Muthiah Manoharan

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 42

Top Venues

Nucleic acids research

Organic letters

RNA (New York, N.Y.)

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Mikyung Yu, June Qin, Xiumin Liu, Diane Ramsden, Brian Williams, Ivan Zlatev, Dale Guenther, Shigeo Matsuda, Roxanne Tymon, Justin Darcy, Catrina Wong, Jamie Tsung, Peter Zawaneh, Saeho Chong, Christopher S Theile, Nathan Taneja, Arlin Rogers, Ju Liu, Elena Castellanos-Rizaldos, Sarah Bond, Kawai So, Jason Denoncourt, Adam Castoreno, Muthiah Manoharan, Jing-Tao Wu, Kevin Fitzgerald, Martin A Maier, Vasant Jadhav, Jayaprakash K Nair
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates. Nucleic acids research 52 (10) (2024)
Mikyung Yu, June Qin, Xiumin Liu, Diane Ramsden, Brian Williams, Ivan Zlatev, Dale Guenther, Shigeo Matsuda, Roxanne Tymon, Justin Darcy, Catrina Wong, Jamie Tsung, Peter Zawaneh, Saeho Chong, Christopher S Theile, Nathan Taneja, Arlin Rogers, Ju Liu, Elena Castellanos-Rizaldos, Sarah Bond, Kawai So, Jason Denoncourt, Adam Castoreno, Muthiah Manoharan, Jing-Tao Wu, Kevin Fitzgerald, Martin A Maier, Vasant Jadhav, Jayaprakash K Nair
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates. Nucleic acids research (2024)
Mikyung Yu, June Qin, Xiumin Liu, Diane Ramsden, Brian Williams, Ivan Zlatev, Dale Guenther, Shigeo Matsuda, Roxanne Tymon, Justin Darcy, Catrina Wong, Jamie Tsung, Peter Zawaneh, Saeho Chong, Christopher S Theile, Nathan Taneja, Arlin Rogers, Ju Liu, Elena Castellanos-Rizaldos, Sarah Bond, Kawai So, Jason Denoncourt, Adam Castoreno, Muthiah Manoharan, Jing-Tao Wu, Kevin Fitzgerald, Martin A Maier, Vasant Jadhav, Jayaprakash K Nair
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates. Nucleic acids research 52 (10) (2024)
Krishna N Ganesh, Muthiah Manoharan
Helical Twists in 70 Years of Nucleic Acids Research. ACS omega 9 (20) (2024)
Mikyung Yu, June Qin, Xiumin Liu, Diane Ramsden, Brian Williams, Ivan Zlatev, Dale Guenther, Shigeo Matsuda, Roxanne Tymon, Justin Darcy, Catrina Wong, Jamie Tsung, Peter Zawaneh, Saeho Chong, Christopher S Theile, Nathan Taneja, Arlin Rogers, Ju Liu, Elena Castellanos-Rizaldos, Sarah Bond, Kawai So, Jason Denoncourt, Adam Castoreno, Muthiah Manoharan, Jing-Tao Wu, Kevin Fitzgerald, Martin A Maier, Vasant Jadhav, Jayaprakash K Nair
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates. Nucleic acids research 52 (10) (2024)
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L S Willoughby, Nate Taneja, Jonathan O'Shea, Anna Bisbe, Rajar M Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K Nair, Klaus Charisse, Martin A Maier, Kallanthottathil G Rajeev, Martin Egli, Muthiah Manoharan
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of medicinal chemistry 66 (4) (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L S Willoughby, Nate Taneja, Jonathan O'Shea, Anna Bisbe, Rajar M Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K Nair, Klaus Charisse, Martin A Maier, Kallanthottathil G Rajeev, Martin Egli, Muthiah Manoharan
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of medicinal chemistry (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L S Willoughby, Nate Taneja, Jonathan O'Shea, Anna Bisbe, Rajar M Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K Nair, Klaus Charisse, Martin A Maier, Kallanthottathil G Rajeev, Martin Egli, Muthiah Manoharan
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of medicinal chemistry 66 (4) (2023)
Atanu Ghosh, Masaaki Akabane-Nakata, Jayanta Kundu, Joel M Harp, Mimouna Madaoui, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic letters 25 (6) (2023)
