan synthase is a latent tyrosine synthase. Nature chemical biology 20 (8) (2024)
Patrick J Almhjell, Kadina E Johnston, Nicholas J Porter, Jennifer L Kennemur, Vignesh C Bhethanabotla, Julie Ducharme, Frances H Arnold
The β-subunit of tryptophan synthase is a latent tyrosine synthase. Nature chemical biology 20 (8) (2024)
Daniel J Wackelin, Runze Mao, Kathleen M Sicinski, Yutao Zhao, Anuvab Das, Kai Chen, Frances H Arnold
Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society 146 (2) (2024)
Deirdre Hanley, Zi-Qi Li, Shilong Gao, Scott C Virgil, Frances H Arnold, Edwin Alfonzo
Stereospecific Enzymatic Conversion of Boronic Acids to Amines. Journal of the American Chemical Society 146 (28) (2024)
Torben Rogge, Qingyang Zhou, Nicholas J Porter, Frances H Arnold, Kendall N Houk
Iron Heme Enzyme-Catalyzed Cyclopropanations with Diazirines as Carbene Precursors: Computational Explorations of Diazirine Activation and Cyclopropanation Mechanism. Journal of the American Chemical Society 146 (5) (2024)
Anuvab Das, Shilong Gao, Ravi G Lal, Madeline H Hicks, Paul H Oyala, Frances H Arnold
Reaction Discovery Using Spectroscopic Insights from an Enzymatic C-H Amination Intermediate. Journal of the American Chemical Society 146 (30) (2024)
Anuvab Das, Shilong Gao, Ravi G Lal, Madeline H Hicks, Paul H Oyala, Frances H Arnold
Reaction Discovery Using Spectroscopic Insights from an Enzymatic C-H Amination Intermediate. Journal of the American Chemical Society (2024)
Jason Yang, Julie Ducharme, Kadina E Johnston, Francesca-Zhoufan Li, Yisong Yue, Frances H Arnold
Correction to "DeCOIL: Optimization of Degenerate Codon Libraries for Machine Learning-Assisted Protein Engineering". ACS synthetic biology 13 (2) (2024)
Daniel J Wackelin, Runze Mao, Kathleen M Sicinski, Yutao Zhao, Anuvab Das, Kai Chen, Frances H Arnold
Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society 146 (2) (2024)
Nicholas S Sarai, Tyler J Fulton, Ryen L O'Meara, Kadina E Johnston, Sabine Brinkmann-Chen, Ryan R Maar, Ron E Tecklenburg, John M Roberts, Jordan C T Reddel, Dimitris E Katsoulis, Frances H Arnold
Directed evolution of enzymatic silicon-carbon bond cleavage in siloxanes. Science (New York, N.Y.) 383 (6681) (2024)
Deirdre Hanley, Zi-Qi Li, Shilong Gao, Scott C Virgil, Frances H Arnold, Edwin Alfonzo
Stereospecific Enzymatic Conversion of Boronic Acids to Amines. Journal of the American Chemical Society (2024)
Patrick J Almhjell, Kadina E Johnston, Nicholas J Porter, Jennifer L Kennemur, Vignesh C Bhethanabotla, Julie Ducharme, Frances H Arnold
The β-subunit of tryptophan synthase is a latent tyrosine synthase. Nature chemical biology (2024)
Daniel J Wackelin, Runze Mao, Kathleen M Sicinski, Yutao Zhao, Anuvab Das, Kai Chen, Frances H Arnold
Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society 146 (2) (2024)
Torben Rogge, Qingyang Zhou, Nicholas J Porter, Frances H Arnold, Kendall N Houk
Iron Heme Enzyme-Catalyzed Cyclopropanations with Diazirines as Carbene Precursors: Computational Explorations of Diazirine Activation and Cyclopropanation Mechanism. Journal of the American Chemical Society 146 (5) (2024)
Deirdre Hanley, Zi-Qi Li, Shilong Gao, Scott C Virgil, Frances H Arnold, Edwin Alfonzo
Stereospecific Enzymatic Conversion of Boronic Acids to Amines. Journal of the American Chemical Society 146 (28) (2024)
Daniel J Wackelin, Runze Mao, Kathleen M Sicinski, Yutao Zhao, Anuvab Das, Kai Chen, Frances H Arnold
Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society 146 (2) (2024)
Jason Yang, Francesca-Zhoufan Li, Frances H Arnold
Opportunities and Challenges for Machine Learning-Assisted Enzyme Engineering. ACS central science 10 (2) (2024)
Torben Rogge, Qingyang Zhou, Nicholas J Porter, Frances H Arnold, Kendall N Houk
Iron Heme Enzyme-Catalyzed Cyclopropanations with Diazirines as Carbene Precursors: Computational Explorations of Diazirine Activation and Cyclopropanation Mechanism. Journal of the American Chemical Society (2024)
Kadina E Johnston, Patrick J Almhjell, Ella J Watkins, Grace Liu, Nicholas J Porter, Jason Yang, Frances H Arnold
