Viviana Gradinaru

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 48

Top Topics

Top Venues

bioRxiv : the preprint server for biology

Nature biotechnology

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Timothy F Miles, Seongmin Jang, Tyler J Brittain, Xinhong Chen, Beth Walker, Claire Tebbutt, Yujie Fan, Damien A Wolfe, Cynthia M Arokiaraj, Erin E Sullivan, Xiaozhe Ding, Ting-Yu Wang, Yaping Lei, Miguel R Chuapoco, Tsui-Fen Chou, Viviana Gradinaru
Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder. Nature communications 15 (1) (2024)
Michael James Flynn, Acacia M H Mayfield, Rongrong Du, Viviana Gradinaru, Michael B Elowitz
Synthetic dosage-compensating miRNA circuits allow precision gene therapy for Rett syndrome. bioRxiv : the preprint server for biology (2024)
Michael James Flynn, Acacia M H Mayfield, Rongrong Du, Viviana Gradinaru, Michael B Elowitz
Synthetic dosage-compensating miRNA circuits allow precision gene therapy for Rett syndrome. bioRxiv : the preprint server for biology (2024)
Michael James Flynn, Acacia M H Mayfield, Rongrong Du, Viviana Gradinaru, Michael B Elowitz
Synthetic dosage-compensating miRNA circuits for quantitative gene therapy. bioRxiv : the preprint server for biology (2024)
Min J Jang, Gerard M Coughlin, Cameron R Jackson, Xinhong Chen, Miguel R Chuapoco, Julia L Vendemiatti, Alexander Z Wang, Viviana Gradinaru
Spatial transcriptomics for profiling the tropism of viral vectors in tissues. Nature biotechnology (2023)
Min J Jang, Gerard M Coughlin, Cameron R Jackson, Xinhong Chen, Miguel R Chuapoco, Julia L Vendemiatti, Alexander Z Wang, Viviana Gradinaru
Spatial transcriptomics for profiling the tropism of viral vectors in tissues. Nature biotechnology (2023)
Reem Abdel-Haq, Johannes C M Schlachetzki, Joseph C Boktor, Thaisa M Cantu-Jungles, Taren Thron, Mengying Zhang, John W Bostick, Tahmineh Khazaei, Sujatha Chilakala, Livia H Morais, Greg Humphrey, Ali Keshavarzian, Jonathan E Katz, Matthew Thomson, Rob Knight, Viviana Gradinaru, Bruce R Hamaker, Christopher K Glass, Sarkis K Mazmanian
Correction: A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice. eLife 12 (2023)
Min J Jang, Gerard M Coughlin, Cameron R Jackson, Xinhong Chen, Miguel R Chuapoco, Julia L Vendemiatti, Alexander Z Wang, Viviana Gradinaru
Spatial transcriptomics for profiling the tropism of viral vectors in tissues. Nature biotechnology (2023)
Miguel Chuapoco, Nicholas Flytzanis, Nick Goeden, J Octeau, Kristina Roxas, Ken Chan, Jon Scherrer, Janet Winchester, Roy Blackburn, Lillian Campos, Kwun-Nok Man, Junqing Sun, Xinhong Chen, Arthur Lefevre, Vikram Singh, Cynthia M Arokiaraj, Timothy F Miles, Julia Vendemiatti, Min Jang, John Mich, Yeme Bishaw, Bryan Gore, Victora Omstead, Naz Taskin, Natalie Weed, Jonathan Ting, Cory Miller, Benjamin Deverman, James Pickel, Lin Tian, Andrew Fox, Viviana Gradinaru
Intravenous functional gene transfer throughout the brain of non-human primates using AAV. Research square (2023)
Gerard M Coughlin, Mate Borsos, Nathan Appling, Bre'Anna H Barcelona, Acacia M H Mayfield, Elisha D Mackey, Rana A Eser, Xinhong Chen, Sripriya Ravindra Kumar, Viviana Gradinaru
Spatial genomics of AAVs reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo. bioRxiv : the preprint server for biology (2023)
