Ulf J Nilsson (U J Nilsson)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 49

Top Topics

Molecular Dynamics Simulations

Mesenchymal Stem Cells

Acute Lymphoblastic Leukemia

Top Venues

Journal of medicinal chemistry

Journal of immunology (Baltimore, Md. : 1950)

International journal of molecular sciences

This page only lists publications with an associated author ORCID identifier.

Publications

Fredrik R Zetterberg, Kristoffer Peterson, Ulf J Nilsson, Kajsa Andréasson Dahlgren, Carl Diehl, Ian Holyer, Maria Håkansson, Areej Khabut, Barbro Kahl-Knutson, Hakon Leffler, Alison C MacKinnon, James A Roper, Robert J Slack, Reihaneh Zarrizi, Anders Pedersen
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer. Journal of medicinal chemistry 67 (11) (2024)
Henry Kim, Louis Kretz, Céline Ronin, Christina Starck, James A Roper, Barbro Kahl-Knutson, Kristoffer Peterson, Hakon Leffler, Ulf J Nilsson, Anders Pedersen, Fredrik R Zetterberg, Robert J Slack
Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance. International journal of molecular sciences 25 (12) (2024)
Edvin Purić, Ulf J Nilsson, Marko Anderluh
Galectin-8 inhibition and functions in immune response and tumor biology. Medicinal research reviews 44 (5) (2024)
Edvin Purić, Ulf J Nilsson, Marko Anderluh
Galectin-8 inhibition and functions in immune response and tumor biology. Medicinal research reviews (2024)
Henry Kim, Louis Kretz, Céline Ronin, Christina Starck, James A Roper, Barbro Kahl-Knutson, Kristoffer Peterson, Hakon Leffler, Ulf J Nilsson, Anders Pedersen, Fredrik R Zetterberg, Robert J Slack
Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance. International journal of molecular sciences 25 (12) (2024)
Henry Kim, Louis Kretz, Céline Ronin, Christina Starck, James A Roper, Barbro Kahl-Knutson, Kristoffer Peterson, Hakon Leffler, Ulf J Nilsson, Anders Pedersen, Fredrik R Zetterberg, Robert J Slack
Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance. International journal of molecular sciences 25 (12) (2024)
Edvin Purić, Ulf J Nilsson, Marko Anderluh
Galectin-8 inhibition and functions in immune response and tumor biology. Medicinal research reviews 44 (5) (2024)
Sjors van Klaveren, Mujtaba Hassan, Maria Håkansson, Richard E Johnsson, Jessica Larsson, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Tihomir Tomašič, Ulf J Nilsson
Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket. ACS medicinal chemistry letters 15 (8) (2024)
Sjors van Klaveren, Mujtaba Hassan, Maria Håkansson, Richard E Johnsson, Jessica Larsson, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Tihomir Tomašič, Ulf J Nilsson
Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket. ACS medicinal chemistry letters 15 (8) (2024)
Fredrik R Zetterberg, Kristoffer Peterson, Ulf J Nilsson, Kajsa Andréasson Dahlgren, Carl Diehl, Ian Holyer, Maria Håkansson, Areej Khabut, Barbro Kahl-Knutson, Hakon Leffler, Alison C MacKinnon, James A Roper, Robert J Slack, Reihaneh Zarrizi, Anders Pedersen
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer. Journal of medicinal chemistry (2024)
Abdulraouf Ramadan, Zhiyi Cao, Mujtaba Hassan, Fredrik Zetterberg, Ulf J Nilsson, Mihaela Gadjeva, Vijay Rathinam, Noorjahan Panjwani
Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis. Journal of immunology (Baltimore, Md. : 1950) 210 (4) (2023)
Abdulraouf Ramadan, Zhiyi Cao, Mujtaba Hassan, Fredrik Zetterberg, Ulf J Nilsson, Mihaela Gadjeva, Vijay Rathinam, Noorjahan Panjwani
Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis. Journal of immunology (Baltimore, Md. : 1950) (2023)
Mukul Mahanti, Kumar Bhaskar Pal, Rohit Kumar, Markus Schulze, Hakon Leffler, Derek T Logan, Ulf J Nilsson
Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds. Journal of medicinal chemistry (2023)
Fredrik R Zetterberg, Carl Diehl, Maria Håkansson, Barbro Kahl-Knutson, Hakon Leffler, Ulf J Nilsson, Kristoffer Peterson, James A Roper, Robert J Slack
Discovery of Selective and Orally Available Galectin-1 Inhibitors. Journal of medicinal chemistry (2023)
Abdulraouf Ramadan, Zhiyi Cao, Mujtaba Hassan, Fredrik Zetterberg, Ulf J Nilsson, Mihaela Gadjeva, Vijay Rathinam, Noorjahan Panjwani
Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis. Journal of immunology (Baltimore, Md. : 1950) 210 (4) (2023)
Abdulraouf Ramadan, Zhiyi Cao, Mujtaba Hassan, Fredrik Zetterberg, Ulf J Nilsson, Mihaela Gadjeva, Vijay Rathinam, Noorjahan Panjwani
Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis. Journal of immunology (Baltimore, Md. : 1950) 210 (4) (2023)
László Lázár, Anastasia S Tsagkarakou, George Stravodimos, George Kontopidis, Hakon Leffler, Ulf J Nilsson, László Somsák, Demetrios D Leonidas
Strong Binding of C -Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds. Journal of medicinal chemistry (2023)
Abdulraouf Ramadan, Zhiyi Cao, Mujtaba Hassan, Fredrik Zetterberg, Ulf J Nilsson, Mihaela Gadjeva, Vijay Rathinam, Noorjahan Panjwani
Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis. Journal of immunology (Baltimore, Md. : 1950) 210 (4) (2023)
Abdulraouf Ramadan, Zhiyi Cao, Mujtaba Hassan, Fredrik Zetterberg, Ulf J Nilsson, Mihaela Gadjeva, Vijay Rathinam, Noorjahan Panjwani
Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis. Journal of immunology (Baltimore, Md. : 1950) 210 (4) (2023)
Felix Tobola, Martin Lepsik, Syeda Rehana Zia, Hakon Leffler, Ulf J Nilsson, Nina Persson, Anne Imberty, Birgit Wiltschi
Engineering the Ligand Specificity of the Human Galectin-1 by Incorporation of Tryptophan Analogues. Chembiochem : a European journal of chemical biology 23 (5) (2022)
Sjors van Klaveren, Jaka Dernovšek, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Ulf J Nilsson, Tihomir Tomašič
Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors. RSC advances 12 (29) (2022)
Tiago Bozzola, Ulf J Nilsson, Ulf Ellervik
Direct sialic acid 4-OAc substitution by nitrogen, sulfur and carbon nucleophiles with retention of stereochemistry. RSC advances 12 (19) (2022)
Khuchtumur Bum-Erdene, Patrick M Collins, Matthew W Hugo, Somayeh S Tarighat, Fei Fei, Chandan Kishor, Hakon Leffler, Ulf J Nilsson, John Groffen, I Darren Grice, Nora Heisterkamp, Helen Blanchard
Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia. Journal of medicinal chemistry 65 (8) (2022)
Fredrik R Zetterberg, Alison MacKinnon, Thomas Brimert, Lise Gravelle, Richard E Johnsson, Barbro Kahl-Knutson, Hakon Leffler, Ulf J Nilsson, Anders Pedersen, Kristoffer Peterson, James A Roper, Hans Schambye, Robert J Slack, Susan Tantawi
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease. Journal of medicinal chemistry 65 (19) (2022)
Tiago Bozzola, Mariafrancesca Scalise, Christer U Larsson, Michael C Newton-Vesty, Caterina Rovegno, Ankita Mitra, Jonathan Cramer, Weixiao Yuan Wahlgren, Partha Radhakrishnan Santhakumari, Richard E Johnsson, Oliver Schwardt, Beat Ernst, Rosmarie Friemann, Renwick C J Dobson, Cesare Indiveri, Jenny Schelin, Ulf J Nilsson, Ulf Ellervik
Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth. ACS chemical biology 17 (7) (2022)
Dharma Pally, Mallar Banerjee, Shahid Hussain, Rekha V Kumar, Alexandra Petersson, Ebba Rosendal, Ludvig Gunnarsson, Kristoffer Peterson, Hakon Leffler, Ulf J Nilsson, Ramray Bhat
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix. ACS chemical biology 17 (6) (2022)
Sjors van Klaveren, Anders P Sundin, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Ulf J Nilsson, Tihomir Tomašič
Selective Galectin-8N Ligands: The Design and Synthesis of Phthalazinone-d-Galactals. ChemMedChem 17 (6) (2021)
Tímea Kaszás, Ivett Cservenyák, Éva Juhász-Tóth, Andrea E Kulcsár, Paola Granatino, Ulf J Nilsson, László Somsák, Marietta Tóth
Coupling of N-tosylhydrazones with tetrazoles: synthesis of 2-β-D-glycopyranosylmethyl-5-substituted-2H-tetrazole type glycomimetics. Organic & biomolecular chemistry 19 (3) (2021)
Johan Wallerstein, Vilhelm Ekberg, Majda Misini Ignjatović, Rohit Kumar, Octav Caldararu, Kristoffer Peterson, Sven Wernersson, Ulrika Brath, Hakon Leffler, Esko Oksanen, Derek T Logan, Ulf J Nilsson, Ulf Ryde, Mikael Akke
Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C. JACS Au 1 (4) (2021)
Lucía Sanjurjo, Iris A Schulkens, Pauline Touarin, Roy Heusschen, Ed Aanhane, Kitty C M Castricum, Tanja D De Gruijl, Ulf J Nilsson, Hakon Leffler, Arjan W Griffioen, Latifa Elantak, Rory R Koenen, Victor L J L Thijssen
Chemokines modulate glycan binding and the immunoregulatory activity of galectins. Communications biology 4 (1) (2021)
Mujtaba Hassan, Floriane Baussière, Samo Guzelj, Anders P Sundin, Maria Håkansson, Rebeka Kovačič, Hakon Leffler, Tihomir Tomašič, Marko Anderluh, Žiga Jakopin, Ulf J Nilsson
Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain. ACS medicinal chemistry letters 12 (11) (2021)
Olof Stenström, Carl Diehl, Kristofer Modig, Ulf J Nilsson, Mikael Akke
Mapping the energy landscape of protein-ligand binding via linear free energy relationships determined by protein NMR relaxation dispersion. RSC chemical biology 2 (1) (2020)
Chunxia Wu, Can Yong, Qiuju Zhong, Zhouyu Wang, Ulf J Nilsson, Yuanyuan Zhang
Synthesis of tricyclic carbohydrate-benzene hybrids as selective inhibitors of galectin-1 and galectin-8 N-terminal domains. RSC advances 10 (33) (2020)
Klas Erik Bratteby, Edvard Torkelsson, Elina Tampio L'Estrade, Kristoffer Peterson, Vladimir Shalgunov, Mengfei Xiong, Hakon Leffler, Fredrik R Zetterberg, Tomas G Olsson, Nic Gillings, Ulf J Nilsson, Matthias Manfred Herth, Maria Erlandsson
In Vivo Veritas: 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors. Journal of medicinal chemistry 63 (2) (2020)
Alexander Dahlqvist, Axel Furevi, Niklas Warlin, Hakon Leffler, Ulf J Nilsson
Stereo- and regioselective hydroboration of 1-exo-methylene pyranoses: discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors. Beilstein journal of organic chemistry 15 (2019)
Alexander Dahlqvist, Fredrik R Zetterberg, Hakon Leffler, Ulf J Nilsson
Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors. MedChemComm 10 (6) (2019)
Lynda Vuong, Eleni Kouverianou, Claire M Rooney, Brian J McHugh, Sarah E M Howie, Christopher D Gregory, Stuart J Forbes, Neil Cowan Henderson, Fredrik R Zetterberg, Ulf J Nilsson, Hakon Leffler, Paul Ford, Anders Pedersen, Lise Gravelle, Susan Tantawi, Hans Schambye, Tariq Sethi, Alison C MacKinnon
