James A Spudich

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 24

Top Topics

Binding Protein

Hypertrophic Cardiomyopathy

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Science advances

Nature communications

The EMBO journal

This page only lists publications with an associated author ORCID identifier.

Publications

Chao Liu, Anastasia Karabina, Artur Meller, Ayan Bhattacharjee, Colby J Agostino, Gregory R Bowman, Kathleen M Ruppel, James A Spudich, Leslie A Leinwand
Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation. Proceedings of the National Academy of Sciences of the United States of America 121 (9) (2024)
Soah Lee, Alison S Vander Roest, Cheavar A Blair, Kerry Kao, Samantha B Bremner, Matthew Carter Childers, Divya Pathak, Paul Heinrich, Daniel Lee, Orlando Chirikian, Saffie E Mohran, Brock Roberts, Jacqueline E Smith, James W Jahng, David T Paik, Joseph C Wu, Ruwanthi N Gunawardane, Kathleen M Ruppel, David L Mack, Beth L Pruitt, Michael Regnier, Sean M Wu, James A Spudich, Daniel Bernstein
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Soah Lee, Alison S Vander Roest, Cheavar A Blair, Kerry Kao, Samantha B Bremner, Matthew Carter Childers, Divya Pathak, Paul Heinrich, Daniel Lee, Orlando Chirikian, Saffie E Mohran, Brock Roberts, Jacqueline E Smith, James W Jahng, David T Paik, Joseph C Wu, Ruwanthi N Gunawardane, Kathleen M Ruppel, David L Mack, Beth L Pruitt, Michael Regnier, Sean M Wu, James A Spudich, Daniel Bernstein
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Chao Liu, Anastasia Karabina, Artur Meller, Ayan Bhattacharjee, Colby J Agostino, Gregory R Bowman, Kathleen M Ruppel, James A Spudich, Leslie A Leinwand
Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation. Proceedings of the National Academy of Sciences of the United States of America 121 (9) (2024)
Soah Lee, Alison S Vander Roest, Cheavar A Blair, Kerry Kao, Samantha B Bremner, Matthew Carter Childers, Divya Pathak, Paul Heinrich, Daniel Lee, Orlando Chirikian, Saffie E Mohran, Brock Roberts, Jacqueline E Smith, James W Jahng, David T Paik, Joseph C Wu, Ruwanthi N Gunawardane, Kathleen M Ruppel, David L Mack, Beth L Pruitt, Michael Regnier, Sean M Wu, James A Spudich, Daniel Bernstein
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Chao Liu, Anastasia Karabina, Artur Meller, Ayan Bhattacharjee, Colby J Agostino, Gregory R Bowman, Kathleen M Ruppel, James A Spudich, Leslie A Leinwand
Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation. Proceedings of the National Academy of Sciences of the United States of America 121 (9) (2024)
Soah Lee, Alison S Vander Roest, Cheavar A Blair, Kerry Kao, Samantha B Bremner, Matthew Carter Childers, Divya Pathak, Paul Heinrich, Daniel Lee, Orlando Chirikian, Saffie E Mohran, Brock Roberts, Jacqueline E Smith, James W Jahng, David T Paik, Joseph C Wu, Ruwanthi N Gunawardane, Kathleen M Ruppel, David L Mack, Beth L Pruitt, Michael Regnier, Sean M Wu, James A Spudich, Daniel Bernstein
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
James A Spudich, Neha Nandwani, Julien Robert-Paganin, Anne Houdusse, Kathleen M Ruppel
Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy. The EMBO journal (2024)
Neha Nandwani, Debanjan Bhowmik, Matthew C Childers, Rama Reddy Goluguri, Aminah Dawood, Michael Regnier, James A Spudich, Kathleen M Ruppel
Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically. bioRxiv : the preprint server for biology (2024)
Chao Liu, Anastasia Karabina, Artur Meller, Ayan Bhattacharjee, Colby J Agostino, Gregory R Bowman, Kathleen M Ruppel, James A Spudich, Leslie A Leinwand
Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation. Proceedings of the National Academy of Sciences of the United States of America 121 (9) (2024)
Chao Liu, Anastasia Karabina, Artur Meller, Ayan Bhattacharjee, Colby J Agostino, Gregory R Bowman, Kathleen M Ruppel, James A Spudich, Leslie A Leinwand
Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation. Proceedings of the National Academy of Sciences of the United States of America 121 (9) (2024)
Chao Liu, Anastasia Karabina, Artur Meller, Ayan Bhattacharjee, Colby J Agostino, Gregory R Bowman, Kathleen M Ruppel, James A Spudich, Leslie A Leinwand
Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation. Proceedings of the National Academy of Sciences of the United States of America 121 (9) (2024)
Soah Lee, Alison S Vander Roest, Cheavar A Blair, Kerry Kao, Samantha B Bremner, Matthew Carter Childers, Divya Pathak, Paul Heinrich, Daniel Lee, Orlando Chirikian, Saffie E Mohran, Brock Roberts, Jacqueline E Smith, James W Jahng, David T Paik, Joseph C Wu, Ruwanthi N Gunawardane, Kathleen M Ruppel, David L Mack, Beth L Pruitt, Michael Regnier, Sean M Wu, James A Spudich, Daniel Bernstein
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Soah Lee, Alison S Vander Roest, Cheavar A Blair, Kerry Kao, Samantha B Bremner, Matthew Carter Childers, Divya Pathak, Paul Heinrich, Daniel Lee, Orlando Chirikian, Saffie E Mohran, Brock Roberts, Jacqueline E Smith, James W Jahng, David T Paik, Joseph C Wu, Ruwanthi N Gunawardane, Kathleen M Ruppel, David L Mack, Beth L Pruitt, Michael Regnier, Sean M Wu, James A Spudich, Daniel Bernstein
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Soah Lee, Alison S Vander Roest, Cheavar A Blair, Kerry Kao, Samantha B Bremner, Matthew Carter Childers, Divya Pathak, Paul Heinrich, Daniel Lee, Orlando Chirikian, Saffie E Mohran, Brock Roberts, Jacqueline E Smith, James W Jahng, David T Paik, Joseph C Wu, Ruwanthi N Gunawardane, Kathleen M Ruppel, David L Mack, Beth L Pruitt, Michael Regnier, Sean M Wu, James A Spudich, Daniel Bernstein
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Alessandro Grinzato, Daniel Auguin, Carlos Kikuti, Neha Nandwani, Dihia Moussaoui, Divya Pathak, Eaazhisai Kandiah, Kathleen M Ruppel, James A Spudich, Anne Houdusse, Julien Robert-Paganin
Cryo-EM structure of the folded-back state of human β-cardiac myosin. Nature communications 14 (1) (2023)
Suman Nag, Sampath K Gollapudi, Carlos L Del Rio, James A Spudich, Robert McDowell
Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients. Science advances 9 (30) (2023)
Alison Schroer Vander Roest, Chao Liu, Makenna M Morck, Kristina Bezold Kooiker, Gwanghyun Jung, Dan Song, Aminah Dawood, Arnav Jhingran, Gaspard Pardon, Sara Ranjbarvaziri, Giovanni Fajardo, Mingming Zhao, Kenneth S Campbell, Beth L Pruitt, James A Spudich, Kathleen M Ruppel, Daniel Bernstein
Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state. Proceedings of the National Academy of Sciences of the United States of America 118 (24) (2021)
Saswata S Sarkar, Darshan V Trivedi, Makenna M Morck, Arjun S Adhikari, Shaik N Pasha, Kathleen M Ruppel, James A Spudich
The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin. Science advances 6 (14) (2020)
Arjun S Adhikari, Darshan V Trivedi, Saswata S Sarkar, Dan Song, Kristina B Kooiker, Daniel Bernstein, James A Spudich, Kathleen M Ruppel
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity. Nature communications 10 (1) (2019)
James A Spudich
Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations. Pflugers Archiv : European journal of physiology 471 (5) (2019)
Chao Liu, Masataka Kawana, Dan Song, Kathleen M Ruppel, James A Spudich
Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level. Nature structural & molecular biology 25 (6) (2018)
Masataka Kawana, Saswata S Sarkar, Shirley C Sutton, Kathleen M Ruppel, James A Spudich
Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy. Science advances 3 (2) (2017)
Darshan V Trivedi, Arjun S Adhikari, Saswata S Sarkar, Kathleen M Ruppel, James A Spudich
Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light. Biophysical reviews 10 (1) (2017)