Amy Henrickson, Xiaozhe Ding, Austin G Seal, Zhe Qu, Lauren Tomlinson, John Forsey, Viviana Gradinaru, Kazuhiro Oka, Borries Demeler
Characterization and quantification of adeno-associated virus capsid-loading states by multi-wavelength analytical ultracentrifugation with UltraScan. Nanomedicine (London, England) (2023)
Gerard M Coughlin, Mate Borsos, Nathan Appling, Bre'Anna H Barcelona, Acacia M H Mayfield, Elisha D Mackey, Rana A Eser, Xinhong Chen, Sripriya Ravindra Kumar, Viviana Gradinaru
Spatial genomics of AAVs reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo. bioRxiv : the preprint server for biology (2023)
Timothy F Miles, Erin E Sullivan, Xiaozhe Ding, Xinhong Chen, Sripriya Ravindra Kumar, David Goertsen, David Brown, Anaya Crosby, Jost Vielmetter, Mate Borsos, Damien A Wolfe, Annie W Lam, Viviana Gradinaru
Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors. Science advances 9 (16) (2023)
Miguel R Chuapoco, Nicholas C Flytzanis, Nick Goeden, J Christopher Octeau, Kristina M Roxas, Ken Y Chan, Jon Scherrer, Janet Winchester, Roy J Blackburn, Lillian J Campos, Kwun Nok Mimi Man, Junqing Sun, Xinhong Chen, Arthur Lefevre, Vikram Pal Singh, Cynthia M Arokiaraj, Timothy F Miles, Julia Vendemiatti, Min J Jang, John K Mich, Yemeserach Bishaw, Bryan B Gore, Victoria Omstead, Naz Taskin, Natalie Weed, Boaz P Levi, Jonathan T Ting, Cory T Miller, Benjamin E Deverman, James Pickel, Lin Tian, Andrew S Fox, Viviana Gradinaru
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain. Nature nanotechnology (2023)
Xinhong Chen, Damien A Wolfe, Dhanesh Sivadasan Bindu, Mengying Zhang, Naz Taskin, David Goertsen, Timothy F Miles, Erin E Sullivan, Sheng-Fu Huang, Sripriya Ravindra Kumar, Cynthia M Arokiaraj, Viktor M Plattner, Lillian J Campos, John K Mich, Deja Monet, Victoria Ngo, Xiaozhe Ding, Victoria Omstead, Natalie Weed, Yeme Bishaw, Bryan B Gore, Ed S Lein, Athena Akrami, Cory Miller, Boaz P Levi, Annika Keller, Jonathan T Ting, Andrew S Fox, Cagla Eroglu, Viviana Gradinaru
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Nature communications 14 (1) (2023)
Miguel Chuapoco, Nicholas Flytzanis, Nick Goeden, J Octeau, Kristina Roxas, Ken Chan, Jon Scherrer, Janet Winchester, Roy Blackburn, Lillian Campos, Kwun-Nok Man, Junqing Sun, Xinhong Chen, Arthur Lefevre, Vikram Singh, Cynthia M Arokiaraj, Timothy F Miles, Julia Vendemiatti, Min Jang, John Mich, Yeme Bishaw, Bryan Gore, Victora Omstead, Naz Taskin, Natalie Weed, Jonathan Ting, Cory Miller, Benjamin Deverman, James Pickel, Lin Tian, Andrew Fox, Viviana Gradinaru
Intravenous functional gene transfer throughout the brain of non-human primates using AAV. Research square (2023)
Rajib Schubert, Taegeun Bae, Branko Simic, Sheena N Smith, Seong-Ho Park, Gabriela Nagy-Davidescu, Viviana Gradinaru, Andreas Plückthun, Junho K Hur
CRISPR-clear imaging of melanin-rich B16-derived solid tumors. Communications biology 6 (1) (2023)
Gerard M Coughlin, Mate Borsos, Nathan Appling, Bre'Anna H Barcelona, Acacia M H Mayfield, Elisha D Mackey, Rana A Eser, Xinhong Chen, Sripriya Ravindra Kumar, Viviana Gradinaru
Spatial genomics of AAVs reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo. bioRxiv : the preprint server for biology (2023)
