Susan S Taylor (S S Taylor, Susan Taylor)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 36

Top Topics

Molecular Dynamics Simulations

Top Venues

Science advances

The Biochemical journal

Acta crystallographica. Section D, Structural biology

This page only lists publications with an associated author ORCID identifier.

Publications

Pallavi Kaila Sharma, Jui-Hung Weng, Jascha T Manschwetus, Jian Wu, Wen Ma, Friedrich W Herberg, Susan S Taylor
Role of the leucine-rich repeat protein kinase 2 C-terminal tail in domain cross-talk. The Biochemical journal 481 (4) (2024)
Pallavi Kaila Sharma, Jui-Hung Weng, Jascha T Manschwetus, Jian Wu, Wen Ma, Friedrich W Herberg, Susan S Taylor
Role of the leucine-rich repeat protein kinase 2 C-terminal tail in domain cross-talk. The Biochemical journal 481 (4) (2024)
Cristina Olivieri, Yingjie Wang, Caitlin Walker, Manu Veliparambil Subrahmanian, Kim N Ha, David Bernlohr, Jiali Gao, Carlo Camilloni, Christopher M Dobson, Susan S Taylor, Gianluigi Veglia
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A. eLife 12 (2024)
Cristina Olivieri, Yingjie Wang, Caitlin Walker, Manu Veliparambil Subrahmanian, Kim N Ha, David Bernlohr, Jiali Gao, Carlo Camilloni, Christopher M Dobson, Susan S Taylor, Gianluigi Veglia
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A. eLife 12 (2024)
Cristina Olivieri, Yingjie Wang, Caitlin Walker, Manu Veliparambil Subrahmanian, Kim N Ha, David Bernlohr, Jiali Gao, Carlo Camilloni, Christopher M Dobson, Susan S Taylor, Gianluigi Veglia
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A. eLife 12 (2024)
Pallavi Kaila Sharma, Jui-Hung Weng, Jascha T Manschwetus, Jian Wu, Wen Ma, Friedrich W Herberg, Susan S Taylor
Role of the leucine-rich repeat protein kinase 2 C-terminal tail in domain cross-talk. The Biochemical journal 481 (4) (2024)
Cristina Olivieri, Yingjie Wang, Caitlin Walker, Manu Veliparambil Subrahmanian, Kim N Ha, David Bernlohr, Jiali Gao, Carlo Camilloni, Christopher M Dobson, Susan S Taylor, Gianluigi Veglia
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A. eLife 12 (2024)
Jian Wu, Nisha A Jonniya, Sophia P Hirakis, Cristina Olivieri, Gianluigi Veglia, Alexandr P Kornev, Susan S Taylor
Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop. bioRxiv : the preprint server for biology (2023)
David C Wych, Phillip C Aoto, Lily Vu, Alexander M Wolff, David L Mobley, Brian K Shoichet, Susan S Taylor, Michael E Wall
Molecular-dynamics simulation methods for macromolecular crystallography. Acta crystallographica. Section D, Structural biology 79 (Pt 1) (2023)
David C Wych, Phillip C Aoto, Lily Vu, Alexander M Wolff, David L Mobley, Brian K Shoichet, Susan S Taylor, Michael E Wall
Molecular-dynamics simulation methods for macromolecular crystallography. Acta crystallographica. Section D, Structural biology 79 (Pt 1) (2023)
Jui-Hung Weng, Wen Ma, Jian Wu, Pallavi Kaila Sharma, Steve Silletti, James Andrew McCammon, Susan S Taylor
Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors. ACS chemical biology (2023)
David C Wych, Phillip C Aoto, Lily Vu, Alexander M Wolff, David L Mobley, Brian K Shoichet, Susan S Taylor, Michael E Wall
Molecular-dynamics simulation methods for macromolecular crystallography. Acta crystallographica. Section D, Structural biology 79 (Pt 1) (2023)
Susan S Taylor, Friedrich W Herberg, Gianluigi Veglia, Jian Wu
Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A. IUBMB life (2023)
Jui-Hung Weng, Phillip C Aoto, Robin Lorenz, Jian Wu, Sven H Schmidt, Jascha T Manschwetus, Pallavi Kaila-Sharma, Steve Silletti, Sebastian Mathea, Deep Chatterjee, Stefan Knapp, Friedrich W Herberg, Susan S Taylor
LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains. PLoS biology 20 (2) (2022)
John T Happ, Corvin D Arveseth, Jessica Bruystens, Daniela Bertinetti, Isaac B Nelson, Cristina Olivieri, Jingyi Zhang, Danielle S Hedeen, Ju-Fen Zhu, Jacob L Capener, Jan W Bröckel, Lily Vu, C C King, Victor L Ruiz-Perez, Xuecai Ge, Gianluigi Veglia, Friedrich W Herberg, Susan S Taylor, Benjamin R Myers
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction. Nature structural & molecular biology 29 (10) (2022)
Anita Alexa, Péter Sok, Fridolin Gross, Krisztián Albert, Evan Kobori, Ádám L Póti, Gergő Gógl, Isabel Bento, Ersheng Kuang, Susan S Taylor, Fanxiu Zhu, Andrea Ciliberto, Attila Reményi
A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host. Nature communications 13 (1) (2022)
Cristina Olivieri, Geoffrey C Li, Yingjie Wang, Manu Veliparambil Subrahmanian, Caitlin Walker, Jonggul Kim, Carlo Camilloni, Alfonso De Simone, Christopher M Dobson, David A Bernlohr, Susan S Taylor, Gianluigi Veglia
ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy. Science advances 8 (30) (2022)
