Jason R Spence (Jason Spence)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 48

Top Topics

Escherichia Coli

Pluripotent Stem Cells

Transcription Factor

Top Venues

Development (Cambridge, England)

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A patterned human neural tube model using microfluidic gradients. Nature (2024)
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A patterned human neural tube model using microfluidic gradients. Nature 628 (8007) (2024)
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A patterned human neural tube model using microfluidic gradients. Nature 628 (8007) (2024)
Paramita Ray, Sangeeta Jaiswal, Daysha Ferrer-Torres, Zhuwen Wang, Derek Nancarrow, Meghan C Curtin, May San Martinho, Shannon M Lacy, Srimathi Kasturirangan, Dafydd G Thomas, Jason R Spence, Matthias C Truttmann, Kiran H Lagisetty, Theodore S Lawrence, Thomas D Wang, David G Beer, Dipankar Ray
GRAIL1 stabilizes misfolded mutant p53 through a ubiquitin ligase-independent, chaperone regulatory function. Molecular cancer research : MCR (2024)
Paramita Ray, Sangeeta Jaiswal, Daysha Ferrer-Torres, Zhuwen Wang, Derek Nancarrow, Meghan C Curtin, May San Martinho, Shannon M Lacy, Srimathi Kasturirangan, Dafydd G Thomas, Jason R Spence, Matthias C Truttmann, Kiran H Lagisetty, Theodore S Lawrence, Thomas D Wang, David G Beer, Dipankar Ray
GRAIL1 stabilizes misfolded mutant p53 through a ubiquitin ligase-independent, chaperone regulatory function. Molecular cancer research : MCR (2024)
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A patterned human neural tube model using microfluidic gradients. Nature (2024)
Kyoung Jo, Zong-Yuan Liu, Gauri Patel, Zhiyuan Yu, LiAng Yao, Seth Teague, Craig Johnson, Jason R Spence, Idse Heemskerk
Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids. bioRxiv : the preprint server for biology (2024)
Kyoung Jo, Zong-Yuan Liu, Gauri Patel, Zhiyuan Yu, LiAng Yao, Seth Teague, Craig Johnson, Jason R Spence, Idse Heemskerk
Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids. bioRxiv : the preprint server for biology (2024)
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A patterned human neural tube model using microfluidic gradients. Nature 628 (8007) (2024)
Ji-Hoon Lee, Julia C Lecher, Eric Parigoris, Noriyuki Shinagawa, Jason Sentosa, Candela Manfredi, Shu Ling Goh, Ramyani De, Sijia Tao, Keivan Zandi, Franck Amblard, Eric J Sorscher, Jason R Spence, Rabindra M Tirouvanziam, Raymond F Schinazi, Shuichi Takayama
Stably-Inverted Apical-Out Human Upper Airway Organoids for SARS-CoV-2 Infection and Therapeutic Testing. bioRxiv : the preprint server for biology (2024)
Ji-Hoon Lee, Julia C Lecher, Eric Parigoris, Noriyuki Shinagawa, Jason Sentosa, Candela Manfredi, Shu Ling Goh, Ramyani De, Sijia Tao, Keivan Zandi, Franck Amblard, Eric J Sorscher, Jason R Spence, Rabindra M Tirouvanziam, Raymond F Schinazi, Shuichi Takayama
Development of robust antiviral assays using relevant apical-out human airway organoids. bioRxiv : the preprint server for biology (2024)
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A patterned human neural tube model using microfluidic gradients. Nature 628 (8007) (2024)
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A patterned human neural tube model using microfluidic gradients. Nature 628 (8007) (2024)
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A patterned human neural tube model using microfluidic gradients. Nature (2024)
Ji-Hoon Lee, Julia C Lecher, Eric Parigoris, Noriyuki Shinagawa, Jason Sentosa, Candela Manfredi, Shu Ling Goh, Ramyani De, Sijia Tao, Keivan Zandi, Franck Amblard, Eric J Sorscher, Jason R Spence, Rabindra M Tirouvanziam, Raymond F Schinazi, Shuichi Takayama
Stably-Inverted Apical-Out Human Upper Airway Organoids for SARS-CoV-2 Infection and Therapeutic Testing. bioRxiv : the preprint server for biology (2024)
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A patterned human neural tube model using microfluidic gradients. Nature (2024)
Ji-Hoon Lee, Julia C Lecher, Eric Parigoris, Noriyuki Shinagawa, Jason Sentosa, Candela Manfredi, Shu Ling Goh, Ramyani De, Sijia Tao, Keivan Zandi, Franck Amblard, Eric J Sorscher, Jason R Spence, Rabindra M Tirouvanziam, Raymond F Schinazi, Shuichi Takayama
Development of robust antiviral assays using relevant apical-out human airway organoids. bioRxiv : the preprint server for biology (2024)
