Giuseppe Melacini (G Melacini)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 30

Top Topics

Plasmodium Falciparum

Molecular Dynamics Simulations

Top Venues

Chemical science

Journal of the American Chemical Society

This page only lists publications with an associated author ORCID identifier.

Publications

Karla Martinez Pomier, Rashik Ahmed, Jinfeng Huang, Giuseppe Melacini
Inhibition of toxic metal-alpha synuclein interactions by human serum albumin. Chemical science 15 (10) (2024)
Karla Martinez Pomier, Rashik Ahmed, Jinfeng Huang, Giuseppe Melacini
Inhibition of toxic metal-alpha synuclein interactions by human serum albumin. Chemical science 15 (10) (2024)
Evelyn Rose Kamski-Hennekam, Jinfeng Huang, Rashik Ahmed, Giuseppe Melacini
Toward a molecular mechanism for the interaction of ATP with alpha-synuclein. Chemical science 14 (36) (2023)
Bryan VanSchouwen, Giuseppe Melacini
Probing ligand selectivity in pathogens. eLife 12 (2023)
Bryan VanSchouwen, Giuseppe Melacini
Probing ligand selectivity in pathogens. eLife 12 (2023)
Bryan VanSchouwen, Giuseppe Melacini
Probing ligand selectivity in pathogens. eLife 12 (2023)
Jinfeng Huang, Rashik Ahmed, Madoka Akimoto, Karla Martinez Pomier, Giuseppe Melacini
Early-Onset Parkinson Mutation Remodels Monomer-Fibril Interactions to Allosterically Amplify Synuclein's Amyloid Cascade. JACS Au 3 (12) (2023)
Bryan VanSchouwen, Leonardo Della Libera, Giuseppe Melacini
Fractionation factors reveal hidden frustration in an ancient allosteric module. The Journal of chemical physics 158 (12) (2023)
Jinfeng Huang, Rashik Ahmed, Madoka Akimoto, Karla Martinez Pomier, Giuseppe Melacini
Early-Onset Parkinson Mutation Remodels Monomer-Fibril Interactions to Allosterically Amplify Synuclein's Amyloid Cascade. JACS Au 3 (12) (2023)
Jinfeng Huang, Rashik Ahmed, Madoka Akimoto, Karla Martinez Pomier, Giuseppe Melacini
Early-Onset Parkinson Mutation Remodels Monomer-Fibril Interactions to Allosterically Amplify Synuclein's Amyloid Cascade. JACS Au 3 (12) (2023)
Madoka Akimoto, Karla Martinez Pomier, Bryan VanSchouwen, Jung Ah Byun, Mariia Khamina, Giuseppe Melacini
Allosteric pluripotency: challenges and opportunities. The Biochemical journal 479 (7) (2022)
Hebatallah Mohamed, Hongzhao Shao, Madoka Akimoto, Patrick Darveau, Marc R MacKinnon, Jakob Magolan, Giuseppe Melacini
QSAR models reveal new EPAC-selective allosteric modulators. RSC chemical biology 3 (10) (2022)
Naeimeh Jafari, Jason Del Rio, Madoka Akimoto, Jung Ah Byun, Stephen Boulton, Kody Moleschi, Yousif Alsayyed, Pascale Swanson, Jinfeng Huang, Karla Martinez Pomier, Chi Lee, Jian Wu, Susan S Taylor, Giuseppe Melacini
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations. Proceedings of the National Academy of Sciences of the United States of America 118 (21) (2021)
Jung Ah Byun, Bryan VanSchouwen, Nishi Parikh, Madoka Akimoto, Eric Tyler McNicholl, Giuseppe Melacini
State-selective frustration as a key driver of allosteric pluripotency. Chemical science 12 (34) (2021)
Rashik Ahmed, Jinfeng Huang, Madoka Akimoto, Tongyu Shi, Giuseppe Melacini
Atomic Resolution Map of Hierarchical Self-Assembly for an Amyloidogenic Protein Probed through Thermal 15N-R2 Correlation Matrices. Journal of the American Chemical Society 143 (12) (2021)
Eric Tyler McNicholl, Rahul Das, Soumita SilDas, Jung Ah Byun, Madoka Akimoto, Naeimeh Jafari, Giuseppe Melacini
Backbone resonance assignment of the cAMP-binding domains of the protein kinase A regulatory subunit Iα. Biomolecular NMR assignments 15 (2) (2021)
Jinfeng Huang, Jung Ah Byun, Bryan VanSchouwen, Philipp Henning, Friedrich W Herberg, Choel Kim, Giuseppe Melacini
