J David Lawson

ORCID

Publication Activity (10 Years)

Years Active: 2022-2024
Publications (10 Years): 21

Top Venues

Journal of medicinal chemistry

RSC medicinal chemistry

Molecular cancer therapeutics

Nature medicine

This page only lists publications with an associated author ORCID identifier.

Publications

John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry 67 (6) (2024)
John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry 67 (6) (2024)
John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry 67 (6) (2024)
Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos, Lars D Engstrom, Jade Laguer, Andrew Calinisan, Allan Hebbert, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, John M Ketcham, Anthony Ivetac, Christopher R Smith, J David Lawson, Lisa Rahbaek, Jeffrey Clarine, Natalie Nguyen, Barbara Saechao, Cody Parker, Adam J Elliott, Darin Vanderpool, Quanyuan He, Laura D Hover, Julio Fernandez-Banet, Silvia Coma, Jonathan A Pachter, Jill Hallin, Matthew A Marx, David M Briere, James G Christensen, Peter Olson, Jacob Haling, Shilpi Khare
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading. Molecular cancer therapeutics (2024)
John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry 67 (6) (2024)
John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry (2024)
John M Ketcham, Stephen J Harwood, Ruth Aranda, Athenea N Aloiau, Briana M Bobek, David M Briere, Aaron C Burns, Kersti Caddell Haatveit, Andrew Calinisan, Jeffery Clarine, Adam Elliott, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Benjamin Jones, Jon Kuehler, J David Lawson, Natalie Nguyen, Cody Parker, Kelly E Pearson, Lisa Rahbaek, Barbara Saechao, Xiaolun Wang, Anna Waters, Laura Waters, Ashlee H Watkins, Peter Olson, Christopher R Smith, James G Christensen, Matthew A Marx
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. Journal of medicinal chemistry 67 (6) (2024)
Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos, Lars D Engstrom, Jade Laguer, Andrew Calinisan, Allan Hebbert, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, John M Ketcham, Anthony Ivetac, Christopher R Smith, J David Lawson, Lisa Rahbaek, Jeffrey Clarine, Natalie Nguyen, Barbara Saechao, Cody Parker, Adam J Elliott, Darin Vanderpool, Quanyuan He, Laura D Hover, Julio Fernandez-Banet, Silvia Coma, Jonathan A Pachter, Jill Hallin, Matthew A Marx, David M Briere, James G Christensen, Peter Olson, Jacob Haling, Shilpi Khare
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading. Molecular cancer therapeutics (2024)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Lars D Engstrom, Ruth Aranda, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, David Trinh, Allan Hebbert, Christopher R Smith, Svitlana Kulyk, J David Lawson, Quanyuan He, Laura D Hover, Julio Fernandez-Banet, Jill Hallin, Darin Vanderpool, David M Briere, Alice Blaj, Matthew A Marx, Jordi Rodon Ahnert, Michael D Offin, Kathryn C Arbour, Melissa Lynne Johnson, David J Kwiatkowski, Pasi A Janne, Candace L Haddox, Kyriakos P Papadopoulos, Jason T Henry, Konstantinos Leventakos, James G Christensen, Ronald Shazer, Peter Olson
MRTX1719 is an MTA-cooperative PRMT5 inhibitor that exhibits synthetic lethality in preclinical models and patients with MTAP deleted cancer. Cancer discovery (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Svitlana Kulyk, Misbha Ud Din Ahmad, Valentina Arkhipova, James G Christensen, Robin J Gunn, Anthony Ivetac, John M Ketcham, Jon Kuehler, J David Lawson, Nicole C Thomas, Xiaolun Wang, Matthew A Marx
Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. RSC medicinal chemistry 13 (12) (2022)
Jill Hallin, Vickie Bowcut, Andrew Calinisan, David M Briere, Lauren Hargis, Lars D Engstrom, Jade Laguer, James Medwid, Darin Vanderpool, Ella Lifset, David Trinh, Natalie Hoffman, Xiaolun Wang, J David Lawson, Robin J Gunn, Christopher R Smith, Nicole C Thomas, Matthew Martinson, Alex Bergstrom, Francis Sullivan, Karyn Bouhana, Shannon Winski, Leo He, Julio Fernandez-Banet, Adam Pavlicek, Jacob R Haling, Lisa Rahbaek, Matthew A Marx, Peter Olson, James G Christensen
Anti-tumor efficacy of a potent and selective non-covalent KRAS<sup>G12D</sup> inhibitor. Nature medicine 28 (10) (2022)
John M Ketcham, Jacob Haling, Shilpi Khare, Vickie Bowcut, David M Briere, Aaron C Burns, Robin J Gunn, Anthony Ivetac, Jon Kuehler, Svitlana Kulyk, Jade Laguer, J David Lawson, Krystal Moya, Natalie Nguyen, Lisa Rahbaek, Barbara Saechao, Christopher R Smith, Niranjan Sudhakar, Nicole C Thomas, Laura Vegar, Darin Vanderpool, Xiaolun Wang, Larry Yan, Peter Olson, James G Christensen, Matthew A Marx
Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. Journal of medicinal chemistry 65 (14) (2022)
Christopher R Smith, Svitlana Kulyk, Misbha Ud Din Ahmad, Valentina Arkhipova, James G Christensen, Robin J Gunn, Anthony Ivetac, John M Ketcham, Jon Kuehler, J David Lawson, Nicole C Thomas, Xiaolun Wang, Matthew A Marx
Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. RSC medicinal chemistry 13 (12) (2022)

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Publication Activity (10 Years)

Top Topics

Top Venues

J David Lawson