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A Patterned Human Neural Tube Model Using Microfluidic Gradients. Nature (2024)
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A patterned human neural tube model using microfluidic gradients. Nature 628 (8007) (2024)
Kyoung Jo, Zong-Yuan Liu, Gauri Patel, Zhiyuan Yu, LiAng Yao, Seth Teague, Craig Johnson, Jason R Spence, Idse Heemskerk
Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids. bioRxiv : the preprint server for biology (2024)
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C K Wong, M Azim Surani, Jason R Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, Jianping Fu
A Patterned Human Neural Tube Model Using Microfluidic Gradients. Nature (2024)
Akaljot Singh, Holly M Poling, Praneet Chaturvedi, Konrad Thorner, Nambirajan Sundaram, Daniel O Kechele, Charlie J Childs, Heather A McCauley, Garrett W Fisher, Nicole E Brown, Jason R Spence, James M Wells, Michael A Helmrath
Transplanted human intestinal organoids: A resource for modeling human intestinal development. Development (Cambridge, England) (2023)
Tristan Frum, Peggy P Hsu, Renee F C Hein, Ansley S Conchola, Charles J Zhang, Olivia R Utter, Abhinav Anand, Yi Zhang, Sydney G Clark, Ian Glass, Jonathan Z Sexton, Jason R Spence
Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung. NPJ Regenerative medicine 8 (1) (2023)
Tristan Frum, Peggy P Hsu, Renee F C Hein, Ansley S Conchola, Charles J Zhang, Olivia R Utter, Abhinav Anand, Yi Zhang, Sydney G Clark, Ian A Glass, Jonathan Z Sexton, Jason R Spence
Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung. bioRxiv : the preprint server for biology (2023)
Tristan Frum, Peggy P Hsu, Renee F C Hein, Ansley S Conchola, Charles J Zhang, Olivia R Utter, Abhinav Anand, Yi Zhang, Sydney G Clark, Ian A Glass, Jonathan Z Sexton, Jason R Spence
Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung. bioRxiv : the preprint server for biology (2023)
Daysha Ferrer-Torres, Joshua H Wu, Charles J Zhang, Max A Hammer, Michael K Dame, Angeline Wu, Emily M Holloway, Kateryna Karpoff, Caroline L McCarthy, Margaret S Bohm, Ashley J Cuttitta, Dominic J Tigani, Sha Huang, Yu-Hwai Tsai, Alyssa J Miller, Taylor Walker, David E Bayer, Simon P Hogan, Danielle Kim Turgeon, Jules Lin, Peter D R Higgins, Jonathan Z Sexton, Jason R Spence
Mapping the adult human esophagus in vivo and in vitro. Development (Cambridge, England) 149 (20) (2022)
Preetish Kadur Lakshminarasimha Murthy, Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Lauren Macadlo, Kenichi Okuda, Ansley S Conchola, Satoko Nakano, Simon Gregory, Lisa A Miller, Jason R Spence, John F Engelhardt, Richard C Boucher, Jason R Rock, Scott H Randell, Purushothama Rao Tata
Human distal lung maps and lineage hierarchies reveal a bipotent progenitor. Nature 604 (7904) (2022)
Kyoung Jo, Seth Teague, Bohan Chen, Hina Aftab Khan, Emily Freeburne, Hunter Li, Bolin Li, Ran Ran, Jason R Spence, Idse Heemskerk
Efficient differentiation of human primordial germ cells through geometric control reveals a key role for Nodal signaling. eLife 11 (2022)
Renee F C Hein, Ansley S Conchola, Alexis S Fine, Zhiwei Xiao, Tristan Frum, Lindy K Brastrom, Mayowa A Akinwale, Charlie J Childs, Yu-Hwai Tsai, Emily M Holloway, Sha Huang, John E Mahoney, Idse Heemskerk, Jason R Spence
Stable iPSC-derived NKX2-1+ lung bud tip progenitor organoids give rise to airway and alveolar cell types. Development (Cambridge, England) 149 (20) (2022)
Charlie J Childs, Madeline K Eiken, Jason R Spence
Approaches to benchmark and characterize in vitro human model systems. Development (Cambridge, England) 149 (20) (2022)
Yu-Chi Shen, Adrienne Niederriter Shami, Lindsay Moritz, Hailey Larose, Gabriel L Manske, Qianyi Ma, Xianing Zheng, Meena Sukhwani, Michael Czerwinski, Caleb Sultan, Haolin Chen, Stephen J Gurczynski, Jason R Spence, Kyle E Orwig, Michelle Tallquist, Jun Z Li, Saher Sue Hammoud
TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice. Nature communications 12 (1) (2021)
Samaneh K Sarvestani, Steven Signs, Bo Hu, Yunku Yeu, Hao Feng, Ying Ni, David R Hill, Robert C Fisher, Sylvain Ferrandon, Reece K DeHaan, Jennifer Stiene, Michael Cruise, Tae Hyun Hwang, Xiling Shen, Jason R Spence, Emina H Huang
Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity. Nature communications 12 (1) (2021)
Renee F Conway, Tristan Frum, Ansley S Conchola, Jason R Spence
