Lori L Isom (Lori Isom)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 30

Top Venues

Molecular pharmacology

Brain communications

Annals of clinical and translational neurology

Nature neuroscience

University of Michigan Medical School

Vanderbilt University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Michigan Medical School Oct 01 2015

United States

Maurice H. Seevers Professor and Chair of Pharmacology :: Pharmacology

University of Michigan

United States

Professor :: Pharmacology

University of Michigan - Oct 01 2015

United States

Interim Chair :: Pharmacology

University of Michigan

United States

Assistant Dean for Graduate Education :: Medical School

University of Michigan

United States

Director :: Program in Biomedical Sciences

University of Washington

United States

Lecturer :: Pharmacology

Education History

Vanderbilt University

United States

PHD :: Pharmacology

Publications

Nicholas Denomme, Ciria C Hernandez, Hailey A Bock, Rachel F Ohana, Shreeya Bakshi, Alexander M Sherwood, John D McCorvy, Paul F Daley, Wyeth B Callaway, Jacob M Hull, Andrew Alt, Lori L Isom, Nicholas V Cozzi
N -(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels. Molecular pharmacology 106 (2) (2024)
Nicholas Denomme, Ciria C Hernandez, Hailey A Bock, Rachel F Ohana, Shreeya Bakshi, Alexander M Sherwood, John D McCorvy, Paul F Daley, Wyeth B Callaway, Jacob M Hull, Andrew Alt, Lori L Isom, Nicholas V Cozzi
XOB: A novel phenylalkylamine antagonist of 5-HT 2A receptors and voltage-gated sodium channels. Molecular pharmacology (2024)
Nicholas Denomme, Ciria C Hernandez, Hailey A Bock, Rachel F Ohana, Shreeya Bakshi, Alexander M Sherwood, John D McCorvy, Paul F Daley, Wyeth B Callaway, Jacob M Hull, Andrew Alt, Lori L Isom, Nicholas V Cozzi
N -(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels. Molecular pharmacology 106 (2) (2024)
Johannes W Hell, Stefan Herlitze, Lori L Isom, Amy Lee, Vladimir Yarov-Yarovoy
William Albert Catterall (1946-2024). Nature neuroscience 27 (6) (2024)
Johannes W Hell, Stefan Herlitze, Lori L Isom, Amy Lee, Vladimir Yarov-Yarovoy
William Albert Catterall (1946-2024). Nature neuroscience 27 (6) (2024)
Nicholas Denomme, Ciria C Hernandez, Hailey A Bock, Rachel F Ohana, Shreeya Bakshi, Alexander M Sherwood, John D McCorvy, Paul F Daley, Wyeth B Callaway, Jacob M Hull, Andrew Alt, Lori L Isom, Nicholas V Cozzi
N -(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels. Molecular pharmacology 106 (2) (2024)
Nicholas Denomme, Ciria C Hernandez, Hailey A Bock, Rachel F Ohana, Shreeya Bakshi, Alexander M Sherwood, John D McCorvy, Paul F Daley, Wyeth B Callaway, Jacob M Hull, Andrew Alt, Lori L Isom, Nicholas V Cozzi
N -(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels. Molecular pharmacology 106 (2) (2024)
Johannes W Hell, Stefan Herlitze, Lori L Isom, Amy Lee, Vladimir Yarov-Yarovoy
William Albert Catterall (1946-2024). Nature neuroscience (2024)
Lori L Isom
Memorial Tribute to William Albert Catterall (1946-2024). Molecular pharmacology 106 (1) (2024)
Nicholas Denomme, Ciria C Hernandez, Hailey A Bock, Rachel F Ohana, Shreeya Bakshi, Alexander M Sherwood, John D McCorvy, Paul F Daley, Wyeth B Callaway, Jacob M Hull, Andrew Alt, Lori L Isom, Nicholas V Cozzi
N -(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels. Molecular pharmacology 106 (2) (2024)
Chunling Chen, Julie Ziobro, Larissa Robinson-Cooper, Samantha L Hodges, Yan Chen, Nnamdi Edokobi, Luis Lopez-Santiago, Karl Habig, Chloe Moore, Joe Minton, Sabrina Bramson, Caroline Scheuing, Noor Daddo, Katalin Štěrbová, Sarah Weckhuysen, Jack M Parent, Lori L Isom
Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B -linked developmental and epileptic encephalopathy. Brain communications 5 (6) (2023)
Chunling Chen, Julie Ziobro, Larissa Robinson-Cooper, Samantha L Hodges, Yan Chen, Nnamdi Edokobi, Luis Lopez-Santiago, Karl Habig, Chloe Moore, Joe Minton, Sabrina Bramson, Caroline Scheuing, Noor Daddo, Katalin Štěrbová, Sarah Weckhuysen, Jack M Parent, Lori L Isom
Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B -linked developmental and epileptic encephalopathy. Brain communications 5 (6) (2023)
Yukun Yuan, Luis Lopez-Santiago, Nicholas Denomme, Chunling Chen, Heather A O'Malley, Samantha L Hodges, Sophina Ji, Zhou Han, Anne Christiansen, Lori L Isom
ASO restores excitability, GABA signalling and sodium current density in a model of Dravet syndrome. Brain : a journal of neurology (2023)
Chunling Chen, Julie Ziobro, Larissa Robinson-Cooper, Samantha L Hodges, Yan Chen, Nnamdi Edokobi, Luis Lopez-Santiago, Karl Habig, Chloe Moore, Joe Minton, Sabrina Bramson, Caroline Scheuing, Noor Daddo, Katalin Štěrbová, Sarah Weckhuysen, Jack M Parent, Lori L Isom
Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B -linked developmental and epileptic encephalopathy. Brain communications 5 (6) (2023)
Chunling Chen, Julie Ziobro, Larissa Robinson-Cooper, Samantha L Hodges, Yan Chen, Nnamdi Edokobi, Luis Lopez-Santiago, Karl Habig, Chloe Moore, Joe Minton, Sabrina Bramson, Caroline Scheuing, Noor Daddo, Katalin Štěrbová, Sarah Weckhuysen, Jack M Parent, Lori L Isom
Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B -linked developmental and epileptic encephalopathy. Brain communications 5 (6) (2023)
Juliet K Knowles, Ingo Helbig, Cameron S Metcalf, Laura S Lubbers, Lori L Isom, Scott T Demarest, Ethan M Goldberg, Alfred L George, Holger Lerche, Sarah Weckhuysen, Vicky Whittemore, Samuel Frank Berkovic, Daniel H Lowenstein
Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress. Epilepsia 63 (10) (2022)
Samantha L Hodges, Alexandra A Bouza, Lori L Isom
Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules. Pharmacological reviews 74 (4) (2022)
Zhou Han, Chunling Chen, Anne Christiansen, Sophina Ji, Qian Lin, Charles Anumonwo, Chante Liu, Steven C Leiser, null Meena, Isabel Aznarez, Gene Liau, Lori L Isom
Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome. Science translational medicine 12 (558) (2021)
Lori L Isom, Kelly G Knupp
Dravet Syndrome: Novel Approaches for the Most Common Genetic Epilepsy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 18 (3) (2021)
Yao-Chang Tsan, Samuel J DePalma, Yan-Ting Zhao, Adela Capilnasiu, Yu-Wei Wu, Brynn Elder, Isabella Panse, Kathryn Ufford, Daniel L Matera, Sabrina Friedline, Thomas S O'Leary, Nadab Wubshet, Kenneth Kwun Yin Ho, Michael J Previs, David Nordsletten, Lori L Isom, Brendon M Baker, Allen P Liu, Adam S Helms
Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform. Nature communications 12 (1) (2021)
Jacob M Hull, Heather A O'Malley, Chunling Chen, Yukun Yuan, Nicholas Denomme, Alexandra A Bouza, Charles Anumonwo, Luis F Lopez-Santiago, Lori L Isom
Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Annals of clinical and translational neurology 7 (11) (2020)
Alexandra A Bouza, Julie M Philippe, Nnamdi Edokobi, Alexa M Pinsky, James Offord, Jeffrey D Calhoun, Mariana Lopez-Florán, Luis F Lopez-Santiago, Paul M Jenkins, Lori L Isom
Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis. The Journal of biological chemistry 295 (30) (2020)
Heather A O'Malley, Jacob M Hull, Brittany C Clawson, Chunling Chen, Gic Owens-Fiestan, Margaret B Jameson, Sara J Aton, Jack M Parent, Lori L Isom
Scn1b deletion in adult mice results in seizures and SUDEP. Annals of clinical and translational neurology 6 (6) (2019)
Lori L Isom, Karen S Wilcox, Amy Brooks-Kayal
Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conference Power Hour Summary. Epilepsy currents 19 (4) (2019)
Yukun Yuan, Heather A O'Malley, Melissa A Smaldino, Alexandra A Bouza, Jacob M Hull, Lori L Isom
Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome. Scientific reports 9 (1) (2019)
Alec Aeby, Claudine Sculier, Alexandra A Bouza, Brandon Askar, Damien Lederer, Anne-Sofie Schoonjans, Marc Vander Ghinst, Berten Ceulemans, James Offord, Luis F Lopez-Santiago, Lori L Isom
SCN1B-linked early infantile developmental and epileptic encephalopathy. Annals of clinical and translational neurology 6 (12) (2019)
Chunling Chen, Jerrah K Holth, Rosie Bunton-Stasyshyn, Charles K Anumonwo, Miriam H Meisler, Jeffrey L Noebels, Lori L Isom
Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy. Annals of clinical and translational neurology 5 (8) (2018)
Luis F Lopez-Santiago, Yukun Yuan, Jacy L Wagnon, Jacob M Hull, Chad R Frasier, Heather A O'Malley, Miriam H Meisler, Lori L Isom
Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy. Proceedings of the National Academy of Sciences of the United States of America 114 (9) (2017)
Larisa C Kruger, Heather A O'Malley, Jacob M Hull, Amanda Kleeman, Gustavo A Patino, Lori L Isom
β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function. The Journal of neuroscience : the official journal of the Society for Neuroscience 36 (23) (2017)
Chad R Frasier, Jacy L Wagnon, Yangyang Oliver Bao, Luke G McVeigh, Luis F Lopez-Santiago, Miriam H Meisler, Lori L Isom
Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy. Proceedings of the National Academy of Sciences of the United States of America 113 (45) (2016)

Lori L Isom.css-eqlu8i{font-size:small;padding-left:4px;} (Lori Isom)

Publication Activity (10 Years)

Top Topics

Top Venues

Lori L Isom (Lori Isom)