Keqiang Ye

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 42

Top Topics

Traumatic Brain Injury

Oxidative Stress

Cognitive Decline

Top Venues

Molecular psychiatry

Nature communications

The EMBO journal

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Tal Frolinger, Funda Korkmaz, Steven Sims, Fazilet Sen, Farhath Sultana, Victoria Laurencin, Liam Cullen, Anusha Rani Pallapati, Avi Liu, Satish Rojekar, Georgii Pevnev, Uliana Cheliadinova, Darya Vasilyeva, Guzel Burganova, Anne Macdonald, Mansi Saxena, Ki Ann Goosens, Clifford Rosen, Orly Barak, Daria Lizneva, Anisa Gumerova, Keqiang Ye, Vitaly Ryu, Tony Yuen, Mone Zaidi
Gene-Dose-Dependent Reduction Fshr Expression Improves Spatial Memory Deficits in Alzheimer's Mice. Research square (2024)
Zhengjiang Qian, ZhiHao Wang, Bowei Li, Xin Meng, Zhonghua Kuang, Yanjiao Li, Yongfeng Yang, Keqiang Ye
Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer's disease. Molecular psychiatry (2024)
Tal Frolinger, Funda Korkmaz, Steven Sims, Fazilet Sen, Farhath Sultana, Victoria Laurencin, Liam Cullen, Anusha Rani Pallapati, Avi Liu, Satish Rojekar, Georgii Pevnev, Uliana Cheliadinova, Darya Vasilyeva, Guzel Burganova, Anne Macdonald, Mansi Saxena, Ki Ann Goosens, Clifford Rosen, Orly Barak, Daria Lizneva, Anisa Gumerova, Keqiang Ye, Vitaly Ryu, Tony Yuen, Mone Zaidi
Gene-Dose-Dependent Reduction Fshr Expression Improves Spatial Memory Deficits in Alzheimer's Mice. Research square (2024)
Jing Xiong, Seong Su Kang, Mengmeng Wang, Zhihao Wang, Yiyuan Xia, Jianming Liao, Xia Liu, Shan Ping Yu, Zhaohui Zhang, Vitaly Ryu, Tony Yuen, Mone Zaidi, Keqiang Ye
FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBPβ/δ-secretase in female mice. Nature communications 14 (1) (2023)
Zhengjiang Qian, Bowei Li, Xin Meng, Jianming Liao, Guangxing Wang, Yanjiao Li, Qian Luo, Keqiang Ye
Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer's disease in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2023)
Yiyuan Xia, Yifan Xiao, Zhi-Hao Wang, Xia Liu, Ashfaqul M Alam, John P Haran, Beth A McCormick, Xiji Shu, Xiao-Chuan Wang, Keqiang Ye
Bacteroides Fragilis in the gut microbiomes of Alzheimer's disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice. Nature communications 14 (1) (2023)
Ashok Iyaswamy, Abhimanyu Thakur, Xin-Jie Guan, Senthilkumar Krishnamoorthi, Tsz Yan Fung, Kejia Lu, Isha Gaurav, Zhijun Yang, Cheng-Fu Su, Kwok-Fai Lau, Kui Zhang, Roy Chun-Laam Ng, Qizhou Lian, King-Ho Cheung, Keqiang Ye, Huanhuan Joyce Chen, Min Li
Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease. Signal transduction and targeted therapy 8 (1) (2023)
Jing Xiong, Seong Su Kang, Zhihao Wang, Xia Liu, Tan-Chun Kuo, Funda Korkmaz, Ashley D Padilla, Sari Miyashita, Pokman Chan, Zhaohui Zhang, Pavel Katsel, Jocoll Burgess, Anisa Gumerova, Kseniia Ievleva, Damini Sant, Shan Ping Yu, Valeriia Muradova, Tal Frolinger, Daria Lizneva, Jameel Iqbal, Ki Ann Goosens, Sakshi Gera, Clifford J Rosen, Vahram Haroutunian, Vitaly Ryu, Tony Yuen, Mone Zaidi, Keqiang Ye
FSH blockade improves cognition in mice with Alzheimer's disease. Nature 603 (7901) (2022)
Jianming Liao, Guiqin Chen, Xia Liu, Zheng Zachory Wei, Shan Ping Yu, Qian-Xue Chen, Keqiang Ye
C/EBPβ/AEP signaling couples atherosclerosis to the pathogenesis of Alzheimer's disease. Molecular psychiatry 27 (7) (2022)
Pai Liu, Zhi-Hao Wang, Seong Su Kang, Xia Liu, Yiyuan Xia, Chi-Bun Chan, Keqiang Ye
