Francis Gosselin

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 34

Top Topics

Liquid Chromatography

Density Functional Theory

Room Temperature

Top Venues

Journal of the American Chemical Society

Organic letters

The Journal of organic chemistry

Analytical chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Brittany C Haas, Ngiap-Kie Lim, Janis Jermaks, Eden Gaster, Melody C Guo, Thomas C Malig, Jacob Werth, Haiming Zhang, F Dean Toste, Francis Gosselin, Scott J Miller, Matthew S Sigman
Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation. Journal of the American Chemical Society (2024)
Brittany C Haas, Ngiap-Kie Lim, Janis Jermaks, Eden Gaster, Melody C Guo, Thomas C Malig, Jacob Werth, Haiming Zhang, F Dean Toste, Francis Gosselin, Scott J Miller, Matthew S Sigman
Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation. Journal of the American Chemical Society 146 (12) (2024)
Matthew M Pompeo, Sean M Kelly, Frédéric St-Jean, Thomas M Bass, Derek M Dalton, Daniel Zell, Chong Han, Lauren E Sirois, Francis Gosselin
Umpolung Flow Chemistry for the Synthesis of a 3-Oxo-3 H -spiro[benzofuran-2,4'-piperidine] Building Block. The Journal of organic chemistry 89 (11) (2024)
Brittany C Haas, Ngiap-Kie Lim, Janis Jermaks, Eden Gaster, Melody C Guo, Thomas C Malig, Jacob Werth, Haiming Zhang, F Dean Toste, Francis Gosselin, Scott J Miller, Matthew S Sigman
Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation. Journal of the American Chemical Society 146 (12) (2024)
Brittany C Haas, Ngiap-Kie Lim, Janis Jermaks, Eden Gaster, Melody C Guo, Thomas C Malig, Jacob Werth, Haiming Zhang, F Dean Toste, Francis Gosselin, Scott J Miller, Matthew S Sigman
Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation. Journal of the American Chemical Society 146 (12) (2024)
Brittany C Haas, Ngiap-Kie Lim, Janis Jermaks, Eden Gaster, Melody C Guo, Thomas C Malig, Jacob Werth, Haiming Zhang, F Dean Toste, Francis Gosselin, Scott J Miller, Matthew S Sigman
Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation. Journal of the American Chemical Society (2024)
Matthew M Pompeo, Sean M Kelly, Frédéric St-Jean, Thomas M Bass, Derek M Dalton, Daniel Zell, Chong Han, Lauren E Sirois, Francis Gosselin
Umpolung Flow Chemistry for the Synthesis of a 3-Oxo-3 H -spiro[benzofuran-2,4'-piperidine] Building Block. The Journal of organic chemistry (2024)
Matthew M Pompeo, Sean M Kelly, Frédéric St-Jean, Thomas M Bass, Derek M Dalton, Daniel Zell, Chong Han, Lauren E Sirois, Francis Gosselin
Umpolung Flow Chemistry for the Synthesis of a 3-Oxo-3 H -spiro[benzofuran-2,4'-piperidine] Building Block. The Journal of organic chemistry (2024)
Brittany C Haas, Ngiap-Kie Lim, Janis Jermaks, Eden Gaster, Melody C Guo, Thomas C Malig, Jacob Werth, Haiming Zhang, F Dean Toste, Francis Gosselin, Scott J Miller, Matthew S Sigman
Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation. Journal of the American Chemical Society 146 (12) (2024)
Jie Xu, Ngiap-Kie Lim, Jacob C Timmerman, Jeff Shen, Kyle Clagg, Ugo Orcel, Raphael Bigler, Etienne Trachsel, Roland Meier, Nicholas A White, Johannes A Burkhard, Lauren E Sirois, Qingping Tian, Remy Angelaud, Stephan Bachmann, Haiming Zhang, Francis Gosselin
Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036. Organic letters 25 (19) (2023)
