Mark K Schlegel

ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 17

Top Venues

RNA (New York, N.Y.)

Nucleic acids research

Nature biotechnology

Journal of the American Chemical Society

University of Pennsylvania (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

University of Pennsylvania

United States

PHD :: Chemistry

Publications

Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic (S)-Glycol Nucleic Acid (S-GNA) Modification of siRNAs Improves the Safety of RNAi Therapeutics While Maintaining Potency. RNA (New York, N.Y.) (2023)
Shigeo Matsuda, Saikat Bala, Jen-Yu Liao, Dhrubajyoti Datta, Atsushi Mikami, Lauren Woods, Joel M Harp, Jason A Gilbert, Anna Bisbe, Rajar M Manoharan, MaryBeth Kim, Christopher S Theile, Dale C Guenther, Yongfeng Jiang, Saket Agarwal, Rajanikanth Maganti, Mark K Schlegel, Ivan Zlatev, Klaus Charisse, Kallanthottathil G Rajeev, Adam Castoreno, Martin Maier, Maja M Janas, Martin Egli, John C Chaput, Muthiah Manoharan
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs. Journal of the American Chemical Society (2023)
Megha Subramanian, James McIninch, Ivan Zlatev, Mark K Schlegel, Charalambos Kaittanis, Tuyen Nguyen, Saket Agarwal, Timothy Racie, Martha Arbaiza Alvarado, Kelly Wassarman, Thomas S Collins, Tyler Chickering, Christopher R Brown, Karyn Schmidt, Adam B Castoreno, Svetlana Shulga-Morskaya, Elena Stamenova, Kira Buckowing, Daniel Berman, Joseph D Barry, Anna Bisbe, Martin A Maier, Kevin Fitzgerald, Vasant Jadhav
RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes. Nature communications 14 (1) (2023)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Kirk M Brown, Jayaprakash K Nair, Maja M Janas, Yesseinia I Anglero-Rodriguez, Lan T H Dang, Haiyan Peng, Christopher S Theile, Elena Castellanos-Rizaldos, Christopher Brown, Donald Foster, Jeffrey Kurz, Jeffrey Allen, Rajanikanth Maganti, Jing Li, Shigeo Matsuda, Matthew Stricos, Tyler Chickering, Michelle Jung, Kelly Wassarman, Jeff Rollins, Lauren Woods, Alex Kelin, Dale C Guenther, Melissa W Mobley, John Petrulis, Robin McDougall, Timothy Racie, Jessica Bombardier, Diana Cha, Saket Agarwal, Lei Johnson, Yongfeng Jiang, Scott Lentini, Jason Gilbert, Tuyen Nguyen, Samantha Chigas, Sarah LeBlanc, Urjana Poreci, Anne Kasper, Arlin B Rogers, Saeho Chong, Wendell Davis, Jessica E Sutherland, Adam Castoreno, Stuart Milstein, Mark K Schlegel, Ivan Zlatev, Klaus Charisse, Mark Keating, Muthiah Manoharan, Kevin Fitzgerald, Jing-Tao Wu, Martin A Maier, Vasant Jadhav
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates. Nature biotechnology 40 (10) (2022)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Masaaki Akabane-Nakata, Tyler Chickering, Joel M Harp, Mark K Schlegel, Shigeo Matsuda, Martin Egli, Muthiah Manoharan
RNAs Containing Carbocyclic Ribonucleotides. Organic letters 24 (2) (2021)
Mark K Schlegel, Shigeo Matsuda, Christopher R Brown, Joel M Harp, Joseph D Barry, Daniel Berman, Adam Castoreno, Sally Schofield, John Szeto, Muthiah Manoharan, Klaus Charissé, Martin Egli, Martin A Maier
Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs. Nucleic acids research 49 (19) (2021)
Pradeep S Pallan, Terry P Lybrand, Mark K Schlegel, Joel M Harp, Hartmut Jahns, Muthiah Manoharan, Martin Egli
Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost. Biochemistry 59 (49) (2020)
Ivan Zlatev, Adam Castoreno, Christopher R Brown, June Qin, Scott Waldron, Mark K Schlegel, Rohan Degaonkar, Svetlana Shulga-Morskaya, Huilei Xu, Swati Gupta, Shigeo Matsuda, Akin Akinc, Kallanthottathil G Rajeev, Muthiah Manoharan, Martin A Maier, Vasant Jadhav
Reversal of siRNA-mediated gene silencing in vivo. Nature biotechnology 36 (6) (2018)
Mark K Schlegel, Donald J Foster, Alexander V Kel'in, Ivan Zlatev, Anna Bisbe, Muthusamy Jayaraman, Jeremy G Lackey, Kallanthottathil G Rajeev, Klaus Charissé, Joel Harp, Pradeep S Pallan, Martin A Maier, Martin Egli, Muthiah Manoharan
Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA. Journal of the American Chemical Society 139 (25) (2017)

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Publication Activity (10 Years)

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Mark K Schlegel