A combinatorially complete epistatic fitness landscape in an enzyme active site. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Kadina E Johnston, Patrick J Almhjell, Ella J Watkins, Grace Liu, Nicholas J Porter, Jason Yang, Frances H Arnold
A combinatorially complete epistatic fitness landscape in an enzyme active site. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Jason Yang, Francesca-Zhoufan Li, Frances H Arnold
Opportunities and Challenges for Machine Learning-Assisted Enzyme Engineering. ACS central science 10 (2) (2024)
Daniel J Wackelin, Runze Mao, Kathleen M Sicinski, Yutao Zhao, Anuvab Das, Kai Chen, Frances H Arnold
Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society (2024)
Torben Rogge, Qingyang Zhou, Nicholas J Porter, Frances H Arnold, Kendall N Houk
Iron Heme Enzyme-Catalyzed Cyclopropanations with Diazirines as Carbene Precursors: Computational Explorations of Diazirine Activation and Cyclopropanation Mechanism. Journal of the American Chemical Society 146 (5) (2024)
Deirdre Hanley, Zi-Qi Li, Shilong Gao, Scott C Virgil, Frances H Arnold, Edwin Alfonzo
Stereospecific Enzymatic Conversion of Boronic Acids to Amines. Journal of the American Chemical Society 146 (28) (2024)
Zi-Yang Qin, Shilong Gao, Yike Zou, Zhen Liu, James B Wang, Kendall N Houk, Frances H Arnold
Biocatalytic Construction of Chiral Pyrrolidines and Indolines via Intramolecular C(sp 3 )-H Amination. ACS central science 9 (12) (2023)
Runze Mao, Daniel J Wackelin, Cooper S Jamieson, Torben Rogge, Shilong Gao, Anuvab Das, Doris Mia Taylor, K N Houk, Frances H Arnold
Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates. Research square (2023)
Runze Mao, Daniel J Wackelin, Cooper S Jamieson, Torben Rogge, Shilong Gao, Anuvab Das, Doris Mia Taylor, K N Houk, Frances H Arnold
Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates. Research square (2023)
Jason Yang, Julie Ducharme, Kadina E Johnston, Francesca-Zhoufan Li, Yisong Yue, Frances H Arnold
DeCOIL: Optimization of Degenerate Codon Libraries for Machine Learning-Assisted Protein Engineering. ACS synthetic biology (2023)
Zi-Yang Qin, Shilong Gao, Yike Zou, Zhen Liu, James B Wang, Kendall N Houk, Frances H Arnold
Biocatalytic Construction of Chiral Pyrrolidines and Indolines via Intramolecular C(sp 3 )-H Amination. ACS central science 9 (12) (2023)
Shilong Gao, Anuvab Das, Edwin Alfonzo, Kathleen M Sicinski, Dominic Rieger, Frances H Arnold
Enzymatic Nitrogen Incorporation Using Hydroxylamine. Journal of the American Chemical Society (2023)
Runze Mao, Daniel J Wackelin, Cooper S Jamieson, Torben Rogge, Shilong Gao, Anuvab Das, Doris Mia Taylor, K N Houk, Frances H Arnold
Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates. Research square (2023)
Zi-Yang Qin, Shilong Gao, Yike Zou, Zhen Liu, James B Wang, Kendall N Houk, Frances H Arnold
Biocatalytic Construction of Chiral Pyrrolidines and Indolines via Intramolecular C(sp 3 )-H Amination. ACS central science 9 (12) (2023)
Runze Mao, Daniel J Wackelin, Cooper S Jamieson, Torben Rogge, Shilong Gao, Anuvab Das, Doris Mia Taylor, K N Houk, Frances H Arnold
Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates. Research square (2023)
Runze Mao, Daniel J Wackelin, Cooper S Jamieson, Torben Rogge, Shilong Gao, Anuvab Das, Doris Mia Taylor, Kendall N Houk, Frances H Arnold
Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from ( Z / E )-Trisubstituted Enol Acetates. Journal of the American Chemical Society (2023)
Emma Danelius, Nicholas J Porter, Johan Unge, Frances H Arnold, Tamir Gonen
MicroED Structure of a Protoglobin Reactive Carbene Intermediate. Journal of the American Chemical Society (2023)
David C Miller, Ravi G Lal, Luca A Marchetti, Frances H Arnold
Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement. Journal of the American Chemical Society 144 (11) (2022)
Nicholas J Porter, Emma Danelius, Tamir Gonen, Frances H Arnold
Biocatalytic Carbene Transfer Using Diazirines. Journal of the American Chemical Society 144 (20) (2022)