High-fat diet-induced diabetes couples to Alzheimer's disease through inflammation-activated C/EBPβ/AEP pathway. Molecular psychiatry 27 (8) (2022)
Guiqin Chen, Eun Hee Ahn, Seong Su Kang, Yiyuan Xia, Xia Liu, Zhaohui Zhang, Keqiang Ye
UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 9 (7) (2022)
Eun Hee Ahn, Xia Liu, Ashfaqul M Alam, Seong Su Kang, Keqiang Ye
Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson's disease. Molecular psychiatry 28 (3) (2022)
Jing Xiong, Jianming Liao, Xia Liu, Zhaohui Zhang, Jonathan Adams, Roberto Pacifici, Keqiang Ye
A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin. Nature communications 13 (1) (2022)
Seong Su Kang, Zhourui Wu, Xia Liu, Laura Edgington-Mitchell, Keqiang Ye
Treating Parkinson's Disease via Activation of BDNF/TrkB Signaling Pathways and Inhibition of Delta-Secretase. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 19 (4) (2022)
Eun Hee Ahn, Xia Liu, Ashfaqul M Alam, Seong Su Kang, Keqiang Ye
Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson's disease. Molecular psychiatry 28 (3) (2022)
Eun Hee Ahn, Xia Liu, Ashfaqul M Alam, Seong Su Kang, Keqiang Ye
Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson's disease. Molecular psychiatry (2022)
Eun Hee Ahn, Xia Liu, Ashfaqul M Alam, Seong Su Kang, Keqiang Ye
Helicobacter hepaticus augmentation triggers Dopaminergic degeneration and motor disorders in mice with Parkinson's disease. Molecular psychiatry 28 (3) (2022)
Eun Hee Ahn, Kecheng Lei, Seong Su Kang, Zhi-Hao Wang, Xia Liu, Wei Hong, Yu Tian Wang, Laura E Edgington-Mitchell, Lingjing Jin, Keqiang Ye
Mitochondrial dysfunction triggers the pathogenesis of Parkinson's disease in neuronal C/EBPβ transgenic mice. Molecular psychiatry (2021)
Chun Chen, Yunzhe Zhou, Hualong Wang, Ashfaqul Alam, Seong Su Kang, Eun Hee Ahn, Xia Liu, Jian-Ping Jia, Keqiang Ye
Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer's disease. The EMBO journal 40 (17) (2021)
Guiqin Chen, Seong Su Kang, Zhihao Wang, Eun Hee Ahn, Yiyuan Xia, Xia Liu, Ivette M Sandoval, Fredric P Manfredsson, Zhaohui Zhang, Keqiang Ye
Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies. Science advances 7 (16) (2021)
Zhourui Wu, Chun Chen, Seong Su Kang, Xia Liu, Xiaohuan Gu, Shan Ping Yu, C Dirk Keene, Liming Cheng, Keqiang Ye
Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 118 (25) (2021)
Seong Su Kang, Eun Hee Ahn, Xia Liu, Matthew Bryson, Gary W Miller, David Weinshenker, Keqiang Ye
ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease. Acta neuropathologica 142 (1) (2021)
Chun Chen, Eun H Ahn, Xia Liu, Zhi-Hao Wang, Shilin Luo, Jianming Liao, Keqiang Ye
Optimized TrkB Agonist Ameliorates Alzheimer's Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase. ACS chemical neuroscience 12 (13) (2021)
Eun Hee Ahn, Seong Su Kang, Qi Qi, Xia Liu, Keqiang Ye
Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 117 (39) (2020)
Mélissa Jasmin, Eun Hee Ahn, Merja H Voutilainen, Joanna Fombonne, Catherine Guix, Tuulikki Viljakainen, Seong Su Kang, Li-Ying Yu, Mart Saarma, Patrick Mehlen, Keqiang Ye
Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features. The EMBO journal 40 (3) (2020)
Seong Su Kang, Eun Hee Ahn, Keqiang Ye
Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease. Experimental & molecular medicine 52 (8) (2020)
Chun Chen, Eun Hee Ahn, Seong Su Kang, Xia Liu, Ashfaqul Alam, Keqiang Ye
Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model. Science advances 6 (31) (2020)