Caila A Pilo, Timothy R Baffi, Alexandr P Kornev, Maya T Kunkel, Mario Malfavon, Dong-Hui Chen, Leigh-Ana Rossitto, Daniel X Chen, Liang-Chin Huang, Cheryl Longman, Natarajan Kannan, Wendy H Raskind, David J Gonzalez, Susan S Taylor, George Gorrie, Alexandra C Newton
Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition. Science signaling 15 (753) (2022)
Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V S Manu, Fernando Porcelli, Donald K Blumenthal, David Dt Thomas, David A Bernlohr, Sanford M Simon, Susan S Taylor, Gianluigi Veglia
Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A. Communications biology 4 (1) (2021)
Robin Lorenz, Jian Wu, Friedrich W Herberg, Susan S Taylor, Richard Alan Engh
Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics. Biochemistry 60 (46) (2021)
Susan S Taylor, Maximilian Wallbott, Erik M F Machal, Kristoffer Søberg, Faihaa Ahmed, Jessica Bruystens, Lily Vu, Blaine Baker, Jian Wu, Francesco Raimondi, Elimelda M Ongeri, Friedrich W Herberg, Bjørn S Skålhegg
PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies. The Biochemical journal 478 (11) (2021)
Timothy R Baffi, Gema Lordén, Jacob M Wozniak, Andreas Feichtner, Wayland Yeung, Alexandr P Kornev, Charles C King, Jason C Del Rio, Ameya J Limaye, Julijus Bogomolovas, Christine M Gould, Ju Chen, Eileen J Kennedy, Natarajan Kannan, David J Gonzalez, Eduard Stefan, Susan S Taylor, Alexandra C Newton
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Science signaling 14 (678) (2021)
Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V S Manu, Fernando Porcelli, Donald K Blumenthal, David Dt Thomas, David A Bernlohr, Sanford M Simon, Susan S Taylor, Gianluigi Veglia
Author Correction: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A. Communications biology 4 (1) (2021)
Tsan-Wen Lu, Phillip C Aoto, Jui-Hung Weng, Cole Nielsen, Jennifer N Cash, James E Hall, Ping Zhang, Sanford M Simon, Michael A Cianfrocco, Susan S Taylor
Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. PLoS biology 18 (12) (2020)
Cristina Olivieri, Yingjie Wang, Geoffrey C Li, Manu V S, Jonggul Kim, Benjamin R Stultz, Matthew Neibergall, Fernando Porcelli, Joseph M Muretta, David Dt Thomas, Jiali Gao, Donald K Blumenthal, Susan S Taylor, Gianluigi Veglia
Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A. eLife 9 (2020)
Jung Ah Byun, Madoka Akimoto, B VanSchouwen, T S Lazarou, Susan S Taylor, Giuseppe Melacini
Allosteric pluripotency as revealed by protein kinase A. Science advances 6 (25) (2020)
Yuxin Hao, Jeneffer P England, Luca Bellucci, Emanuele Paci, H Courtney Hodges, Susan S Taylor, Rodrigo A Maillard
Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains. Nature communications 10 (1) (2019)
Caitlin Walker, Yingjie Wang, Cristina Olivieri, Adak Karamafrooz, Jordan Casby, Kerstin Bathon, Davide Calebiro, Jiali Gao, David A Bernlohr, Susan S Taylor, Gianluigi Veglia
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity. Science advances 5 (8) (2019)
Yingjie Wang, Manu V S, Jonggul Kim, Geoffrey Li, Lalima G Ahuja, Phillip C Aoto, Susan S Taylor, Gianluigi Veglia
Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle. Nature communications 10 (1) (2019)
Oksana Gerlits, Kevin L Weiss, Matthew P Blakeley, Gianluigi Veglia, Susan S Taylor, Andrey Y Kovalevsky
Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex. Science advances 5 (3) (2019)
Jenna L Jewell, Vivian Fu, Audrey W Hong, Fa-Xing Yu, Delong Meng, Chase H Melick, Huanyu Wang, Wai-Ling Macrina Lam, Hai-Xin Yuan, Susan S Taylor, Kun-Liang Guan
GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. eLife 8 (2019)
Ruth Röck, Johanna E Mayrhofer, Omar Torres-Quesada, Florian Enzler, Andrea Raffeiner, Philipp Raffeiner, Andreas Feichtner, Roland G Huber, Shohei Koide, Susan S Taylor, Jakob Troppmair, Eduard Stefan
BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS. Science advances 5 (8) (2019)
Saravanan Raju, Daniel M Whalen, Meron Mengistu, Carter Swanson, John G Quinn, Susan S Taylor, Joshua D Webster, Kim Newton, Andrey S Shaw
Kinase domain dimerization drives RIPK3-dependent necroptosis. Science signaling 11 (544) (2018)
Michael D Tomasini, Yingjie Wang, Adak Karamafrooz, Geoffrey Li, Thijs Beuming, Jiali Gao, Susan S Taylor, Gianluigi Veglia, Sanford M Simon
Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma. Scientific reports 8 (1) (2018)
Ronit Ilouz, Varda Lev-Ram, Eric A Bushong, Travis L Stiles, Dinorah Friedmann-Morvinski, Christopher Douglas, Jeffrey L Goldberg, Mark H Ellisman, Susan S Taylor
Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain. eLife 6 (2017)
Yuxin Hao, Clare Canavan, Susan S Taylor, Rodrigo A Maillard
Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers. Scientific reports 7 (1) (2017)