Celia A Schiffer

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 49

Top Topics

Infectious Diseases

Machine Learning

Hepatitis C Virus

Crystal Structure

Top Venues

ACS infectious diseases

Journal of chemical theory and computation

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Julia M Flynn, Sarah N Zvornicanin, Tenzin Tsepal, Ala M Shaqra, Nese Kurt Yilmaz, Weiping Jia, Stephanie Moquin, Dustin Dovala, Celia A Schiffer, Daniel N A Bolon
Contributions of Hyperactive Mutations in M pro from SARS-CoV-2 to Drug Resistance. ACS infectious diseases 10 (4) (2024)
Julia M Flynn, Sarah N Zvornicanin, Tenzin Tsepal, Ala M Shaqra, Nese Kurt Yilmaz, Weiping Jia, Stephanie Moquin, Dustin Dovala, Celia A Schiffer, Daniel N A Bolon
Contributions of Hyperactive Mutations in M pro from SARS-CoV-2 to Drug Resistance. ACS infectious diseases (2024)
Julia M Flynn, Sarah N Zvornicanin, Tenzin Tsepal, Ala M Shaqra, Nese Kurt Yilmaz, Weiping Jia, Stephanie Moquin, Dustin Dovala, Celia A Schiffer, Daniel N A Bolon
Contributions of Hyperactive Mutations in M pro from SARS-CoV-2 to Drug Resistance. ACS infectious diseases 10 (4) (2024)
Julia M Flynn, Sarah N Zvornicanin, Tenzin Tsepal, Ala M Shaqra, Nese Kurt Yilmaz, Weiping Jia, Stephanie Moquin, Dustin Dovala, Celia A Schiffer, Daniel N A Bolon
Contributions of Hyperactive Mutations in M pro from SARS-CoV-2 to Drug Resistance. ACS infectious diseases 10 (4) (2024)
Julia M Flynn, Sarah N Zvornicanin, Tenzin Tsepal, Ala M Shaqra, Nese Kurt Yilmaz, Weiping Jia, Stephanie Moquin, Dustin Dovala, Celia A Schiffer, Daniel N A Bolon
Contributions of Hyperactive Mutations in M pro from SARS-CoV-2 to Drug Resistance. ACS infectious diseases 10 (4) (2024)
Julia M Flynn, Sarah N Zvornicanin, Tenzin Tsepal, Ala M Shaqra, Nese Kurt Yilmaz, Weiping Jia, Stephanie Moquin, Dustin Dovala, Celia A Schiffer, Daniel N A Bolon
Contributions of Hyperactive Mutations in M pro from SARS-CoV-2 to Drug Resistance. ACS infectious diseases 10 (4) (2024)
Sarah N Zvornicanin, Ala M Shaqra, Qiu Yu J Huang, Elizabeth Ornelas, Mallika Moghe, Mark Knapp, Stephanie Moquin, Dustin Dovala, Celia A Schiffer, Nese Kurt Yilmaz
Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses. Viruses 15 (3) (2023)
Julia M Flynn, Qiu Yu J Huang, Sarah N Zvornicanin, Gila Schneider-Nachum, Ala M Shaqra, Nese Kurt Yilmaz, Stephanie A Moquin, Dustin Dovala, Celia A Schiffer, Daniel N A Bolon
Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease. ACS infectious diseases (2023)
Spencer T Adams, Jacqueto Zephyr, Markus F Bohn, Celia A Schiffer, Stephen C Miller
FruitFire: a luciferase based on a fruit fly metabolic enzyme. bioRxiv : the preprint server for biology (2023)
Sarah N Zvornicanin, Ala M Shaqra, Qiu Yu J Huang, Elizabeth Ornelas, Mallika Moghe, Mark Knapp, Stephanie Moquin, Dustin Dovala, Celia A Schiffer, Nese Kurt Yilmaz
Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses. Viruses 15 (3) (2023)
Ean Spielvogel, Sook-Kyung Lee, Shuntai Zhou, Gordon J Lockbaum, Mina Henes, Amy Sondgeroth, Klajdi Kosovrasti, Ellen A Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer, Ronald Swanstrom
Selection of HIV-1 for resistance to fifth generation protease inhibitors reveals two independent pathways to high-level resistance. eLife 12 (2023)