An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade. Cancer research 79 (7) (2019)
Ž Bojić-Trbojević, M Jovanović Krivokuća, A Vilotić, N Kolundžić, I Stefanoska, Fredrik R Zetterberg, Ulf J Nilsson, Hakon Leffler, Lj Vićovac
Human trophoblast requires galectin-3 for cell migration and invasion. Scientific reports 9 (1) (2019)
John Stegmayr, Fredrik R Zetterberg, Michael C Carlsson, Xiaoli Huang, Gunjan Sharma, Barbro Kahl-Knutson, Hans Schambye, Ulf J Nilsson, Stina Oredsson, Hakon Leffler
Extracellular and intracellular small-molecule galectin-3 inhibitors. Scientific reports 9 (1) (2019)
Maria Luisa Verteramo, Olof Stenström, Majda Misini Ignjatović, Octav Caldararu, Martin A Olsson, Francesco Manzoni, Hakon Leffler, Esko Oksanen, Derek T Logan, Ulf J Nilsson, Ulf Ryde, Mikael Akke
Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding. Journal of the American Chemical Society 141 (5) (2019)
Kumar Bhaskar Pal, Mukul Mahanti, Hakon Leffler, Ulf J Nilsson
A Galactoside-Binding Protein Tricked into Binding Unnatural Pyranose Derivatives: 3-Deoxy-3-Methyl-Gulosides Selectively Inhibit Galectin-1. International journal of molecular sciences 20 (15) (2019)
Rohit Kumar, Majda Misini Ignjatović, Kristoffer Peterson, Martin Olsson, Hakon Leffler, Ulf Ryde, Ulf J Nilsson, Derek T Logan
Structure and Energetics of Ligand-Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides: Insight into Solvation Effects and Multipolar Interactions. ChemMedChem 14 (16) (2019)
Sauli Haataja, Priya Verma, Ou Fu, Anastassios C Papageorgiou, Sakari Pöysti, Roland J Pieters, Ulf J Nilsson, Jukka Finne
Rationally Designed Chemically Modified Glycodendrimer Inhibits Streptococcus suis Adhesin SadP at Picomolar Concentrations. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (8) (2018)
Kumar Bhaskar Pal, Mukul Mahanti, Ulf J Nilsson
Arynes in the Monoarylation of Unprotected Carbohydrate Amines. Organic letters 20 (3) (2018)
Weixiao Y Wahlgren, Elin Dunevall, Rachel A North, Aviv Paz, Mariafrancesca Scalise, Paola Bisignano, Johan Bengtsson-Palme, Parveen Goyal, Elin Claesson, Rhawnie Caing-Carlsson, Rebecka Andersson, Konstantinos Beis, Ulf J Nilsson, Anne Farewell, Lorena Pochini, Cesare Indiveri, Michael Grabe, Renwick C J Dobson, Jeff Abramson, S Ramaswamy, Rosmarie Friemann
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site. Nature communications 9 (1) (2018)
Kristoffer Peterson, Patrick M Collins, Xiaoli Huang, Barbro Kahl-Knutsson, Sofia Essén, Fredrik R Zetterberg, Stina Oredsson, Hakon Leffler, Helen Blanchard, Ulf J Nilsson
Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands. RSC advances 8 (44) (2018)
Kristoffer Peterson, Rohit Kumar, Olof Stenström, Priya Verma, Prashant R Verma, Maria Håkansson, Barbro Kahl-Knutsson, Fredrik Zetterberg, Hakon Leffler, Mikael Akke, Derek T Logan, Ulf J Nilsson
Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity. Journal of medicinal chemistry 61 (3) (2018)
Jérémy Magescas, Lucie Sengmanivong, Amandine Viau, Adeline Mayeux, Tien Dang, Martine Burtin, Ulf J Nilsson, Hakon Leffler, Françoise Poirier, Fabiola Terzi, Delphine Delacour
Spindle pole cohesion requires glycosylation-mediated localization of NuMA. Scientific reports 7 (1) (2017)
A-L Noresson, O Aurelius, C T Öberg, O Engström, A P Sundin, M Håkansson, Olof Stenström, M Akke, Derek T Logan, Hakon Leffler, Ulf J Nilsson
Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions. Chemical science 9 (4) (2017)