Yiyuan Xia, Zhi-Hao Wang, Jichun Zhang, Xia Liu, Shan Ping Yu, Karen X Ye, Jian-Zhi Wang, Keqiang Ye, Xiao-Chuan Wang
C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease. Molecular psychiatry (2020)
Yiyuan Xia, Zhi-Hao Wang, Pai Liu, Laura Edgington-Mitchell, Xia Liu, Xiao-Chuan Wang, Keqiang Ye
TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies. Molecular psychiatry 26 (7) (2020)
Zhourui Wu, Yiyuan Xia, Zhihao Wang, Seong Su Kang, Kecheng Lei, Xia Liu, Lingjing Jin, Xiaochuan Wang, Liming Cheng, Keqiang Ye
C/EBPβ/δ-secretase signaling mediates Parkinson's disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOB. Molecular psychiatry 26 (2) (2020)
Zhourui Wu, Xia Liu, Liming Cheng, Keqiang Ye
Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice. Cell death & disease 11 (12) (2020)
Eun Hee Ahn, Seong Su Kang, Xia Liu, Guiqin Chen, Zhentao Zhang, Bindu Chandrasekharan, Ashfaqul M Alam, Andrew S Neish, Xuebing Cao, Keqiang Ye
Initiation of Parkinson's disease from gut to brain by δ-secretase. Cell research 30 (1) (2019)
Shuai Zhang, Hao Sheng, Xiaoya Zhang, Qi Qi, Chi Bun Chan, Leilei Li, Changliang Shan, Keqiang Ye
Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation. Cell death & disease 10 (3) (2019)
Xiao-Guang Li, Xiao-Yue Hong, Ya-Li Wang, Shu-Juan Zhang, Jun-Fei Zhang, Xia-Chun Li, Yan-Chao Liu, Dong-Shen Sun, Qiong Feng, Jin-Wang Ye, Yuan Gao, Dan Ke, Qun Wang, Hong-Lian Li, Keqiang Ye, Gong-Ping Liu, Jian-Zhi Wang
Tau accumulation triggers STAT1-dependent memory deficits by suppressing NMDA receptor expression. EMBO reports 20 (6) (2019)
Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P Manfredsson, Ivette M Sandoval, Peter F Johnson, Jianping Jia, Jian-Zhi Wang, Keqiang Ye
Author Correction: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease. Nature communications 10 (1) (2019)
Zhentao Zhang, Xiao-Guang Li, Zhi-Hao Wang, Mingke Song, Shan Ping Yu, Seong Su Kang, Xia Liu, Zhaohui Zhang, Manling Xie, Gong-Ping Liu, Jian-Zhi Wang, Keqiang Ye
δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Molecular psychiatry 26 (2) (2018)
Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P Manfredsson, Ivette M Sandoval, Peter F Johnson, Jianping Jia, Jian-Zhi Wang, Keqiang Ye
C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease. Nature communications 9 (1) (2018)
Shilin Luo, Kecheng Lei, Daxiong Xiang, Keqiang Ye
NQO1 Is Regulated by PTEN in Glioblastoma, Mediating Cell Proliferation and Oxidative Stress. Oxidative medicine and cellular longevity 2018 (2018)
Zhi-Hao Wang, Pai Liu, Xia Liu, Shan Ping Yu, Jian-Zhi Wang, Keqiang Ye
Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies. The Journal of experimental medicine 215 (12) (2018)
Seong Su Kang, Eun Hee Ahn, Zhentao Zhang, Xia Liu, Fredric P Manfredsson, Ivette M Sandoval, Susov Dhakal, P Michael Iuvone, Xuebing Cao, Keqiang Ye
α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease. The EMBO journal 37 (12) (2018)
Zhentao Zhang, Seong Su Kang, Xia Liu, Eun Hee Ahn, Zhaohui Zhang, Li He, P Michael Iuvone, Duc M Duong, Nicholas T Seyfried, Matthew J Benskey, Fredric P Manfredsson, Ling-Jing Jin, Yi E Sun, Jian-Zhi Wang, Keqiang Ye
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease. Nature structural & molecular biology 24 (8) (2017)
Qi Qi, Obiamaka Obianyo, Yuhong Du, Haian Fu, Shiyong Li, Keqiang Ye
Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis. Journal of medicinal chemistry 60 (17) (2017)