Bruce J Wittmann, Kadina E Johnston, Patrick J Almhjell, Frances H Arnold
evSeq: Cost-Effective Amplicon Sequencing of Every Variant in a Protein Library. ACS synthetic biology 11 (3) (2022)
Soumitra V Athavale, Shilong Gao, Anuvab Das, Sharath Chandra Mallojjala, Edwin Alfonzo, Yueming Long, Jennifer S Hirschi, Frances H Arnold
Enzymatic Nitrogen Insertion into Unactivated C-H Bonds. Journal of the American Chemical Society 144 (41) (2022)
Ella J Watkins, Noah P Dunham, Sabine Straathof, Soma Turi, Frances H Arnold, Andrew R Buller
Asymmetric Alkylation of Ketones Catalyzed by Engineered TrpB. Angewandte Chemie (International ed. in English) 60 (39) (2021)
Zhen Liu, Carla Calvó-Tusell, Andrew Z Zhou, Kai Chen, Marc Garcia-Borràs, Frances H Arnold
Dual-function enzyme catalysis for enantioselective carbon-nitrogen bond formation. Nature chemistry 13 (12) (2021)
Zhen Liu, Zi-Yang Qin, Ledong Zhu, Soumitra V Athavale, Arkajyoti Sengupta, Zhi-Jun Jia, Marc Garcia-Borràs, Kendall N Houk, Frances H Arnold
An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes. Journal of the American Chemical Society 144 (1) (2021)
Yang Yang, Frances H Arnold
Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer. Accounts of chemical research 54 (5) (2021)
Marc Garcia-Borràs, S B Jennifer Kan, Russell D Lewis, Allison Tang, Gonzalo Jiménez-Osés, Frances H Arnold, Kendall N Houk
Origin and Control of Chemoselectivity in Cytochrome c Catalyzed Carbene Transfer into Si-H and N-H bonds. Journal of the American Chemical Society 143 (18) (2021)
Soumitra V Athavale, Shilong Gao, Zhen Liu, Sharath Chandra Mallojjala, Jennifer S Hirschi, Frances H Arnold
Biocatalytic, Intermolecular C-H Bond Functionalization for the Synthesis of Enantioenriched Amides. Angewandte Chemie (International ed. in English) 60 (47) (2021)
Nicholas S Sarai, Benjamin J Levin, John M Roberts, Dimitris E Katsoulis, Frances H Arnold
Biocatalytic Transformations of Silicon-the Other Group 14 Element. ACS central science 7 (6) (2021)
Ella Watkins-Dulaney, Sabine Straathof, Frances H Arnold
Tryptophan Synthase: Biocatalyst Extraordinaire. Chembiochem : a European journal of chemical biology 22 (1) (2020)
Zachary Wu, Kevin K Yang, Michael J Liszka, Alycia Lee, Alina Batzilla, David Wernick, David P Weiner, Frances H Arnold
Signal Peptides Generated by Attention-Based Neural Networks. ACS synthetic biology 9 (8) (2020)
Susanne Bähr, Sabine Brinkmann-Chen, Marc Garcia-Borràs, John M Roberts, Dimitris E Katsoulis, Kendall N Houk, Frances H Arnold
Selective Enzymatic Oxidation of Silanes to Silanols. Angewandte Chemie (International ed. in English) 59 (36) (2020)
Kai Chen, Frances H Arnold
Engineering Cytochrome P450s for Enantioselective Cyclopropenation of Internal Alkynes. Journal of the American Chemical Society 142 (15) (2020)
Adam J Pluchinsky, Daniel J Wackelin, Xiongyi Huang, Frances H Arnold, Milan Mrksich
High Throughput Screening with SAMDI Mass Spectrometry for Directed Evolution. Journal of the American Chemical Society 142 (47) (2020)
Zhi-Jun Jia, Shilong Gao, Frances H Arnold
Enzymatic Primary Amination of Benzylic and Allylic C(sp3)-H Bonds. Journal of the American Chemical Society 142 (23) (2020)
Noah P Dunham, Frances H Arnold
Nature's Machinery, Repurposed: Expanding the Repertoire of Iron-Dependent Oxygenases. ACS catalysis 10 (20) (2020)
Gordon Rix, Ella J Watkins-Dulaney, Patrick J Almhjell, Christina E Boville, Frances H Arnold, Chang C Liu
Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities. Nature communications 11 (1) (2020)
Claire N Bedbrook, Kevin K Yang, J Elliott Robinson, Elisha D Mackey, Viviana Gradinaru, Frances H Arnold
Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics. Nature methods 16 (11) (2019)
Oliver F Brandenberg, Kai Chen, Frances H Arnold
Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds. Journal of the American Chemical Society 141 (22) (2019)
Ella J Watkins, Patrick J Almhjell, Frances H Arnold
