László Somsák

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 20

Top Topics

Molecular Docking

Reactive Oxygen Species

Top Venues

International journal of molecular sciences

Molecules (Basel, Switzerland)

Journal of medicinal chemistry

Organic & biomolecular chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Levente Homolya, Rachel T Mathomes, Luca Varga, Tibor Docsa, László Juhász, Joseph M Hayes, László Somsák
Synthesis, In Silico and Kinetics Evaluation of N -(β-d-glucopyranosyl)-2-arylimidazole-4(5)-carboxamides and N -(β-d-glucopyranosyl)-4(5)-arylimidazole-2-carboxamides as Glycogen Phosphorylase Inhibitors. International journal of molecular sciences 25 (9) (2024)
Levente Homolya, Rachel T Mathomes, Luca Varga, Tibor Docsa, László Juhász, Joseph M Hayes, László Somsák
Synthesis, In Silico and Kinetics Evaluation of N -(β-d-glucopyranosyl)-2-arylimidazole-4(5)-carboxamides and N -(β-d-glucopyranosyl)-4(5)-arylimidazole-2-carboxamides as Glycogen Phosphorylase Inhibitors. International journal of molecular sciences 25 (9) (2024)
Sándor Kun, Rachel T Mathomes, Tibor Docsa, László Somsák, Joseph M Hayes
Design and Synthesis of 3-(β-d-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential. Molecules (Basel, Switzerland) 28 (7) (2023)
István Kacsir, Adrienn Sipos, Evelin Major, Nikolett Bajusz, Attila Csaba Bényei, Péter Buglyó, László Somsák, Gábor Kardos, Péter Bai, Éva Bokor
Half-Sandwich Type Platinum-Group Metal Complexes of C -Glucosaminyl Azines: Synthesis and Antineoplastic and Antimicrobial Activities. Molecules (Basel, Switzerland) 28 (7) (2023)
Tímea Kaszás, Balázs Áron Baráth, Bernadett Balázs, Tekla Blága, László Juhász, László Somsák, Marietta Tóth
Coupling Reactions of Anhydro-Aldose Tosylhydrazones with Boronic Acids. Molecules (Basel, Switzerland) 27 (6) (2022)
Éva Bokor, Attila Ferenczi, Mahir Hashimov, Éva Juhász-Tóth, Zsófia Götz, Alshimaa Ibrahim Zaki, László Somsák
First Synthesis of 3-Glycopyranosyl-1,2,4-Triazines and Some Cycloadditions Thereof. Molecules (Basel, Switzerland) 27 (22) (2022)
Mariann Kiss, István Timári, Teréz Barna, Zuzana Mészáros, Kristýna Slámová, Pavla Bojarová, Vladimir Kren, Joseph M Hayes, László Somsák
2-Acetamido-2-deoxy-d-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes. International journal of molecular sciences 23 (3) (2022)
Nándor Kánya, Sándor Kun, László Somsák
Glycopyranosylidene-Spiro-Morpholinones: Evaluation of the Synthetic Possibilities Based on Glyculosonamide Derivatives and a New Method for the Construction of the Morpholine Ring. Molecules (Basel, Switzerland) 27 (22) (2022)
István Kacsir, Adrienn Sipos, Attila Csaba Bényei, Eszter Janka, Péter Buglyó, László Somsák, Péter Bai, Éva Bokor
Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models. International journal of molecular sciences 23 (2) (2022)
István Kacsir, Adrienn Sipos, Gyula Ujlaki, Péter Buglyó, László Somsák, Péter Bai, Éva Bokor
Ruthenium Half-Sandwich Type Complexes with Bidentate Monosaccharide Ligands Show Antineoplastic Activity in Ovarian Cancer Cell Models through Reactive Oxygen Species Production. International journal of molecular sciences 22 (19) (2021)