Sarah N Zvornicanin, Ala M Shaqra, Qiu Yu J Huang, Elizabeth Ornelas, Mallika Moghe, Mark Knapp, Stephanie Moquin, Dustin Dovala, Celia A Schiffer, Nese Kurt Yilmaz
Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses. Viruses 15 (3) (2023)
Celia A Schiffer, Daria J Hazuda
Call for Papers: Drug Resistance in Infectious Diseases and Beyond. ACS infectious diseases 8 (4) (2022)
Julia M Flynn, Neha Samant, Gily Schneider-Nachum, David T Barkan, Nese Kurt Yilmaz, Celia A Schiffer, Stephanie A Moquin, Dustin Dovala, Daniel N A Bolon
Comprehensive fitness landscape of SARS-CoV-2 M pro reveals insights into viral resistance mechanisms. eLife 11 (2022)
Atanu Maiti, Adam K Hedger, Wazo Myint, Vanivilasini Balachandran, Jonathan K Watts, Celia A Schiffer, Hiroshi Matsuo
Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state. Nature communications 13 (1) (2022)
Ala M Shaqra, Sarah N Zvornicanin, Qiu Yu J Huang, Gordon J Lockbaum, Mark Knapp, Laura Tandeske, David T Bakan, Julia M Flynn, Daniel N A Bolon, Stephanie Moquin, Dustin Dovala, Nese Kurt Yilmaz, Celia A Schiffer
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nature communications 13 (1) (2022)
Santanu Mondal, Yongzhi Chen, Gordon J Lockbaum, Sudeshna Sen, Sauradip Chaudhuri, Archie C Reyes, Jeong Min Lee, Arshia N Kaur, Nadia Sultana, Michael D Cameron, Scott A Shaffer, Celia A Schiffer, Katherine A Fitzgerald, Paul R Thompson
Dual Inhibitors of Main Protease (M Pro ) and Cathepsin L as Potent Antivirals against SARS-CoV2. Journal of the American Chemical Society 144 (46) (2022)
Gordon J Lockbaum, Mina Henes, Jeong Min Lee, Jennifer Timm, Ellen A Nalivaika, Paul R Thompson, Nese Kurt Yilmaz, Celia A Schiffer
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode. Biochemistry 60 (39) (2021)
Gordon J Lockbaum, Archie C Reyes, Jeong Min Lee, Ronak Tilvawala, Ellen A Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Paul R Thompson, Celia A Schiffer
Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188. Viruses 13 (2) (2021)
Nese Kurt Yilmaz, Celia A Schiffer
Introduction: Drug Resistance. Chemical reviews 121 (6) (2021)
Ashley N Matthew, Florian Leidner, Gordon J Lockbaum, Mina Henes, Jacqueto Zephyr, Shurong Hou, Desaboini Nageswara Rao, Jennifer Timm, Linah N Rusere, Debra A Ragland, Janet L Paulsen, Kristina Prachanronarong, Djade I Soumana, Ellen A Nalivaika, Nese Kurt Yilmaz, Akbar Ali, Celia A Schiffer
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond. Chemical reviews 121 (6) (2021)
Florian Leidner, Nese Kurt Yilmaz, Celia A Schiffer
Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning. Journal of chemical information and modeling 61 (6) (2021)
Desaboini Nageswara Rao, Jacqueto Zephyr, Mina Henes, Elise T Chan, Ashley N Matthew, Adam K Hedger, Hasahn L Conway, Mohsan Saeed, Alicia Newton, Christos J Petropoulos, Wei Huang, Nese Kurt Yilmaz, Celia A Schiffer, Akbar Ali
Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants. Journal of medicinal chemistry 64 (16) (2021)
Wayne D Harshbarger, Derrick Deming, Gordon J Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew, Shurong Hou, Mohan Somasundaran, Jennifer P Wang, Robert W Finberg, Quan Karen Zhu, Celia A Schiffer, Wayne A Marasco
Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses. Nature communications 12 (1) (2021)
Gordon J Lockbaum, Mina Henes, Nathaniel Talledge, Linah N Rusere, Klajdi Kosovrasti, Ellen A Nalivaika, Mohan Somasundaran, Akbar Ali, Louis M Mansky, Nese Kurt Yilmaz, Celia A Schiffer
Inhibiting HTLV-1 Protease: A Viable Antiviral Target. ACS chemical biology 16 (3) (2021)
Florian Leidner, Nese Kurt Yilmaz, Celia A Schiffer
Deciphering Complex Mechanisms of Resistance and Loss of Potency through Coupled Molecular Dynamics and Machine Learning. Journal of chemical theory and computation 17 (4) (2021)
Monir Ejemel, Qi Li, Shurong Hou, Zachary A Schiller, Julia A Tree, Aaron Wallace, Alla Amcheslavsky, Nese Kurt Yilmaz, Karen R Buttigieg, Michael J Elmore, Kerry Godwin, Naomi Coombes, Jacqueline R Toomey, Ryan Schneider, Anudeep S Ramchetty, Brianna J Close, Da-Yuan Chen, Hasahn L Conway, Mohsan Saeed, Chandrashekar Ganesa, Miles W Carroll, Lisa A Cavacini, Mark S Klempner, Celia A Schiffer, Yang Wang
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction. Nature communications 11 (1) (2020)
Erica P Cai, Yuki Ishikawa, Wei Zhang, Nayara Carvalho Leite, Jian Li, Shurong Hou, Badr Kiaf, Jennifer Hollister-Lock, Nese Kurt Yilmaz, Celia A Schiffer, Douglas A Melton, Stephen M Kissler, Peng Yi
Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes. Nature metabolism 2 (9) (2020)
Monir Ejemel, Qi Li, Shurong Hou, Zachary A Schiller, Aaron L Wallace, Alla Amcheslavsky, Nese Kurt Yilmaz, Jacqueline R Toomey, Ryan Schneider, Brianna J Close, Da-Yuan Chen, Hasahn L Conway, Mohsan Saeed, Lisa A Cavacini, Mark S Klempner, Celia A Schiffer, Yang Wang
IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity. bioRxiv : the preprint server for biology (2020)
Jennifer Timm, Klajdi Kosovrasti, Mina Henes, Florian Leidner, Shurong Hou, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer
Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir. ACS chemical biology 15 (2) (2020)
Troy W Whitfield, Debra A Ragland, Konstantin B Zeldovich, Celia A Schiffer
Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease. Journal of chemical theory and computation 16 (2) (2020)
Linah N Rusere, Gordon J Lockbaum, Mina Henes, Sook-Kyung Lee, Ean Spielvogel, Desaboini Nageswara Rao, Klajdi Kosovrasti, Ellen A Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A Schiffer, Akbar Ali
Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere. Journal of medicinal chemistry 63 (15) (2020)
Florian Leidner, Nese Kurt Yilmaz, Celia A Schiffer
Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints. Journal of chemical information and modeling 59 (9) (2019)
Linah N Rusere, Gordon J Lockbaum, Sook-Kyung Lee, Mina Henes, Klajdi Kosovrasti, Ean Spielvogel, Ellen A Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A Schiffer, Akbar Ali
HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope. Journal of medicinal chemistry 62 (17) (2019)
Tania V Silvas, Celia A Schiffer
APOBEC3s: DNA-editing human cytidine deaminases. Protein science : a publication of the Protein Society 28 (9) (2019)
Mina Henes, Gordon J Lockbaum, Klajdi Kosovrasti, Florian Leidner, Gily S Nachum, Ellen A Nalivaika, Sook-Kyung Lee, Ean Spielvogel, Shuntai Zhou, Ronald Swanstrom, Daniel N A Bolon, Nese Kurt Yilmaz, Celia A Schiffer