Miguel Chuapoco, Nicholas Flytzanis, Nick Goeden, J Octeau, Kristina Roxas, Ken Chan, Jon Scherrer, Janet Winchester, Roy Blackburn, Lillian Campos, Kwun-Nok Man, Junqing Sun, Xinhong Chen, Arthur Lefevre, Vikram Singh, Cynthia M Arokiaraj, Timothy F Miles, Julia Vendemiatti, Min Jang, John Mich, Yeme Bishaw, Bryan Gore, Victora Omstead, Naz Taskin, Natalie Weed, Jonathan Ting, Cory Miller, Benjamin Deverman, James Pickel, Lin Tian, Andrew Fox, Viviana Gradinaru
Intravenous functional gene transfer throughout the brain of non-human primates using AAV. Research square (2023)
Gerard M Coughlin, Mate Borsos, Nathan Appling, Bre'Anna H Barcelona, Acacia M H Mayfield, Elisha D Mackey, Rana A Eser, Xinhong Chen, Sripriya Ravindra Kumar, Viviana Gradinaru
Spatial genomics of AAVs reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo. bioRxiv : the preprint server for biology (2023)
Gerard M Coughlin, Mate Borsos, Nathan Appling, Bre'Anna H Barcelona, Acacia M H Mayfield, Elisha D Mackey, Rana A Eser, Xinhong Chen, Sripriya Ravindra Kumar, Viviana Gradinaru
Spatial genomics of AAVs reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo. bioRxiv : the preprint server for biology (2023)
Reem Abdel-Haq, Johannes C M Schlachetzki, Joseph C Boktor, Thaisa M Cantu-Jungles, Taren Thron, Mengying Zhang, John W Bostick, Tahmineh Khazaei, Sujatha Chilakala, Livia H Morais, Greg Humphrey, Ali Keshavarzian, Jonathan E Katz, Matthew Thomson, Rob Knight, Viviana Gradinaru, Bruce R Hamaker, Christopher K Glass, Sarkis K Mazmanian
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice. eLife 11 (2022)
Fumito Endo, Atsushi Kasai, Joselyn S Soto, Xinzhu Yu, Zhe Qu, Hitoshi Hashimoto, Viviana Gradinaru, Riki Kawaguchi, Baljit S Khakh
Molecular basis of astrocyte diversity and morphology across the CNS in health and disease. Science (New York, N.Y.) 378 (6619) (2022)
Yangyang Duan, Tao Ye, Zhe Qu, Yuewen Chen, Abigail Miranda, Xiaopu Zhou, Ka-Chun Lok, Yu Chen, Amy K Y Fu, Viviana Gradinaru, Nancy Y Ip
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer's disease alleviates amyloid-related pathologies in mice. Nature biomedical engineering (2021)
Ashley R Helseth, Ricardo Hernández-Martinez, Victoria L Hall, Matthew L Oliver, Brandon D Turner, Zachary F Caffall, Joseph E Rittiner, Miranda K Shipman, Connor S King, Viviana Gradinaru, Charles R Gerfen, Mauro Costa-Mattioli, Nicole Calakos
Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice. Science (New York, N.Y.) 372 (6540) (2021)
Wei-Li Wu, Mark D Adame, Chia-Wei Liou, Jacob T Barlow, Tzu-Ting Lai, Gil Sharon, Catherine E Schretter, Brittany D Needham, Madelyn I Wang, Weiyi Tang, James Ousey, Yuan-Yuan Lin, Tzu-Hsuan Yao, Reem Abdel-Haq, Keith Beadle, Viviana Gradinaru, Rustem F Ismagilov, Sarkis K Mazmanian
Microbiota regulate social behaviour via stress response neurons in the brain. Nature 595 (7867) (2021)
Meng Zhu, Marta N Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de Los Santos, Magdalena Zernicka Goetz
Human embryo polarization requires PLC signaling to mediate trophectoderm specification. eLife 10 (2021)
David Goertsen, Nicholas C Flytzanis, Nick Goeden, Miguel R Chuapoco, Alexander Cummins, Yijing Chen, Yingying Fan, Qiangge Zhang, Jitendra Sharma, Yangyang Duan, Li-Ping Wang, Guoping Feng, Yu Chen, Nancy Y Ip, James Pickel, Viviana Gradinaru