Dynamical Basis of Allosteric Activation for the Plasmodium falciparum Protein Kinase G. The journal of physical chemistry. B 125 (24) (2021)
Karla Martinez Pomier, Rashik Ahmed, Giuseppe Melacini
Catechins as Tools to Understand the Molecular Basis of Neurodegeneration. Molecules (Basel, Switzerland) 25 (16) (2020)
Hongzhao Shao, Hebatallah Mohamed, Stephen Boulton, Jinfeng Huang, Pingyuan Wang, Haiying Chen, Jia Zhou, Urszula Luchowska-Stańska, Nicholas G Jentsch, Alison L Armstrong, Jakob Magolan, Stephen Yarwood, Giuseppe Melacini
Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist. Journal of medicinal chemistry 63 (9) (2020)
Jung Ah Byun, Katherine Van, Jinfeng Huang, Philipp Henning, Eugen Franz, Madoka Akimoto, Friedrich W Herberg, Choel Kim, Giuseppe Melacini
Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase. The Journal of biological chemistry 295 (25) (2020)
Jung Ah Byun, Madoka Akimoto, B VanSchouwen, T S Lazarou, Susan S Taylor, Giuseppe Melacini
Allosteric pluripotency as revealed by protein kinase A. Science advances 6 (25) (2020)
Rashik Ahmed, Jinfeng Huang, Daniel K Weber, Tata Gopinath, Gianluigi Veglia, Madoka Akimoto, Adree Khondker, Maikel C Rheinstädter, Vincent Huynh, Ryan Gavin Wylie, José C Bozelli, Richard M Epand, Giuseppe Melacini
Molecular Mechanism for the Suppression of Alpha Synuclein Membrane Toxicity by an Unconventional Extracellular Chaperone. Journal of the American Chemical Society 142 (21) (2020)
Sara García-Viñuales, Rashik Ahmed, Michele F M Sciacca, Valeria Lanza, Maria Laura Giuffrida, Stefania Zimbone, Valeria Romanucci, Armando Zarrelli, Corrado Bongiorno, Natalia Spinella, Clelia Galati, Giovanni Di Fabio, Giuseppe Melacini, Danilo Milardi
Trehalose Conjugates of Silybin as Prodrugs for Targeting Toxic Aβ Aggregates. ACS chemical neuroscience 11 (17) (2020)
Muhammad M Shoaib, Vincent Huynh, Yousuf Shad, Rashik Ahmed, Alexander H Jesmer, Giuseppe Melacini, Ryan Gavin Wylie
Controlled degradation of low-fouling poly(oligo(ethylene glycol)methyl ether methacrylate) hydrogels. RSC advances 9 (33) (2019)
Stephen Boulton, Rajeevan Selvaratnam, Rashik Ahmed, Katherine Van, Xiaodong Cheng, Giuseppe Melacini
Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators. Journal of medicinal chemistry 62 (10) (2019)
Rashik Ahmed, Michael Akcan, Adree Khondker, Maikel C Rheinstädter, José C Bozelli, Richard M Epand, Vincent Huynh, Ryan Gavin Wylie, Stephen Boulton, Jinfeng Huang, Chris P Verschoor, Giuseppe Melacini
Atomic resolution map of the soluble amyloid beta assembly toxic surfaces. Chemical science 10 (24) (2019)
Bryan VanSchouwen, Giuseppe Melacini
Role of Dimers in the cAMP-Dependent Activation of Hyperpolarization-Activated Cyclic-Nucleotide-Modulated (HCN) Ion Channels. The journal of physical chemistry. B 122 (8) (2018)
Stephen Boulton, Rajeevan Selvaratnam, Jean-Paul Blondeau, Frank Lezoualc'h, Giuseppe Melacini
Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist. Journal of the American Chemical Society 140 (30) (2018)
Ylan Nguyen, Stephen Boulton, E Tyler McNicholl, Madoka Akimoto, Hanjeong Harvey, Francisca Aidoo, Giuseppe Melacini, Lori L Burrows
A Highly Dynamic Loop of the Pseudomonas aeruginosa PA14 Type IV Pilin Is Essential for Pilus Assembly. ACS infectious diseases 4 (6) (2018)
Rashik Ahmed, Bryan VanSchouwen, Naeimeh Jafari, Xiaodan Ni, Joaquin Ortega, Giuseppe Melacini
Molecular Mechanism for the (-)-Epigallocatechin Gallate-Induced Toxic to Nontoxic Remodeling of Aβ Oligomers. Journal of the American Chemical Society 139 (39) (2017)