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance. ACS chemical biology 14 (11) (2019)
Mina Henes, Klajdi Kosovrasti, Gordon J Lockbaum, Florian Leidner, Gily S Nachum, Ellen A Nalivaika, Daniel N A Bolon, Nese Kurt Yilmaz, Celia A Schiffer, Troy W Whitfield
Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance. Biochemistry 58 (35) (2019)
Gordon J Lockbaum, Florian Leidner, Linah N Rusere, Mina Henes, Klajdi Kosovrasti, Gily S Nachum, Ellen A Nalivaika, Daniel N A Bolon, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer
Correction to Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS infectious diseases 5 (6) (2019)
Rieko Ishima, Nese Kurt Yilmaz, Celia A Schiffer
NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations. Journal of biomolecular NMR 73 (6-7) (2019)
Shurong Hou, Tania V Silvas, Florian Leidner, Ellen A Nalivaika, Hiroshi Matsuo, Nese Kurt Yilmaz, Celia A Schiffer
Structural Analysis of the Active Site and DNA Binding of Human Cytidine Deaminase APOBEC3B. Journal of chemical theory and computation 15 (1) (2018)
Atanu Maiti, Wazo Myint, Tapan Kanai, Krista A Delviks-Frankenberry, Christina Sierra Rodriguez, Vinay K Pathak, Celia A Schiffer, Hiroshi Matsuo
Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA. Nature communications 9 (1) (2018)
Florian Leidner, Nese Kurt Yilmaz, Janet Paulsen, Yves A Muller, Celia A Schiffer
Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease. Journal of chemical theory and computation 14 (5) (2018)
Gordon J Lockbaum, Florian Leidner, Linah N Rusere, Mina Henes, Klajdi Kosovrasti, Gily S Nachum, Ellen A Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer
Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease. ACS infectious diseases 5 (2) (2018)
Alexis Kaushansky, Lizbeth Hedstrom, Aaron Goldman, Juswinder Singh, Priscilla L Yang, Pradipsinh K Rathod, Michael Cynamon, Dominik Wodarz, Daruka Mahadevan, Andrew Tomaras, Manuel A Navia, Celia A Schiffer
A call to arms: Unifying the fight against resistance. Science signaling 11 (553) (2018)
Shahid N Khan, John D Persons, Janet L Paulsen, Michel Guerrero, Celia A Schiffer, Nese Kurt Yilmaz, Rieko Ishima
Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance. Biochemistry 57 (10) (2018)
Debra A Ragland, Troy W Whitfield, Sook-Kyung Lee, Ronald Swanstrom, Konstantin B Zeldovich, Nese Kurt Yilmaz, Celia A Schiffer
Elucidating the Interdependence of Drug Resistance from Combinations of Mutations. Journal of chemical theory and computation 13 (11) (2017)
Ashley N Matthew, Jacqueto Zephyr, Caitlin J Hill, Muhammad Jahangir, Alicia Newton, Christos J Petropoulos, Wei Huang, Nese Kurt-Yilmaz, Celia A Schiffer, Akbar Ali
Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants. Journal of medicinal chemistry 60 (13) (2017)
Ashley N Matthew, Nese Kurt Yilmaz, Celia A Schiffer
Mavyret: A Pan-Genotypic Combination Therapy for the Treatment of Hepatitis C InfectionPublished as part of the Biochemistry series "Biochemistry to Bedside". Biochemistry 57 (5) (2017)
Janet L Paulsen, Florian Leidner, Debra A Ragland, Nese Kurt Yilmaz, Celia A Schiffer
Interdependence of Inhibitor Recognition in HIV-1 Protease. Journal of chemical theory and computation 13 (5) (2017)