Jie Xu, Ngiap-Kie Lim, Jacob C Timmerman, Jeff Shen, Kyle Clagg, Ugo Orcel, Raphael Bigler, Etienne Trachsel, Roland Meier, Nicholas A White, Johannes A Burkhard, Lauren E Sirois, Qingping Tian, Remy Angelaud, Stephan Bachmann, Haiming Zhang, Francis Gosselin
Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036. Organic letters (2023)
Lucy van Dijk, Brittany C Haas, Ngiap-Kie Lim, Kyle Clagg, Jordan J Dotson, Sean M Treacy, Katarzyna A Piechowicz, Vladislav A Roytman, Haiming Zhang, F Dean Toste, Scott J Miller, Francis Gosselin, Matthew S Sigman
Data Science-Enabled Palladium-Catalyzed Enantioselective Aryl-Carbonylation of Sulfonimidamides. Journal of the American Chemical Society (2023)
Jie Xu, Ngiap-Kie Lim, Jacob C Timmerman, Jeff Shen, Kyle Clagg, Ugo Orcel, Raphael Bigler, Etienne Trachsel, Roland Meier, Nicholas A White, Johannes A Burkhard, Lauren E Sirois, Qingping Tian, Remy Angelaud, Stephan Bachmann, Haiming Zhang, Francis Gosselin
Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036. Organic letters 25 (19) (2023)
Carmela Molinaro, Sean M Kelly, Allison Tang, Hans Iding, Patrik Stocker, Xin Linghu, Francis Gosselin
Asymmetric Synthesis of N -Alkyl Amino Acids through a Biocatalytic Dynamic Kinetic Resolution of PEGylated N -Alkyl Amino Esters. Organic letters (2023)
Jordan J Dotson, Lucy van Dijk, Jacob C Timmerman, Samantha Grosslight, Richard C Walroth, Francis Gosselin, Kurt Püntener, Kyle A Mack, Matthew S Sigman
Data-Driven Multi-Objective Optimization Tactics for Catalytic Asymmetric Reactions Using Bisphosphine Ligands. Journal of the American Chemical Society 145 (1) (2022)
Jordan J Dotson, Lucy van Dijk, Jacob C Timmerman, Samantha Grosslight, Richard C Walroth, Francis Gosselin, Kurt Püntener, Kyle A Mack, Matthew S Sigman
Data-Driven Multi-Objective Optimization Tactics for Catalytic Asymmetric Reactions Using Bisphosphine Ligands. Journal of the American Chemical Society 145 (1) (2022)
Jordan J Dotson, Lucy van Dijk, Jacob C Timmerman, Samantha Grosslight, Richard C Walroth, Francis Gosselin, Kurt Püntener, Kyle A Mack, Matthew S Sigman
Data-Driven Multi-Objective Optimization Tactics for Catalytic Asymmetric Reactions Using Bisphosphine Ligands. Journal of the American Chemical Society (2022)
Carmela Molinaro, Yukie Kawasaki, George Wanyoike, Taiki Nishioka, Tsuyoshi Yamamoto, Brad Snedecor, Sarah J Robinson, Francis Gosselin
Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics. Journal of the American Chemical Society 144 (32) (2022)
Frédéric St-Jean, Rémy Angelaud, Stephan Bachmann, Diane E Carrera, Travis Remarchuk, Katarzyna A Piechowicz, Katrin Niedermann, Hans Iding, Roland Meier, Haiyun Hou, Lauren E Sirois, Jie Xu, Martin Olbrich, Pankaj Rege, Maud Guillemot-Plass, Francis Gosselin
Stereoselective Synthesis of the IDO Inhibitor Navoximod. The Journal of organic chemistry 87 (7) (2022)
Jie Xu, Samantha Grosslight, Kyle A Mack, Sierra C Nguyen, Kyle Clagg, Ngiap-Kie Lim, Jacob C Timmerman, Jeff Shen, Nicholas A White, Lauren E Sirois, Chong Han, Haiming Zhang, Matthew S Sigman, Francis Gosselin
Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036. Journal of the American Chemical Society 144 (45) (2022)
Jordan J Dotson, Lucy van Dijk, Jacob C Timmerman, Samantha Grosslight, Richard C Walroth, Francis Gosselin, Kurt Püntener, Kyle A Mack, Matthew S Sigman
Data-Driven Multi-Objective Optimization Tactics for Catalytic Asymmetric Reactions Using Bisphosphine Ligands. Journal of the American Chemical Society 145 (1) (2022)
