Kathleen M Ruppel

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 6

Top Topics

Binding Protein

Hypertrophic Cardiomyopathy

Pluripotent Stem Cells

Top Venues

Nature communications

The EMBO journal

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

James A Spudich, Neha Nandwani, Julien Robert-Paganin, Anne Houdusse, Kathleen M Ruppel
Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy. The EMBO journal (2024)
Neha Nandwani, Debanjan Bhowmik, Matthew C Childers, Rama Reddy Goluguri, Aminah Dawood, Michael Regnier, James A Spudich, Kathleen M Ruppel
Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically. bioRxiv : the preprint server for biology (2024)
Alessandro Grinzato, Daniel Auguin, Carlos Kikuti, Neha Nandwani, Dihia Moussaoui, Divya Pathak, Eaazhisai Kandiah, Kathleen M Ruppel, James A Spudich, Anne Houdusse, Julien Robert-Paganin
Cryo-EM structure of the folded-back state of human β-cardiac myosin. Nature communications 14 (1) (2023)
Makenna M Morck, Debanjan Bhowmik, Divya Pathak, Aminah Dawood, James Spudich, Kathleen M Ruppel
Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function. eLife 11 (2022)
Saswata S Sarkar, Darshan V Trivedi, Makenna M Morck, Arjun S Adhikari, Shaik N Pasha, Kathleen M Ruppel, James A Spudich
The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin. Science advances 6 (14) (2020)
Arjun S Adhikari, Darshan V Trivedi, Saswata S Sarkar, Dan Song, Kristina B Kooiker, Daniel Bernstein, James A Spudich, Kathleen M Ruppel
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity. Nature communications 10 (1) (2019)