Ádám Sipos, Eszter Szennyes, Nikolett Éva Hajnal, Sándor Kun, Katalin E Szabó, Karen Uray, László Somsák, Tibor Docsa, Éva Bokor
Dual-Target Compounds against Type 2 Diabetes Mellitus: Proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors. Pharmaceuticals (Basel, Switzerland) 14 (4) (2021)
Tímea Kaszás, Ivett Cservenyák, Éva Juhász-Tóth, Andrea E Kulcsár, Paola Granatino, Ulf J Nilsson, László Somsák, Marietta Tóth
Coupling of N-tosylhydrazones with tetrazoles: synthesis of 2-β-D-glycopyranosylmethyl-5-substituted-2H-tetrazole type glycomimetics. Organic & biomolecular chemistry 19 (3) (2021)
Magdolna Csávás, Dániel Eszenyi, Erika Mező, László Lázár, Nóra Debreczeni, Marietta Tóth, László Somsák, Aniko Borbás
Stereoselective Synthesis of Carbon-Sulfur-Bridged Glycomimetics by Photoinitiated Thiol-Ene Coupling Reactions. International journal of molecular sciences 21 (2) (2020)
David Goyard, Bálint Kónya, Katalin Czifrák, Paolo Larini, Fanny Demontrond, Jérémy Leroy, Sophie Balzarin, Michel Tournier, Didier Tousch, Pierre Petit, Cédric Duret, Patrick Maurel, Tibor Docsa, Pál Gergely, László Somsák, Jean-Pierre Praly, Jacqueline Azay-Milhau, Sébastien Vidal
Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition. Organic & biomolecular chemistry 18 (5) (2020)
János József, Nóra Debreczeni, Dániel Eszenyi, Aniko Borbás, László Juhász, László Somsák
Synthesis and photoinitiated thiol-ene reactions of exo -mannals - a new route to C -β-d-mannosyl derivatives. RSC advances 10 (57) (2020)
Katalin E Szabó, Efthimios Kyriakis, Anna-Maria G Psarra, Aikaterini G Karra, Ádám Sipos, Tibor Docsa, George A Stravodimos, Elisabeth Katsidou, Vassiliki T Skamnaki, Panagiota G V Liggri, Spyros E Zographos, Attila Mándi, Sándor Balázs Király, Tibor Kurtán, Demetrios D Leonidas, László Somsák
Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography. Journal of medicinal chemistry 62 (13) (2019)
Sándor Kun, Nándor Kánya, Norbert Galó, András Páhi, Attila Mándi, Tibor Kurtán, Péter Makleit, Szilvia Veres, Ádám Sipos, Tibor Docsa, László Somsák
Glucopyranosylidene-spiro-benzo[ b][1,4]oxazinones and -benzo[ b][1,4]thiazinones: Synthesis and Investigation of Their Effects on Glycogen Phosphorylase and Plant Growth Inhibition. Journal of agricultural and food chemistry 67 (24) (2019)
Daniel Barr, Eszter Szennyes, Éva Bokor, Ziad H Al-Oanzi, Colin Moffatt, Sándor Kun, Tibor Docsa, Ádám Sipos, Matthew P Davies, Rachel T Mathomes, Timothy J Snape, Loranne Agius, László Somsák, Joseph M Hayes
Identification of C-β-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies. ACS chemical biology 14 (7) (2019)
Sándor Kun, Éva Bokor, Ádám Sipos, Tibor Docsa, László Somsák
Synthesis of New C- and N-β-d-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase. Molecules (Basel, Switzerland) 23 (3) (2018)
Éva Bokor, Efthimios Kyriakis, Theodora G A Solovou, Csenge Koppány, Anastassia L Kantsadi, Katalin E Szabó, Andrea Szakács, George A Stravodimos, Tibor Docsa, Vassiliki T Skamnaki, Spyros E Zographos, Pál Gergely, Demetrios D Leonidas, László Somsák
Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study. Journal of medicinal chemistry 60 (22) (2017)