Atanu Ghosh, Masaaki Akabane-Nakata, Jayanta Kundu, Joel M Harp, Mimouna Madaoui, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic letters (2023)
Atanu Ghosh, Masaaki Akabane-Nakata, Jayanta Kundu, Joel M Harp, Mimouna Madaoui, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic letters 25 (6) (2023)
Dhrubajyoti Datta, Christopher S Theile, Kelly Wassarman, June Qin, Tim Racie, Karyn Schmidt, Yongfeng Jiang, Rachel Sigel, Maja M Janas, Martin Egli, Muthiah Manoharan
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex. Chemical communications (Cambridge, England) (2023)
Atanu Ghosh, Masaaki Akabane-Nakata, Jayanta Kundu, Joel M Harp, Mimouna Madaoui, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic letters 25 (6) (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic (S)-Glycol Nucleic Acid (S-GNA) Modification of siRNAs Improves the Safety of RNAi Therapeutics While Maintaining Potency. RNA (New York, N.Y.) (2023)
Atanu Ghosh, Masaaki Akabane-Nakata, Jayanta Kundu, Joel M Harp, Mimouna Madaoui, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic letters 25 (6) (2023)
Shigeo Matsuda, Saikat Bala, Jen-Yu Liao, Dhrubajyoti Datta, Atsushi Mikami, Lauren Woods, Joel M Harp, Jason A Gilbert, Anna Bisbe, Rajar M Manoharan, MaryBeth Kim, Christopher S Theile, Dale C Guenther, Yongfeng Jiang, Saket Agarwal, Rajanikanth Maganti, Mark K Schlegel, Ivan Zlatev, Klaus Charisse, Kallanthottathil G Rajeev, Adam Castoreno, Martin Maier, Maja M Janas, Martin Egli, John C Chaput, Muthiah Manoharan
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs. Journal of the American Chemical Society (2023)
Martin Egli, Muthiah Manoharan
Chemistry, structure and function of approved oligonucleotide therapeutics. Nucleic acids research (2023)
Dhrubajyoti Datta, Christopher S Theile, Kelly Wassarman, June Qin, Tim Racie, Karyn Schmidt, Yongfeng Jiang, Rachel Sigel, Maja M Janas, Martin Egli, Muthiah Manoharan
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex. Chemical communications (Cambridge, England) 59 (42) (2023)
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L S Willoughby, Nate Taneja, Jonathan O'Shea, Anna Bisbe, Rajar M Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K Nair, Klaus Charisse, Martin A Maier, Kallanthottathil G Rajeev, Martin Egli, Muthiah Manoharan
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of medicinal chemistry 66 (4) (2023)
Arnab Das, Atanu Ghosh, Jayanta Kundu, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Studies of High-Affinity Morpholino Oligomers Containing G-Clamp Analogs. The Journal of organic chemistry (2023)
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L S Willoughby, Nate Taneja, Jonathan O'Shea, Anna Bisbe, Rajar M Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K Nair, Klaus Charisse, Martin A Maier, Kallanthottathil G Rajeev, Martin Egli, Muthiah Manoharan
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of medicinal chemistry 66 (4) (2023)
Dale C Guenther, Shohei Mori, Shigeo Matsuda, Jason A Gilbert, Jennifer L S Willoughby, Sarah Hyde, Anna Bisbe, Yongfeng Jiang, Saket Agarwal, Mimouna Madaoui, Maja M Janas, Klaus Charisse, Martin A Maier, Martin Egli, Muthiah Manoharan
Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β- C -methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects. Journal of the American Chemical Society 144 (32) (2022)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Kirk M Brown, Jayaprakash K Nair, Maja M Janas, Yesseinia I Anglero-Rodriguez, Lan T H Dang, Haiyan Peng, Christopher S Theile, Elena Castellanos-Rizaldos, Christopher Brown, Donald Foster, Jeffrey Kurz, Jeffrey Allen, Rajanikanth Maganti, Jing Li, Shigeo Matsuda, Matthew Stricos, Tyler Chickering, Michelle Jung, Kelly Wassarman, Jeff Rollins, Lauren Woods, Alex Kelin, Dale C Guenther, Melissa W Mobley, John Petrulis, Robin McDougall, Timothy Racie, Jessica Bombardier, Diana Cha, Saket Agarwal, Lei Johnson, Yongfeng Jiang, Scott Lentini, Jason Gilbert, Tuyen Nguyen, Samantha Chigas, Sarah LeBlanc, Urjana Poreci, Anne Kasper, Arlin B Rogers, Saeho Chong, Wendell Davis, Jessica E Sutherland, Adam Castoreno, Stuart Milstein, Mark K Schlegel, Ivan Zlatev, Klaus Charisse, Mark Keating, Muthiah Manoharan, Kevin Fitzgerald, Jing-Tao Wu, Martin A Maier, Vasant Jadhav
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates. Nature biotechnology 40 (10) (2022)
Dhrubajyoti Datta, Shohei Mori, Mimouna Madaoui, Kelly Wassarman, Ivan Zlatev, Muthiah Manoharan
Aminooxy Click Chemistry as a Tool for Bis-homo and Bis-hetero Ligand Conjugation to Nucleic Acids. Organic letters 24 (25) (2022)
Mimouna Madaoui, Dhrubajyoti Datta, Kelly Wassarman, Ivan Zlatev, Martin Egli, Bruce S Ross, Muthiah Manoharan
A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups. Organic letters 24 (33) (2022)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Masaaki Akabane-Nakata, Tyler Chickering, Joel M Harp, Mark K Schlegel, Shigeo Matsuda, Martin Egli, Muthiah Manoharan
RNAs Containing Carbocyclic Ribonucleotides. Organic letters 24 (2) (2021)
Mark K Schlegel, Shigeo Matsuda, Christopher R Brown, Joel M Harp, Joseph D Barry, Daniel Berman, Adam Castoreno, Sally Schofield, John Szeto, Muthiah Manoharan, Klaus Charissé, Martin Egli, Martin A Maier
Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs. Nucleic acids research 49 (19) (2021)
Hartmut Jahns, Nate Taneja, Jennifer L S Willoughby, Masaaki Akabane-Nakata, Christopher R Brown, Tuyen Nguyen, Anna Bisbe, Shigeo Matsuda, Matt Hettinger, Rajar M Manoharan, Kallanthottathil G Rajeev, Martin A Maier, Ivan Zlatev, Klaus Charisse, Martin Egli, Muthiah Manoharan
Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo. Nucleic acids research (2021)
Hartmut Jahns, Rohan Degaonkar, Peter Podbevsek, Swati Gupta, Anna Bisbe, Krishna Aluri, John Szeto, Pawan Kumar, Sarah LeBlanc, Tim Racie, Christopher R Brown, Adam Castoreno, Dale C Guenther, Vasant Jadhav, Martin A Maier, Janez Plavec, Martin Egli, Muthiah Manoharan, Ivan Zlatev
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing. Nucleic acids research 49 (18) (2021)
Pradeep S Pallan, Terry P Lybrand, Mark K Schlegel, Joel M Harp, Hartmut Jahns, Muthiah Manoharan, Martin Egli
Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost. Biochemistry 59 (49) (2020)
Pramod Bhingardeve, Bharath Raj Madhanagopal, Hemanth Naick, Prashant Jain, Muthiah Manoharan, Krishna N Ganesh
Receptor-Specific Delivery of Peptide Nucleic Acids Conjugated to Three Sequentially Linked N-Acetyl Galactosamine Moieties into Hepatocytes. The Journal of organic chemistry 85 (14) (2020)
Masaaki Akabane-Nakata, Pawan Kumar, Rajat S Das, Namrata D Erande, Shigeo Matsuda, Martin Egli, Muthiah Manoharan
Synthesis and Biophysical Characterization of RNAs Containing 2'-Fluorinated Northern Methanocarbacyclic Nucleotides. Organic letters 21 (7) (2019)
Martin Egli, Muthiah Manoharan
Re-Engineering RNA Molecules into Therapeutic Agents. Accounts of chemical research 52 (4) (2019)
Wei Hao, Justyna Aleksandra Wojdyla, Rong Zhao, Ruiyun Han, Rajat S Das, Ivan Zlatev, Muthiah Manoharan, Meitian Wang, Sheng Cui
Crystal structure of Middle East respiratory syndrome coronavirus helicase. PLoS pathogens 13 (6) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Muthiah Manoharan