James A Irving (James Irving)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 17

Top Venues

The FEBS journal

American journal of respiratory cell and molecular biology

EMBO molecular medicine

Cellular and molecular life sciences : CMLS

University of Cambridge

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge

United Kingdom

Research Associate :: Cambridge Institute for Medical Research

Publications

Kamila Kamuda, Riccardo Ronzoni, Avik Majumdar, Fiona H X Guan, James A Irving, David A Lomas
A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate. The FEBS journal 291 (13) (2024)
Kamila Kamuda, Riccardo Ronzoni, Avik Majumdar, Fiona H X Guan, James A Irving, David A Lomas
A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate. The FEBS journal (2024)
Kyle Varkoly, Roxana Beladi, Mostafa Hamada, Grant McFadden, James A Irving, Alexandra R Lucas
Viral SERPINS-A Family of Highly Potent Immune-Modulating Therapeutic Proteins. Biomolecules 13 (9) (2023)
Stefania Ottaviani, Giulia Bartoli, Tomás P Carroll, Fabrizio Gangemi, Alice M Balderacchi, Valentina Barzon, Alessandra Corino, Davide Piloni, Noel G McElvaney, Angelo G Corsico, James A Irving, Annamaria Fra, Ilaria Ferrarotti
Comprehensive Clinical Diagnostic Pipelines Reveal New Variants in Alpha-1-Antitrypsin Deficiency. American journal of respiratory cell and molecular biology (2023)
Andrea Denardo, Emna Ben Khlifa, Mattia Bignotti, Roberta Giuliani, Emanuela D'Acunto, Elena Miranda, James A Irving, Annamaria Fra
Probing of the reactive center loop region of alpha-1-antitrypsin by mutagenesis predicts new type-2 dysfunctional variants. Cellular and molecular life sciences : CMLS 81 (1) (2023)
Marie-Christine Bouton, Margarethe Geiger, William P Sheffield, James A Irving, David A Lomas, Sihong Song, Ritvik S Satyanarayanan, Liqiang Zhang, Grant McFadden, Alexandra R Lucas
The under-appreciated world of the serpin family of serine proteinase inhibitors. EMBO molecular medicine (2023)
Alina Chrzastek, Ioanna A Thanasi, James A Irving, Vijay Chudasama, James Richard Baker
Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation. Chemical science 13 (39) (2022)
Samuele Raccosta, Fabio Librizzi, Alistair M Jagger, Rosina Noto, Vincenzo Martorana, David A Lomas, James A Irving, Mauro Manno
Scaling Concepts in Serpin Polymer Physics. Materials (Basel, Switzerland) 14 (10) (2021)
David A Lomas, James A Irving, Christopher Arico-Muendel, Svetlana Belyanskaya, Andrew Brewster, Murray Brown, Chun-Wa Chung, Hitesh Dave, Alexis Denis, Nerina Dodic, Anthony Dossang, Peter Eddershaw, Diana Klimaszewska, Imran Haq, Duncan S Holmes, Jonathan P Hutchinson, Alistair M Jagger, Toral Jakhria, Emilie Jigorel, John Liddle, Ken Lind, Stefan J Marciniak, Jeff Messer, Margaret Neu, Allison Olszewski, Adriana Ordonez, Riccardo Ronzoni, James Rowedder, Martin Rüdiger, Steve Skinner, Kathrine J Smith, Rebecca Terry, Lionel Trottet, Iain Uings, Steve Wilson, Zhengrong Zhu, Andrew C Pearce
Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin. EMBO molecular medicine 13 (3) (2021)
Riccardo Ronzoni, Ilaria Ferrarotti, Emanuela D'Acunto, Alice Maria Balderacchi, Stefania Ottaviani, David A Lomas, James A Irving, Elena Miranda, Annamaria Fra
The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant. International journal of molecular sciences 22 (11) (2021)
Sarah V Faull, Emma L K Elliston, Bibek Gooptu, Alistair M Jagger, Ibrahim Aldobiyan, Adam Redzej, Magd Badaoui, Nina Heyer-Chauhan, Sheikh Tamir Rashid, Gary M Reynolds, David H Adams, Elena Miranda, Elena V Orlova, James A Irving, David A Lomas
The structural basis for Z α1-antitrypsin polymerization in the liver. Science advances 6 (43) (2020)
Riccardo Ronzoni, Nina Heyer-Chauhan, Annamaria Fra, Andrew C Pearce, Martin Rüdiger, Elena Miranda, James A Irving, David A Lomas
The molecular species responsible for α1 -antitrypsin deficiency are suppressed by a small molecule chaperone. The FEBS journal 288 (7) (2020)
Alistair M Jagger, Christopher A Waudby, James A Irving, John Christodoulou, David A Lomas
High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin. Nature communications 11 (1) (2020)
Mattia Laffranchi, Emma L K Elliston, Fabrizio Gangemi, Romina Berardelli, David A Lomas, James A Irving, Annamaria Fra
Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population. PloS one 14 (1) (2019)
Li Yang, James A Irving, Weiwen Dai, Marie-Isabel Aguilar, Stephen P Bottomley
Probing the folding pathway of a consensus serpin using single tryptophan mutants. Scientific reports 8 (1) (2018)
Elena Miranda, Ilaria Ferrarotti, Romina Berardelli, Mattia Laffranchi, Marta Cerea, Fabrizio Gangemi, Imran Haq, Stefania Ottaviani, David A Lomas, James A Irving, Annamaria Fra
The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization. The FEBS journal 284 (13) (2017)
Imran Haq, James A Irving, Aarash D Saleh, Louis Dron, Gemma L Regan-Mochrie, Neda Motamedi-Shad, John R Hurst, Bibek Gooptu, David A Lomas
Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization. American journal of respiratory cell and molecular biology 54 (1) (2016)

James A Irving.css-eqlu8i{font-size:small;padding-left:4px;} (James Irving)

Publication Activity (10 Years)

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James A Irving (James Irving)