Gordon J Lockbaum

Publication Activity (10 Years)

Years Active: 2018-2022
Publications (10 Years): 11

Top Topics

Molecular Dynamics Simulations

Angiotensin Converting Enzyme

Structural Basis

Top Venues

ACS chemical biology

ACS infectious diseases

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Ala M Shaqra, Sarah N Zvornicanin, Qiu Yu J Huang, Gordon J Lockbaum, Mark Knapp, Laura Tandeske, David T Bakan, Julia M Flynn, Daniel N A Bolon, Stephanie Moquin, Dustin Dovala, Nese Kurt Yilmaz, Celia A Schiffer
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nature communications 13 (1) (2022)
Santanu Mondal, Yongzhi Chen, Gordon J Lockbaum, Sudeshna Sen, Sauradip Chaudhuri, Archie C Reyes, Jeong Min Lee, Arshia N Kaur, Nadia Sultana, Michael D Cameron, Scott A Shaffer, Celia A Schiffer, Katherine A Fitzgerald, Paul R Thompson
Dual Inhibitors of Main Protease (M Pro ) and Cathepsin L as Potent Antivirals against SARS-CoV2. Journal of the American Chemical Society 144 (46) (2022)
Gordon J Lockbaum, Mina Henes, Jeong Min Lee, Jennifer Timm, Ellen A Nalivaika, Paul R Thompson, Nese Kurt Yilmaz, Celia A Schiffer
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode. Biochemistry 60 (39) (2021)
Ashley N Matthew, Florian Leidner, Gordon J Lockbaum, Mina Henes, Jacqueto Zephyr, Shurong Hou, Desaboini Nageswara Rao, Jennifer Timm, Linah N Rusere, Debra A Ragland, Janet L Paulsen, Kristina Prachanronarong, Djade I Soumana, Ellen A Nalivaika, Nese Kurt Yilmaz, Akbar Ali, Celia A Schiffer
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond. Chemical reviews 121 (6) (2021)
Gordon J Lockbaum, Mina Henes, Nathaniel Talledge, Linah N Rusere, Klajdi Kosovrasti, Ellen A Nalivaika, Mohan Somasundaran, Akbar Ali, Louis M Mansky, Nese Kurt Yilmaz, Celia A Schiffer
Inhibiting HTLV-1 Protease: A Viable Antiviral Target. ACS chemical biology 16 (3) (2021)
Linah N Rusere, Gordon J Lockbaum, Mina Henes, Sook-Kyung Lee, Ean Spielvogel, Desaboini Nageswara Rao, Klajdi Kosovrasti, Ellen A Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A Schiffer, Akbar Ali
Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere. Journal of medicinal chemistry 63 (15) (2020)
Linah N Rusere, Gordon J Lockbaum, Sook-Kyung Lee, Mina Henes, Klajdi Kosovrasti, Ean Spielvogel, Ellen A Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A Schiffer, Akbar Ali
HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope. Journal of medicinal chemistry 62 (17) (2019)
Mina Henes, Gordon J Lockbaum, Klajdi Kosovrasti, Florian Leidner, Gily S Nachum, Ellen A Nalivaika, Sook-Kyung Lee, Ean Spielvogel, Shuntai Zhou, Ronald Swanstrom, Daniel N A Bolon, Nese Kurt Yilmaz, Celia A Schiffer
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance. ACS chemical biology 14 (11) (2019)
Mina Henes, Klajdi Kosovrasti, Gordon J Lockbaum, Florian Leidner, Gily S Nachum, Ellen A Nalivaika, Daniel N A Bolon, Nese Kurt Yilmaz, Celia A Schiffer, Troy W Whitfield
Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance. Biochemistry 58 (35) (2019)
Gordon J Lockbaum, Florian Leidner, Linah N Rusere, Mina Henes, Klajdi Kosovrasti, Gily S Nachum, Ellen A Nalivaika, Daniel N A Bolon, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer
Correction to Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS infectious diseases 5 (6) (2019)
Gordon J Lockbaum, Florian Leidner, Linah N Rusere, Mina Henes, Klajdi Kosovrasti, Gily S Nachum, Ellen A Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer
Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS infectious diseases 5 (2) (2018)