Christopher R Smith

Publication Activity (10 Years)

Years Active: 2022-2024
Publications (10 Years): 18

Top Topics

Bioinformatics Analysis

Tyrosine Kinase

Top Venues

Journal of medicinal chemistry

International journal of molecular sciences

RSC medicinal chemistry

Molecular cancer therapeutics

This page only lists publications with an associated author ORCID identifier.

Publications

Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos, Lars D Engstrom, Jade Laguer, Andrew Calinisan, Allan Hebbert, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, John M Ketcham, Anthony Ivetac, Christopher R Smith, J David Lawson, Lisa Rahbaek, Jeffrey Clarine, Natalie Nguyen, Barbara Saechao, Cody Parker, Adam J Elliott, Darin Vanderpool, Quanyuan He, Laura D Hover, Julio Fernandez-Banet, Silvia Coma, Jonathan A Pachter, Jill Hallin, Matthew A Marx, David M Briere, James G Christensen, Peter Olson, Jacob Haling, Shilpi Khare
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading. Molecular cancer therapeutics (2024)
Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos, Lars D Engstrom, Jade Laguer, Andrew Calinisan, Allan Hebbert, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, John M Ketcham, Anthony Ivetac, Christopher R Smith, J David Lawson, Lisa Rahbaek, Jeffrey Clarine, Natalie Nguyen, Barbara Saechao, Cody Parker, Adam J Elliott, Darin Vanderpool, Quanyuan He, Laura D Hover, Julio Fernandez-Banet, Silvia Coma, Jonathan A Pachter, Jill Hallin, Matthew A Marx, David M Briere, James G Christensen, Peter Olson, Jacob Haling, Shilpi Khare
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading. Molecular cancer therapeutics (2024)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Stephen J Harwood, Christopher R Smith, J David Lawson, John M Ketcham
Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway. International journal of molecular sciences 24 (8) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Lars D Engstrom, Ruth Aranda, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, David Trinh, Allan Hebbert, Christopher R Smith, Svitlana Kulyk, J David Lawson, Quanyuan He, Laura D Hover, Julio Fernandez-Banet, Jill Hallin, Darin Vanderpool, David M Briere, Alice Blaj, Matthew A Marx, Jordi Rodon Ahnert, Michael D Offin, Kathryn C Arbour, Melissa Lynne Johnson, David J Kwiatkowski, Pasi A Janne, Candace L Haddox, Kyriakos P Papadopoulos, Jason T Henry, Konstantinos Leventakos, James G Christensen, Ronald Shazer, Peter Olson
MRTX1719 is an MTA-cooperative PRMT5 inhibitor that exhibits synthetic lethality in preclinical models and patients with MTAP deleted cancer. Cancer discovery (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Stephen J Harwood, Christopher R Smith, J David Lawson, John M Ketcham
Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway. International journal of molecular sciences 24 (8) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Stephen J Harwood, Christopher R Smith, J David Lawson, John M Ketcham
Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway. International journal of molecular sciences 24 (8) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Dan Chen, James G Christensen, René Coulombe, James Féthière, Robin J Gunn, Johan Hollander, Benjamin Jones, John M Ketcham, Shilpi Khare, Jon Kuehler, J David Lawson, Matthew A Marx, Peter Olson, Kelly E Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van't Veer, Xiaolun Wang, Anthony Ivetac
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. Journal of medicinal chemistry 67 (1) (2023)
Christopher R Smith, Ruth Aranda, Thomas P Bobinski, David M Briere, Aaron C Burns, James G Christensen, Jeffery Clarine, Lars D Engstrom, Robin J Gunn, Anthony Ivetac, Ronald Jean-Baptiste, John M Ketcham, Masakazu Kobayashi, Jon Kuehler, Svitlana Kulyk, J David Lawson, Krystal Moya, Peter Olson, Lisa Rahbaek, Nicole C Thomas, Xiaolun Wang, Laura M Waters, Matthew A Marx
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. Journal of medicinal chemistry 65 (3) (2022)
Christopher R Smith, Svitlana Kulyk, Misbha Ud Din Ahmad, Valentina Arkhipova, James G Christensen, Robin J Gunn, Anthony Ivetac, John M Ketcham, Jon Kuehler, J David Lawson, Nicole C Thomas, Xiaolun Wang, Matthew A Marx
Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. RSC medicinal chemistry 13 (12) (2022)
Jill Hallin, Vickie Bowcut, Andrew Calinisan, David M Briere, Lauren Hargis, Lars D Engstrom, Jade Laguer, James Medwid, Darin Vanderpool, Ella Lifset, David Trinh, Natalie Hoffman, Xiaolun Wang, J David Lawson, Robin J Gunn, Christopher R Smith, Nicole C Thomas, Matthew Martinson, Alex Bergstrom, Francis Sullivan, Karyn Bouhana, Shannon Winski, Leo He, Julio Fernandez-Banet, Adam Pavlicek, Jacob R Haling, Lisa Rahbaek, Matthew A Marx, Peter Olson, James G Christensen
Anti-tumor efficacy of a potent and selective non-covalent KRAS<sup>G12D</sup> inhibitor. Nature medicine 28 (10) (2022)
Christopher R Smith, Svitlana Kulyk, Misbha Ud Din Ahmad, Valentina Arkhipova, James G Christensen, Robin J Gunn, Anthony Ivetac, John M Ketcham, Jon Kuehler, J David Lawson, Nicole C Thomas, Xiaolun Wang, Matthew A Marx
Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. RSC medicinal chemistry 13 (12) (2022)