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset. Nature neuroscience (2021)
Ana Badimon, Hayley J Strasburger, Pinar Ayata, Xinhong Chen, Aditya Nair, Ako Ikegami, Philip Hwang, Andrew T Chan, Steven M Graves, Joseph O Uweru, Carola Ledderose, Munir Gunes Kutlu, Michael A Wheeler, Anat Kahan, Masago Ishikawa, Ying-Chih Wang, Yong-Hwee E Loh, Jean X Jiang, Dalton James Surmeier, Simon C Robson, Wolfgang G Junger, Robert Sebra, Erin S Calipari, Paul J Kenny, Ukpong B Eyo, Marco Colonna, Francisco J Quintana, Hiroaki Wake, Viviana Gradinaru, Anne Schaefer
Negative feedback control of neuronal activity by microglia. Nature 586 (7829) (2020)
Jai Woong Seo, Elizabeth S Ingham, Lisa Mahakian, Spencer Tumbale, Bo Wu, Sadaf Aghevlian, Shahin Shams, Mo Baikoghli, Poorva Jain, Xiaozhe Ding, Nick Goeden, Tatyana Dobreva, Nicholas C Flytzanis, Michael Chavez, Kratika Singhal, Ryan D Leib, Michelle L James, David J Segal, R Holland Cheng, Eduardo A Silva, Viviana Gradinaru, Katherine W Ferrara
Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation. Nature communications 11 (1) (2020)
Timothy Robert Sampson, Collin Challis, Neha Jain, Anastasiya Moiseyenko, Mark S Ladinsky, Gauri G Shastri, Taren Thron, Brittany D Needham, Istvan Horvath, Justine W Debelius, Stefan Janssen, Rob Knight, Pernilla Wittung-Stafshede, Viviana Gradinaru, Matthew Chapman, Sarkis K Mazmanian
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice. eLife 9 (2020)
Sripriya Ravindra Kumar, Timothy F Miles, Xinhong Chen, David Brown, Tatyana Dobreva, Qin Huang, Xiaozhe Ding, Yicheng Luo, Pétur H Einarsson, Alon Greenbaum, Min J Jang, Benjamin E Deverman, Viviana Gradinaru
Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types. Nature methods 17 (5) (2020)
Shenqin Yao, Peng Yuan, Ben Ouellette, Thomas Zhou, Marty Mortrud, Pooja Balaram, Soumya Chatterjee, Yun Wang, Tanya L Daigle, Bosiljka Tasic, Xiuli Kuang, Hui Gong, Qingming Luo, Shaoqun Zeng, Andrew Curtright, Ajay Dhaka, Anat Kahan, Viviana Gradinaru, Radoslaw Chrapkiewicz, Mark J Schnitzer, Hongkui Zeng, Ali Cetin
RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations. Nature methods 17 (4) (2020)
Hiroki R Ueda, Ali Erturk, Kwanghun Chung, Viviana Gradinaru, Alain Chédotal, Pavel Tomancak, Philipp J Keller
Tissue clearing and its applications in neuroscience. Nature reviews. Neuroscience 21 (2) (2020)
Collin Challis, Acacia Hori, Timothy R Sampson, Bryan B Yoo, Rosemary C Challis, Adam M Hamilton, Sarkis K Mazmanian, Laura A Volpicelli-Daley, Viviana Gradinaru
Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice. Nature neuroscience 23 (3) (2020)
Jennifer N Rauch, Gabriel Luna, Elmer Guzman, Morgane Audouard, Collin Challis, Youssef E Sibih, Carolina Leshuk, Israel Hernandez, Susanne Wegmann, Bradley T Hyman, Viviana Gradinaru, Martin Edward Kampmann, Kenneth S Kosik
LRP1 is a master regulator of tau uptake and spread. Nature 580 (7803) (2020)
Claire N Bedbrook, Kevin K Yang, J Elliott Robinson, Elisha D Mackey, Viviana Gradinaru, Frances H Arnold
Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics. Nature methods 16 (11) (2019)