Understanding Human Lung Development through In Vitro Model Systems. BioEssays : news and reviews in molecular, cellular and developmental biology 42 (6) (2020)
Tristan Frum, Jason R Spence
hPSC-derived organoids: models of human development and disease. Journal of molecular medicine (Berlin, Germany) 99 (4) (2020)
Tristan Frum, Jason R Spence
Correction to: hPSC-derived organoids: models of human development and disease. Journal of molecular medicine (Berlin, Germany) (2020)
Sha Wang, James P Roy, Abigail J Tomlinson, Ellen B Wang, Yu-Hwai Tsai, Lisa Cameron, Julie Underwood, Jason R Spence, Katherine D Walton, Steven A Stacker, Deborah L Gumucio, Terry Lechler
RYK-mediated filopodial pathfinding facilitates midgut elongation. Development (Cambridge, England) 147 (20) (2020)
Madeline R Barron, Roberto J Cieza, David R Hill, Sha Huang, Veda K Yadagiri, Jason R Spence, Vincent B Young
The Lumen of Human Intestinal Organoids Poses Greater Stress to Bacteria Compared to the Germ-Free Mouse Intestine: Escherichia coli Deficient in RpoS as a Colonization Probe. mSphere 5 (6) (2020)
Brisa Palikuqi, Duc-Huy T Nguyen, Ge Li, Ryan Schreiner, Alessandro Filippo Pellegata, Ying Liu, David Redmond, Fuqiang Geng, Yang Lin, Jesus Maria Gomez Salinero, Masataka Yokoyama, Paul Zumbo, Tuo Zhang, Balvir Kunar, Mavee Witherspoon, Teng Han, Alfonso M Tedeschi, Federico Scottoni, Steven M Lipkin, Lukas E Dow, Olivier Elemento, Jenny Z Xiang, Koji Shido, Jason R Spence, Qiao J Zhou, Robert E Schwartz, Paolo de Coppi, Sina Y Rabbany, Shahin Rafii
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis. Nature 585 (7825) (2020)
Emily M Holloway, Meghan M Capeling, Jason R Spence
Biologically inspired approaches to enhance human organoid complexity. Development (Cambridge, England) 146 (8) (2019)
Alyssa J Miller, Briana R Dye, Daysha Ferrer-Torres, David R Hill, Arend W Overeem, Lonnie D Shea, Jason R Spence
Generation of lung organoids from human pluripotent stem cells in vitro. Nature protocols 14 (2) (2019)
Namit Kumar, Yu-Hwai Tsai, Lei Chen, Anbo Zhou, Kushal K Banerjee, Madhurima Saxena, Sha Huang, Natalie H Toke, Jinchuan Xing, Ramesh A Shivdasani, Jason R Spence, Michael P Verzi
The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development. Development (Cambridge, England) 146 (5) (2019)
Michael K Dame, Durga Attili, Shannon D McClintock, Priya H Dedhia, Peter Ouillette, Olaf Hardt, Alana M Chin, Xiang Xue, Julie Laliberte, Erica L Katz, Gina M Newsome, David R Hill, Alyssa J Miller, Yu-Hwai Tsai, David Agorku, Christopher H Altheim, Andreas Bosio, Becky Simon, Linda C Samuelson, Jay A Stoerker, Henry D Appelman, James Varani, Max S Wicha, Dean E Brenner, Yatrik M Shah, Jason R Spence, Justin A Colacino
Identification, isolation and characterization of human LGR5-positive colon adenoma cells. Development (Cambridge, England) 145 (6) (2018)
Rajasree Menon, Edgar A Otto, Austin Kokoruda, Jian Zhou, Zidong Zhang, Euisik Yoon, Yu-Chih Chen, Olga Troyanskaya, Jason R Spence, Matthias Kretzler, Cristina Cebrián
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney. Development (Cambridge, England) 145 (16) (2018)
Ricardo Cruz-Acuña, Miguel Quiros, Attila E Farkas, Priya H Dedhia, Sha Huang, Dorothée Siuda, Vicky García-Hernández, Alyssa J Miller, Jason R Spence, Asma Nusrat, Andres J Garcia
Synthetic hydrogels for human intestinal organoid generation and colonic wound repair. Nature cell biology 19 (11) (2017)
Naoya Sakamoto, Ying Feng, Carmine Stolfi, Yuki Kurosu, Maranne Green, Jeffry Lin, Megan E Green, Kazuhiro Sentani, Wataru Yasui, Martin McMahon, Karin M Hardiman, Jason R Spence, Nobukatsu Horita, Joel K Greenson, Rork Kuick, Kathleen R Cho, Eric R Fearon
BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis. eLife 6 (2017)
David R Hill, Sha Huang, Melinda S Nagy, Veda K Yadagiri, Courtney Fields, Dishari Mukherjee, Brooke Bons, Priya H Dedhia, Alana M Chin, Yu-Hwai Tsai, Shrikar Thodla, Thomas M Schmidt, Seth Walk, Vincent B Young, Jason R Spence
Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium. eLife 6 (2017)
Yu-Hwai Tsai, Roy Nattiv, Priya H Dedhia, Melinda S Nagy, Alana M Chin, Matthew Thomson, Ophir D Klein, Jason R Spence
In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. Development (Cambridge, England) 144 (6) (2016)
Briana R Dye, Priya H Dedhia, Alyssa J Miller, Melinda S Nagy, Eric S White, Lonnie D Shea, Jason R Spence
A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids. eLife 5 (2016)