Direct Enzymatic Synthesis of a Deep-Blue Fluorescent Noncanonical Amino Acid from Azulene and Serine. Chembiochem : a European journal of chemical biology 21 (1-2) (2019)
Nathaniel W Goldberg, Anders M Knight, Ruijie K Zhang, Frances H Arnold
Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Ligands. Journal of the American Chemical Society 141 (50) (2019)
Markus Dick, Nicholas S Sarai, Michael W Martynowycz, Tamir Gonen, Frances H Arnold
Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation. Journal of the American Chemical Society 141 (50) (2019)
Inha Cho, Christopher K Prier, Zhi-Jun Jia, Ruijie K Zhang, Tamás Görbe, Frances H Arnold
Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein. Angewandte Chemie (International ed. in English) 58 (10) (2019)
Yang Yang, Inha Cho, Xiaotian Qi, Peng Liu, Frances H Arnold
An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp3)-H bonds. Nature chemistry 11 (11) (2019)
Juner Zhang, Xiongyi Huang, Ruijie K Zhang, Frances H Arnold
Enantiodivergent α-Amino C-H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s. Journal of the American Chemical Society 141 (25) (2019)
Frances H Arnold
Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture). Angewandte Chemie (International ed. in English) 58 (41) (2019)
Kai Chen, Xiongyi Huang, Shuo-Qing Zhang, Andrew Z Zhou, S B Jennifer Kan, Xin Hong, Frances H Arnold
Engineered Cytochrome c-Catalyzed Lactone-Carbene B-H Insertion. Synlett : accounts and rapid communications in synthetic organic chemistry 30 (4) (2019)
Inha Cho, Zhi-Jun Jia, Frances H Arnold
Site-selective enzymatic C‒H amidation for synthesis of diverse lactams. Science (New York, N.Y.) 364 (6440) (2019)
Stephan C Hammer, Grzegorz Kubik, Ella J Watkins, Shan Huang, Hannah Minges, Frances H Arnold
Anti-Markovnikov alkene oxidation by metal-oxo-mediated enzyme catalysis. Science (New York, N.Y.) 358 (6360) (2018)
Christina E Boville, Remkes A Scheele, Philipp Koch, Sabine Brinkmann-Chen, Andrew R Buller, Frances H Arnold
Engineered Biosynthesis of β-Alkyl Tryptophan Analogues. Angewandte Chemie (International ed. in English) 57 (45) (2018)
Kai Chen, Shuo-Qing Zhang, Oliver F Brandenberg, Xin Hong, Frances H Arnold
Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions. Journal of the American Chemical Society 140 (48) (2018)
Kai Chen, Xiongyi Huang, S B Jennifer Kan, Ruijie K Zhang, Frances H Arnold
Enzymatic construction of highly strained carbocycles. Science (New York, N.Y.) 360 (6384) (2018)
Christina E Boville, David K Romney, Patrick J Almhjell, Michaela Sieben, Frances H Arnold
Improved Synthesis of 4-Cyanotryptophan and Other Tryptophan Analogues in Aqueous Solvent Using Variants of TrpB from Thermotoga maritima. The Journal of organic chemistry 83 (14) (2018)
Andrew R Buller, Paul van Roye, Jackson K B Cahn, Remkes A Scheele, Michael Herger, Frances H Arnold
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble. Journal of the American Chemical Society 140 (23) (2018)
Frances H Arnold
Directed Evolution: Bringing New Chemistry to Life. Angewandte Chemie (International ed. in English) 57 (16) (2017)
Steven A Loskot, David K Romney, Frances H Arnold, Brian M Stoltz
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C-H Oxidation Enabled by an Engineered P450 Enzyme. Journal of the American Chemical Society 139 (30) (2017)
David K Romney, Javier Murciano-Calles, Jöri E Wehrmüller, Frances H Arnold
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues. Journal of the American Chemical Society 139 (31) (2017)
Christopher K Prier, Todd K Hyster, Christopher C Farwell, Audrey Huang, Frances H Arnold
Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy. Angewandte Chemie (International ed. in English) 55 (15) (2016)
Andrew R Buller, Paul van Roye, Javier Murciano-Calles, Frances H Arnold
Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity. Biochemistry 55 (51) (2016)

Frances H Arnold.css-eqlu8i{font-size:small;padding-left:4px;} (Frances Arnold)

Publication Activity (10 Years)

Top Topics

Top Venues

Frances H Arnold (Frances Arnold)