John M Ketcham

ORCID

Publication Activity (10 Years)

Years Active: 2022-2024
Publications (10 Years): 28

Top Venues

Journal of medicinal chemistry

The Journal of organic chemistry

International journal of molecular sciences

Molecular cancer therapeutics

This page only lists publications with an associated author ORCID identifier.

Publications

Athenea N Aloiau, Briana M Bobek, Kersti Caddell Haatveit, Kelly E Pearson, Ashlee H Watkins, Benjamin Jones, Christopher R Smith, John M Ketcham, Matthew A Marx, Stephen J Harwood
Stereoselective Amine Synthesis Mediated by a Zirconocene Hydride to Accelerate a Drug Discovery Program. The Journal of organic chemistry 89 (6) (2024)
John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry 67 (6) (2024)
John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry 67 (6) (2024)
John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry 67 (6) (2024)
Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos, Lars D Engstrom, Jade Laguer, Andrew Calinisan, Allan Hebbert, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, John M Ketcham, Anthony Ivetac, Christopher R Smith, J David Lawson, Lisa Rahbaek, Jeffrey Clarine, Natalie Nguyen, Barbara Saechao, Cody Parker, Adam J Elliott, Darin Vanderpool, Quanyuan He, Laura D Hover, Julio Fernandez-Banet, Silvia Coma, Jonathan A Pachter, Jill Hallin, Matthew A Marx, David M Briere, James G Christensen, Peter Olson, Jacob Haling, Shilpi Khare
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading. Molecular cancer therapeutics (2024)
Athenea N Aloiau, Briana M Bobek, Kelly E Pearson, Kendall E Cherry, Christopher R Smith, John M Ketcham, Matthew A Marx, Stephen J Harwood
Zirconium Hydride Catalysis Initiated by Tetrabutylammonium Fluoride. The Journal of organic chemistry 89 (16) (2024)
Athenea N Aloiau, Briana M Bobek, Kersti Caddell Haatveit, Kelly E Pearson, Ashlee H Watkins, Benjamin Jones, Christopher R Smith, John M Ketcham, Matthew A Marx, Stephen J Harwood
Stereoselective Amine Synthesis Mediated by a Zirconocene Hydride to Accelerate a Drug Discovery Program. The Journal of organic chemistry 89 (6) (2024)
Athenea N Aloiau, Briana M Bobek, Kersti Caddell Haatveit, Kelly E Pearson, Ashlee H Watkins, Benjamin Jones, Christopher R Smith, John M Ketcham, Matthew A Marx, Stephen J Harwood
Stereoselective Amine Synthesis Mediated by a Zirconocene Hydride to Accelerate a Drug Discovery Program. The Journal of organic chemistry 89 (6) (2024)
Athenea N Aloiau, Briana M Bobek, Kersti Caddell Haatveit, Kelly E Pearson, Ashlee H Watkins, Benjamin Jones, Christopher R Smith, John M Ketcham, Matthew A Marx, Stephen J Harwood
Stereoselective Amine Synthesis Mediated by a Zirconocene Hydride to Accelerate a Drug Discovery Program. The Journal of organic chemistry (2024)
Athenea N Aloiau, Briana M Bobek, Kelly E Pearson, Kendall E Cherry, Christopher R Smith, John M Ketcham, Matthew A Marx, Stephen J Harwood
Zirconium Hydride Catalysis Initiated by Tetrabutylammonium Fluoride. The Journal of organic chemistry (2024)
Athenea N Aloiau, Briana M Bobek, Kersti Caddell Haatveit, Kelly E Pearson, Ashlee H Watkins, Benjamin Jones, Christopher R Smith, John M Ketcham, Matthew A Marx, Stephen J Harwood
Stereoselective Amine Synthesis Mediated by a Zirconocene Hydride to Accelerate a Drug Discovery Program. The Journal of organic chemistry 89 (6) (2024)
Athenea N Aloiau, Briana M Bobek, Kersti Caddell Haatveit, Kelly E Pearson, Ashlee H Watkins, Benjamin Jones, Christopher R Smith, John M Ketcham, Matthew A Marx, Stephen J Harwood
Stereoselective Amine Synthesis Mediated by a Zirconocene Hydride to Accelerate a Drug Discovery Program. The Journal of organic chemistry 89 (6) (2024)
John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry 67 (6) (2024)
John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry (2024)
John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry 67 (6) (2024)
Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos, Lars D Engstrom, Jade Laguer, Andrew Calinisan, Allan Hebbert, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, John M Ketcham, Anthony Ivetac, Christopher R Smith, J David Lawson, Lisa Rahbaek, Jeffrey Clarine, Natalie Nguyen, Barbara Saechao, Cody Parker, Adam J Elliott, Darin Vanderpool, Quanyuan He, Laura D Hover, Julio Fernandez-Banet, Silvia Coma, Jonathan A Pachter, Jill Hallin, Matthew A Marx, David M Briere, James G Christensen, Peter Olson, Jacob Haling, Shilpi Khare
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading. Molecular cancer therapeutics (2024)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Stephen J Harwood, Christopher R Smith, J David Lawson, John M Ketcham
Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway. International journal of molecular sciences 24 (8) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Stephen J Harwood, Christopher R Smith, J David Lawson, John M Ketcham
Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway. International journal of molecular sciences 24 (8) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Stephen J Harwood, Christopher R Smith, J David Lawson, John M Ketcham
Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway. International journal of molecular sciences 24 (8) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
John M Ketcham, Jacob Haling, Shilpi Khare, Vickie Bowcut, David M Briere, Aaron C Burns, Robin J Gunn, Anthony Ivetac, Jon Kuehler, Svitlana Kulyk, Jade Laguer, J David Lawson, Krystal Moya, Natalie Nguyen, Lisa Rahbaek, Barbara Saechao, Christopher R Smith, Niranjan Sudhakar, Nicole C Thomas, Laura Vegar, Darin Vanderpool, Xiaolun Wang, Larry Yan, Peter Olson, James G Christensen, Matthew A Marx
Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. Journal of medicinal chemistry 65 (14) (2022)

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Publication Activity (10 Years)

Top Topics

Top Venues

John M Ketcham