Daniel Zell, Cian Kingston, Janis Jermaks, Sleight R Smith, Natalie Seeger, Jana Wassmer, Lauren E Sirois, Chong Han, Haiming Zhang, Matthew S Sigman, Francis Gosselin
Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings. Journal of the American Chemical Society 143 (45) (2021)
Alexandre Goyon, Colin Masui, Lauren E Sirois, Chong Han, Peter Yehl, Francis Gosselin, Kelly Zhang
Achiral-Chiral Two-Dimensional Liquid Chromatography Platform to Support Automated High-Throughput Experimentation in the Field of Drug Development. Analytical chemistry 92 (22) (2020)
Nicholas A White, Kyle Clagg, Lauren E Sirois, Kyle A Mack, Mohammad A Al-Sayah, William A Nack, Paul D O'Shea, Haiming Zhang, Francis Gosselin
Phosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2-a]pyrimidine Isomers. Organic letters 21 (23) (2019)
Nicholas Wong, Filip Petronijević, Allen Y Hong, Xin Linghu, Sean M Kelly, Haiyun Hou, Theresa Cravillion, Ngiap-Kie Lim, Sarah J Robinson, Chong Han, Carmela Molinaro, C Gregory Sowell, Francis Gosselin
Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338. Organic letters 21 (22) (2019)
Ngiap-Kie Lim, Xin Linghu, Nicholas Wong, Haiming Zhang, C Gregory Sowell, Francis Gosselin
Macrolactamization Approaches to Arylomycin Antibiotics Core. Organic letters 21 (1) (2018)
Haiming Zhang, Beryl X Li, Brian Wong, Andreas Stumpf, C Gregory Sowell, Francis Gosselin
Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C-H Arylation toward Dihydrobenzothienooxepines. The Journal of organic chemistry 84 (8) (2018)
Scott Savage, Andrew McClory, Haiming Zhang, Theresa Cravillion, Ngiap-Kie Lim, Colin Masui, Sarah J Robinson, Chong Han, Christoph Ochs, Pankaj D Rege, Francis Gosselin
Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin. The Journal of organic chemistry 83 (19) (2018)
Ian S Young, Anna-Lena Glass, Theresa Cravillion, Chong Han, Haiming Zhang, Francis Gosselin
Palladium-Catalyzed Site-Selective Amidation of Dichloroazines. Organic letters 20 (13) (2018)
Ngiap-Kie Lim, Theresa Cravillion, Scott Savage, Andrew McClory, Chong Han, Haiming Zhang, Antonio DiPasquale, Francis Gosselin
Synthesis of a Selective Estrogen Receptor Degrader via a Stereospecific Elimination Approach. Organic letters 20 (4) (2018)
Beryl X Li, Diane N Le, Kyle A Mack, Andrew McClory, Ngiap-Kie Lim, Theresa Cravillion, Scott Savage, Chong Han, David B Collum, Haiming Zhang, Francis Gosselin
Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-Carbon Olefins via Enol Tosylation and Suzuki-Miyaura Coupling. Journal of the American Chemical Society 139 (31) (2017)
Kyle A Mack, Andrew McClory, Haiming Zhang, Francis Gosselin, David B Collum
Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities. Journal of the American Chemical Society 139 (35) (2017)
Ngiap-Kie Lim, Patrick Weiss, Beryl X Li, Christina H McCulley, Stephanie R Hare, Bronwyn L Bensema, Teresa A Palazzo, Dean Joseph Tantillo, Haiming Zhang, Francis Gosselin
Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach. Organic letters 19 (22) (2017)
Chong Han, Scott Savage, Mohammad Al-Sayah, Herbert Yajima, Travis Remarchuk, Reinhard Reents, Beat Wirz, Hans Iding, Stephan Bachmann, Serena M Fantasia, Michelangelo Scalone, André Hell, Pirmin Hidber, Francis Gosselin
Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib. Organic letters 19 (18) (2017)