J Elliott Robinson, Gerard M Coughlin, Acacia M Hori, Jounhong Ryan Cho, Elisha D Mackey, Zeynep Turan, Tommaso Patriarchi, Lin Tian, Viviana Gradinaru
Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1. eLife 8 (2019)
Tommaso Patriarchi, Jounhong Ryan Cho, Katharina Merten, Aaron Marley, Gerard Joey Broussard, Ruqiang Liang, John Williams, Axel Nimmerjahn, Mark von Zastrow, Viviana Gradinaru, Lin Tian
Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators. Nature protocols 14 (12) (2019)
Tomoyuki Mano, Alexandre Albanese, Hans-Ulrich Dodt, Ali Erturk, Viviana Gradinaru, Jennifer B Treweek, Atsushi Miyawaki, Kwanghun Chung, Hiroki R Ueda
Whole-Brain Analysis of Cells and Circuits by Tissue Clearing and Light-Sheet Microscopy. The Journal of neuroscience : the official journal of the Society for Neuroscience 38 (44) (2019)
Pradeep S Rajendran, Rosemary C Challis, Charless C Fowlkes, Peter Hanna, John D Tompkins, Maria C Jordan, Sarah Hiyari, Beth A Gabris-Weber, Alon Greenbaum, Ken Y Chan, Benjamin E Deverman, Heike Münzberg, Jeffrey L Ardell, Guy Salama, Viviana Gradinaru, Kalyanam Shivkumar
Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies. Nature communications 10 (1) (2019)
Rosemary C Challis, Sripriya Ravindra Kumar, Ken Y Chan, Collin Challis, Keith Beadle, Min J Jang, Hyun Min Kim, Pradeep S Rajendran, John D Tompkins, Kalyanam Shivkumar, Benjamin E Deverman, Viviana Gradinaru
Systemic AAV vectors for widespread and targeted gene delivery in rodents. Nature protocols 14 (2) (2019)
Tommaso Patriarchi, Jounhong Ryan Cho, Katharina Merten, Mark W Howe, Aaron Marley, Wei-Hong Xiong, Robert W Folk, Gerard Joey Broussard, Ruqiang Liang, Min Jee Jang, Haining Zhong, Daniel Dombeck, Mark Von Zastrow, Axel Nimmerjahn, Viviana Gradinaru, John T Williams, Lin Tian
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors. Science (New York, N.Y.) 360 (6396) (2018)
Alon Greenabum, Ken Y Chan, Tatyana Dobreva, David Brown, Deepak H Balani, Rogely Boyce, Henry M Kronenberg, Helen J McBride, Viviana Gradinaru
Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow. Science translational medicine 9 (387) (2018)
Haowen Ruan, Joshua Brake, J Elliott Robinson, Yan Liu, Mooseok Jang, Cheng Xiao, Chunyi Zhou, Viviana Gradinaru, Changhuei Yang
Deep tissue optical focusing and optogenetic modulation with time-reversed ultrasonically encoded light. Science advances 3 (12) (2017)
Ken Y Chan, Min J Jang, Bryan B Yoo, Alon Greenbaum, Namita Ravi, Wei-Li Wu, Luis Sánchez-Guardado, Carlos Lois, Sarkis K Mazmanian, Benjamin E Deverman, Viviana Gradinaru
Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems. Nature neuroscience 20 (8) (2017)
Min Pan, Michael A Reid, Xazmin H Lowman, Rajan P Kulkarni, Thai Q Tran, Xiaojing Liu, Ying Yang, Jenny E Hernandez-Davies, Kimberly K Rosales, Haiqing Li, Willy Hugo, Chunying Song, Xiangdong Xu, Dustin E Schones, David K Ann, Viviana Gradinaru, Roger S Lo, Jason W Locasale, Mei Kong
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. Nature cell biology 18 (10) (2016)
Benjamin E Deverman, Piers L Pravdo, Bryan P Simpson, Sripriya Ravindra Kumar, Ken Y Chan, Abhik Banerjee, Wei-Li Wu, Bin Yang, Nina Huber, Sergiu P Pasca, Viviana Gradinaru
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nature biotechnology 34 (2) (2016)